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Advanced Urothelial Carcinoma

MedGen UID:
1662312
Concept ID:
C4725076
Neoplastic Process

Definition

Urothelial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Tregunna R
Nat Rev Urol 2021 Jul;18(7):383. doi: 10.1038/s41585-021-00489-7. PMID: 34113021
Andreev-Drakhlin AY, Egoryan G, Shah AY, Msaouel P, Alhalabi O, Gao J
Curr Opin Oncol 2021 May 1;33(3):221-230. doi: 10.1097/CCO.0000000000000722. PMID: 33818541
Hanna KS, Campbell M, Kolling A, Husak A, Sturm S, Bello D, Blake K
J Oncol Pharm Pract 2021 Mar;27(2):435-444. Epub 2020 Nov 3 doi: 10.1177/1078155220971026. PMID: 33143526

Recent clinical studies

Etiology

van der Heijden MS, Sonpavde G, Powles T, Necchi A, Burotto M, Schenker M, Sade JP, Bamias A, Beuzeboc P, Bedke J, Oldenburg J, Chatta G, Ürün Y, Ye D, He Z, Valderrama BP, Ku JH, Tomita Y, Filian J, Wang L, Purcea D, Patel MY, Nasroulah F, Galsky MD; CheckMate 901 Trial Investigators
N Engl J Med 2023 Nov 9;389(19):1778-1789. Epub 2023 Oct 22 doi: 10.1056/NEJMoa2309863. PMID: 37870949
Powles T, Csőszi T, Özgüroğlu M, Matsubara N, Géczi L, Cheng SY, Fradet Y, Oudard S, Vulsteke C, Morales Barrera R, Fléchon A, Gunduz S, Loriot Y, Rodriguez-Vida A, Mamtani R, Yu EY, Nam K, Imai K, Homet Moreno B, Alva A; KEYNOTE-361 Investigators
Lancet Oncol 2021 Jul;22(7):931-945. Epub 2021 May 26 doi: 10.1016/S1470-2045(21)00152-2. PMID: 34051178
Powles T, Rosenberg JE, Sonpavde GP, Loriot Y, Durán I, Lee JL, Matsubara N, Vulsteke C, Castellano D, Wu C, Campbell M, Matsangou M, Petrylak DP
N Engl J Med 2021 Mar 25;384(12):1125-1135. Epub 2021 Feb 12 doi: 10.1056/NEJMoa2035807. PMID: 33577729Free PMC Article
Powles T, Park SH, Voog E, Caserta C, Valderrama BP, Gurney H, Kalofonos H, Radulović S, Demey W, Ullén A, Loriot Y, Sridhar SS, Tsuchiya N, Kopyltsov E, Sternberg CN, Bellmunt J, Aragon-Ching JB, Petrylak DP, Laliberte R, Wang J, Huang B, Davis C, Fowst C, Costa N, Blake-Haskins JA, di Pietro A, Grivas P
N Engl J Med 2020 Sep 24;383(13):1218-1230. Epub 2020 Sep 18 doi: 10.1056/NEJMoa2002788. PMID: 32945632
Bellmunt J, de Wit R, Vaughn DJ, Fradet Y, Lee JL, Fong L, Vogelzang NJ, Climent MA, Petrylak DP, Choueiri TK, Necchi A, Gerritsen W, Gurney H, Quinn DI, Culine S, Sternberg CN, Mai Y, Poehlein CH, Perini RF, Bajorin DF; KEYNOTE-045 Investigators
N Engl J Med 2017 Mar 16;376(11):1015-1026. Epub 2017 Feb 17 doi: 10.1056/NEJMoa1613683. PMID: 28212060Free PMC Article

Diagnosis

Duan X, Xia L, Zhang Z, Ren Y, Pomper MG, Rowe SP, Li X, Li N, Zhang N, Zhu H, Yang Z, Sheng X, Yang X
Clin Cancer Res 2023 Sep 1;29(17):3395-3407. doi: 10.1158/1078-0432.CCR-23-0609. PMID: 37093191
Dariane C, Timsit MO
Eur Surg Res 2022;63(4):155-164. Epub 2022 Aug 9 doi: 10.1159/000526415. PMID: 35944490
Alhalabi O, Campbell M, Shah A, Siefker-Radtke A, Gao J
Curr Opin Oncol 2020 May;32(3):232-239. doi: 10.1097/CCO.0000000000000618. PMID: 32209822
Dietrich B, Siefker-Radtke AO, Srinivas S, Yu EY
Am Soc Clin Oncol Educ Book 2018 May 23;38:342-353. doi: 10.1200/EDBK_201193. PMID: 30231356
Castellano D, Carles J, Esteban E, Trigo JM, Climent MÁ, Maroto JP, del Muro XG, Font A, Paz-Ares L, Arranz JÁ, Bellmunt J
Cancer Treat Rev 2012 Aug;38(5):431-41. Epub 2011 Nov 23 doi: 10.1016/j.ctrv.2011.10.004. PMID: 22116017

Therapy

van der Heijden MS, Sonpavde G, Powles T, Necchi A, Burotto M, Schenker M, Sade JP, Bamias A, Beuzeboc P, Bedke J, Oldenburg J, Chatta G, Ürün Y, Ye D, He Z, Valderrama BP, Ku JH, Tomita Y, Filian J, Wang L, Purcea D, Patel MY, Nasroulah F, Galsky MD; CheckMate 901 Trial Investigators
N Engl J Med 2023 Nov 9;389(19):1778-1789. Epub 2023 Oct 22 doi: 10.1056/NEJMoa2309863. PMID: 37870949
Powles T, Csőszi T, Özgüroğlu M, Matsubara N, Géczi L, Cheng SY, Fradet Y, Oudard S, Vulsteke C, Morales Barrera R, Fléchon A, Gunduz S, Loriot Y, Rodriguez-Vida A, Mamtani R, Yu EY, Nam K, Imai K, Homet Moreno B, Alva A; KEYNOTE-361 Investigators
Lancet Oncol 2021 Jul;22(7):931-945. Epub 2021 May 26 doi: 10.1016/S1470-2045(21)00152-2. PMID: 34051178
Powles T, Rosenberg JE, Sonpavde GP, Loriot Y, Durán I, Lee JL, Matsubara N, Vulsteke C, Castellano D, Wu C, Campbell M, Matsangou M, Petrylak DP
N Engl J Med 2021 Mar 25;384(12):1125-1135. Epub 2021 Feb 12 doi: 10.1056/NEJMoa2035807. PMID: 33577729Free PMC Article
Powles T, Park SH, Voog E, Caserta C, Valderrama BP, Gurney H, Kalofonos H, Radulović S, Demey W, Ullén A, Loriot Y, Sridhar SS, Tsuchiya N, Kopyltsov E, Sternberg CN, Bellmunt J, Aragon-Ching JB, Petrylak DP, Laliberte R, Wang J, Huang B, Davis C, Fowst C, Costa N, Blake-Haskins JA, di Pietro A, Grivas P
N Engl J Med 2020 Sep 24;383(13):1218-1230. Epub 2020 Sep 18 doi: 10.1056/NEJMoa2002788. PMID: 32945632
Bellmunt J, de Wit R, Vaughn DJ, Fradet Y, Lee JL, Fong L, Vogelzang NJ, Climent MA, Petrylak DP, Choueiri TK, Necchi A, Gerritsen W, Gurney H, Quinn DI, Culine S, Sternberg CN, Mai Y, Poehlein CH, Perini RF, Bajorin DF; KEYNOTE-045 Investigators
N Engl J Med 2017 Mar 16;376(11):1015-1026. Epub 2017 Feb 17 doi: 10.1056/NEJMoa1613683. PMID: 28212060Free PMC Article

Prognosis

Duan X, Xia L, Zhang Z, Ren Y, Pomper MG, Rowe SP, Li X, Li N, Zhang N, Zhu H, Yang Z, Sheng X, Yang X
Clin Cancer Res 2023 Sep 1;29(17):3395-3407. doi: 10.1158/1078-0432.CCR-23-0609. PMID: 37093191
Powles T, Park SH, Caserta C, Valderrama BP, Gurney H, Ullén A, Loriot Y, Sridhar SS, Sternberg CN, Bellmunt J, Aragon-Ching JB, Wang J, Huang B, Laliberte RJ, di Pietro A, Grivas P
J Clin Oncol 2023 Jul 1;41(19):3486-3492. Epub 2023 Apr 18 doi: 10.1200/JCO.22.01792. PMID: 37071838Free PMC Article
Siefker-Radtke AO, Necchi A, Park SH, García-Donas J, Huddart RA, Burgess EF, Fleming MT, Rezazadeh Kalebasty A, Mellado B, Varlamov S, Joshi M, Duran I, Tagawa ST, Zakharia Y, Akapame S, Santiago-Walker AE, Monga M, O'Hagan A, Loriot Y; BLC2001 Study Group
Lancet Oncol 2022 Feb;23(2):248-258. Epub 2022 Jan 11 doi: 10.1016/S1470-2045(21)00660-4. PMID: 35030333
Powles T, Sridhar SS, Loriot Y, Bellmunt J, Mu XJ, Ching KA, Pu J, Sternberg CN, Petrylak DP, Tambaro R, Dourthe LM, Alvarez-Fernandez C, Aarts M, di Pietro A, Grivas P, Davis CB
Nat Med 2021 Dec;27(12):2200-2211. Epub 2021 Dec 10 doi: 10.1038/s41591-021-01579-0. PMID: 34893775
Bellmunt J, de Wit R, Vaughn DJ, Fradet Y, Lee JL, Fong L, Vogelzang NJ, Climent MA, Petrylak DP, Choueiri TK, Necchi A, Gerritsen W, Gurney H, Quinn DI, Culine S, Sternberg CN, Mai Y, Poehlein CH, Perini RF, Bajorin DF; KEYNOTE-045 Investigators
N Engl J Med 2017 Mar 16;376(11):1015-1026. Epub 2017 Feb 17 doi: 10.1056/NEJMoa1613683. PMID: 28212060Free PMC Article

Clinical prediction guides

Grivas P, Park SH, Voog E, Caserta C, Gurney H, Bellmunt J, Kalofonos H, Ullén A, Loriot Y, Sridhar SS, Yamamoto Y, Petrylak DP, Sternberg CN, Gupta S, Huang B, Costa N, Laliberte RJ, di Pietro A, Valderrama BP, Powles T
Eur Urol 2023 Jul;84(1):95-108. Epub 2023 Apr 28 doi: 10.1016/j.eururo.2023.03.030. PMID: 37121850
Duan X, Xia L, Zhang Z, Ren Y, Pomper MG, Rowe SP, Li X, Li N, Zhang N, Zhu H, Yang Z, Sheng X, Yang X
Clin Cancer Res 2023 Sep 1;29(17):3395-3407. doi: 10.1158/1078-0432.CCR-23-0609. PMID: 37093191
Powles T, Csőszi T, Özgüroğlu M, Matsubara N, Géczi L, Cheng SY, Fradet Y, Oudard S, Vulsteke C, Morales Barrera R, Fléchon A, Gunduz S, Loriot Y, Rodriguez-Vida A, Mamtani R, Yu EY, Nam K, Imai K, Homet Moreno B, Alva A; KEYNOTE-361 Investigators
Lancet Oncol 2021 Jul;22(7):931-945. Epub 2021 May 26 doi: 10.1016/S1470-2045(21)00152-2. PMID: 34051178
Yu EY, Petrylak DP, O'Donnell PH, Lee JL, van der Heijden MS, Loriot Y, Stein MN, Necchi A, Kojima T, Harrison MR, Hoon Park S, Quinn DI, Heath EI, Rosenberg JE, Steinberg J, Liang SY, Trowbridge J, Campbell M, McGregor B, Balar AV
Lancet Oncol 2021 Jun;22(6):872-882. Epub 2021 May 12 doi: 10.1016/S1470-2045(21)00094-2. PMID: 33991512
Bellmunt J, de Wit R, Vaughn DJ, Fradet Y, Lee JL, Fong L, Vogelzang NJ, Climent MA, Petrylak DP, Choueiri TK, Necchi A, Gerritsen W, Gurney H, Quinn DI, Culine S, Sternberg CN, Mai Y, Poehlein CH, Perini RF, Bajorin DF; KEYNOTE-045 Investigators
N Engl J Med 2017 Mar 16;376(11):1015-1026. Epub 2017 Feb 17 doi: 10.1056/NEJMoa1613683. PMID: 28212060Free PMC Article

Recent systematic reviews

Ferro M, Crocetto F, Tataru S, Barone B, Dolce P, Lucarelli G, Sonpavde G, Musi G, Antonelli A, Veccia A, Terracciano D, Busetto GM, Del Giudice F, Marchioni M, Schips L, Porpiglia F, Fiori C, Carrieri G, Lasorsa F, Verde A, Scafuri L, Buonerba C, Di Lorenzo G
Clin Genitourin Cancer 2023 Oct;21(5):574-583. Epub 2023 May 27 doi: 10.1016/j.clgc.2023.05.017. PMID: 37419854
Kawada T, Yanagisawa T, Mostafaei H, Sari Motlagh R, Quhal F, Rajwa P, Laukhtina E, von Deimling M, Bianchi A, Majdoub M, Pallauf M, Pradere B, Teoh JY, Karakiewicz PI, Araki M, Shariat SF
Eur Urol Focus 2023 Mar;9(2):264-274. Epub 2023 Feb 9 doi: 10.1016/j.euf.2023.01.019. PMID: 36774273
Martini A, Raggi D, Fallara G, Nocera L, Schultz JG, Belladelli F, Marandino L, Salonia A, Briganti A, Montorsi F, Powles T, Necchi A
Cancer Treat Rev 2022 Mar;104:102360. Epub 2022 Feb 10 doi: 10.1016/j.ctrv.2022.102360. PMID: 35176685
Di Nunno V, De Luca E, Buttigliero C, Tucci M, Vignani F, Gatto L, Zichi C, Ardizzoni A, Di Maio M, Massari F
Crit Rev Oncol Hematol 2018 Sep;129:124-132. Epub 2018 Jul 19 doi: 10.1016/j.critrevonc.2018.07.004. PMID: 30097230
Raggi D, Miceli R, Sonpavde G, Giannatempo P, Mariani L, Galsky MD, Bellmunt J, Necchi A
Ann Oncol 2016 Jan;27(1):49-61. Epub 2015 Oct 20 doi: 10.1093/annonc/mdv509. PMID: 26487582

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