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Refractory Acute Leukemia

MedGen UID:
1662593
Concept ID:
C4725027
Neoplastic Process

Definition

Acute leukemia that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

Soliman R, Heneghan C, Bolous NS, Sidhom I, Ahmed S, Roberts N, Oke J, Elhaddad A
Expert Rev Hematol 2022 Apr;15(4):345-357. Epub 2022 May 4 doi: 10.1080/17474086.2022.2069096. PMID: 35485262
Campbell CT, Haladyna JN, Drubin DA, Thomson TM, Maria MJ, Yamauchi T, Waters NJ, Olhava EJ, Pollock RM, Smith JJ, Copeland RA, Blakemore SJ, Bernt KM, Daigle SR
Mol Cancer Ther 2017 Aug;16(8):1669-1679. Epub 2017 Apr 20 doi: 10.1158/1535-7163.MCT-16-0693. PMID: 28428443
Takahashi I, Hara M, Adachi T, Takaoka K, Sakano M, Lai M, Kohi F, Yorimitsu S, Tokioka M, Kitajima K, Kimura I, Sanada H
Acta Med Okayama 1980 Nov;34(5):349-54. doi: 10.18926/AMO/30544. PMID: 6449134

Recent clinical studies

Etiology

Nath K, Lee J, Elko TA, Levy L, Preston E, Devlin SM, Ponce DM, Lin RJ, Shaffer BC, Cho C, Politikos I, Jakubowski AA, Park JH, Rampal R, Perales MA, Tallman MS, Barker JN, Berman E, Tamari R, Stein E, Giralt SA, Gyurkocza B
Am J Hematol 2023 Dec;98(12):1869-1876. Epub 2023 Sep 9 doi: 10.1002/ajh.27084. PMID: 37688521Free PMC Article
Kobayashi S, Kanda Y, Konuma T, Inamoto Y, Matsumoto K, Uchida N, Ikegame K, Miyamoto T, Doki N, Nakamae H, Katayama Y, Takahashi S, Shiratori S, Saito S, Kawakita T, Kanda J, Fukuda T, Atsuta Y, Kimura F
Bone Marrow Transplant 2022 Jan;57(1):43-50. Epub 2021 Oct 8 doi: 10.1038/s41409-021-01485-6. PMID: 34625663
Moiseev I, Bondarenko S, Morozova E, Vlasova Y, Dotsenko A, Epifanovskaya O, Babenko E, Botina A, Baykov V, Surkova E, Lapin S, Beynarovich A, Borzenkova E, Golosgchapov O, Kanunnikov M, Kudyasheva O, Ovechkina V, Pirogova O, Porunova V, Rudakova T, Smikova O, Smirnova A, Afansyev B
Transplant Cell Ther 2021 Jul;27(7):601.e1-601.e7. Epub 2021 May 7 doi: 10.1016/j.jtct.2021.03.032. PMID: 33845259
Toporski J, Król L, Dykes J, Håkansson Y, Pronk C, Turkiewicz D
Pediatr Hematol Oncol 2021 Apr;38(3):216-226. Epub 2020 Nov 5 doi: 10.1080/08880018.2020.1838012. PMID: 33150834
Darwish M, Megason G, Bond M, Hellriegel E, Robertson P Jr, Grasela T, Phillips L
Curr Med Res Opin 2014 Nov;30(11):2305-15. Epub 2014 Aug 11 doi: 10.1185/03007995.2014.941976. PMID: 25105914

Diagnosis

Di Mambro A, Arroyo-Berdugo Y, Fioretti T, Randles M, Cozzuto L, Rajeeve V, Cevenini A, Austin MJ, Esposito G, Ponomarenko J, Lucas CM, Cutillas P, Gribben J, Williams O, Calle Y, Patel B, Esposito MT
Oncogene 2023 Dec;42(50):3670-3683. Epub 2023 Oct 27 doi: 10.1038/s41388-023-02840-1. PMID: 37891368Free PMC Article
Nath K, Lee J, Elko TA, Levy L, Preston E, Devlin SM, Ponce DM, Lin RJ, Shaffer BC, Cho C, Politikos I, Jakubowski AA, Park JH, Rampal R, Perales MA, Tallman MS, Barker JN, Berman E, Tamari R, Stein E, Giralt SA, Gyurkocza B
Am J Hematol 2023 Dec;98(12):1869-1876. Epub 2023 Sep 9 doi: 10.1002/ajh.27084. PMID: 37688521Free PMC Article
Sun Q, Wu B, Meng F, Yao Q, Huang Z, Xu J, Zhu Z
Hematology 2023 Dec;28(1):2204620. doi: 10.1080/16078454.2023.2204620. PMID: 37199372
Kurt H, Zheng L, Kantarjian HM, Tang G, Ravandi-Kashani F, Garcia-Manero G, Gong Z, Amin HM, Konoplev SN, Routbort MJ, Han X, Wang W, Medeiros LJ, Hu S
Mod Pathol 2018 Jul;31(7):1141-1154. Epub 2018 Feb 14 doi: 10.1038/s41379-018-0014-x. PMID: 29449681
Seiter K, Katragadda S, Ponce D, Rasul M, Ahmed N
J Hematol Oncol 2009 May 22;2:21. doi: 10.1186/1756-8722-2-21. PMID: 19463179Free PMC Article

Therapy

Di Mambro A, Arroyo-Berdugo Y, Fioretti T, Randles M, Cozzuto L, Rajeeve V, Cevenini A, Austin MJ, Esposito G, Ponomarenko J, Lucas CM, Cutillas P, Gribben J, Williams O, Calle Y, Patel B, Esposito MT
Oncogene 2023 Dec;42(50):3670-3683. Epub 2023 Oct 27 doi: 10.1038/s41388-023-02840-1. PMID: 37891368Free PMC Article
Nath K, Lee J, Elko TA, Levy L, Preston E, Devlin SM, Ponce DM, Lin RJ, Shaffer BC, Cho C, Politikos I, Jakubowski AA, Park JH, Rampal R, Perales MA, Tallman MS, Barker JN, Berman E, Tamari R, Stein E, Giralt SA, Gyurkocza B
Am J Hematol 2023 Dec;98(12):1869-1876. Epub 2023 Sep 9 doi: 10.1002/ajh.27084. PMID: 37688521Free PMC Article
Kurt H, Zheng L, Kantarjian HM, Tang G, Ravandi-Kashani F, Garcia-Manero G, Gong Z, Amin HM, Konoplev SN, Routbort MJ, Han X, Wang W, Medeiros LJ, Hu S
Mod Pathol 2018 Jul;31(7):1141-1154. Epub 2018 Feb 14 doi: 10.1038/s41379-018-0014-x. PMID: 29449681
Habringer S, Lapa C, Herhaus P, Schottelius M, Istvanffy R, Steiger K, Slotta-Huspenina J, Schirbel A, Hänscheid H, Kircher S, Buck AK, Götze K, Vick B, Jeremias I, Schwaiger M, Peschel C, Oostendorp R, Wester HJ, Grigoleit GU, Keller U
Theranostics 2018;8(2):369-383. Epub 2018 Jan 1 doi: 10.7150/thno.21397. PMID: 29290814Free PMC Article
Larson RA
Semin Oncol 2007 Dec;34(6 Suppl 5):S13-20. doi: 10.1053/j.seminoncol.2007.11.002. PMID: 18086342

Prognosis

Di Mambro A, Arroyo-Berdugo Y, Fioretti T, Randles M, Cozzuto L, Rajeeve V, Cevenini A, Austin MJ, Esposito G, Ponomarenko J, Lucas CM, Cutillas P, Gribben J, Williams O, Calle Y, Patel B, Esposito MT
Oncogene 2023 Dec;42(50):3670-3683. Epub 2023 Oct 27 doi: 10.1038/s41388-023-02840-1. PMID: 37891368Free PMC Article
Chen Z, Xue Q, Yao S
Mini Rev Med Chem 2023;23(7):787-803. doi: 10.2174/1389557523666221216095821. PMID: 36529918
Ogasawara M, Miyashita M, Yamagishi Y, Ota S
Ther Apher Dial 2022 Jun;26(3):537-547. Epub 2022 Mar 10 doi: 10.1111/1744-9987.13828. PMID: 35249263
Kobayashi S, Kanda Y, Konuma T, Inamoto Y, Matsumoto K, Uchida N, Ikegame K, Miyamoto T, Doki N, Nakamae H, Katayama Y, Takahashi S, Shiratori S, Saito S, Kawakita T, Kanda J, Fukuda T, Atsuta Y, Kimura F
Bone Marrow Transplant 2022 Jan;57(1):43-50. Epub 2021 Oct 8 doi: 10.1038/s41409-021-01485-6. PMID: 34625663
Ding G, Chen H
Sci China Life Sci 2016 Jul;59(7):673-7. Epub 2016 May 3 doi: 10.1007/s11427-016-0017-3. PMID: 27142351

Clinical prediction guides

Nath K, Lee J, Elko TA, Levy L, Preston E, Devlin SM, Ponce DM, Lin RJ, Shaffer BC, Cho C, Politikos I, Jakubowski AA, Park JH, Rampal R, Perales MA, Tallman MS, Barker JN, Berman E, Tamari R, Stein E, Giralt SA, Gyurkocza B
Am J Hematol 2023 Dec;98(12):1869-1876. Epub 2023 Sep 9 doi: 10.1002/ajh.27084. PMID: 37688521Free PMC Article
Chen Z, Xue Q, Yao S
Mini Rev Med Chem 2023;23(7):787-803. doi: 10.2174/1389557523666221216095821. PMID: 36529918
Ogasawara M, Miyashita M, Yamagishi Y, Ota S
Ther Apher Dial 2022 Jun;26(3):537-547. Epub 2022 Mar 10 doi: 10.1111/1744-9987.13828. PMID: 35249263
Kurt H, Zheng L, Kantarjian HM, Tang G, Ravandi-Kashani F, Garcia-Manero G, Gong Z, Amin HM, Konoplev SN, Routbort MJ, Han X, Wang W, Medeiros LJ, Hu S
Mod Pathol 2018 Jul;31(7):1141-1154. Epub 2018 Feb 14 doi: 10.1038/s41379-018-0014-x. PMID: 29449681
Grupp SA, Kalos M, Barrett D, Aplenc R, Porter DL, Rheingold SR, Teachey DT, Chew A, Hauck B, Wright JF, Milone MC, Levine BL, June CH
N Engl J Med 2013 Apr 18;368(16):1509-1518. Epub 2013 Mar 25 doi: 10.1056/NEJMoa1215134. PMID: 23527958Free PMC Article

Recent systematic reviews

Soliman R, Heneghan C, Bolous NS, Sidhom I, Ahmed S, Roberts N, Oke J, Elhaddad A
Expert Rev Hematol 2022 Apr;15(4):345-357. Epub 2022 May 4 doi: 10.1080/17474086.2022.2069096. PMID: 35485262

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