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Increased HDL cholesterol concentration

MedGen UID:
1636134
•Concept ID:
C4551591
•
Finding
Synonyms: High blood HDL level; Hyperalphalipoproteinemia; Increased circulating high-density lipoprotein levels
 
HPO: HP:0012184

Definition

An elevated concentration of high-density lipoprotein cholesterol (HDL) in the blood. [from HPO]

Conditions with this feature

Hyperalphalipoproteinemia 1
MedGen UID:
460812
•Concept ID:
C3149462
•
Disease or Syndrome
See: Condition Record
Hyperlipidemia due to hepatic triglyceride lipase deficiency
MedGen UID:
462816
•Concept ID:
C3151466
•
Disease or Syndrome
Hepatic lipase deficiency is characterized by premature atherosclerosis, elevated total cholesterol, triglycerides (TG), and very low density lipoprotein (VLDL), as well as TG-rich low density lipoprotein (LDL) and HDL subfractions (summary by Hegele et al., 1991).
See: Condition Record
Apolipoprotein c-III deficiency
MedGen UID:
462817
•Concept ID:
C3151467
•
Disease or Syndrome
See: Condition Record
Apolipoprotein c-III deficiency
Hyperalphalipoproteinemia 1
Hyperlipidemia due to hepatic triglyceride lipase deficiency

Professional guidelines

PubMed

Efficacy of low carbohydrate diet for type 2 diabetes mellitus management: A systematic review and meta-analysis of randomized controlled trials.
Meng Y, Bai H, Wang S, Li Z, Wang Q, Chen L
Diabetes Res Clin Pract 2017 Sep;131:124-131. Epub 2017 Jul 8 doi: 10.1016/j.diabres.2017.07.006. PMID: 28750216
Association of paraoxonase-1 M55L genotype and alcohol consumption with coronary atherosclerosis: the Helsinki Sudden Death Study.
Rontu R, Lehtimäki T, Ilveskoski E, Mikkelsson J, Kajander O, Goebeler S, Perola M, Penttilä A, Karhunen PJ
Pharmacogenetics 2004 Aug;14(8):479-85. doi: 10.1097/01.fpc.0000114746.08559.00. PMID: 15284530
Effect of nicardipine treatment on carbohydrate and lipoprotein metabolism in patients with hypertension.
Wang DJ, Shen DC, Sheu WH, Chu NF, Fuh MM, Chen LM
Clin Exp Hypertens 1993 May;15(3):557-73. doi: 10.3109/10641969309041629. PMID: 8490596

Recent clinical studies

Etiology

Effect of whole milk compared with skimmed milk on fasting blood lipids in healthy adults: a 3-week randomized crossover study.
Engel S, Elhauge M, Tholstrup T
Eur J Clin Nutr 2018 Feb;72(2):249-254. Epub 2017 Dec 11 doi: 10.1038/s41430-017-0042-5. PMID: 29229955
Efficacy of low carbohydrate diet for type 2 diabetes mellitus management: A systematic review and meta-analysis of randomized controlled trials.
Meng Y, Bai H, Wang S, Li Z, Wang Q, Chen L
Diabetes Res Clin Pract 2017 Sep;131:124-131. Epub 2017 Jul 8 doi: 10.1016/j.diabres.2017.07.006. PMID: 28750216
Association of paraoxonase-1 M55L genotype and alcohol consumption with coronary atherosclerosis: the Helsinki Sudden Death Study.
Rontu R, Lehtimäki T, Ilveskoski E, Mikkelsson J, Kajander O, Goebeler S, Perola M, Penttilä A, Karhunen PJ
Pharmacogenetics 2004 Aug;14(8):479-85. doi: 10.1097/01.fpc.0000114746.08559.00. PMID: 15284530

Therapy

Effect of whole milk compared with skimmed milk on fasting blood lipids in healthy adults: a 3-week randomized crossover study.
Engel S, Elhauge M, Tholstrup T
Eur J Clin Nutr 2018 Feb;72(2):249-254. Epub 2017 Dec 11 doi: 10.1038/s41430-017-0042-5. PMID: 29229955
Efficacy of low carbohydrate diet for type 2 diabetes mellitus management: A systematic review and meta-analysis of randomized controlled trials.
Meng Y, Bai H, Wang S, Li Z, Wang Q, Chen L
Diabetes Res Clin Pract 2017 Sep;131:124-131. Epub 2017 Jul 8 doi: 10.1016/j.diabres.2017.07.006. PMID: 28750216
Effect of dietary sphingomyelin on absorption and fractional synthetic rate of cholesterol and serum lipid profile in humans.
Ramprasath VR, Jones PJ, Buckley DD, Woollett LA, Heubi JE
Lipids Health Dis 2013 Aug 19;12:125. doi: 10.1186/1476-511X-12-125. PMID: 23958473Free PMC Article
Association of paraoxonase-1 M55L genotype and alcohol consumption with coronary atherosclerosis: the Helsinki Sudden Death Study.
Rontu R, Lehtimäki T, Ilveskoski E, Mikkelsson J, Kajander O, Goebeler S, Perola M, Penttilä A, Karhunen PJ
Pharmacogenetics 2004 Aug;14(8):479-85. doi: 10.1097/01.fpc.0000114746.08559.00. PMID: 15284530
Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production.
Guivernau M, Meza N, Barja P, Roman O
Prostaglandins Leukot Essent Fatty Acids 1994 Nov;51(5):311-6. doi: 10.1016/0952-3278(94)90002-7. PMID: 7846101

Clinical prediction guides

Effect of whole milk compared with skimmed milk on fasting blood lipids in healthy adults: a 3-week randomized crossover study.
Engel S, Elhauge M, Tholstrup T
Eur J Clin Nutr 2018 Feb;72(2):249-254. Epub 2017 Dec 11 doi: 10.1038/s41430-017-0042-5. PMID: 29229955
Effect of dietary sphingomyelin on absorption and fractional synthetic rate of cholesterol and serum lipid profile in humans.
Ramprasath VR, Jones PJ, Buckley DD, Woollett LA, Heubi JE
Lipids Health Dis 2013 Aug 19;12:125. doi: 10.1186/1476-511X-12-125. PMID: 23958473Free PMC Article

Recent systematic reviews

Efficacy of low carbohydrate diet for type 2 diabetes mellitus management: A systematic review and meta-analysis of randomized controlled trials.
Meng Y, Bai H, Wang S, Li Z, Wang Q, Chen L
Diabetes Res Clin Pract 2017 Sep;131:124-131. Epub 2017 Jul 8 doi: 10.1016/j.diabres.2017.07.006. PMID: 28750216

Supplemental Content

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    Clinical resources

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    Related information

    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • PMC Articles
      Related information in PubMed Central Links
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