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Nephrotic Syndrome with Lesion of Endothelial Glomerulonephritis

MedGen UID:: 163589
•Concept ID:: C0866111
•: Disease or Syndrome

Definition

A renal functional disorder characterized by proteinuria, edema, hyperlipidemia and hypoalbuminemia. It results from damage to the renal vascular filtration apparatus. It is further characterized by an inflammatory reaction in the endovascular lining of the glomerular capillaries. Sequelae may include hypertension, atherosclerosis, infection, hypercoagulablity and renal failure. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNephrotic Syndrome with Lesion of Endothelial Glomerulonephritis

Congenital Systemic Disorder
- Abnormality of the genitourinary system
  - Abnormality of the urinary system
    - Abnormality of the urinary system physiology
      - Abnormal renal physiology
        Nephrotic syndrome
        Nephrotic Syndrome with Lesion of Endothelial Glomerulonephritis

Recent clinical studies

Etiology

Morphofunctional Effects of C5 Convertase Blockade in Immune Complex-Mediated Membranoproliferative Glomerulonephritis: Report of Two Cases with Evidence of Terminal Complement Activation.

Carrara C, Podestà MA, Abbate M, Rizzo P, Piras R, Alberti M, Daina E, Ruggenenti P, Remuzzi G; on behalf of the EAGLE Study Group
Nephron 2020;144(4):195-203. Epub 2020 Feb 12 doi: 10.1159/000505403. PMID: 32050203

Focal segmental glomerulosclerosis lesion associated with inhibition of tyrosine kinases by lenvatinib: a case report.

Furuto Y, Hashimoto H, Namikawa A, Outi H, Takahashi H, Horiuti H, Honda K, Shibuya Y
BMC Nephrol 2018 Oct 19;19(1):273. doi: 10.1186/s12882-018-1074-3. PMID: 30340546 Free PMC Article

Glomerular endothelial cell injury and focal segmental glomerulosclerosis lesion in idiopathic membranous nephropathy.

Morita M, Mii A, Shimizu A, Yasuda F, Shoji J, Masuda Y, Ohashi R, Nagahama K, Kaneko T, Tsuruoka S
PLoS One 2015;10(4):e0116700. Epub 2015 Apr 15 doi: 10.1371/journal.pone.0116700. PMID: 25875837 Free PMC Article

Idiopathic collapsing glomerulopathy in children.

Singh HK, Baldree LA, McKenney DW, Hogan SL, Jennette JC
Pediatr Nephrol 2000 Feb;14(2):132-7. doi: 10.1007/s004670050028. PMID: 10684363

The different forms of glomerulonephritis morphological and clinical aspects, analyzed in 2500 patients.

Bohle A, Eichenseher N, Fischbach H, Neild GH, Wehner H, Edel HH, Losse H, Renner E, Reichel W, Schütterle G
Klin Wochenschr 1976 Jan 15;54(2):59-73. doi: 10.1007/BF01468771. PMID: 1249903

See all (8)

Diagnosis

Nephrotic syndrome due to preeclampsia before 20 weeks of gestation: a case report.

Suzuki T, Ichikawa D, Nakata M, Watanabe S, Han W, Kohatsu K, Shirai S, Imai N, Koike J, Shibagaki Y
BMC Nephrol 2020 Jun 29;21(1):240. doi: 10.1186/s12882-020-01876-9. PMID: 32600286 Free PMC Article

Focal segmental glomerulosclerosis lesion associated with inhibition of tyrosine kinases by lenvatinib: a case report.

Furuto Y, Hashimoto H, Namikawa A, Outi H, Takahashi H, Horiuti H, Honda K, Shibuya Y
BMC Nephrol 2018 Oct 19;19(1):273. doi: 10.1186/s12882-018-1074-3. PMID: 30340546 Free PMC Article

Human immunodeficiency virus nephropathy.

Strauss J, Zilleruelo G, Abitbol C, Montane B, Pardo V
Pediatr Nephrol 1993 Apr;7(2):220-5. doi: 10.1007/BF00864411. PMID: 8476724

The different forms of glomerulonephritis morphological and clinical aspects, analyzed in 2500 patients.

Bohle A, Eichenseher N, Fischbach H, Neild GH, Wehner H, Edel HH, Losse H, Renner E, Reichel W, Schütterle G
Klin Wochenschr 1976 Jan 15;54(2):59-73. doi: 10.1007/BF01468771. PMID: 1249903

Extramembranous glomerulonephritis in childhood: relationship to systemic lupus erythematosus.

Libit SA, Burke B, Michael AF, Vernier RL
J Pediatr 1976 Mar;88(3):394-402. doi: 10.1016/s0022-3476(76)80253-3. PMID: 1245950

See all (13)

Therapy

Current Trends in Anti-Cancer Molecular Targeted Therapies: Renal Complications and Their Histological Features.

Tonooka A, Ohashi R
J Nippon Med Sch 2022 May 12;89(2):128-138. Epub 2021 Nov 26 doi: 10.1272/jnms.JNMS.2022_89-221. PMID: 34840210

Membranous nephropathy with thrombotic microangiopathy-like lesions successfully treated with tocilizumab in a patient with idiopathic multicentric Castleman disease.

Tosaki T, Okabe M, Suzuki T, Shimizu A, Koike K, Tsuboi N, Kawamura T, Ohashi R, Yano S, Yokoo T
CEN Case Rep 2021 May;10(2):265-272. Epub 2021 Jan 2 doi: 10.1007/s13730-020-00559-6. PMID: 33389670 Free PMC Article

Nephrotic syndrome due to preeclampsia before 20 weeks of gestation: a case report.

Focal segmental glomerulosclerosis lesion associated with inhibition of tyrosine kinases by lenvatinib: a case report.

Furuto Y, Hashimoto H, Namikawa A, Outi H, Takahashi H, Horiuti H, Honda K, Shibuya Y
BMC Nephrol 2018 Oct 19;19(1):273. doi: 10.1186/s12882-018-1074-3. PMID: 30340546 Free PMC Article

Human immunodeficiency virus nephropathy.

Strauss J, Zilleruelo G, Abitbol C, Montane B, Pardo V
Pediatr Nephrol 1993 Apr;7(2):220-5. doi: 10.1007/BF00864411. PMID: 8476724

See all (16)

Prognosis

Drug-induced kidney disease: a study of the Japan Renal Biopsy Registry from 2007 to 2015.

Yokoyama H, Narita I, Sugiyama H, Nagata M, Sato H, Ueda Y, Matsuo S
Clin Exp Nephrol 2016 Oct;20(5):720-730. Epub 2015 Nov 21 doi: 10.1007/s10157-015-1201-4. PMID: 26590949 Free PMC Article

Glomerular endothelial cell injury and focal segmental glomerulosclerosis lesion in idiopathic membranous nephropathy.

Idiopathic IgA nephropathy with diffuse crescent formation.

Tang Z, Wu Y, Wang QW, Yu YS, Hu WX, Yao XD, Chen HP, Liu ZH, Li LS
Am J Nephrol 2002 Sep-Dec;22(5-6):480-6. doi: 10.1159/000065281. PMID: 12381947

Human immunodeficiency virus nephropathy.

Strauss J, Zilleruelo G, Abitbol C, Montane B, Pardo V
Pediatr Nephrol 1993 Apr;7(2):220-5. doi: 10.1007/BF00864411. PMID: 8476724

The different forms of glomerulonephritis morphological and clinical aspects, analyzed in 2500 patients.

Bohle A, Eichenseher N, Fischbach H, Neild GH, Wehner H, Edel HH, Losse H, Renner E, Reichel W, Schütterle G
Klin Wochenschr 1976 Jan 15;54(2):59-73. doi: 10.1007/BF01468771. PMID: 1249903

See all (8)

Clinical prediction guides

Current Trends in Anti-Cancer Molecular Targeted Therapies: Renal Complications and Their Histological Features.

Tonooka A, Ohashi R
J Nippon Med Sch 2022 May 12;89(2):128-138. Epub 2021 Nov 26 doi: 10.1272/jnms.JNMS.2022_89-221. PMID: 34840210

Morphofunctional Effects of C5 Convertase Blockade in Immune Complex-Mediated Membranoproliferative Glomerulonephritis: Report of Two Cases with Evidence of Terminal Complement Activation.

Glomerular endothelial cell injury and focal segmental glomerulosclerosis lesion in idiopathic membranous nephropathy.

High sirolimus levels may induce focal segmental glomerulosclerosis de novo.

Letavernier E, Bruneval P, Mandet C, Duong Van Huyen JP, Péraldi MN, Helal I, Noël LH, Legendre C
Clin J Am Soc Nephrol 2007 Mar;2(2):326-33. Epub 2007 Feb 7 doi: 10.2215/CJN.03751106. PMID: 17699432

Pathogenesis of glomerular damage in glomerulonephritis.

Couser WG
Nephrol Dial Transplant 1998;13 Suppl 1:10-5. doi: 10.1093/ndt/13.suppl_1.10. PMID: 9507491

See all (14)

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Nephrotic Syndrome with Lesion of Endothelial Glomerulonephritis

Definition

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Practice guidelines

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