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Appendiceal neoplasm

MedGen UID:
1629
•Concept ID:
C0003614
•
Neoplastic Process
Synonyms: Appendiceal Neoplasm; Appendiceal Neoplasms; Neoplasm, Appendiceal; Neoplasms, Appendiceal
SNOMED CT: Neoplasm of appendix (126846004); Appendiceal tumor (126846004); Tumor of appendix (126846004)
 
Monarch Initiative: MONDO:0001236

Definition

A benign or malignant neoplasm involving the appendix. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAppendiceal neoplasm

Professional guidelines

PubMed

Treatment Variation and Long-Term Outcomes of Low-Grade Appendiceal Neoplasms.
White MG, Bhutiani N, Helmink BA, Taggart M, Foo WC, Mansfield PF, Fournier KF, Scally CP
Ann Surg Oncol 2023 Dec;30(13):8138-8143. Epub 2023 Sep 13 doi: 10.1245/s10434-023-13501-8. PMID: 37702905
Diagnostic and therapeutic laparoscopy in assessment and management of patients with appendiceal neoplasms.
Tan GHC, Shamji T, Mehta A, Chandrakumaran K, Dayal S, Mohamed F, Carr NJ, Rowaiye B, Cecil T, Moran BJ
Int J Hyperthermia 2018 May;34(3):336-340. Epub 2017 Jun 28 doi: 10.1080/02656736.2017.1338363. PMID: 28605985
Mucinous appendiceal neoplasms: Incidence, diagnosis and surgical treatment.
Nutu OA, Marcacuzco Quinto AA, Manrique Municio A, Justo Alonso I, Calvo Pulido J, García-Conde M, Cambra Molero F, Jiménez Romero LC
Cir Esp 2017 Jun-Jul;95(6):321-327. Epub 2017 Jun 24 doi: 10.1016/j.ciresp.2017.05.008. PMID: 28655402

Recent clinical studies

Etiology

Appendiceal neoplasms-A practical guide.
Rossi A, Maloney Patel N
J Surg Oncol 2023 Jun;127(8):1300-1305. doi: 10.1002/jso.27304. PMID: 37222692
Lymph node positive pseudomyxoma peritonei.
Sugarbaker PH, Chang D
Eur J Surg Oncol 2022 Dec;48(12):2369-2377. Epub 2022 Jul 31 doi: 10.1016/j.ejso.2022.07.018. PMID: 35941031
Risk of appendiceal neoplasm after interval appendectomy for complicated appendicitis: A systematic review and meta-analysis.
Peltrini R, Cantoni V, Green R, Lionetti R, D'Ambra M, Bartolini C, De Luca M, Bracale U, Cuocolo A, Corcione F
Surgeon 2021 Dec;19(6):e549-e558. Epub 2021 Feb 25 doi: 10.1016/j.surge.2021.01.010. PMID: 33640282
A retrospective analysis and literature review of neoplastic appendiceal mucinous lesions.
Matias-García B, Mendoza-Moreno F, Blasco-Martínez A, Busteros-Moraza JI, Diez-Alonso M, Garcia-Moreno Nisa F
BMC Surg 2021 Feb 11;21(1):79. doi: 10.1186/s12893-021-01091-9. PMID: 33573654Free PMC Article
Diagnostic and therapeutic laparoscopy in assessment and management of patients with appendiceal neoplasms.
Tan GHC, Shamji T, Mehta A, Chandrakumaran K, Dayal S, Mohamed F, Carr NJ, Rowaiye B, Cecil T, Moran BJ
Int J Hyperthermia 2018 May;34(3):336-340. Epub 2017 Jun 28 doi: 10.1080/02656736.2017.1338363. PMID: 28605985

Diagnosis

Lymph node positive pseudomyxoma peritonei.
Sugarbaker PH, Chang D
Eur J Surg Oncol 2022 Dec;48(12):2369-2377. Epub 2022 Jul 31 doi: 10.1016/j.ejso.2022.07.018. PMID: 35941031
A retrospective analysis and literature review of neoplastic appendiceal mucinous lesions.
Matias-García B, Mendoza-Moreno F, Blasco-Martínez A, Busteros-Moraza JI, Diez-Alonso M, Garcia-Moreno Nisa F
BMC Surg 2021 Feb 11;21(1):79. doi: 10.1186/s12893-021-01091-9. PMID: 33573654Free PMC Article
Appendicitis and beyond: a pictorial review of various appendiceal abnormalities.
Fenwick AKC, Hartery A
Emerg Radiol 2021 Jun;28(3):651-664. Epub 2021 Jan 31 doi: 10.1007/s10140-021-01908-3. PMID: 33517502
Updates in Appendix Pathology: The Precarious Cutting Edge.
Carr NJ
Surg Pathol Clin 2020 Sep;13(3):469-484. Epub 2020 Jul 11 doi: 10.1016/j.path.2020.05.006. PMID: 32773195
Diagnostic and therapeutic laparoscopy in assessment and management of patients with appendiceal neoplasms.
Tan GHC, Shamji T, Mehta A, Chandrakumaran K, Dayal S, Mohamed F, Carr NJ, Rowaiye B, Cecil T, Moran BJ
Int J Hyperthermia 2018 May;34(3):336-340. Epub 2017 Jun 28 doi: 10.1080/02656736.2017.1338363. PMID: 28605985

Therapy

Incidence rate and histology of appendiceal neoplasms in complicated versus uncomplicated appendicitis: A meta-analysis and systematic review.
Solis-Pazmino P, Oka K, La K, Termeie O, Figueroa LA, Pilatuna E, Solis-Pazmino D, Harnegie MP, Cohen J, Barnajian M, Nasseri Y
Langenbecks Arch Surg 2023 Nov 9;408(1):432. doi: 10.1007/s00423-023-03164-0. PMID: 37940770Free PMC Article
The association between appendicitis severity and patient age with appendiceal neoplasm histology-a population-based study.
Alajääski J, Lietzén E, Grönroos JM, Mecklin JP, Leppäniemi A, Nordström P, Rautio T, Rantanen T, Sand J, Paajanen H, Ollila H, Salminen P
Int J Colorectal Dis 2022 May;37(5):1173-1180. Epub 2022 Apr 26 doi: 10.1007/s00384-022-04132-8. PMID: 35474547Free PMC Article
Risk of appendiceal neoplasm after interval appendectomy for complicated appendicitis: A systematic review and meta-analysis.
Peltrini R, Cantoni V, Green R, Lionetti R, D'Ambra M, Bartolini C, De Luca M, Bracale U, Cuocolo A, Corcione F
Surgeon 2021 Dec;19(6):e549-e558. Epub 2021 Feb 25 doi: 10.1016/j.surge.2021.01.010. PMID: 33640282
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for colorectal and appendiceal peritoneal metastases - The Hong Kong experience and literature review.
Chow FC, Yip J, Foo DC, Wei R, Choi HK, Ng KK, Lo OS
Asian J Surg 2021 Jan;44(1):221-228. Epub 2020 Jun 27 doi: 10.1016/j.asjsur.2020.05.010. PMID: 32605790
Outcomes from cytoreduction and hyperthermic intraperitoneal chemotherapy for appendiceal epithelial neoplasms.
Narasimhan V, Pham T, Warrier S, Craig Lynch A, Michael M, Tie J, Ramsay R, Heriot A
ANZ J Surg 2019 Sep;89(9):1035-1040. Epub 2019 Jan 26 doi: 10.1111/ans.14985. PMID: 30685879

Prognosis

Appendiceal neoplasms-A practical guide.
Rossi A, Maloney Patel N
J Surg Oncol 2023 Jun;127(8):1300-1305. doi: 10.1002/jso.27304. PMID: 37222692
Lymph node positive pseudomyxoma peritonei.
Sugarbaker PH, Chang D
Eur J Surg Oncol 2022 Dec;48(12):2369-2377. Epub 2022 Jul 31 doi: 10.1016/j.ejso.2022.07.018. PMID: 35941031
Updates in Appendix Pathology: The Precarious Cutting Edge.
Carr NJ
Surg Pathol Clin 2020 Sep;13(3):469-484. Epub 2020 Jul 11 doi: 10.1016/j.path.2020.05.006. PMID: 32773195
Mucinous appendiceal neoplasms: classification, imaging, and HIPEC.
Bartlett DJ, Thacker PG Jr, Grotz TE, Graham RP, Fletcher JG, VanBuren WM, Iyer VR, Fidler JL, Menias CO, Wasif N, Sheedy SP
Abdom Radiol (NY) 2019 May;44(5):1686-1702. doi: 10.1007/s00261-018-01888-y. PMID: 30610247
Mucinous appendiceal neoplasms: pathologic classification, clinical implications, imaging spectrum and mimics.
Van Hooser A, Williams TR, Myers DT
Abdom Radiol (NY) 2018 Nov;43(11):2913-2922. doi: 10.1007/s00261-018-1561-9. PMID: 29564494

Clinical prediction guides

A retrospective analysis and literature review of neoplastic appendiceal mucinous lesions.
Matias-García B, Mendoza-Moreno F, Blasco-Martínez A, Busteros-Moraza JI, Diez-Alonso M, Garcia-Moreno Nisa F
BMC Surg 2021 Feb 11;21(1):79. doi: 10.1186/s12893-021-01091-9. PMID: 33573654Free PMC Article
Risk factors for appendiceal neoplasm and malignancy among patients with acute appendicitis.
Brunner M, Lapins P, Langheinrich M, Baecker J, Krautz C, Kersting S, Weber GF, Grützmann R, Maak M
Int J Colorectal Dis 2020 Jan;35(1):157-163. Epub 2019 Dec 6 doi: 10.1007/s00384-019-03453-5. PMID: 31811385
Clinical characteristics of appendiceal diverticular disease.
Çakar E, Bayrak S, Çolak Ş, Dal F, Gürbulak B, Bektaş H, Yarıkkaya E, Ferlengez AG
Int J Colorectal Dis 2019 Dec;34(12):2035-2041. Epub 2019 Nov 4 doi: 10.1007/s00384-019-03410-2. PMID: 31686198
Early recurrence in peritoneal metastasis of appendiceal neoplasm: Survival and prognostic factors.
Kyang LS, Alzahrani NA, Alshahrani MS, Rahman MK, Liauw W, Morris DL
Eur J Surg Oncol 2019 Dec;45(12):2392-2397. Epub 2019 Jun 22 doi: 10.1016/j.ejso.2019.06.015. PMID: 31253546
Outcomes from cytoreduction and hyperthermic intraperitoneal chemotherapy for appendiceal epithelial neoplasms.
Narasimhan V, Pham T, Warrier S, Craig Lynch A, Michael M, Tie J, Ramsay R, Heriot A
ANZ J Surg 2019 Sep;89(9):1035-1040. Epub 2019 Jan 26 doi: 10.1111/ans.14985. PMID: 30685879

Recent systematic reviews

Incidence rate and histology of appendiceal neoplasms in complicated versus uncomplicated appendicitis: A meta-analysis and systematic review.
Solis-Pazmino P, Oka K, La K, Termeie O, Figueroa LA, Pilatuna E, Solis-Pazmino D, Harnegie MP, Cohen J, Barnajian M, Nasseri Y
Langenbecks Arch Surg 2023 Nov 9;408(1):432. doi: 10.1007/s00423-023-03164-0. PMID: 37940770Free PMC Article
Efficacy and safety in the use of intraperitoneal hyperthermia chemotherapy and peritoneal cytoreductive surgery for pseudomyxoma peritonei from appendiceal neoplasm: A systematic review.
Floriano I, Silvinato A, Reis JC, Cafalli C, Bernardo WM
Clinics (Sao Paulo) 2022;77:100039. Epub 2022 May 13 doi: 10.1016/j.clinsp.2022.100039. PMID: 35576869Free PMC Article
Risk of appendiceal neoplasm after interval appendectomy for complicated appendicitis: A systematic review and meta-analysis.
Peltrini R, Cantoni V, Green R, Lionetti R, D'Ambra M, Bartolini C, De Luca M, Bracale U, Cuocolo A, Corcione F
Surgeon 2021 Dec;19(6):e549-e558. Epub 2021 Feb 25 doi: 10.1016/j.surge.2021.01.010. PMID: 33640282
Acute appendicitis, inflammatory appendiceal mass and the risk of a hidden malignant tumor: a systematic review of the literature.
Teixeira FJR Jr, Couto Netto SDD, Akaishi EH, Utiyama EM, Menegozzo CAM, Rocha MC
World J Emerg Surg 2017;12:12. Epub 2017 Mar 9 doi: 10.1186/s13017-017-0122-9. PMID: 28286544Free PMC Article
Management of an unexpected appendiceal neoplasm.
Murphy EM, Farquharson SM, Moran BJ
Br J Surg 2006 Jul;93(7):783-92. doi: 10.1002/bjs.5385. PMID: 16775823

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