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Norwegian scabies

MedGen UID:
14409
•Concept ID:
C0028425
•
Disease or Syndrome
Synonyms: Crusted scabies; crusted scabies; Norwegian Scabies; seven year itch
SNOMED CT: Norwegian scabies (128870005); Crusted scabies (128870005)
 
Monarch Initiative: MONDO:0001951

Definition

A rare, severe form of scabies that is associated with immunosuppression. It is characterized by an immense number of mites and hyperkeratotic crusted lesions, and is usually accompanied by lymphadenopathy and eosinophilia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNorwegian scabies

Professional guidelines

PubMed

Norwegian Scabies in an Atopic Patient Under Dupilumab Treatment.
Rodriguez-Lago L, Borrego L
Dermatitis 2022 Sep-Oct 01;33(5):e54-e55. Epub 2022 Aug 9 doi: 10.1097/DER.0000000000000926. PMID: 35943363
Clinical diagnosis and treatment of scabies, a neglected tropical disease.
Motswaledi HM
S Afr Fam Pract (2004) 2021 Jul 9;63(1):e1-e6. doi: 10.4102/safp.v63i1.5224. PMID: 34342482Free PMC Article
Controlling scabies in institutional settings: a review of medications, treatment models, and implementation.
Scheinfeld N
Am J Clin Dermatol 2004;5(1):31-7. doi: 10.2165/00128071-200405010-00005. PMID: 14979741

Recent clinical studies

Etiology

A systematic review of immunosuppressive risk factors and comorbidities associated with the development of crusted scabies.
Bergamin G, Hudson J, Currie BJ, Mounsey KE
Int J Infect Dis 2024 Jun;143:107036. Epub 2024 Apr 1 doi: 10.1016/j.ijid.2024.107036. PMID: 38570134
Neonatal Norwegian scabies.
Arun Babu T, Sharmila V, Nagendran P
Trop Doct 2023 Jan;53(1):199-201. Epub 2022 Jun 30 doi: 10.1177/00494755221088449. PMID: 35775149
Mass drug administration campaigns for scabies and impetigo: protocol for a systematic review and meta-analysis.
Ghosh P, Tesfaye W, Manandhar A, Calma T, Bushell M, Oguoma VM, Kosari S, McMillan F, Peterson G, Thomas J
BMJ Paediatr Open 2021;5(1):e001132. Epub 2021 Jun 29 doi: 10.1136/bmjpo-2021-001132. PMID: 34263086Free PMC Article
Scratching the itch: management of scabies in A&E.
Hadfield-Law L
Accid Emerg Nurs 2000 Oct;8(4):230-2. doi: 10.1054/aaen.2000.0171. PMID: 11760327
Scabies in AIDS.
Orkin M
Semin Dermatol 1993 Mar;12(1):9-14. PMID: 8476736

Diagnosis

Neonatal Norwegian scabies.
Arun Babu T, Sharmila V, Nagendran P
Trop Doct 2023 Jan;53(1):199-201. Epub 2022 Jun 30 doi: 10.1177/00494755221088449. PMID: 35775149
Norwegian scabies.
Matsuura H, Senoo A, Saito M, Fujimoto Y
Cleve Clin J Med 2019 Mar;86(3):163-164. doi: 10.3949/ccjm.86a.18081. PMID: 30849040
Scabies, crusted (Norwegian) scabies and the diagnosis of mite sensitisation.
Sánchez-Borges M, González-Aveledo L, Capriles-Hulett A, Caballero-Fonseca F
Allergol Immunopathol (Madr) 2018 May-Jun;46(3):276-280. Epub 2017 Dec 24 doi: 10.1016/j.aller.2017.05.006. PMID: 29279260
Norwegian Scabies.
Burns P, Yang S, Strote J
West J Emerg Med 2015 Jul;16(4):587. Epub 2015 Jul 10 doi: 10.5811/westjem.2015.5.27383. PMID: 26265977Free PMC Article
Neonatal scabies.
Camassa F, Fania M, Ditano G, Silvestris AM, Lomuto M
Cutis 1995 Oct;56(4):210-2. PMID: 8575219

Therapy

Norwegian scabies.
Matsuura H, Senoo A, Saito M, Fujimoto Y
Cleve Clin J Med 2019 Mar;86(3):163-164. doi: 10.3949/ccjm.86a.18081. PMID: 30849040
Norwegian Scabies.
Burns P, Yang S, Strote J
West J Emerg Med 2015 Jul;16(4):587. Epub 2015 Jul 10 doi: 10.5811/westjem.2015.5.27383. PMID: 26265977Free PMC Article
Neonatal scabies.
Camassa F, Fania M, Ditano G, Silvestris AM, Lomuto M
Cutis 1995 Oct;56(4):210-2. PMID: 8575219
Scabies therapy--1993.
Orkin M, Maibach HI
Semin Dermatol 1993 Mar;12(1):22-5. PMID: 7682833
Scabies.
Sterling GB, Janniger CK, Kihiczak G, Schwartz RA, Fox MD
Am Fam Physician 1992 Oct;46(4):1237-41. PMID: 1384301

Prognosis

Crusted (Norwegian) Scabies: Nine-Month Course With Iatrogenic Immunosuppression.
Tolkachjov SN, Davis MDP, Yiannias JA
J Drugs Dermatol 2018 Oct 1;17(10):1131-1133. PMID: 30365596
Novel signal transducer and activator of transcription 1 mutation disrupts small ubiquitin-related modifier conjugation causing gain of function.
Sampaio EP, Ding L, Rose SR, Cruz P, Hsu AP, Kashyap A, Rosen LB, Smelkinson M, Tavella TA, Ferre EMN, Wierman MK, Zerbe CS, Lionakis MS, Holland SM
J Allergy Clin Immunol 2018 May;141(5):1844-1853.e2. Epub 2017 Aug 30 doi: 10.1016/j.jaci.2017.07.027. PMID: 28859974Free PMC Article
Crusted scabies due to indiscriminate use of glucocorticoid therapy in infant.
Lima FCDR, Cerqueira AMM, Guimarães MBS, Padilha CBS, Craide FH, Bombardelli M
An Bras Dermatol 2017 May-Jun;92(3):383-385. doi: 10.1590/abd1806-4841.20174433. PMID: 29186253Free PMC Article
Severe and Norwegian scabies are strongly associated with retroviral (HIV-1/HTLV-1) infection in Bahia, Brazil.
Brites C, Weyll M, Pedroso C, Badaró R
AIDS 2002 Jun 14;16(9):1292-3. doi: 10.1097/00002030-200206140-00015. PMID: 12045498
Neonatal scabies.
Camassa F, Fania M, Ditano G, Silvestris AM, Lomuto M
Cutis 1995 Oct;56(4):210-2. PMID: 8575219

Clinical prediction guides

Norwegian scabies presenting as erythroderma in HIV: A case report.
Paparizos V, Vasalou V, Velissariou E, Kourkounti S, Daskalakis E, Rigopoulos D
Infez Med 2019 Sep 1;27(3):332-335. PMID: 31545779
Crusted scabies mimicking an acrodermatitis continua of Hallopeau.
Roldán-Franco MS, de Nitsch MJY, Sarti HM
Bol Med Hosp Infant Mex 2019;76(4):198-202. doi: 10.24875/BMHIM.19000012. PMID: 31303653
Scabies, crusted (Norwegian) scabies and the diagnosis of mite sensitisation.
Sánchez-Borges M, González-Aveledo L, Capriles-Hulett A, Caballero-Fonseca F
Allergol Immunopathol (Madr) 2018 May-Jun;46(3):276-280. Epub 2017 Dec 24 doi: 10.1016/j.aller.2017.05.006. PMID: 29279260
New insights into disease pathogenesis in crusted (Norwegian) scabies: the skin immune response in crusted scabies.
Walton SF, Beroukas D, Roberts-Thomson P, Currie BJ
Br J Dermatol 2008 Jun;158(6):1247-55. Epub 2008 Apr 12 doi: 10.1111/j.1365-2133.2008.08541.x. PMID: 18422789
Severe and Norwegian scabies are strongly associated with retroviral (HIV-1/HTLV-1) infection in Bahia, Brazil.
Brites C, Weyll M, Pedroso C, Badaró R
AIDS 2002 Jun 14;16(9):1292-3. doi: 10.1097/00002030-200206140-00015. PMID: 12045498

Recent systematic reviews

A systematic review of immunosuppressive risk factors and comorbidities associated with the development of crusted scabies.
Bergamin G, Hudson J, Currie BJ, Mounsey KE
Int J Infect Dis 2024 Jun;143:107036. Epub 2024 Apr 1 doi: 10.1016/j.ijid.2024.107036. PMID: 38570134

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