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Adenocarcinoma of penis

MedGen UID:
1637360
•Concept ID:
C2212153
•
Neoplastic Process
Synonyms: Adenocarcinoma of the penis; Penile adenocarcinoma
SNOMED CT: Adenocarcinoma of penis (764846009); Penile adenocarcinoma (764846009)
 
Orphanet: ORPHA398053

Definition

An extremely rare penile epithelial neoplasm, histologically composed of nests of epithelial cells floating in lakes of extracellular, PAS-positive mucin, with clinical characteristics of a nonhealing ulcer or soft mass in the preputium or glans area, with itching and burning often preceding appearance of the lesion. Lymphadenopathy may indicate dissemination. Mucinous metaplasia of the penis may be a risk factor. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma of penis

Professional guidelines

PubMed

Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Current Disease Management of Primary Urethral Carcinoma.
Janisch F, Abufaraj M, Fajkovic H, Kimura S, Iwata T, Nyirady P, Rink M, Shariat SF
Eur Urol Focus 2019 Sep;5(5):722-734. Epub 2019 Jul 13 doi: 10.1016/j.euf.2019.07.001. PMID: 31307949
Surgical correction of bladder neck contracture following prostate cancer treatment.
Bugeja S, Andrich DE, Mundy AR
Arch Esp Urol 2014 Jan-Feb;67(1):77-91. PMID: 24531675

Recent clinical studies

Etiology

The 2022 revision of the World Health Organization classification of tumors of the urinary system and male genital organs: advances and challenges.
Mohanty SK, Lobo A, Cheng L
Hum Pathol 2023 Jun;136:123-143. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.006. PMID: 36084769
Mucinous adenocarcinoma of the prostatic urethra after brachytherapy for prostatic adenocarcinoma: a case series.
Zhao T, Chuang HW, Cornejo KM, Crotty RK, Dahl DM, Wszolek MF, Zlatev DV, Zietman AL, Wu CL
Hum Pathol 2022 Oct;128:101-109. Epub 2022 Aug 1 doi: 10.1016/j.humpath.2022.07.018. PMID: 35926810
The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783
Value of frozen sections in uropathology.
Algaba F
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):23-8. PMID: 26072631
Male genital cancers.
Gilliland FD, Key CR
Cancer 1995 Jan 1;75(1 Suppl):295-315. doi: 10.1002/1097-0142(19950101)75:1+<295::aid-cncr2820751313>3.0.co;2-u. PMID: 8001002

Diagnosis

The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783
Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Penoscrotal Paget's disease.
Dauendorffer JN, Herms F, Baroudjian B, Basset-Seguin N, Cavelier-Balloy B, Fouéré S, Bagot M, Lebbé C
Ann Dermatol Venereol 2021 Jun;148(2):71-76. Epub 2021 Jan 16 doi: 10.1016/j.annder.2020.08.051. PMID: 33461789
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Ductal adenocarcinoma of the prostate: histogenesis, biology and clinicopathological features.
Seipel AH, Delahunt B, Samaratunga H, Egevad L
Pathology 2016 Aug;48(5):398-405. Epub 2016 Jun 16 doi: 10.1016/j.pathol.2016.04.001. PMID: 27321992

Therapy

Efficacy and safety of HpD-PDT for Extramammary Paget's Disease refractory to conventional therapy: A prospective, open-label and single arm pilot study.
Wang D, Wang P, Li C, Zhou Z, Zhang L, Zhang G, Wang X
Photodiagnosis Photodyn Ther 2022 Mar;37:102670. Epub 2021 Dec 7 doi: 10.1016/j.pdpdt.2021.102670. PMID: 34883272
Histopathological Subtypes and PD-L1 Expression in Primary Urethral Adenocarcinoma: A Series of 5 Cases.
Padilla-Ansala C, García-Fernández E, González-Peramato P
Int J Surg Pathol 2021 Aug;29(5):488-495. Epub 2021 Jan 19 doi: 10.1177/1066896920988348. PMID: 33463392
Gastric Adenocarcinoma Arising in Gastrocystoplasty.
Tran THT, Melamed J, Deng FM
Urology 2021 Feb;148:270-273. Epub 2020 Jul 16 doi: 10.1016/j.urology.2020.07.003. PMID: 32683064
Efficacy and safety of topical ALA-PDT in the treatment of EMPD.
Gao Y, Zhang XC, Wang WS, Yang Y, Wang HL, Lu YG, Fan DL
Photodiagnosis Photodyn Ther 2015 Mar;12(1):92-7. Epub 2014 Dec 3 doi: 10.1016/j.pdpdt.2014.11.004. PMID: 25479094
Surgical correction of bladder neck contracture following prostate cancer treatment.
Bugeja S, Andrich DE, Mundy AR
Arch Esp Urol 2014 Jan-Feb;67(1):77-91. PMID: 24531675

Prognosis

Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Ductal adenocarcinoma of the prostate: histogenesis, biology and clinicopathological features.
Seipel AH, Delahunt B, Samaratunga H, Egevad L
Pathology 2016 Aug;48(5):398-405. Epub 2016 Jun 16 doi: 10.1016/j.pathol.2016.04.001. PMID: 27321992
Mammary and extramammary Paget's disease.
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article
Male genital cancers.
Gilliland FD, Key CR
Cancer 1995 Jan 1;75(1 Suppl):295-315. doi: 10.1002/1097-0142(19950101)75:1+<295::aid-cncr2820751313>3.0.co;2-u. PMID: 8001002

Clinical prediction guides

Electron radiotherapy for EMPD of penis and scrotum.
Lee HK, Youn SM, Shim SJ, Lee MJ
J Cancer Res Ther 2023 Jan 1;19(Suppl 2):S998-S1001. Epub 2023 Apr 28 doi: 10.4103/jcrt.jcrt_506_21. PMID: 38384101
Histopathological Subtypes and PD-L1 Expression in Primary Urethral Adenocarcinoma: A Series of 5 Cases.
Padilla-Ansala C, García-Fernández E, González-Peramato P
Int J Surg Pathol 2021 Aug;29(5):488-495. Epub 2021 Jan 19 doi: 10.1177/1066896920988348. PMID: 33463392
Expression of lipoma preferred partner in mammary and extramammary Paget disease.
Liu Y, Wang Y, Qi R, Mao X, Jin F
Medicine (Baltimore) 2020 Dec 18;99(51):e23443. doi: 10.1097/MD.0000000000023443. PMID: 33371071Free PMC Article
Paget's disease of scrotum and penis case report of a re-irradiation and review of the literature.
Piras A, Sanfratello A, Boldrini L, La Vecchia M, Venuti V, Amari ML, Orlando M, Zichichi L, Angileri T, Daidone A
Dermatol Ther 2020 Nov;33(6):e13890. Epub 2020 Jul 25 doi: 10.1111/dth.13890. PMID: 32584449
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904

Recent systematic reviews

Current Disease Management of Primary Urethral Carcinoma.
Janisch F, Abufaraj M, Fajkovic H, Kimura S, Iwata T, Nyirady P, Rink M, Shariat SF
Eur Urol Focus 2019 Sep;5(5):722-734. Epub 2019 Jul 13 doi: 10.1016/j.euf.2019.07.001. PMID: 31307949

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