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Abnormal buccal mucosa cell morphology

MedGen UID:
1617669
•Concept ID:
C4531098
•
Anatomical Abnormality
HPO: HP:0031476

Definition

Any structural anomaly of the cells of the mucosa of the oral cavity in the region of the cheek (buccal mucosa cells). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal buccal mucosa cell morphology

Professional guidelines

PubMed

Genotoxic and cytotoxic effects of Haas appliance in exfoliated buccal mucosa cells during orthodontic treatment.
Cunha AS, Castillo WO, Takahashi CS, Küchler EC, Segato RAB, da Silva LAB, Romano FL, Matsumoto MAN, Nelson-Filho P
Angle Orthod 2018 Sep;88(5):590-595. Epub 2018 May 15 doi: 10.2319/101117-687.1. PMID: 29761706Free PMC Article
Pre-cancer risk assessment in habitual smokers from DIC images of oral exfoliative cells using active contour and SVM analysis.
Dey S, Sarkar R, Chatterjee K, Datta P, Barui A, Maity SP
Tissue Cell 2017 Apr;49(2 Pt B):296-306. Epub 2017 Feb 9 doi: 10.1016/j.tice.2017.01.009. PMID: 28222889
The XXY (Klinefelter's) syndrome in childhood: detection and treatment.
Caldwell PD, Smith DW
J Pediatr 1972 Feb;80(2):250-8. doi: 10.1016/s0022-3476(72)80586-9. PMID: 5008821

Recent clinical studies

Etiology

Age features of buccal epithelium in practically healthy people.
Bazarnyi VV, Mandra YV, Sidenkova AP, Polushina LG, Maksimova AY, Sementsova EA, Svetlakova EN, Nasretdinova NY, Kotikova AY
Klin Lab Diagn 2022 Jun 20;67(6):345-349. doi: 10.51620/0869-2084-2022-67-6-345-349. PMID: 35749599
Human papillomavirus and Chlamydia trachomatis in oral and genital mucosa of women with normal and abnormal cervical cytology.
Mosmann JP, Zayas S, Kiguen AX, Venezuela RF, Rosato O, Cuffini CG
BMC Infect Dis 2021 May 5;21(1):422. doi: 10.1186/s12879-021-06118-3. PMID: 33952203Free PMC Article
Characteristics of lingual papillae in diabetic rats.
Ortug G, Ignak S, Ortug A
Morphologie 2018 Dec;102(339):250-254. Epub 2018 Sep 13 doi: 10.1016/j.morpho.2018.08.003. PMID: 30219545
Cytogenetic damage in the buccal cells of photocopying workers in Lahore, Pakistan.
Javed H, Ghani N
J Pak Med Assoc 2017 Feb;67(2):275-279. PMID: 28138185
Nuclear abnormalities in buccal mucosa cells of patients with type I and II diabetes treated with folic acid.
Gómez-Meda BC, Zamora-Perez AL, Muñoz-Magallanes T, Sánchez-Parada MG, García Bañuelos JJ, Guerrero-Velázquez C, Sánchez-Orozco LV, Vera-Cruz JM, Armendáriz-Borunda J, Zúñiga-González GM
Mutat Res Genet Toxicol Environ Mutagen 2016 Feb;797:1-8. Epub 2015 Dec 18 doi: 10.1016/j.mrgentox.2015.12.003. PMID: 26921015

Diagnosis

Adult stem cells in endometrial regeneration: Molecular insights and clinical applications.
Lv Q, Wang L, Luo X, Chen X
Mol Reprod Dev 2021 Jun;88(6):379-394. Epub 2021 May 20 doi: 10.1002/mrd.23476. PMID: 34014590Free PMC Article
Tissue-engineered oral mucosa.
Moharamzadeh K, Colley H, Murdoch C, Hearnden V, Chai WL, Brook IM, Thornhill MH, Macneil S
J Dent Res 2012 Jul;91(7):642-50. Epub 2012 Jan 19 doi: 10.1177/0022034511435702. PMID: 22266525
The buccal cytome and micronucleus frequency is substantially altered in Down's syndrome and normal ageing compared to young healthy controls.
Thomas P, Harvey S, Gruner T, Fenech M
Mutat Res 2008 Feb 1;638(1-2):37-47. Epub 2007 Sep 1 doi: 10.1016/j.mrfmmm.2007.08.012. PMID: 17920640
Single-cell analysis of unstable genes.
Daniels R, Holding C, Kontogianni E, Monk M
J Assist Reprod Genet 1996 Feb;13(2):163-9. doi: 10.1007/BF02072539. PMID: 8688590
Hereditary mucoepithelial dysplasia.
Rogers M, Kourt G, Cameron A
Pediatr Dermatol 1994 Jun;11(2):133-8. doi: 10.1111/j.1525-1470.1994.tb00567.x. PMID: 8041653

Therapy

Use of liquid-based cytology samples reveals genomic instability and cell death in patients undergoing orthodontic treatment.
Carrillo-Novia I, Lara-Carrillo E, Torres-Bugarin O, Morales-Valenzuela AA, Salmerón-Valdés EN, Hegazy-Hassan W, Velázquez-Enríquez U, Toral-Rizo VH
J Oral Sci 2023 Jan 11;65(1):24-28. Epub 2022 Dec 16 doi: 10.2334/josnusd.22-0235. PMID: 36529513
Characteristics of lingual papillae in diabetic rats.
Ortug G, Ignak S, Ortug A
Morphologie 2018 Dec;102(339):250-254. Epub 2018 Sep 13 doi: 10.1016/j.morpho.2018.08.003. PMID: 30219545
Genotoxic and cytotoxic effects of Haas appliance in exfoliated buccal mucosa cells during orthodontic treatment.
Cunha AS, Castillo WO, Takahashi CS, Küchler EC, Segato RAB, da Silva LAB, Romano FL, Matsumoto MAN, Nelson-Filho P
Angle Orthod 2018 Sep;88(5):590-595. Epub 2018 May 15 doi: 10.2319/101117-687.1. PMID: 29761706Free PMC Article
Nuclear abnormalities in buccal mucosa cells of patients with type I and II diabetes treated with folic acid.
Gómez-Meda BC, Zamora-Perez AL, Muñoz-Magallanes T, Sánchez-Parada MG, García Bañuelos JJ, Guerrero-Velázquez C, Sánchez-Orozco LV, Vera-Cruz JM, Armendáriz-Borunda J, Zúñiga-González GM
Mutat Res Genet Toxicol Environ Mutagen 2016 Feb;797:1-8. Epub 2015 Dec 18 doi: 10.1016/j.mrgentox.2015.12.003. PMID: 26921015
Clinical and cytological study of the oral mucosa of smoking and non-smoking qat chewers in Yemen.
Hijazi M, Jentsch H, Al-Sanabani J, Tawfik M, Remmerbach TW
Clin Oral Investig 2016 May;20(4):771-9. Epub 2015 Aug 29 doi: 10.1007/s00784-015-1569-2. PMID: 26319978

Prognosis

Mildly dysplastic oral lesions with optically-detectable abnormalities share genetic similarities with severely dysplastic lesions.
Brenes DR, Nipper AJ, Tan MT, Gleber-Netto FO, Schwarz RA, Pickering CR, Williams MD, Vigneswaran N, Gillenwater AM, Sikora AG, Richards-Kortum RR
Oral Oncol 2022 Dec;135:106232. Epub 2022 Nov 3 doi: 10.1016/j.oraloncology.2022.106232. PMID: 36335817Free PMC Article
Expression of p63 protein and mRNA in oral epithelial dysplasia.
Chen YK, Hsue SS, Lin LM
J Oral Pathol Med 2005 Apr;34(4):232-9. doi: 10.1111/j.1600-0714.2004.00277.x. PMID: 15752259
Buccal mucosal urethral replacement.
Duckett JW, Coplen D, Ewalt D, Baskin LS
J Urol 1995 May;153(5):1660-3. PMID: 7715003
Epithelial cells kinetics. A review of methods of study and their application to oral mucosa in health and disease. Part B. Comparison of cell kinetics in normal and abnormal epithelia.
Scragg MA, Johnson NW
J Oral Pathol 1982 Apr;11(2):102-37. doi: 10.1111/j.1600-0714.1982.tb00149.x. PMID: 6802942
Epithelial cell kinetics--A review of methods of study and their application to oral mucosa in health and disease. Part A. Methods for studying cell proliferation and some sources of variation.
Scragg MA, Johnson NW
J Oral Pathol 1980 Nov;9(6):309-41. doi: 10.1111/j.1600-0714.1980.tb00389.x. PMID: 6785401

Clinical prediction guides

Use of liquid-based cytology samples reveals genomic instability and cell death in patients undergoing orthodontic treatment.
Carrillo-Novia I, Lara-Carrillo E, Torres-Bugarin O, Morales-Valenzuela AA, Salmerón-Valdés EN, Hegazy-Hassan W, Velázquez-Enríquez U, Toral-Rizo VH
J Oral Sci 2023 Jan 11;65(1):24-28. Epub 2022 Dec 16 doi: 10.2334/josnusd.22-0235. PMID: 36529513
Labial Mucosa Stem Cells: Isolation, Characterization, and Their Potential for Corneal Epithelial Reconstruction.
Zhurenkov KE, Alexander-Sinkler EI, Gavrilyik IO, Yartseva NM, Aleksandrova SA, Mashel TV, Khorolskaya JI, Blinova MI, Kulikov AN, Churashov SV, Chernysh VF, Mikhailova NA
Invest Ophthalmol Vis Sci 2022 Jul 8;63(8):16. doi: 10.1167/iovs.63.8.16. PMID: 35848889Free PMC Article
Periodontitis: Genomic instability implications and associated risk factors.
Borba TT, Molz P, Schlickmann DS, Santos C, Oliveira CF, Prá D, Neto LK, Franke SIR
Mutat Res Genet Toxicol Environ Mutagen 2019 Apr;840:20-23. Epub 2019 Jan 17 doi: 10.1016/j.mrgentox.2019.01.005. PMID: 30857729
Characteristics of lingual papillae in diabetic rats.
Ortug G, Ignak S, Ortug A
Morphologie 2018 Dec;102(339):250-254. Epub 2018 Sep 13 doi: 10.1016/j.morpho.2018.08.003. PMID: 30219545
Genotoxic and cytotoxic effects of Haas appliance in exfoliated buccal mucosa cells during orthodontic treatment.
Cunha AS, Castillo WO, Takahashi CS, Küchler EC, Segato RAB, da Silva LAB, Romano FL, Matsumoto MAN, Nelson-Filho P
Angle Orthod 2018 Sep;88(5):590-595. Epub 2018 May 15 doi: 10.2319/101117-687.1. PMID: 29761706Free PMC Article

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