Abnormal PR interval

MedGen UID:: 1634800
•Concept ID:: C4703431
•: Finding

HPO:	HP:0031593

Definition

An anomaly of the PR interval, which is the portion of the ECG from the onset of the P wave to the beginning of the QRS complex. A normal PR interval in adults is 0.12-0.2 seconds. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal PR interval

Abnormal Cardiac Study
- Abnormal EKG
  - Abnormal PR interval
    - Prolonged PR interval
    - Shortened PR interval

Conditions with this feature

Sick sinus syndrome 4

MedGen UID:: 1794159
•Concept ID:: C5561949
•: Disease or Syndrome

Sick sinus syndrome-4 (SSS4) is characterized by early and progressive sinus node and atrioventricular conduction dysfunction. Patients show bradycardia and chronotropic incompetence, and may experience syncope. Atrioventricular conduction block ranges from mild to severe, and some patients also have intermittent atrial fibrillation. Many require implantation of a pacemaker, but sudden cardiac death has not been reported (Stallmeyer et al., 2017). For a general phenotypic description and discussion of genetic heterogeneity of sick sinus syndrome, see SSS1 (608567).

See: Condition Record

Sick sinus syndrome 4

Professional guidelines

PubMed

Associations between primary care electrocardiography and non-Alzheimer dementia.

Isaksen JL, Ghouse J, Skov MW, Olesen MS, Holst AG, Pietersen A, Nielsen JB, Maier A, Graff C, Frikke-Schmidt R, Kanters JK
J Stroke Cerebrovasc Dis 2022 Sep;31(9):106640. Epub 2022 Jul 10 doi: 10.1016/j.jstrokecerebrovasdis.2022.106640. PMID: 35830834

Could Aspirin Treatment Modify the Assessment of the Uterine Arteries?

Vallejo GM, Uriel M, Porras-Ramírez A, Romero XC
Rev Bras Ginecol Obstet 2022 Mar;44(3):231-237. Epub 2022 Feb 9 doi: 10.1055/s-0042-1742411. PMID: 35139575 Free PMC Article

Nutritional assessment and risk factors associated to malnutrition in patients with esophageal cancer.

Cao J, Xu H, Li W, Guo Z, Lin Y, Shi Y, Hu W, Ba Y, Li S, Li Z, Wang K, Wu J, He Y, Yang J, Xie C, Zhou F, Song X, Chen G, Ma W, Luo S, Chen Z, Cong M, Ma H, Zhou C, Wang W, Qi Luo, Shi Y, Qi Y, Jiang H, Guan W, Chen J, Chen J, Fang Y, Zhou L, Feng Y, Tan R, Ou J, Zhao Q, Wu J, Xin Lin, Yang L, Fu Z, Wang C, Deng L, Li T, Song C, Shi H; Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group, Chinese Society of Nutritional Oncology
Curr Probl Cancer 2021 Feb;45(1):100638. Epub 2020 Aug 14 doi: 10.1016/j.currproblcancer.2020.100638. PMID: 32829957

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Recent clinical studies

Etiology

Behavior of the PR interval with increasing heart rate in patients with COVID-19.

Pavri BB, Kloo J, Farzad D, Riley JM
Heart Rhythm 2020 Sep;17(9):1434-1438. Epub 2020 Jun 11 doi: 10.1016/j.hrthm.2020.06.009. PMID: 32535142 Free PMC Article

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.

van Setten J, Brody JA, Jamshidi Y, Swenson BR, Butler AM, Campbell H, Del Greco FM, Evans DS, Gibson Q, Gudbjartsson DF, Kerr KF, Krijthe BP, Lyytikäinen LP, Müller C, Müller-Nurasyid M, Nolte IM, Padmanabhan S, Ritchie MD, Robino A, Smith AV, Steri M, Tanaka T, Teumer A, Trompet S, Ulivi S, Verweij N, Yin X, Arnar DO, Asselbergs FW, Bader JS, Barnard J, Bis J, Blankenberg S, Boerwinkle E, Bradford Y, Buckley BM, Chung MK, Crawford D, den Hoed M, Denny JC, Dominiczak AF, Ehret GB, Eijgelsheim M, Ellinor PT, Felix SB, Franco OH, Franke L, Harris TB, Holm H, Ilaria G, Iorio A, Kähönen M, Kolcic I, Kors JA, Lakatta EG, Launer LJ, Lin H, Lin HJ, Loos RJF, Lubitz SA, Macfarlane PW, Magnani JW, Leach IM, Meitinger T, Mitchell BD, Munzel T, Papanicolaou GJ, Peters A, Pfeufer A, Pramstaller PP, Raitakari OT, Rotter JI, Rudan I, Samani NJ, Schlessinger D, Silva Aldana CT, Sinner MF, Smith JD, Snieder H, Soliman EZ, Spector TD, Stott DJ, Strauch K, Tarasov KV, Thorsteinsdottir U, Uitterlinden AG, Van Wagoner DR, Völker U, Völzke H, Waldenberger M, Jan Westra H, Wild PS, Zeller T, Alonso A, Avery CL, Bandinelli S, Benjamin EJ, Cucca F, Dörr M, Ferrucci L, Gasparini P, Gudnason V, Hayward C, Heckbert SR, Hicks AA, Jukema JW, Kääb S, Lehtimäki T, Liu Y, Munroe PB, Parsa A, Polasek O, Psaty BM, Roden DM, Schnabel RB, Sinagra G, Stefansson K, Stricker BH, van der Harst P, van Duijn CM, Wilson JF, Gharib SA, de Bakker PIW, Isaacs A, Arking DE, Sotoodehnia N
Nat Commun 2018 Jul 25;9(1):2904. doi: 10.1038/s41467-018-04766-9. PMID: 30046033 Free PMC Article

PR-Interval Components and Atrial Fibrillation Risk (from the Atherosclerosis Risk in Communities Study).

Smith JW, O'Neal WT, Shoemaker MB, Chen LY, Alonso A, Whalen SP, Soliman EZ
Am J Cardiol 2017 Feb 1;119(3):466-472. Epub 2016 Nov 1 doi: 10.1016/j.amjcard.2016.10.016. PMID: 27889043 Free PMC Article

Evaluation of fetuses in a study of intravenous immunoglobulin as preventive therapy for congenital heart block: Results of a multicenter, prospective, open-label clinical trial.

Friedman DM, Llanos C, Izmirly PM, Brock B, Byron J, Copel J, Cummiskey K, Dooley MA, Foley J, Graves C, Hendershott C, Kates R, Komissarova EV, Miller M, Paré E, Phoon CK, Prosen T, Reisner D, Ruderman E, Samuels P, Yu JK, Kim MY, Buyon JP
Arthritis Rheum 2010 Apr;62(4):1138-46. doi: 10.1002/art.27308. PMID: 20391423 Free PMC Article

Utility of cardiac monitoring in fetuses at risk for congenital heart block: the PR Interval and Dexamethasone Evaluation (PRIDE) prospective study.

Friedman DM, Kim MY, Copel JA, Davis C, Phoon CK, Glickstein JS, Buyon JP; PRIDE Investigators
Circulation 2008 Jan 29;117(4):485-93. Epub 2008 Jan 14 doi: 10.1161/CIRCULATIONAHA.107.707661. PMID: 18195175

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Diagnosis

Behavior of the PR interval with increasing heart rate in patients with COVID-19.

Pavri BB, Kloo J, Farzad D, Riley JM
Heart Rhythm 2020 Sep;17(9):1434-1438. Epub 2020 Jun 11 doi: 10.1016/j.hrthm.2020.06.009. PMID: 32535142 Free PMC Article

Utility of cardiac monitoring in fetuses at risk for congenital heart block: the PR Interval and Dexamethasone Evaluation (PRIDE) prospective study.

See all (2)