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Nuclear Cataract Grade 1

MedGen UID:
1624135
•Concept ID:
C4525723
•
Disease or Syndrome

Definition

A stage of nuclear sclerotic cataract marked by mild yellowing and sclerosis of the lens nucleus. (Modified LOCS II) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNuclear Cataract Grade 1

Professional guidelines

PubMed

Selinexor for the treatment of recurrent or metastatic salivary gland tumors: Results from the GEMS-001 clinical trial.
Hernando-Calvo A, Malone E, Day D, Prawira A, Weinreb I, Yang SYC, Wong H, Rodriguez A, Jennings S, Eliason A, Wang L, Spreafico A, Siu LL, Hansen AR
Cancer Med 2023 Oct;12(20):20299-20310. Epub 2023 Oct 11 doi: 10.1002/cam4.6589. PMID: 37818869Free PMC Article
Management of Severely Subluxated Cataracts Using Femtosecond Laser-Assisted Cataract Surgery.
Chee SP, Wong MH, Jap A
Am J Ophthalmol 2017 Jan;173:7-15. Epub 2016 Sep 23 doi: 10.1016/j.ajo.2016.09.021. PMID: 27670621
Nucleus management with Blumenthal technique: anterior chamber maintainer.
Malik KP, Goel R
Indian J Ophthalmol 2009 Jan-Feb;57(1):23-5. doi: 10.4103/0301-4738.43047. PMID: 19075404Free PMC Article

Recent clinical studies

Etiology

Anterior vitreous detachment and retrolental material during cataract surgery: incidence and risk factors, with pathological evidence.
Lin W, Luo J, Li P, Ji M, Guan H
J Cataract Refract Surg 2023 Jun 1;49(6):578-583. doi: 10.1097/j.jcrs.0000000000001156. PMID: 36745848
Cataract progression after Nd:YAG laser iridotomy in primary angle-closure suspect eyes.
Chang DS, Jiang Y, Kim JA, Huang S, Munoz B, Aung T, He M, Foster PJ, Friedman D
Br J Ophthalmol 2023 Sep;107(9):1264-1268. Epub 2022 May 2 doi: 10.1136/bjophthalmol-2021-320929. PMID: 35501120
Prevalence of Refractive Error in Vientiane Province, Lao People's Democratic Republic.
Patel C, Tan Y, Nygaard S, Guo B, Carrillo C, Burgess J, Souksamone K, Nouansavanh KO, Casson R
Ophthalmic Epidemiol 2023 Feb;30(1):57-65. Epub 2022 Feb 3 doi: 10.1080/09286586.2022.2028294. PMID: 35112939
Grade of Cataract and Its Influence on Measurement of Macular Pigment Optical Density Using Autofluorescence Imaging.
Obana A, Gohto Y, Sasano H, Gellermann W, Sharifzadeh M, Seto T, Bernstein PS
Invest Ophthalmol Vis Sci 2018 Jun 1;59(7):3011-3019. doi: 10.1167/iovs.17-23699. PMID: 30025122Free PMC Article
The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group.
Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, Friend J, McCarthy D, Wu SY
Arch Ophthalmol 1993 Jun;111(6):831-6. doi: 10.1001/archopht.1993.01090060119035. PMID: 8512486

Diagnosis

AI-based diagnosis of nuclear cataract from slit-lamp videos.
Shimizu E, Tanji M, Nakayama S, Ishikawa T, Agata N, Yokoiwa R, Nishimura H, Khemlani RJ, Sato S, Hanyuda A, Sato Y
Sci Rep 2023 Dec 12;13(1):22046. doi: 10.1038/s41598-023-49563-7. PMID: 38086904Free PMC Article
New technology using crystalline lens autofluorescence for presbyopia and cataract grading.
Eom Y, Suh YW, Kim SW, Lee YJ, Jeon HS, Lee SY, Lee IH, Song JS, Kim HM
Graefes Arch Clin Exp Ophthalmol 2023 Jul;261(7):1923-1932. Epub 2023 Feb 24 doi: 10.1007/s00417-023-05999-1. PMID: 36826601
Cataract surgery outcomes in eyes with chorioretinal coloboma.
Sahay P, Maharana PK, Mandal S, Sinha R, Agarwal T, Sharma N, Titiyal JS
J Cataract Refract Surg 2019 May;45(5):630-638. doi: 10.1016/j.jcrs.2019.01.016. PMID: 31030778
Cataract quantification using swept-source optical coherence tomography.
Brás JEG, Sickenberger W, Hirnschall N, Findl O
J Cataract Refract Surg 2018 Dec;44(12):1478-1481. Epub 2018 Nov 2 doi: 10.1016/j.jcrs.2018.08.009. PMID: 30392762
Exome Array Analysis of Nuclear Lens Opacity.
Loomis SJ, Klein AP, Lee KE, Chen F, Bomotti S, Truitt B, Iyengar SK, Klein R, Klein BEK, Duggal P
Ophthalmic Epidemiol 2018 Jun;25(3):215-219. Epub 2017 Nov 28 doi: 10.1080/09286586.2017.1406122. PMID: 29182452Free PMC Article

Therapy

Cataract progression after Nd:YAG laser iridotomy in primary angle-closure suspect eyes.
Chang DS, Jiang Y, Kim JA, Huang S, Munoz B, Aung T, He M, Foster PJ, Friedman D
Br J Ophthalmol 2023 Sep;107(9):1264-1268. Epub 2022 May 2 doi: 10.1136/bjophthalmol-2021-320929. PMID: 35501120
Comparative study of FLACS vs conventional phacoemulsification for complex cataracts in vitrectomized eyes.
Cai L, Ma D, Xu X, Han X, Qiu X, Lu Y, Yang J
J Cataract Refract Surg 2022 Dec 1;48(12):1381-1387. doi: 10.1097/j.jcrs.0000000000000998. PMID: 36449671
Ultrasound energy consumption and macular changes with manual and femtolaser-assisted high-fluidics cataract surgery: a prospective randomized comparison.
Menapace R, Schartmüller D, Röggla V, Reiter GS, Leydolt C, Schwarzenbacher L
Acta Ophthalmol 2022 Mar;100(2):e414-e422. Epub 2021 Sep 20 doi: 10.1111/aos.14983. PMID: 34543523Free PMC Article
Randomized Controlled Trial Comparing Femtosecond Laser-Assisted with Conventional Phacoemulsification on Dense Cataracts.
Chee SP, Yang Y, Wong MHY
Am J Ophthalmol 2021 Sep;229:1-7. Epub 2021 Mar 1 doi: 10.1016/j.ajo.2020.12.024. PMID: 33662301
Torsional and burst mode phacoemulsification for patients with hard nuclear cataract: A randomized control study.
Yang WJ, Wang XH, Zhao F, Mei ZM, Li S, Xiang Y
Medicine (Baltimore) 2019 May;98(22):e15870. doi: 10.1097/MD.0000000000015870. PMID: 31145344Free PMC Article

Prognosis

Anterior vitreous detachment and retrolental material during cataract surgery: incidence and risk factors, with pathological evidence.
Lin W, Luo J, Li P, Ji M, Guan H
J Cataract Refract Surg 2023 Jun 1;49(6):578-583. doi: 10.1097/j.jcrs.0000000000001156. PMID: 36745848
Lens Opacities Classification System III-based artificial intelligence program for automatic cataract grading.
Lu Q, Wei L, He W, Zhang K, Wang J, Zhang Y, Rong X, Zhao Z, Cai L, He X, Wu J, Ding D, Lu Y, Zhu X
J Cataract Refract Surg 2022 May 1;48(5):528-534. doi: 10.1097/j.jcrs.0000000000000790. PMID: 34433780
Influence of Main Ocular Variables in #TheDress Perception: An Ophthalmic Survey.
González-Martín-Moro J, Contreras I, Fuentes-Vega I, Prieto-Garrido F, Castro-Rebollo M, González-Manrique M, Gómez-Sanz F, Zamora J
Perception 2021 Apr;50(4):367-378. doi: 10.1177/0301006621997341. PMID: 33840289
Exome Array Analysis of Nuclear Lens Opacity.
Loomis SJ, Klein AP, Lee KE, Chen F, Bomotti S, Truitt B, Iyengar SK, Klein R, Klein BEK, Duggal P
Ophthalmic Epidemiol 2018 Jun;25(3):215-219. Epub 2017 Nov 28 doi: 10.1080/09286586.2017.1406122. PMID: 29182452Free PMC Article
Myopia and the long-term incidence of cataract and cataract surgery: the Blue Mountains Eye Study.
Kanthan GL, Mitchell P, Rochtchina E, Cumming RG, Wang JJ
Clin Exp Ophthalmol 2014 May-Jun;42(4):347-53. Epub 2013 Oct 11 doi: 10.1111/ceo.12206. PMID: 24024555

Clinical prediction guides

Anterior vitreous detachment and retrolental material during cataract surgery: incidence and risk factors, with pathological evidence.
Lin W, Luo J, Li P, Ji M, Guan H
J Cataract Refract Surg 2023 Jun 1;49(6):578-583. doi: 10.1097/j.jcrs.0000000000001156. PMID: 36745848
Real-time corneal thickness changes during phacoemulsification cataract surgery.
Hu J, Zhao C, Luo Y, Kong J, Shi W, Wang T
Graefes Arch Clin Exp Ophthalmol 2023 Jun;261(6):1609-1618. Epub 2023 Jan 20 doi: 10.1007/s00417-022-05971-5. PMID: 36662235
Cataract quantification using swept-source optical coherence tomography.
Brás JEG, Sickenberger W, Hirnschall N, Findl O
J Cataract Refract Surg 2018 Dec;44(12):1478-1481. Epub 2018 Nov 2 doi: 10.1016/j.jcrs.2018.08.009. PMID: 30392762
Cataract and quality of life in patients with glaucoma.
Skalicky SE, Martin KR, Fenwick E, Crowston JG, Goldberg I, McCluskey P
Clin Exp Ophthalmol 2015 May-Jun;43(4):335-41. Epub 2014 Oct 30 doi: 10.1111/ceo.12454. PMID: 25294739
The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group.
Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, Friend J, McCarthy D, Wu SY
Arch Ophthalmol 1993 Jun;111(6):831-6. doi: 10.1001/archopht.1993.01090060119035. PMID: 8512486

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