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Recurrent Head and Neck Squamous Cell Carcinoma

MedGen UID:
1621629
•Concept ID:
C4524839
•
Neoplastic Process
Synonym: Recurrent Squamous Cell Carcinoma of the Head and Neck

Definition

The reemergence of squamous cell carcinoma in the head and neck region after a period of remission. [from NCI]

Professional guidelines

PubMed

Clinical utility of (18)F-FDG PET/CT for patients with recurrent head and neck squamous cell carcinoma.
Ha SC, Roh JL, Kim JS, Lee JH, Choi SH, Nam SY, Kim SY
Acta Otolaryngol 2019 Sep;139(9):810-815. Epub 2019 Jul 5 doi: 10.1080/00016489.2019.1632483. PMID: 31274365
Upfront PET/CT affects management decisions in patients with recurrent head and neck squamous cell carcinoma.
Rohde M, Nielsen AL, Johansen J, Sørensen JA, Diaz A, Pareek M, Asmussen JT, Gerke O, Thomassen A, Gyldenkerne N, Døssing H, Bjørndal K, Høilund-Carlsen PF, Godballe C
Oral Oncol 2019 Jul;94:1-7. Epub 2019 May 6 doi: 10.1016/j.oraloncology.2019.04.025. PMID: 31178202
Surgical management of local and regional recurrent head and neck squamous cell carcinoma.
Watson JC, Ridge JA
Curr Opin Oncol 1998 May;10(3):207-12. doi: 10.1097/00001622-199805000-00006. PMID: 9619356

Recent clinical studies

Etiology

Intratumoral pan-ErbB targeted CAR-T for head and neck squamous cell carcinoma: interim analysis of the T4 immunotherapy study.
Papa S, Adami A, Metoudi M, Beatson R, George MS, Achkova D, Williams E, Arif S, Reid F, Elstad M, Beckley-Hoelscher N, Douri A, Delord M, Lyne M, Shivapatham D, Fisher C, Hope A, Gooljar S, Mitra A, Gomm L, Morton C, Henley-Smith R, Thavaraj S, Santambrogio A, Andoniadou C, Allen S, Gibson V, Cook GJR, Parente-Pereira AC, Davies DM, Farzaneh F, Schurich A, Guerrero-Urbano T, Jeannon JP, Spicer J, Maher J
J Immunother Cancer 2023 Jun;11(6) doi: 10.1136/jitc-2023-007162. PMID: 37321663Free PMC Article
Immunotherapy in Head and Neck Cancer: Where Do We Stand?
Vallianou NG, Evangelopoulos A, Kounatidis D, Panagopoulos F, Geladari E, Karampela I, Stratigou T, Dalamaga M
Curr Oncol Rep 2023 Aug;25(8):897-912. Epub 2023 May 22 doi: 10.1007/s11912-023-01425-1. PMID: 37213060
Evaluation of Proton Therapy Reirradiation for Patients With Recurrent Head and Neck Squamous Cell Carcinoma.
Lee A, Woods R, Mahfouz A, Kitpanit S, Cartano O, Mohamed N, Youssef I, Marqueen K, Sine K, Mah D, Neal B, Zakeri K, Kang JJ, Riaz N, Yu Y, McBride SM, Chen LD, Tsai CJ, Gelblum DY, Press RH, Michel LS, Sherman EJ, Pfister D, Dunn LA, Ho AL, Fetten J, Wong RJ, Boyle JO, Singh B, Cracchiolo JR, Ganly I, Cohen MA, Lee NY
JAMA Netw Open 2023 Jan 3;6(1):e2250607. doi: 10.1001/jamanetworkopen.2022.50607. PMID: 36689229Free PMC Article
Salvage surgery for recurrent squamous cell carcinoma of the head and neck: Systematic review and meta-analysis.
Bulbul MG, Genovese TJ, Hagan K, Rege S, Qureshi A, Varvares MA
Head Neck 2022 Jan;44(1):275-285. Epub 2021 Nov 3 doi: 10.1002/hed.26898. PMID: 34729845
Platinum rechallenge in recurrent head and neck squamous cell carcinoma after primary chemoradiation.
Rambeau A, Licaj I, Gery B, Gervais R, Florescu C, Babin E, De Raucourt D, Johnson A, Thariat J
Eur Ann Otorhinolaryngol Head Neck Dis 2019 Sep;136(4):257-261. Epub 2019 Apr 16 doi: 10.1016/j.anorl.2019.04.007. PMID: 31003864

Diagnosis

Immunotherapy in Head and Neck Cancer: Where Do We Stand?
Vallianou NG, Evangelopoulos A, Kounatidis D, Panagopoulos F, Geladari E, Karampela I, Stratigou T, Dalamaga M
Curr Oncol Rep 2023 Aug;25(8):897-912. Epub 2023 May 22 doi: 10.1007/s11912-023-01425-1. PMID: 37213060
NI-RADS to Predict Residual or Recurrent Head and Neck Squamous Cell Carcinoma.
Baugnon KL
Neuroimaging Clin N Am 2022 Feb;32(1):1-18. doi: 10.1016/j.nic.2021.08.003. PMID: 34809832
PD-L1 expression in recurrent head and neck squamous cell carcinoma.
Delafoy A, Uguen A, Lemasson G, Conan-Charlet V, Pradier O, Lucia F, Schick U
Eur Arch Otorhinolaryngol 2022 Jan;279(1):343-351. Epub 2021 Apr 1 doi: 10.1007/s00405-021-06777-7. PMID: 33796940
Definition of locally recurrent head and neck squamous cell carcinoma: a systematic review and proposal for the Odense-Birmingham definition.
Rohde M, Rosenberg T, Pareek M, Nankivell P, Sharma N, Mehanna H, Godballe C
Eur Arch Otorhinolaryngol 2020 Jun;277(6):1593-1599. Epub 2020 Apr 7 doi: 10.1007/s00405-020-05953-5. PMID: 32266461
Re-irradiation for head and neck squamous cell carcinoma.
Benson R, Giridhar P, Venkatesulu BP, Mallick S, Raza MW, Rath GK
J Egypt Natl Canc Inst 2017 Mar;29(1):1-9. Epub 2016 Aug 29 doi: 10.1016/j.jnci.2016.07.002. PMID: 27595192

Therapy

Intratumoral pan-ErbB targeted CAR-T for head and neck squamous cell carcinoma: interim analysis of the T4 immunotherapy study.
Papa S, Adami A, Metoudi M, Beatson R, George MS, Achkova D, Williams E, Arif S, Reid F, Elstad M, Beckley-Hoelscher N, Douri A, Delord M, Lyne M, Shivapatham D, Fisher C, Hope A, Gooljar S, Mitra A, Gomm L, Morton C, Henley-Smith R, Thavaraj S, Santambrogio A, Andoniadou C, Allen S, Gibson V, Cook GJR, Parente-Pereira AC, Davies DM, Farzaneh F, Schurich A, Guerrero-Urbano T, Jeannon JP, Spicer J, Maher J
J Immunother Cancer 2023 Jun;11(6) doi: 10.1136/jitc-2023-007162. PMID: 37321663Free PMC Article
Evaluation of Proton Therapy Reirradiation for Patients With Recurrent Head and Neck Squamous Cell Carcinoma.
Lee A, Woods R, Mahfouz A, Kitpanit S, Cartano O, Mohamed N, Youssef I, Marqueen K, Sine K, Mah D, Neal B, Zakeri K, Kang JJ, Riaz N, Yu Y, McBride SM, Chen LD, Tsai CJ, Gelblum DY, Press RH, Michel LS, Sherman EJ, Pfister D, Dunn LA, Ho AL, Fetten J, Wong RJ, Boyle JO, Singh B, Cracchiolo JR, Ganly I, Cohen MA, Lee NY
JAMA Netw Open 2023 Jan 3;6(1):e2250607. doi: 10.1001/jamanetworkopen.2022.50607. PMID: 36689229Free PMC Article
Phase 1/2a, open-label, multicenter study of RM-1929 photoimmunotherapy in patients with locoregional, recurrent head and neck squamous cell carcinoma.
Cognetti DM, Johnson JM, Curry JM, Kochuparambil ST, McDonald D, Mott F, Fidler MJ, Stenson K, Vasan NR, Razaq MA, Campana J, Ha P, Mann G, Ishida K, Garcia-Guzman M, Biel M, Gillenwater AM
Head Neck 2021 Dec;43(12):3875-3887. Epub 2021 Oct 9 doi: 10.1002/hed.26885. PMID: 34626024Free PMC Article
Randomized Phase II Trial of Nivolumab With Stereotactic Body Radiotherapy Versus Nivolumab Alone in Metastatic Head and Neck Squamous Cell Carcinoma.
McBride S, Sherman E, Tsai CJ, Baxi S, Aghalar J, Eng J, Zhi WI, McFarland D, Michel LS, Young R, Lefkowitz R, Spielsinger D, Zhang Z, Flynn J, Dunn L, Ho A, Riaz N, Pfister D, Lee N
J Clin Oncol 2021 Jan 1;39(1):30-37. Epub 2020 Aug 21 doi: 10.1200/JCO.20.00290. PMID: 32822275Free PMC Article
Re-irradiation for head and neck squamous cell carcinoma.
Benson R, Giridhar P, Venkatesulu BP, Mallick S, Raza MW, Rath GK
J Egypt Natl Canc Inst 2017 Mar;29(1):1-9. Epub 2016 Aug 29 doi: 10.1016/j.jnci.2016.07.002. PMID: 27595192

Prognosis

Immunotherapy in Head and Neck Cancer: Where Do We Stand?
Vallianou NG, Evangelopoulos A, Kounatidis D, Panagopoulos F, Geladari E, Karampela I, Stratigou T, Dalamaga M
Curr Oncol Rep 2023 Aug;25(8):897-912. Epub 2023 May 22 doi: 10.1007/s11912-023-01425-1. PMID: 37213060
NI-RADS to Predict Residual or Recurrent Head and Neck Squamous Cell Carcinoma.
Baugnon KL
Neuroimaging Clin N Am 2022 Feb;32(1):1-18. doi: 10.1016/j.nic.2021.08.003. PMID: 34809832
PD-L1 expression in recurrent head and neck squamous cell carcinoma.
Delafoy A, Uguen A, Lemasson G, Conan-Charlet V, Pradier O, Lucia F, Schick U
Eur Arch Otorhinolaryngol 2022 Jan;279(1):343-351. Epub 2021 Apr 1 doi: 10.1007/s00405-021-06777-7. PMID: 33796940
Safety evaluation of pembrolizumab for treating recurrent head and neck squamous cell carcinoma.
Desilets A, Soulières D
Expert Opin Drug Saf 2020 Aug;19(8):927-934. Epub 2020 Jun 11 doi: 10.1080/14740338.2020.1775811. PMID: 32458764
Re-irradiation for head and neck squamous cell carcinoma.
Benson R, Giridhar P, Venkatesulu BP, Mallick S, Raza MW, Rath GK
J Egypt Natl Canc Inst 2017 Mar;29(1):1-9. Epub 2016 Aug 29 doi: 10.1016/j.jnci.2016.07.002. PMID: 27595192

Clinical prediction guides

Intratumoral pan-ErbB targeted CAR-T for head and neck squamous cell carcinoma: interim analysis of the T4 immunotherapy study.
Papa S, Adami A, Metoudi M, Beatson R, George MS, Achkova D, Williams E, Arif S, Reid F, Elstad M, Beckley-Hoelscher N, Douri A, Delord M, Lyne M, Shivapatham D, Fisher C, Hope A, Gooljar S, Mitra A, Gomm L, Morton C, Henley-Smith R, Thavaraj S, Santambrogio A, Andoniadou C, Allen S, Gibson V, Cook GJR, Parente-Pereira AC, Davies DM, Farzaneh F, Schurich A, Guerrero-Urbano T, Jeannon JP, Spicer J, Maher J
J Immunother Cancer 2023 Jun;11(6) doi: 10.1136/jitc-2023-007162. PMID: 37321663Free PMC Article
Immunotherapy in Head and Neck Cancer: Where Do We Stand?
Vallianou NG, Evangelopoulos A, Kounatidis D, Panagopoulos F, Geladari E, Karampela I, Stratigou T, Dalamaga M
Curr Oncol Rep 2023 Aug;25(8):897-912. Epub 2023 May 22 doi: 10.1007/s11912-023-01425-1. PMID: 37213060
Evaluation of Proton Therapy Reirradiation for Patients With Recurrent Head and Neck Squamous Cell Carcinoma.
Lee A, Woods R, Mahfouz A, Kitpanit S, Cartano O, Mohamed N, Youssef I, Marqueen K, Sine K, Mah D, Neal B, Zakeri K, Kang JJ, Riaz N, Yu Y, McBride SM, Chen LD, Tsai CJ, Gelblum DY, Press RH, Michel LS, Sherman EJ, Pfister D, Dunn LA, Ho AL, Fetten J, Wong RJ, Boyle JO, Singh B, Cracchiolo JR, Ganly I, Cohen MA, Lee NY
JAMA Netw Open 2023 Jan 3;6(1):e2250607. doi: 10.1001/jamanetworkopen.2022.50607. PMID: 36689229Free PMC Article
NI-RADS to Predict Residual or Recurrent Head and Neck Squamous Cell Carcinoma.
Baugnon KL
Neuroimaging Clin N Am 2022 Feb;32(1):1-18. doi: 10.1016/j.nic.2021.08.003. PMID: 34809832
PD-L1 expression in recurrent head and neck squamous cell carcinoma.
Delafoy A, Uguen A, Lemasson G, Conan-Charlet V, Pradier O, Lucia F, Schick U
Eur Arch Otorhinolaryngol 2022 Jan;279(1):343-351. Epub 2021 Apr 1 doi: 10.1007/s00405-021-06777-7. PMID: 33796940

Recent systematic reviews

Functional and quality-of-life outcomes following salvage surgery for recurrent squamous cell carcinoma of the head and neck: a systematic review and meta-analysis.
Williamson A, Jashek-Ahmed F, Hardman J, Paleri V
Eur Arch Otorhinolaryngol 2023 Oct;280(10):4597-4618. Epub 2023 Jun 17 doi: 10.1007/s00405-023-08056-z. PMID: 37329358
Salvage surgery for recurrent squamous cell carcinoma of the head and neck: Systematic review and meta-analysis.
Bulbul MG, Genovese TJ, Hagan K, Rege S, Qureshi A, Varvares MA
Head Neck 2022 Jan;44(1):275-285. Epub 2021 Nov 3 doi: 10.1002/hed.26898. PMID: 34729845
Definition of locally recurrent head and neck squamous cell carcinoma: a systematic review and proposal for the Odense-Birmingham definition.
Rohde M, Rosenberg T, Pareek M, Nankivell P, Sharma N, Mehanna H, Godballe C
Eur Arch Otorhinolaryngol 2020 Jun;277(6):1593-1599. Epub 2020 Apr 7 doi: 10.1007/s00405-020-05953-5. PMID: 32266461
Salvage of recurrence after surgery and adjuvant therapy: A systematic review.
Zenga J, Gross J, Fowler S, Chen J, Vila P, Richmon JD, Varvares MA, Pipkorn P
Am J Otolaryngol 2018 Mar-Apr;39(2):223-227. Epub 2018 Feb 2 doi: 10.1016/j.amjoto.2018.01.009. PMID: 29398187
A systematic review and meta-analysis of the role of positron emission tomography in the follow up of head and neck squamous cell carcinoma following radiotherapy or chemoradiotherapy.
Isles MG, McConkey C, Mehanna HM
Clin Otolaryngol 2008 Jun;33(3):210-22. doi: 10.1111/j.1749-4486.2008.01688.x. PMID: 18559026

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