U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Optic ataxia

MedGen UID:
1635801
Concept ID:
C4703584
Finding
SNOMED CT: Optic ataxia (1231201006)
 
HPO: HP:0031868

Definition

Difficulty reaching visually guided goals in peripheral vision, with the deficit, leaves voluntary eye movements largely unaffected. [from HPO]

Term Hierarchy

Conditions with this feature

Alzheimer disease 3
MedGen UID:
334304
Concept ID:
C1843013
Disease or Syndrome
Alzheimer's disease can be classified as early-onset or late-onset. The signs and symptoms of the early-onset form appear between a person's thirties and mid-sixties, while the late-onset form appears during or after a person's mid-sixties. The early-onset form of Alzheimer's disease is much less common than the late-onset form, accounting for less than 10 percent of all cases of Alzheimer's disease.\n\nIndividuals with Alzheimer's disease usually survive 8 to 10 years after the appearance of symptoms, but the course of the disease can range from 1 to 25 years. Survival is usually shorter in individuals diagnosed after age 80 than in those diagnosed at a younger age. In Alzheimer's disease, death usually results from pneumonia, malnutrition, or general body wasting (inanition).\n\nAs the disorder progresses, some people with Alzheimer's disease experience personality and behavioral changes and have trouble interacting in a socially appropriate manner. Other common symptoms include agitation, restlessness, withdrawal, and loss of language skills. People with Alzheimer's disease usually require total care during the advanced stages of the disease.\n\nMemory loss is the most common sign of Alzheimer's disease. Forgetfulness may be subtle at first, but the loss of memory worsens over time until it interferes with most aspects of daily living. Even in familiar settings, a person with Alzheimer's disease may get lost or become confused. Routine tasks such as preparing meals, doing laundry, and performing other household chores can be challenging. Additionally, it may become difficult to recognize people and name objects. Affected people increasingly require help with dressing, eating, and personal care.\n\nAlzheimer's disease is a degenerative disease of the brain that causes dementia, which is a gradual loss of memory, judgment, and ability to function. This disorder usually appears in people older than age 65, but less common forms of the disease appear earlier in adulthood.

Professional guidelines

Recent clinical studies

Etiology

Rounis E, Binkofski F
Stroke 2023 Jan;54(1):30-43. Epub 2022 Dec 21 doi: 10.1161/STROKEAHA.122.037948. PMID: 36542070
Mitchell AG, Rossit S, Pal S, Hornberger M, Warman A, Kenning E, Williamson L, Shapland R, McIntosh RD
Cortex 2022 Apr;149:29-43. Epub 2022 Jan 31 doi: 10.1016/j.cortex.2022.01.003. PMID: 35184013Free PMC Article
Haque S, Vaphiades MS, Lueck CJ
J Neuroophthalmol 2018 Sep;38(3):379-392. doi: 10.1097/WNO.0000000000000556. PMID: 28945627
Singh TD, Josephs KA, Machulda MM, Drubach DA, Apostolova LG, Lowe VJ, Whitwell JL
J Neurol 2015 Jun;262(6):1483-92. Epub 2015 Apr 11 doi: 10.1007/s00415-015-7732-5. PMID: 25862483Free PMC Article
Jackson SR, Newport R, Husain M, Fowlie JE, O'Donoghue M, Bajaj N
Neuropsychologia 2009 May;47(6):1397-408. Epub 2009 Feb 4 doi: 10.1016/j.neuropsychologia.2009.01.035. PMID: 19428405

Diagnosis

Cipriano L, Oliva M, Puoti G, Signoriello E, Bonavita S, Coppola C
Rev Neurosci 2022 Dec 16;33(8):849-858. Epub 2022 Jun 6 doi: 10.1515/revneuro-2022-0003. PMID: 35659868
Mitchell AG, Rossit S, Pal S, Hornberger M, Warman A, Kenning E, Williamson L, Shapland R, McIntosh RD
Cortex 2022 Apr;149:29-43. Epub 2022 Jan 31 doi: 10.1016/j.cortex.2022.01.003. PMID: 35184013Free PMC Article
Berlucchi G, Vallar G
Handb Clin Neurol 2018;151:3-30. doi: 10.1016/B978-0-444-63622-5.00001-2. PMID: 29519464
Haque S, Vaphiades MS, Lueck CJ
J Neuroophthalmol 2018 Sep;38(3):379-392. doi: 10.1097/WNO.0000000000000556. PMID: 28945627
Dutton GN
Eye (Lond) 2003 Apr;17(3):289-304. doi: 10.1038/sj.eye.6700344. PMID: 12724689

Therapy

Fumuro T, Matsuhashi M, Miyazaki T, Inouchi M, Hitomi T, Matsumoto R, Takahashi R, Fukuyama H, Ikeda A
Clin Neurophysiol 2015 Apr;126(4):756-62. Epub 2014 Aug 21 doi: 10.1016/j.clinph.2014.07.026. PMID: 25213350
Gaveau V, Pélisson D, Blangero A, Urquizar C, Prablanc C, Vighetto A, Pisella L
Neuropsychologia 2008 Jan 31;46(2):475-86. Epub 2007 Sep 14 doi: 10.1016/j.neuropsychologia.2007.08.028. PMID: 17963798
Karnath HO, Perenin MT
Cereb Cortex 2005 Oct;15(10):1561-9. Epub 2005 Feb 16 doi: 10.1093/cercor/bhi034. PMID: 15716470
Prablanc C, Desmurget M, Gréa H
Prog Brain Res 2003;142:155-70. doi: 10.1016/S0079-6123(03)42012-8. PMID: 12693260
Merchut MP, Richie B
Arch Neurol 2002 May;59(5):851-4. doi: 10.1001/archneur.59.5.851. PMID: 12020271

Prognosis

Bosco A, Bertini C, Filippini M, Foglino C, Fattori P
J Vis 2022 Sep 2;22(10):3. doi: 10.1167/jov.22.10.3. PMID: 36069943Free PMC Article
Cipriano L, Oliva M, Puoti G, Signoriello E, Bonavita S, Coppola C
Rev Neurosci 2022 Dec 16;33(8):849-858. Epub 2022 Jun 6 doi: 10.1515/revneuro-2022-0003. PMID: 35659868
Sakurai Y, Fujimoto M, Hamada K, Sugimoto I
Cogn Neuropsychiatry 2018 Jan;23(1):1-14. Epub 2017 Dec 2 doi: 10.1080/13546805.2017.1407304. PMID: 29199507
Binkofski F, Buxbaum LJ
Brain Lang 2013 Nov;127(2):222-9. Epub 2012 Aug 11 doi: 10.1016/j.bandl.2012.07.007. PMID: 22889467Free PMC Article
Caminiti R, Chafee MV, Battaglia-Mayer A, Averbeck BB, Crowe DA, Georgopoulos AP
Eur J Neurosci 2010 Jun;31(12):2320-40. Epub 2010 Jun 9 doi: 10.1111/j.1460-9568.2010.07291.x. PMID: 20550568Free PMC Article

Clinical prediction guides

Cipriano L, Oliva M, Puoti G, Signoriello E, Bonavita S, Coppola C
Rev Neurosci 2022 Dec 16;33(8):849-858. Epub 2022 Jun 6 doi: 10.1515/revneuro-2022-0003. PMID: 35659868
Mitchell AG, Rossit S, Pal S, Hornberger M, Warman A, Kenning E, Williamson L, Shapland R, McIntosh RD
Cortex 2022 Apr;149:29-43. Epub 2022 Jan 31 doi: 10.1016/j.cortex.2022.01.003. PMID: 35184013Free PMC Article
Ganel T, Goodale MA
Neuropsychologia 2019 May;128:249-254. Epub 2017 Sep 23 doi: 10.1016/j.neuropsychologia.2017.09.016. PMID: 28951167
Rossetti Y, Pisella L, McIntosh RD
Ann Phys Rehabil Med 2017 Jun;60(3):130-140. Epub 2017 May 23 doi: 10.1016/j.rehab.2017.02.002. PMID: 28545844
Harvey M, Rossit S
Neuropsychologia 2012 May;50(6):1018-28. Epub 2011 Sep 22 doi: 10.1016/j.neuropsychologia.2011.09.030. PMID: 21978832

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...