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Increased tear production

MedGen UID:
1642181
•Concept ID:
C4703505
•
Finding
HPO: HP:0031731

Definition

Increased lacrimation owing to overproduction of tears. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased tear production

Professional guidelines

PubMed

Current trends in pharmaceutical treatment of dry eye disease: A review.
Mohamed HB, Abd El-Hamid BN, Fathalla D, Fouad EA
Eur J Pharm Sci 2022 Aug 1;175:106206. Epub 2022 May 11 doi: 10.1016/j.ejps.2022.106206. PMID: 35568107
A Meta-Analysis of the Efficacy of Hyaluronic Acid Eye Drops for the Treatment of Dry Eye Syndrome.
Yang YJ, Lee WY, Kim YJ, Hong YP
Int J Environ Res Public Health 2021 Mar 1;18(5) doi: 10.3390/ijerph18052383. PMID: 33804439Free PMC Article
Advances in dry eye disease treatment.
O'Neil EC, Henderson M, Massaro-Giordano M, Bunya VY
Curr Opin Ophthalmol 2019 May;30(3):166-178. doi: 10.1097/ICU.0000000000000569. PMID: 30883442Free PMC Article

Recent clinical studies

Etiology

Lactobacillus fermentum HY7302 Improves Dry Eye Symptoms in a Mouse Model of Benzalkonium Chloride-Induced Eye Dysfunction and Human Conjunctiva Epithelial Cells.
Lee K, Jeong JW, Shim JJ, Hong HS, Kim JY, Lee JL
Int J Mol Sci 2023 Jun 20;24(12) doi: 10.3390/ijms241210378. PMID: 37373526Free PMC Article
Efficacy and Safety of Single-dose OC-02 (Simpinicline Solution) Nasal Spray on Signs and Symptoms of Dry Eye Disease: The PEARL Phase II Randomized Trial.
Torkildsen GL, Pattar GR, Jerkins G, Striffler K, Nau J
Clin Ther 2022 Sep;44(9):1178-1186. Epub 2022 Aug 11 doi: 10.1016/j.clinthera.2022.07.006. PMID: 35965109
Extrapulmonary Manifestations COVID-19.
Nelwan EJ, Tunjungputri RN, Tetrasiwi EN, Lauditta RK, Nainggolan L
Acta Med Indones 2022 Apr;54(2):314-315. PMID: 35818654
Effects of phytoestrogen supplementation in postmenopausal women with dry eye syndrome: a randomized clinical trial.
Scuderi G, Contestabile MT, Gagliano C, Iacovello D, Scuderi L, Avitabile T
Can J Ophthalmol 2012 Dec;47(6):489-92. doi: 10.1016/j.jcjo.2012.08.019. PMID: 23217501
Self-reported compliance with topical cyclosporine emulsion 0.05% and onset of the effects of increased tear production as assessed through patient surveys.
Trattler W, Katsev D, Kerney D
Clin Ther 2006 Nov;28(11):1848-56. doi: 10.1016/j.clinthera.2006.11.016. PMID: 17213005

Diagnosis

Efficacy and Safety of Single-dose OC-02 (Simpinicline Solution) Nasal Spray on Signs and Symptoms of Dry Eye Disease: The PEARL Phase II Randomized Trial.
Torkildsen GL, Pattar GR, Jerkins G, Striffler K, Nau J
Clin Ther 2022 Sep;44(9):1178-1186. Epub 2022 Aug 11 doi: 10.1016/j.clinthera.2022.07.006. PMID: 35965109
Extrapulmonary Manifestations COVID-19.
Nelwan EJ, Tunjungputri RN, Tetrasiwi EN, Lauditta RK, Nainggolan L
Acta Med Indones 2022 Apr;54(2):314-315. PMID: 35818654

Therapy

Efficacy and Safety of Single-dose OC-02 (Simpinicline Solution) Nasal Spray on Signs and Symptoms of Dry Eye Disease: The PEARL Phase II Randomized Trial.
Torkildsen GL, Pattar GR, Jerkins G, Striffler K, Nau J
Clin Ther 2022 Sep;44(9):1178-1186. Epub 2022 Aug 11 doi: 10.1016/j.clinthera.2022.07.006. PMID: 35965109
A phase II randomized trial to evaluate the long-term (12-week) efficacy and safety of OC-01 (varenicline solution) nasal spray for dry eye disease: The MYSTIC study.
Quiroz-Mercado H, Hernandez-Quintela E, Chiu KH, Henry E, Nau JA
Ocul Surf 2022 Apr;24:15-21. Epub 2021 Dec 15 doi: 10.1016/j.jtos.2021.12.007. PMID: 34920097
RGN-259 (thymosin β4) improves clinically important dry eye efficacies in comparison with prescription drugs in a dry eye model.
Kim CE, Kleinman HK, Sosne G, Ousler GW, Kim K, Kang S, Yang J
Sci Rep 2018 Jul 12;8(1):10500. doi: 10.1038/s41598-018-28861-5. PMID: 30002412Free PMC Article
Effects of phytoestrogen supplementation in postmenopausal women with dry eye syndrome: a randomized clinical trial.
Scuderi G, Contestabile MT, Gagliano C, Iacovello D, Scuderi L, Avitabile T
Can J Ophthalmol 2012 Dec;47(6):489-92. doi: 10.1016/j.jcjo.2012.08.019. PMID: 23217501
Self-reported compliance with topical cyclosporine emulsion 0.05% and onset of the effects of increased tear production as assessed through patient surveys.
Trattler W, Katsev D, Kerney D
Clin Ther 2006 Nov;28(11):1848-56. doi: 10.1016/j.clinthera.2006.11.016. PMID: 17213005

Prognosis

Self-reported compliance with topical cyclosporine emulsion 0.05% and onset of the effects of increased tear production as assessed through patient surveys.
Trattler W, Katsev D, Kerney D
Clin Ther 2006 Nov;28(11):1848-56. doi: 10.1016/j.clinthera.2006.11.016. PMID: 17213005

Clinical prediction guides

Lactobacillus fermentum HY7302 Improves Dry Eye Symptoms in a Mouse Model of Benzalkonium Chloride-Induced Eye Dysfunction and Human Conjunctiva Epithelial Cells.
Lee K, Jeong JW, Shim JJ, Hong HS, Kim JY, Lee JL
Int J Mol Sci 2023 Jun 20;24(12) doi: 10.3390/ijms241210378. PMID: 37373526Free PMC Article
Efficacy and Safety of Single-dose OC-02 (Simpinicline Solution) Nasal Spray on Signs and Symptoms of Dry Eye Disease: The PEARL Phase II Randomized Trial.
Torkildsen GL, Pattar GR, Jerkins G, Striffler K, Nau J
Clin Ther 2022 Sep;44(9):1178-1186. Epub 2022 Aug 11 doi: 10.1016/j.clinthera.2022.07.006. PMID: 35965109
A phase II randomized trial to evaluate the long-term (12-week) efficacy and safety of OC-01 (varenicline solution) nasal spray for dry eye disease: The MYSTIC study.
Quiroz-Mercado H, Hernandez-Quintela E, Chiu KH, Henry E, Nau JA
Ocul Surf 2022 Apr;24:15-21. Epub 2021 Dec 15 doi: 10.1016/j.jtos.2021.12.007. PMID: 34920097
RGN-259 (thymosin β4) improves clinically important dry eye efficacies in comparison with prescription drugs in a dry eye model.
Kim CE, Kleinman HK, Sosne G, Ousler GW, Kim K, Kang S, Yang J
Sci Rep 2018 Jul 12;8(1):10500. doi: 10.1038/s41598-018-28861-5. PMID: 30002412Free PMC Article
Effects of chondrocyte-derived extracellular matrix in a dry eye mouse model.
Kim CE, Oh HN, Lee JH, Yang JW
Mol Vis 2015;21:1210-23. Epub 2015 Oct 26 PMID: 26604661Free PMC Article

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