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Abnormal Langerhans cell morphology

MedGen UID:
1632975
•Concept ID:
C4703585
•
Cell or Molecular Dysfunction
HPO: HP:0031871

Definition

Any functional anomaly of Langerhans cells, which are dendritic cells in the epidermis and some other locations. Langerhans cells play roles in immune surveillance and homeostasis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal Langerhans cell morphology

Professional guidelines

PubMed

Drug therapy for the treatment of Langerhans cell histiocytosis.
McClain KL
Expert Opin Pharmacother 2005 Nov;6(14):2435-41. doi: 10.1517/14656566.6.14.2435. PMID: 16259575
Neonatal hyperinsulinemic hypoglycemia: heterogeneity of the syndrome and keys for differential diagnosis.
Sempoux C, Guiot Y, Lefevre A, Nihoul-Fékété C, Jaubert F, Saudubray JM, Rahier J
J Clin Endocrinol Metab 1998 May;83(5):1455-61. doi: 10.1210/jcem.83.5.4768. PMID: 9589638
The differential diagnosis of pagetoid cells in the epidermis.
Kohler S, Rouse RV, Smoller BR
Mod Pathol 1998 Jan;11(1):79-92. PMID: 9556428

Recent clinical studies

Etiology

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus.
Xourafa G, Korbmacher M, Roden M
Nat Rev Endocrinol 2024 Jan;20(1):27-49. Epub 2023 Oct 16 doi: 10.1038/s41574-023-00898-1. PMID: 37845351
Smoking-Related Interstitial Lung Diseases.
Alarcon-Calderon A, Vassallo R, Yi ES, Ryu JH
Immunol Allergy Clin North Am 2023 May;43(2):273-287. Epub 2023 Mar 1 doi: 10.1016/j.iac.2023.01.007. PMID: 37055089
Merkel cell polyomavirus and Langerhans cell neoplasm.
Murakami I, Wada N, Nakashima J, Iguchi M, Toi M, Hashida Y, Higuchi T, Daibata M, Matsushita M, Iwasaki T, Kuwamoto S, Horie Y, Nagata K, Hayashi K, Oka T, Yoshino T, Imamura T, Morimoto A, Imashuku S, Gogusev J, Jaubert F
Cell Commun Signal 2018 Aug 22;16(1):49. doi: 10.1186/s12964-018-0261-y. PMID: 30134914Free PMC Article
Autoantibodies in type 1 diabetes.
Taplin CE, Barker JM
Autoimmunity 2008 Feb;41(1):11-8. doi: 10.1080/08916930701619169. PMID: 18176860
Mechanisms linking obesity to insulin resistance and type 2 diabetes.
Kahn SE, Hull RL, Utzschneider KM
Nature 2006 Dec 14;444(7121):840-6. doi: 10.1038/nature05482. PMID: 17167471

Diagnosis

Smoking-Related Interstitial Lung Diseases.
Alarcon-Calderon A, Vassallo R, Yi ES, Ryu JH
Immunol Allergy Clin North Am 2023 May;43(2):273-287. Epub 2023 Mar 1 doi: 10.1016/j.iac.2023.01.007. PMID: 37055089
Bone Pathology for Hematopathologists.
Peker D, Wei S, Siegal GP
Surg Pathol Clin 2019 Sep;12(3):831-847. Epub 2019 May 22 doi: 10.1016/j.path.2019.03.007. PMID: 31352990
Uncommon Neonatal Skin Lesions.
Manning JR, Lee DH
Pediatr Ann 2019 Jan 1;48(1):e30-e35. doi: 10.3928/19382359-20181212-02. PMID: 30653640
Merkel cell polyomavirus and Langerhans cell neoplasm.
Murakami I, Wada N, Nakashima J, Iguchi M, Toi M, Hashida Y, Higuchi T, Daibata M, Matsushita M, Iwasaki T, Kuwamoto S, Horie Y, Nagata K, Hayashi K, Oka T, Yoshino T, Imamura T, Morimoto A, Imashuku S, Gogusev J, Jaubert F
Cell Commun Signal 2018 Aug 22;16(1):49. doi: 10.1186/s12964-018-0261-y. PMID: 30134914Free PMC Article
Cystic Lung Diseases: Algorithmic Approach.
Raoof S, Bondalapati P, Vydyula R, Ryu JH, Gupta N, Raoof S, Galvin J, Rosen MJ, Lynch D, Travis W, Mehta S, Lazzaro R, Naidich D
Chest 2016 Oct;150(4):945-965. Epub 2016 May 13 doi: 10.1016/j.chest.2016.04.026. PMID: 27180915Free PMC Article

Therapy

Smoking-Related Interstitial Lung Diseases.
Alarcon-Calderon A, Vassallo R, Yi ES, Ryu JH
Immunol Allergy Clin North Am 2023 May;43(2):273-287. Epub 2023 Mar 1 doi: 10.1016/j.iac.2023.01.007. PMID: 37055089
The Role of the α Cell in the Pathogenesis of Diabetes: A World beyond the Mirror.
Martínez MS, Manzano A, Olivar LC, Nava M, Salazar J, D'Marco L, Ortiz R, Chacín M, Guerrero-Wyss M, Cabrera de Bravo M, Cano C, Bermúdez V, Angarita L
Int J Mol Sci 2021 Sep 1;22(17) doi: 10.3390/ijms22179504. PMID: 34502413Free PMC Article
Pulmonary langerhans cell histiocytosis.
Suri HS, Yi ES, Nowakowski GS, Vassallo R
Orphanet J Rare Dis 2012 Mar 19;7:16. doi: 10.1186/1750-1172-7-16. PMID: 22429393Free PMC Article
Smoking-related interstitial pneumonias and pulmonary Langerhans cell histiocytosis.
Caminati A, Harari S
Proc Am Thorac Soc 2006 Jun;3(4):299-306. doi: 10.1513/pats.200512-135TK. PMID: 16738193
Drug therapy for the treatment of Langerhans cell histiocytosis.
McClain KL
Expert Opin Pharmacother 2005 Nov;6(14):2435-41. doi: 10.1517/14656566.6.14.2435. PMID: 16259575

Prognosis

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus.
Xourafa G, Korbmacher M, Roden M
Nat Rev Endocrinol 2024 Jan;20(1):27-49. Epub 2023 Oct 16 doi: 10.1038/s41574-023-00898-1. PMID: 37845351
Smoking-Related Interstitial Lung Diseases.
Alarcon-Calderon A, Vassallo R, Yi ES, Ryu JH
Immunol Allergy Clin North Am 2023 May;43(2):273-287. Epub 2023 Mar 1 doi: 10.1016/j.iac.2023.01.007. PMID: 37055089
Bone Pathology for Hematopathologists.
Peker D, Wei S, Siegal GP
Surg Pathol Clin 2019 Sep;12(3):831-847. Epub 2019 May 22 doi: 10.1016/j.path.2019.03.007. PMID: 31352990
Autoantibodies in type 1 diabetes.
Taplin CE, Barker JM
Autoimmunity 2008 Feb;41(1):11-8. doi: 10.1080/08916930701619169. PMID: 18176860
Histiocyte disorders.
Webb DK
Br Med Bull 1996 Oct;52(4):818-25. doi: 10.1093/oxfordjournals.bmb.a011585. PMID: 9039734

Clinical prediction guides

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus.
Xourafa G, Korbmacher M, Roden M
Nat Rev Endocrinol 2024 Jan;20(1):27-49. Epub 2023 Oct 16 doi: 10.1038/s41574-023-00898-1. PMID: 37845351
Merkel cell polyomavirus and Langerhans cell neoplasm.
Murakami I, Wada N, Nakashima J, Iguchi M, Toi M, Hashida Y, Higuchi T, Daibata M, Matsushita M, Iwasaki T, Kuwamoto S, Horie Y, Nagata K, Hayashi K, Oka T, Yoshino T, Imamura T, Morimoto A, Imashuku S, Gogusev J, Jaubert F
Cell Commun Signal 2018 Aug 22;16(1):49. doi: 10.1186/s12964-018-0261-y. PMID: 30134914Free PMC Article
Advances in the etiology and mechanisms of type 1 diabetes.
Pugliese A
Discov Med 2014 Sep;18(98):141-50. PMID: 25227755
Autoantibodies in type 1 diabetes.
Taplin CE, Barker JM
Autoimmunity 2008 Feb;41(1):11-8. doi: 10.1080/08916930701619169. PMID: 18176860
Langerhans cell histiocytosis.
Herzog KM, Tubbs RR
Adv Anat Pathol 1998 Nov;5(6):347-58. doi: 10.1097/00125480-199811000-00001. PMID: 10095876

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