Gastric fluid xenobiotic

MedGen UID:: 1640936
•Concept ID:: C4703720
•: Finding

HPO:	HP:0500101

Definition

Presence of a xenobiotic in gastric fluid. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVGastric fluid xenobiotic

Phenotypic abnormality
- Abnormality of metabolism/homeostasis
  - Presence of xenobiotic
    - Gastric fluid xenobiotic
      - Positive gastric fluid barbiturate test

Recent clinical studies

Etiology

Key Physicochemical Properties Dictating Gastrointestinal Bioaccessibility of Microplastics-Associated Organic Xenobiotics: Insights from a Deep Learning Approach.

Liu X, Gharasoo M, Shi Y, Sigmund G, Hüffer T, Duan L, Wang Y, Ji R, Hofmann T, Chen W
Environ Sci Technol 2020 Oct 6;54(19):12051-12062. Epub 2020 Sep 25 doi: 10.1021/acs.est.0c02838. PMID: 32931256

Polyethylene glycol electrolyte lavage solution increases tablet dissolution of acetaminophen in an in vitro model mimicking acute poisoning.

Nordt SP, Won KJ, Tomaszweski C, Clark RF
Am J Emerg Med 2020 Feb;38(2):325-328. Epub 2019 Sep 12 doi: 10.1016/j.ajem.2019.158444. PMID: 31839515

Differences in absorption, distribution, metabolism and excretion of xenobiotics between the paediatric and adult populations.

Strolin Benedetti M, Whomsley R, Baltes EL
Expert Opin Drug Metab Toxicol 2005 Oct;1(3):447-71. doi: 10.1517/17425255.1.3.447. PMID: 16863455

Paralytic shellfish poisoning: post-mortem analysis of tissue and body fluid samples from human victims in the Patagonia fjords.

García C, del Carmen Bravo M, Lagos M, Lagos N
Toxicon 2004 Feb;43(2):149-58. doi: 10.1016/j.toxicon.2003.11.018. PMID: 15019474

See all (4)

Diagnosis

Key Physicochemical Properties Dictating Gastrointestinal Bioaccessibility of Microplastics-Associated Organic Xenobiotics: Insights from a Deep Learning Approach.

Differences in absorption, distribution, metabolism and excretion of xenobiotics between the paediatric and adult populations.

Strolin Benedetti M, Whomsley R, Baltes EL
Expert Opin Drug Metab Toxicol 2005 Oct;1(3):447-71. doi: 10.1517/17425255.1.3.447. PMID: 16863455

See all (2)

Therapy

In vitro safety signals for potential clinical development of the anti-inflammatory pregnane X receptor agonist FKK6.

Dvořák Z, Vyhlídalová B, Pečinková P, Li H, Anzenbacher P, Špičáková A, Anzenbacherová E, Chow V, Liu J, Krause H, Wilson D, Berés T, Tarkowski P, Chen D, Mani S
Bioorg Chem 2024 Mar;144:107137. Epub 2024 Jan 19 doi: 10.1016/j.bioorg.2024.107137. PMID: 38245951

Polyethylene glycol electrolyte lavage solution increases tablet dissolution of acetaminophen in an in vitro model mimicking acute poisoning.

Nordt SP, Won KJ, Tomaszweski C, Clark RF
Am J Emerg Med 2020 Feb;38(2):325-328. Epub 2019 Sep 12 doi: 10.1016/j.ajem.2019.158444. PMID: 31839515

Paralytic shellfish poisoning: post-mortem analysis of tissue and body fluid samples from human victims in the Patagonia fjords.

García C, del Carmen Bravo M, Lagos M, Lagos N
Toxicon 2004 Feb;43(2):149-58. doi: 10.1016/j.toxicon.2003.11.018. PMID: 15019474

Death following acute poisoning by moclobemide.

Giroud C, Horisberger B, Eap C, Augsburger M, Ménétrey A, Baumann P, Mangin P
Forensic Sci Int 2004 Feb 10;140(1):101-7. doi: 10.1016/j.forsciint.2003.10.021. PMID: 15013171

See all (4)

Prognosis

In vitro safety signals for potential clinical development of the anti-inflammatory pregnane X receptor agonist FKK6.

3β-Acetyl tormentic acid reverts MRP1/ABCC1 mediated cancer resistance through modulation of intracellular levels of GSH and inhibition of GST activity.

Rocha Gda G, Oliveira RR, Kaplan MA, Gattass CR
Eur J Pharmacol 2014 Oct 15;741:140-9. Epub 2014 Aug 9 doi: 10.1016/j.ejphar.2014.07.054. PMID: 25111243

Paralytic shellfish poisoning: post-mortem analysis of tissue and body fluid samples from human victims in the Patagonia fjords.

García C, del Carmen Bravo M, Lagos M, Lagos N
Toxicon 2004 Feb;43(2):149-58. doi: 10.1016/j.toxicon.2003.11.018. PMID: 15019474

See all (3)