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Eccentric visual fixation

MedGen UID:
1624962
•Concept ID:
C0262461
•
Finding
Synonym: Eccentric fixation
 
HPO: HP:0025549

Definition

A uniocular condition in which there is fixation of an object by a point other than the fovea. This point adopts the principal visual direction. The degree of the eccentric fixation is defined by its distance from the fovea in degrees. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEccentric visual fixation

Conditions with this feature

Retinitis pigmentosa 23
MedGen UID:
238456
•Concept ID:
C1419610
•
Disease or Syndrome
Any retinitis pigmentosa in which the cause of the disease is a mutation in the OFD1 gene.
See: Condition Record
Retinitis pigmentosa 23

Professional guidelines

PubMed

Fixation stability improvement after occlusion treatment for severe amblyopia.
Wang S, Zou L, Tian T, Zhan A, Liu Y, Wen W, Liu H
Int Ophthalmol 2022 Mar;42(3):1007-1012. Epub 2021 Oct 19 doi: 10.1007/s10792-021-02084-6. PMID: 34668103
Long-term follow-up of an amblyopia treatment study: change in visual acuity 15 years after occlusion therapy.
Kadhum A, Simonsz-Tóth B, van Rosmalen J, Pijnenburg SJM, Janszen BM, Simonsz HJ, Loudon SE
Acta Ophthalmol 2021 Feb;99(1):e36-e42. Epub 2020 Jul 13 doi: 10.1111/aos.14499. PMID: 32657530Free PMC Article
Red filter treatment in eccentric fixation.
Malik SR, Gupta AK, Choudhry S, Sen DK
Br J Ophthalmol 1968 Nov;52(11):839-42. doi: 10.1136/bjo.52.11.839. PMID: 5696912Free PMC Article

Recent clinical studies

Etiology

Microperimetry Reliability Assessed From Fixation Performance.
Josan AS, Farrance I, Taylor LJ, Adeyoju D, Buckley TMW, Jolly JK, MacLaren RE
Transl Vis Sci Technol 2023 May 1;12(5):21. doi: 10.1167/tvst.12.5.21. PMID: 37219509Free PMC Article
Evaluation of fixation characteristics in amblyopia using microperimetry.
Altinbay D, Sahli E, Bingol Kiziltunc P, Atilla H
Int Ophthalmol 2023 Sep;43(9):3403-3412. Epub 2023 May 15 doi: 10.1007/s10792-023-02748-5. PMID: 37184805
Saccadic movements assessment in eccentric fixation: A study in patients with Stargardt disease.
Giacomelli G, Farini A, Baldini I, Raffaelli M, Bigagli G, Fossetti A, Virgili G
Eur J Ophthalmol 2021 Sep;31(5):2556-2562. Epub 2020 Oct 2 doi: 10.1177/1120672120960336. PMID: 33008267
Using OCT Fixation Shift to Assess Eccentric Fixation in Children With Residual Amblyopia.
Jin J, Apple A, Friess A, Lehman S, Salvin J, Hendricks D, Reid J, Wang J
Transl Vis Sci Technol 2020 Nov;9(12):30. Epub 2020 Nov 24 doi: 10.1167/tvst.9.12.30. PMID: 33262904Free PMC Article
Multifocal intraocular lenses and retinal diseases.
Grzybowski A, Kanclerz P, Tuuminen R
Graefes Arch Clin Exp Ophthalmol 2020 Apr;258(4):805-813. Epub 2020 Jan 18 doi: 10.1007/s00417-020-04603-0. PMID: 31955239Free PMC Article

Diagnosis

Melanopsin enhances image persistence.
Woelders T, Allen AE, Lucas RJ
Curr Biol 2023 Dec 4;33(23):5048-5056.e4. Epub 2023 Nov 14 doi: 10.1016/j.cub.2023.10.039. PMID: 37967553
Microperimetry Reliability Assessed From Fixation Performance.
Josan AS, Farrance I, Taylor LJ, Adeyoju D, Buckley TMW, Jolly JK, MacLaren RE
Transl Vis Sci Technol 2023 May 1;12(5):21. doi: 10.1167/tvst.12.5.21. PMID: 37219509Free PMC Article
Relationship between visual acuity and visual field and its reproducibility in patients with retinitis pigmentosa.
Asaoka R, Miyata M, Oishi A, Fujino Y, Murata H, Azuma K, Obata R, Inoue T
Eye (Lond) 2023 Apr;37(6):1094-1099. Epub 2022 Apr 20 doi: 10.1038/s41433-022-02043-0. PMID: 35444265Free PMC Article
Amblyopia and fixation eye movements.
Ghasia F, Wang J
J Neurol Sci 2022 Oct 15;441:120373. Epub 2022 Aug 3 doi: 10.1016/j.jns.2022.120373. PMID: 36007287
Eye movements in vestibular disorders.
Kheradmand A, Colpak AI, Zee DS
Handb Clin Neurol 2016;137:103-17. doi: 10.1016/B978-0-444-63437-5.00008-X. PMID: 27638066

Therapy

Systematic and Random Mapping Errors in Structure - Function Analysis of the Macula.
Montesano G, Rossetti LM, Allegrini D, Romano MR, Garway-Heath DF, Crabb DP
Transl Vis Sci Technol 2021 Feb 5;10(2):21. doi: 10.1167/tvst.10.2.21. PMID: 34003906Free PMC Article
Multifocal intraocular lenses and retinal diseases.
Grzybowski A, Kanclerz P, Tuuminen R
Graefes Arch Clin Exp Ophthalmol 2020 Apr;258(4):805-813. Epub 2020 Jan 18 doi: 10.1007/s00417-020-04603-0. PMID: 31955239Free PMC Article
Comparison of monocular sensitivities measured with and without occlusion using the head-mounted perimeter imo.
Wakayama A, Matsumoto C, Ayato Y, Shimomura Y
PLoS One 2019;14(1):e0210691. Epub 2019 Jan 17 doi: 10.1371/journal.pone.0210691. PMID: 30653560Free PMC Article
How effective is eccentric viewing training? A systematic literature review.
Gaffney AJ, Margrain TH, Bunce CV, Binns AM
Ophthalmic Physiol Opt 2014 Jul;34(4):427-37. Epub 2014 Apr 15 doi: 10.1111/opo.12132. PMID: 24735182
Current methods of visual rehabilitation.
Trauzettel-Klosinski S
Dtsch Arztebl Int 2011 Dec;108(51-52):871-8. Epub 2011 Dec 26 doi: 10.3238/arztebl.2011.0871. PMID: 22259642Free PMC Article

Prognosis

Melanopsin enhances image persistence.
Woelders T, Allen AE, Lucas RJ
Curr Biol 2023 Dec 4;33(23):5048-5056.e4. Epub 2023 Nov 14 doi: 10.1016/j.cub.2023.10.039. PMID: 37967553
Amblyopia and fixation eye movements.
Ghasia F, Wang J
J Neurol Sci 2022 Oct 15;441:120373. Epub 2022 Aug 3 doi: 10.1016/j.jns.2022.120373. PMID: 36007287
Fixation Characteristics of Severe Amblyopia with Eccentric Fixation and Central Fixation Assessed by the MP-1 Microperimeter.
Wang S, Tian T, Zou L, Wu S, Liu Y, Wen W, Liu H
Semin Ophthalmol 2021 Aug 18;36(5-6):360-365. Epub 2021 Mar 4 doi: 10.1080/08820538.2021.1890142. PMID: 33661718
Amblyopia with Eccentric Fixation: Is Inverse Occlusion Still an Option?
Godts DJM, Mathysen DGP
J Binocul Vis Ocul Motil 2019 Oct-Dec;69(4):131-135. Epub 2019 Oct 4 doi: 10.1080/2576117X.2018.1563450. PMID: 31584348
Microperimetry and clinical practice: an evidence-based review.
Markowitz SN, Reyes SV
Can J Ophthalmol 2013 Oct;48(5):350-7. Epub 2012 Oct 23 doi: 10.1016/j.jcjo.2012.03.004. PMID: 24093179

Clinical prediction guides

Melanopsin enhances image persistence.
Woelders T, Allen AE, Lucas RJ
Curr Biol 2023 Dec 4;33(23):5048-5056.e4. Epub 2023 Nov 14 doi: 10.1016/j.cub.2023.10.039. PMID: 37967553
Amblyopia and fixation eye movements.
Ghasia F, Wang J
J Neurol Sci 2022 Oct 15;441:120373. Epub 2022 Aug 3 doi: 10.1016/j.jns.2022.120373. PMID: 36007287
Atypical visual field asymmetries in redundancy masking.
Yildirim FZ, Coates DR, Sayim B
J Vis 2022 Apr 6;22(5):4. doi: 10.1167/jov.22.5.4. PMID: 35412555Free PMC Article
Binocular visual function and fixational control in patients with macular disease: A review.
Sverdlichenko I, Mandelcorn MS, Issashar Leibovitzh G, Mandelcorn ED, Markowitz SN, Tarita-Nistor L
Ophthalmic Physiol Opt 2022 Mar;42(2):258-271. Epub 2021 Dec 4 doi: 10.1111/opo.12925. PMID: 34862635Free PMC Article
Microperimetry and clinical practice: an evidence-based review.
Markowitz SN, Reyes SV
Can J Ophthalmol 2013 Oct;48(5):350-7. Epub 2012 Oct 23 doi: 10.1016/j.jcjo.2012.03.004. PMID: 24093179

Recent systematic reviews

Role of neural integrators in oculomotor systems: a systematic narrative literature review.
Sanchez K, Rowe FJ
Acta Ophthalmol 2018 Mar;96(2):e111-e118. Epub 2016 Nov 22 doi: 10.1111/aos.13307. PMID: 27874249
How effective is eccentric viewing training? A systematic literature review.
Gaffney AJ, Margrain TH, Bunce CV, Binns AM
Ophthalmic Physiol Opt 2014 Jul;34(4):427-37. Epub 2014 Apr 15 doi: 10.1111/opo.12132. PMID: 24735182
Effectiveness of eccentric viewing training for daily visual activities for individuals with age-related macular degeneration: a systematic review and meta-analysis.
Hong SP, Park H, Kwon JS, Yoo E
NeuroRehabilitation 2014;34(3):587-95. doi: 10.3233/NRE-141055. PMID: 24463233

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