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Neonatal anemia

MedGen UID:
1530
•Concept ID:
C0002891
•
Disease or Syndrome
Synonyms: Anemia Neonatorum; Anemia, Neonatal; Anemias, Neonatal; Neonatal Anemia; Neonatal Anemias
SNOMED CT: Neonatal anemia (234350007)
 
Monarch Initiative: MONDO:0001240

Definition

The mildest form of erythroblastosis fetalis in which anemia is the chief manifestation. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal anemia

Professional guidelines

PubMed

Prenatal Diagnosis of Vasa Previa: Outpatient versus Inpatient Management.
Fishel Bartal M, Sibai BM, Ilan H, Katz S, Schushan Eisen I, Kassif E, Yoeli R, Yinon Y, Mazaki-Tovi S
Am J Perinatol 2019 Mar;36(4):422-427. Epub 2018 Aug 21 doi: 10.1055/s-0038-1669396. PMID: 30130820
Management and prevention of neonatal anemia: current evidence and guidelines.
von Lindern JS, Lopriore E
Expert Rev Hematol 2014 Apr;7(2):195-202. Epub 2014 Feb 13 doi: 10.1586/17474086.2014.878225. PMID: 24524256
Differential diagnosis and management of anemia in the newborn.
Bizzarro MJ, Colson E, Ehrenkranz RA
Pediatr Clin North Am 2004 Aug;51(4):1087-107, xi. doi: 10.1016/j.pcl.2004.03.006. PMID: 15275990

Recent clinical studies

Etiology

Placental abruption and neonatal anemia.
Tweddell SM, Bahr TM, Henry E, Page JM, Ilstrup SJ, Ohls RK, Christensen RD
J Perinatol 2023 Jun;43(6):782-786. Epub 2023 Jan 17 doi: 10.1038/s41372-023-01603-w. PMID: 36650233
Does placental abruption cause neonatal anemia?
Bruinsma MAW, de Boer MA, Prins S, Abheiden CNH
Acta Obstet Gynecol Scand 2022 Aug;101(8):917-922. Epub 2022 May 18 doi: 10.1111/aogs.14376. PMID: 35582929Free PMC Article
Management and prevention of neonatal anemia: current evidence and guidelines.
von Lindern JS, Lopriore E
Expert Rev Hematol 2014 Apr;7(2):195-202. Epub 2014 Feb 13 doi: 10.1586/17474086.2014.878225. PMID: 24524256
Perinatal and neonatal risk factors for autism: a comprehensive meta-analysis.
Gardener H, Spiegelman D, Buka SL
Pediatrics 2011 Aug;128(2):344-55. Epub 2011 Jul 11 doi: 10.1542/peds.2010-1036. PMID: 21746727Free PMC Article
Anemia of prematurity.
Salsbury DC
Neonatal Netw 2001 Aug;20(5):13-20. doi: 10.1891/0730-0832.20.5.13. PMID: 12144218

Diagnosis

Neonatal Anemia.
German KR, Juul SE
Curr Pediatr Rev 2023;19(4):388-394. doi: 10.2174/1573396319666221121140627. PMID: 36411551
Severe Neonatal Anemia Due to Spontaneous Massive Fetomaternal Hemorrhage at Term: An Illustrative Case with Suspected Antenatal Diagnosis and Brief Review of Current Knowledge.
Gică N, Botezatu R, Demetrian M, Vayna AM, Cimpoca-Raptis BA, Ciobanu AM, Gica C, Peltecu G, Panaitescu AM
Medicina (Kaunas) 2021 Nov 23;57(12) doi: 10.3390/medicina57121285. PMID: 34946230Free PMC Article
Hemolytic Disease of the Fetus and Newborn: Historical and Current State.
Jackson ME, Baker JM
Clin Lab Med 2021 Mar;41(1):133-151. Epub 2020 Dec 24 doi: 10.1016/j.cll.2020.10.009. PMID: 33494881
Anemia and transfusion in the neonate.
Colombatti R, Sainati L, Trevisanuto D
Semin Fetal Neonatal Med 2016 Feb;21(1):2-9. Epub 2015 Dec 28 doi: 10.1016/j.siny.2015.12.001. PMID: 26732078
Neonatal anemia.
Aher S, Malwatkar K, Kadam S
Semin Fetal Neonatal Med 2008 Aug;13(4):239-47. Epub 2008 Apr 14 doi: 10.1016/j.siny.2008.02.009. PMID: 18411074

Therapy

Anemia, Iron Supplementation, and the Brain.
Gisslen T, Rao R, Georgieff MK
Clin Perinatol 2023 Dec;50(4):853-868. Epub 2023 Aug 31 doi: 10.1016/j.clp.2023.07.009. PMID: 37866852Free PMC Article
Neonatal Anemia.
German KR, Juul SE
Curr Pediatr Rev 2023;19(4):388-394. doi: 10.2174/1573396319666221121140627. PMID: 36411551
Anemia and transfusion in the neonate.
Colombatti R, Sainati L, Trevisanuto D
Semin Fetal Neonatal Med 2016 Feb;21(1):2-9. Epub 2015 Dec 28 doi: 10.1016/j.siny.2015.12.001. PMID: 26732078
Perinatal and neonatal risk factors for autism: a comprehensive meta-analysis.
Gardener H, Spiegelman D, Buka SL
Pediatrics 2011 Aug;128(2):344-55. Epub 2011 Jul 11 doi: 10.1542/peds.2010-1036. PMID: 21746727Free PMC Article
Neonatal anemia.
Aher S, Malwatkar K, Kadam S
Semin Fetal Neonatal Med 2008 Aug;13(4):239-47. Epub 2008 Apr 14 doi: 10.1016/j.siny.2008.02.009. PMID: 18411074

Prognosis

Neonatal outcomes following intrauterine transfusion for hemolytic disease of the fetus and newborn: a twenty-year service review.
Blyth U, Larsson M, Baird A, Waring G, Athiraman N
J Matern Fetal Neonatal Med 2022 Dec;35(25):10220-10225. Epub 2022 Sep 18 doi: 10.1080/14767058.2022.2122041. PMID: 36121063
Performance of the Kleihauer Betke test in the prediction of neonatal anemia.
Bataille P, Petit L, Winer N
J Matern Fetal Neonatal Med 2022 Oct;35(19):3670-3676. Epub 2020 Oct 26 doi: 10.1080/14767058.2020.1837768. PMID: 33106065
The contribution of red blood cell transfusion to neonatal morbidity and mortality.
Crawford TM, Andersen CC, Hodyl NA, Robertson SA, Stark MJ
J Paediatr Child Health 2019 Apr;55(4):387-392. Epub 2019 Feb 8 doi: 10.1111/jpc.14402. PMID: 30737849
Clinical and research issues in neonatal anemia and thrombocytopenia.
Sallmon H, Sola-Visner M
Curr Opin Pediatr 2012 Feb;24(1):16-22. doi: 10.1097/MOP.0b013e32834ee5cc. PMID: 22227780
Anemia of prematurity. Current concepts in the issue of when to transfuse.
Stockman JA 3rd
Pediatr Clin North Am 1986 Feb;33(1):111-28. doi: 10.1016/s0031-3955(16)34972-0. PMID: 3513096

Clinical prediction guides

Effect of placenta previa on umbilical cord hematocrit value.
Halici-Ozturk F, Beyazit F, Yakut K, Yücel Yetiskin FD, Öztürk M, Sinaci S, Caglar AT
J Matern Fetal Neonatal Med 2022 Dec;35(26):10362-10367. Epub 2022 Sep 29 doi: 10.1080/14767058.2022.2128651. PMID: 36176062
Severe neonatal anemia affected by massive fetomaternal hemorrhage: a single-center retrospective observational study.
Tao E, Ye D, Long G, Hu Y, Fu Q, Yuan T, Jiang M
J Matern Fetal Neonatal Med 2022 Oct;35(20):3972-3978. Epub 2020 Nov 12 doi: 10.1080/14767058.2020.1845313. PMID: 33183095
Performance of the Kleihauer Betke test in the prediction of neonatal anemia.
Bataille P, Petit L, Winer N
J Matern Fetal Neonatal Med 2022 Oct;35(19):3670-3676. Epub 2020 Oct 26 doi: 10.1080/14767058.2020.1837768. PMID: 33106065
Variations in reported outcomes in studies on vasa previa: a systematic review.
Villani LA, Pavalagantharajah S, D'Souza R
Am J Obstet Gynecol MFM 2020 Aug;2(3):100116. Epub 2020 Apr 16 doi: 10.1016/j.ajogmf.2020.100116. PMID: 33345867
Perinatal and neonatal risk factors for autism: a comprehensive meta-analysis.
Gardener H, Spiegelman D, Buka SL
Pediatrics 2011 Aug;128(2):344-55. Epub 2011 Jul 11 doi: 10.1542/peds.2010-1036. PMID: 21746727Free PMC Article

Recent systematic reviews

Perinatal outcome of pregnancy complicated by twin anemia-polycythemia sequence: systematic review and meta-analysis.
Giorgione V, D'antonio F, Manji A, Reed K, Khalil A
Ultrasound Obstet Gynecol 2021 Dec;58(6):813-823. doi: 10.1002/uog.23585. PMID: 33428243
Variations in reported outcomes in studies on vasa previa: a systematic review.
Villani LA, Pavalagantharajah S, D'Souza R
Am J Obstet Gynecol MFM 2020 Aug;2(3):100116. Epub 2020 Apr 16 doi: 10.1016/j.ajogmf.2020.100116. PMID: 33345867
Immunoglobulin for alloimmune hemolytic disease in neonates.
Zwiers C, Scheffer-Rath ME, Lopriore E, de Haas M, Liley HG
Cochrane Database Syst Rev 2018 Mar 18;3(3):CD003313. doi: 10.1002/14651858.CD003313.pub2. PMID: 29551014Free PMC Article
Early erythropoiesis-stimulating agents in preterm or low birth weight infants.
Ohlsson A, Aher SM
Cochrane Database Syst Rev 2017 Nov 16;11(11):CD004863. doi: 10.1002/14651858.CD004863.pub5. PMID: 29145693Free PMC Article
Immunoglobulin infusion for isoimmune haemolytic jaundice in neonates.
Alcock GS, Liley H
Cochrane Database Syst Rev 2002;(3):CD003313. doi: 10.1002/14651858.CD003313. PMID: 12137687

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