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Refractory Breast Carcinoma

MedGen UID:
1647173
•Concept ID:
C4688316
•
Neoplastic Process

Definition

Breast carcinoma that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

Vinorelbine and cisplatin (CIVIC regimen) for the treatment of metastatic breast carcinoma after failure of anthracycline- and/or paclitaxel-containing regimens.
Ray-Coquard I, Biron P, Bachelot T, Guastalla JP, Catimel G, Merrouche Y, Droz JP, Chauvin F, Blay JY
Cancer 1998 Jan 1;82(1):134-40. PMID: 9428489

Recent clinical studies

Diagnosis

Developments in chemotherapy of breast cancer.
Hortobagyi GN
Cancer 2000 Jun 15;88(12 Suppl):3073-9. doi: 10.1002/1097-0142(20000615)88:12+<3073::aid-cncr26>3.3.co;2-i. PMID: 10898354

Therapy

Suppression of poised oncogenes by ZMYND8 promotes chemo-sensitization.
Mukherjee S, Adhikary S, Gadad SS, Mondal P, Sen S, Choudhari R, Singh V, Adhikari S, Mandal P, Chaudhuri S, Sengupta A, Lakshmanaswamy R, Chakrabarti P, Roy S, Das C
Cell Death Dis 2020 Dec 15;11(12):1073. doi: 10.1038/s41419-020-03129-x. PMID: 33323928Free PMC Article
Developments in chemotherapy of breast cancer.
Hortobagyi GN
Cancer 2000 Jun 15;88(12 Suppl):3073-9. doi: 10.1002/1097-0142(20000615)88:12+<3073::aid-cncr26>3.3.co;2-i. PMID: 10898354
Cisplatin and etoposide: an effective treatment for refractory breast carcinoma.
Cox EB, Burton GV, Olsen GA, Vugrin D
Am J Clin Oncol 1989 Feb;12(1):53-6. doi: 10.1097/00000421-198902000-00013. PMID: 2643295
Percutaneous hepatic arterial infusion of cisplatin-vinblastine for refractory breast carcinoma metastatic to the liver.
Fraschini G, Charnsangavej C, Carrasco CH, Buzdar AU, Jabboury KW, Hortobagyi GN
Am J Clin Oncol 1988 Feb;11(1):34-8. doi: 10.1097/00000421-198802000-00008. PMID: 3277374
Adriamycin (doxorubicin), vinblastine, and mitomycin C combination chemotherapy in refractory breast carcinoma.
Luikart SD, Witman GB, Portlock CS
Cancer 1984 Oct 1;54(7):1252-5. doi: 10.1002/1097-0142(19841001)54:7<1252::aid-cncr2820540703>3.0.co;2-6. PMID: 6467151

Prognosis

Suppression of poised oncogenes by ZMYND8 promotes chemo-sensitization.
Mukherjee S, Adhikary S, Gadad SS, Mondal P, Sen S, Choudhari R, Singh V, Adhikari S, Mandal P, Chaudhuri S, Sengupta A, Lakshmanaswamy R, Chakrabarti P, Roy S, Das C
Cell Death Dis 2020 Dec 15;11(12):1073. doi: 10.1038/s41419-020-03129-x. PMID: 33323928Free PMC Article
Cisplatin and etoposide: an effective treatment for refractory breast carcinoma.
Cox EB, Burton GV, Olsen GA, Vugrin D
Am J Clin Oncol 1989 Feb;12(1):53-6. doi: 10.1097/00000421-198902000-00013. PMID: 2643295
Vincristine by continuous infusion in refractory breast cancer: a phase II study.
Hopkins JO, Jackson DV Jr, White DR, Muss HB, Richards F 2nd, Cooper MR, Stuart JJ, Sparr CL, Wells HB
Am J Clin Oncol 1983 Oct;6(5):529-32. PMID: 6613919
Doxorubicin plus VP-16-213 for the treatment of refractory breast carcinoma.
Konits PH, Van Echo DA, Aisner J, Morris D, Wiernik PH
Am J Clin Oncol 1982 Oct;5(5):515-9. PMID: 6758569

Clinical prediction guides

Suppression of poised oncogenes by ZMYND8 promotes chemo-sensitization.
Mukherjee S, Adhikary S, Gadad SS, Mondal P, Sen S, Choudhari R, Singh V, Adhikari S, Mandal P, Chaudhuri S, Sengupta A, Lakshmanaswamy R, Chakrabarti P, Roy S, Das C
Cell Death Dis 2020 Dec 15;11(12):1073. doi: 10.1038/s41419-020-03129-x. PMID: 33323928Free PMC Article
Combination chemotherapy with BCNU, vincristine, mitomycin-C and prednisone in refractory breast carcinoma. A pilot study.
DiBella NJ, Garfield D, Fink K, Anderson P, Speer J, Murphy J
Oncology 1984;41(1):1-3. doi: 10.1159/000225780. PMID: 6422372
Vincristine by continuous infusion in refractory breast cancer: a phase II study.
Hopkins JO, Jackson DV Jr, White DR, Muss HB, Richards F 2nd, Cooper MR, Stuart JJ, Sparr CL, Wells HB
Am J Clin Oncol 1983 Oct;6(5):529-32. PMID: 6613919

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