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Metastatic Non-Functioning Neuroendocrine Tumor

MedGen UID:
1632740
•Concept ID:
C4682865
•
Neoplastic Process
Synonyms: Metastatic Non-Functioning Well Differentiated Neuroendocrine Neoplasm; Metastatic Nonfunctional Neuroendocrine Tumor; Metastatic Nonfunctional Well Differentiated Neuroendocrine Neoplasm; Metastatic Nonfunctioning Well Differentiated Neuroendocrine Neoplasm

Definition

A non-functioning, well-differentiated neuroendocrine neoplasm that has spread from the original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Non-Functioning Neuroendocrine Tumor

Professional guidelines

PubMed

Update on Current Evidence for the Diagnosis and Management of Nonfunctioning Pituitary Neuroendocrine Tumors.
Whyte E, Nezu M, Chik C, Tateno T
Endocrinol Metab (Seoul) 2023 Dec;38(6):631-654. Epub 2023 Nov 15 doi: 10.3803/EnM.2023.1838. PMID: 37964483Free PMC Article
Management of small, asymptomatic, non-functioning pancreatic neuroendocrine tumours: follow-up, ablation, or surgery?
Dąbkowski K, Starzyńska T
Endokrynol Pol 2023;74(1):25-30. Epub 2022 Dec 15 doi: 10.5603/EP.a2022.0080. PMID: 36519652
Nonfunctional Pancreatic Neuroendocrine Tumors: Advances in Diagnosis, Management, and Controversies.
Dumlu EG, Karakoç D, Özdemir A
Int Surg 2015 Jun;100(6):1089-97. Epub 2015 Jan 15 doi: 10.9738/INTSURG-D-14-00204.1. PMID: 25590518Free PMC Article

Recent clinical studies

Etiology

Targeting neuroendocrine tumors with octreotide and lanreotide: Key points for clinical practice from NET specialists.
La Salvia A, Modica R, Rossi RE, Spada F, Rinzivillo M, Panzuto F, Faggiano A, Cinieri S, Fazio N
Cancer Treat Rev 2023 Jun;117:102560. Epub 2023 Apr 17 doi: 10.1016/j.ctrv.2023.102560. PMID: 37088017
COVID-19 in patients with neuroendocrine neoplasms: 2-year results of the INTENSIVE study.
Fazio N, Gervaso L, Halfdanarson TR, Sonbol M, Eiring RA, Pusceddu S, Prinzi N, Lombardi Stocchetti B, Grozinsky-Glasberg S, Gross DJ, Walter T, Robelin P, Lombard-Bohas C, Frassoni S, Bagnardi V, Antonuzzo L, Sparano C, Massironi S, Gelsomino F, Bongiovanni A, Ranallo N, Tafuto S, Rossi M, Cives M, Rasul Kakil I, Hamid H, Chirco A, Squadroni M, La Salvia A, Hernando J, Hofland J, Koumarianou A, Boselli S, Tamayo D, Mazzon C, Rubino M, Spada F
Endocr Relat Cancer 2023 Jun 1;30(6) Epub 2023 Apr 26 doi: 10.1530/ERC-22-0395. PMID: 36930250
Management of small, asymptomatic, non-functioning pancreatic neuroendocrine tumours: follow-up, ablation, or surgery?
Dąbkowski K, Starzyńska T
Endokrynol Pol 2023;74(1):25-30. Epub 2022 Dec 15 doi: 10.5603/EP.a2022.0080. PMID: 36519652
Patients with non-functional metastatic G2 pancreatic neuroendocrine tumor benefit from palliative surgery: A 20-year single-center retrospective analysis.
You T, Tang H, Xu X, Ying H, Sun Z, Cheng Y, Bai C
J Neuroendocrinol 2022 Dec;34(12):e13211. Epub 2022 Nov 13 doi: 10.1111/jne.13211. PMID: 36373196
Imaging neuroendocrine tumors: Characterizing the spectrum of radiographic findings.
Baghdadi A, Ghadimi M, Mirpour S, Hazhirkarzar B, Motaghi M, Pawlik TM, Kamel IR
Surg Oncol 2021 Jun;37:101529. Epub 2021 Jan 31 doi: 10.1016/j.suronc.2021.101529. PMID: 33549952

Diagnosis

Consensus on molecular imaging and theranostics in neuroendocrine neoplasms.
Ambrosini V, Kunikowska J, Baudin E, Bodei L, Bouvier C, Capdevila J, Cremonesi M, de Herder WW, Dromain C, Falconi M, Fani M, Fanti S, Hicks RJ, Kabasakal L, Kaltsas G, Lewington V, Minozzi S, Cinquini M, Öberg K, Oyen WJG, O'Toole D, Pavel M, Ruszniewski P, Scarpa A, Strosberg J, Sundin A, Taïeb D, Virgolini I, Wild D, Herrmann K, Yao J
Eur J Cancer 2021 Mar;146:56-73. Epub 2021 Feb 12 doi: 10.1016/j.ejca.2021.01.008. PMID: 33588146Free PMC Article
Imaging neuroendocrine tumors: Characterizing the spectrum of radiographic findings.
Baghdadi A, Ghadimi M, Mirpour S, Hazhirkarzar B, Motaghi M, Pawlik TM, Kamel IR
Surg Oncol 2021 Jun;37:101529. Epub 2021 Jan 31 doi: 10.1016/j.suronc.2021.101529. PMID: 33549952
Imaging of secretory tumors of the gastrointestinal tract.
ElGuindy YM, Javadi S, Menias CO, Jensen CT, Elsamaloty H, Elsayes KM
Abdom Radiol (NY) 2017 Apr;42(4):1113-1131. doi: 10.1007/s00261-016-0976-4. PMID: 27878636
Nonfunctional Pancreatic Neuroendocrine Tumors: Advances in Diagnosis, Management, and Controversies.
Dumlu EG, Karakoç D, Özdemir A
Int Surg 2015 Jun;100(6):1089-97. Epub 2015 Jan 15 doi: 10.9738/INTSURG-D-14-00204.1. PMID: 25590518Free PMC Article
Pancreatic neuroendocrine tumours.
Alexakis N, Neoptolemos JP
Best Pract Res Clin Gastroenterol 2008;22(1):183-205. doi: 10.1016/j.bpg.2007.10.008. PMID: 18206821

Therapy

Targeting neuroendocrine tumors with octreotide and lanreotide: Key points for clinical practice from NET specialists.
La Salvia A, Modica R, Rossi RE, Spada F, Rinzivillo M, Panzuto F, Faggiano A, Cinieri S, Fazio N
Cancer Treat Rev 2023 Jun;117:102560. Epub 2023 Apr 17 doi: 10.1016/j.ctrv.2023.102560. PMID: 37088017
Consensus on molecular imaging and theranostics in neuroendocrine neoplasms.
Ambrosini V, Kunikowska J, Baudin E, Bodei L, Bouvier C, Capdevila J, Cremonesi M, de Herder WW, Dromain C, Falconi M, Fani M, Fanti S, Hicks RJ, Kabasakal L, Kaltsas G, Lewington V, Minozzi S, Cinquini M, Öberg K, Oyen WJG, O'Toole D, Pavel M, Ruszniewski P, Scarpa A, Strosberg J, Sundin A, Taïeb D, Virgolini I, Wild D, Herrmann K, Yao J
Eur J Cancer 2021 Mar;146:56-73. Epub 2021 Feb 12 doi: 10.1016/j.ejca.2021.01.008. PMID: 33588146Free PMC Article
Recent Updates in the Management of Advanced Pancreatic Neuroendocrine Tumors.
Cho CM
Korean J Gastroenterol 2019 Mar 25;73(3):124-131. doi: 10.4166/kjg.2019.73.3.124. PMID: 31013555
Solid non-functioning endocrine tumors of the pancreas: correlating computed tomography and pathology.
Zamboni GA, Ambrosetti MC, Zivelonghi C, Lombardo F, Butturini G, Cingarlini S, Capelli P, Pozzi Mucelli R
HPB (Oxford) 2017 Nov;19(11):986-991. Epub 2017 Aug 4 doi: 10.1016/j.hpb.2017.06.013. PMID: 28784262
Pancreatic neuroendocrine tumours.
Alexakis N, Neoptolemos JP
Best Pract Res Clin Gastroenterol 2008;22(1):183-205. doi: 10.1016/j.bpg.2007.10.008. PMID: 18206821

Prognosis

Management of small, asymptomatic, non-functioning pancreatic neuroendocrine tumours: follow-up, ablation, or surgery?
Dąbkowski K, Starzyńska T
Endokrynol Pol 2023;74(1):25-30. Epub 2022 Dec 15 doi: 10.5603/EP.a2022.0080. PMID: 36519652
Patients with non-functional metastatic G2 pancreatic neuroendocrine tumor benefit from palliative surgery: A 20-year single-center retrospective analysis.
You T, Tang H, Xu X, Ying H, Sun Z, Cheng Y, Bai C
J Neuroendocrinol 2022 Dec;34(12):e13211. Epub 2022 Nov 13 doi: 10.1111/jne.13211. PMID: 36373196
Clinical implications of cell-of-origin epigenetic characteristics in non-functional pancreatic neuroendocrine tumors.
Dreijerink KM, Hackeng WM, Singhi AD, Heaphy CM, Brosens LA
J Pathol 2022 Feb;256(2):143-148. Epub 2021 Dec 18 doi: 10.1002/path.5834. PMID: 34750813
Recent Updates in the Management of Advanced Pancreatic Neuroendocrine Tumors.
Cho CM
Korean J Gastroenterol 2019 Mar 25;73(3):124-131. doi: 10.4166/kjg.2019.73.3.124. PMID: 31013555
Imaging of secretory tumors of the gastrointestinal tract.
ElGuindy YM, Javadi S, Menias CO, Jensen CT, Elsamaloty H, Elsayes KM
Abdom Radiol (NY) 2017 Apr;42(4):1113-1131. doi: 10.1007/s00261-016-0976-4. PMID: 27878636

Clinical prediction guides

Management of small, asymptomatic, non-functioning pancreatic neuroendocrine tumours: follow-up, ablation, or surgery?
Dąbkowski K, Starzyńska T
Endokrynol Pol 2023;74(1):25-30. Epub 2022 Dec 15 doi: 10.5603/EP.a2022.0080. PMID: 36519652
Clinical implications of cell-of-origin epigenetic characteristics in non-functional pancreatic neuroendocrine tumors.
Dreijerink KM, Hackeng WM, Singhi AD, Heaphy CM, Brosens LA
J Pathol 2022 Feb;256(2):143-148. Epub 2021 Dec 18 doi: 10.1002/path.5834. PMID: 34750813
Recent Updates in the Management of Advanced Pancreatic Neuroendocrine Tumors.
Cho CM
Korean J Gastroenterol 2019 Mar 25;73(3):124-131. doi: 10.4166/kjg.2019.73.3.124. PMID: 31013555
Sporadic pancreatic neuroendocrine tumor: Surgery of the primary tumor.
Deguelte S, de Mestier L, Hentic O, Cros J, Lebtahi R, Hammel P, Kianmanesh R
J Visc Surg 2018 Dec;155(6):483-492. Epub 2018 Nov 15 doi: 10.1016/j.jviscsurg.2018.08.010. PMID: 30448206
Solid non-functioning endocrine tumors of the pancreas: correlating computed tomography and pathology.
Zamboni GA, Ambrosetti MC, Zivelonghi C, Lombardo F, Butturini G, Cingarlini S, Capelli P, Pozzi Mucelli R
HPB (Oxford) 2017 Nov;19(11):986-991. Epub 2017 Aug 4 doi: 10.1016/j.hpb.2017.06.013. PMID: 28784262

Recent systematic reviews

Should surgery be conducted for small nonfunctioning pancreatic neuroendocrine tumors: a systemic review.
Guo J, Zhao J, Bi X, Li Z, Huang Z, Zhang Y, Cai J, Zhao H
Oncotarget 2017 May 23;8(21):35368-35375. doi: 10.18632/oncotarget.15685. PMID: 28430639Free PMC Article

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