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Cutaneous Melanoma of the Extremity

MedGen UID:: 1664542
•Concept ID:: C4743979
•: Neoplastic Process

Synonyms:

Primary Cutaneous Melanoma of the Extremity; Primary Extremity Melanoma; Primary Melanoma of the Extremity

Definition

A cutaneous melanoma that arises from the upper or lower extremity. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVCutaneous Melanoma of the Extremity

Pathological process
- Disease
  - Neoplasm
    - Malignant neoplastic disease
      - Malignant neoplasm of skin
        Malignant melanoma of skin
        Cutaneous Melanoma of the Extremity
        Acral lentiginous melanoma
        Metastatic Acral Lentiginous Melanoma
        Recurrent Acral Lentiginous Melanoma
        Stage I Acral Lentiginous Melanoma AJCC v7
        Stage II Acral Lentiginous Melanoma AJCC v6 and v7
        Stage III Acral Lentiginous Melanoma AJCC v7
        Stage IV Acral Lentiginous Melanoma AJCC v6 and v7
        Unresectable Acral Lentiginous Melanoma
        Advanced Cutaneous Melanoma of the Extremity
        Recurrent Cutaneous Melanoma of the Extremity

Professional guidelines

PubMed

Hyperthermia in the treatment of high-risk soft tissue sarcomas: a systematic review.

Veltsista PD, Oberacker E, Ademaj A, Corradini S, Eckert F, Flörcken A, Kaul D, Lindner LH, Issels R, Ott OJ, Pink D, Potkrajcic V, Reichardt P, Roohani S, Spalek MJ, Riesterer O, Zips D, Ghadjar P
Int J Hyperthermia 2023;40(1):2236337. doi: 10.1080/02656736.2023.2236337. PMID: 37468132

Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.

Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142

Primary excision margins, sentinel lymph node biopsy, and completion lymph node dissection in cutaneous melanoma: a clinical practice guideline.

Wright FC, Souter LH, Kellett S, Easson A, Murray C, Toye J, McCready D, Nessim C, Ghazarian D, Hong NJL, Johnson S, Goldstein DP, Petrella T; Melanoma Disease Site Group
Curr Oncol 2019 Aug;26(4):e541-e550. Epub 2019 Aug 1 doi: 10.3747/co.26.4885. PMID: 31548823 Free PMC Article

See all (173)

Recent clinical studies

Etiology

Melanoma predilection for the lower limbs of women compared with men.

Shakeel M, Jiyad Z, Grant M, Cook MG, Oudit D, Green AC
Arch Dermatol Res 2023 Apr;315(3):633-636. Epub 2022 Sep 14 doi: 10.1007/s00403-022-02375-7. PMID: 36104631

"Location of cutaneous malignant melanoma in Sweden 2004-2018 - mortality and sex differences".

Önefäldt D, Zommorodi S, Falk Delgado A
J Plast Reconstr Aesthet Surg 2022 Sep;75(9):3398-3405. Epub 2022 Jun 20 doi: 10.1016/j.bjps.2022.04.093. PMID: 35803850

Melanoma.

Usatine RP, Heath CR
J Fam Pract 2022 May;71(4):178-179. doi: 10.12788/jfp.0410. PMID: 35730705

Primary excision margins, sentinel lymph node biopsy, and completion lymph node dissection in cutaneous melanoma: a clinical practice guideline.

Diagnosis and treatment of in-transit melanoma metastases.

Testori A, Ribero S, Bataille V
Eur J Surg Oncol 2017 Mar;43(3):544-560. Epub 2016 Oct 27 doi: 10.1016/j.ejso.2016.10.005. PMID: 27923593

See all (1364)

Diagnosis

Melanoma.

Usatine RP, Heath CR
J Fam Pract 2022 May;71(4):178-179. doi: 10.12788/jfp.0410. PMID: 35730705

Primary excision margins, sentinel lymph node biopsy, and completion lymph node dissection in cutaneous melanoma: a clinical practice guideline.

Early detection of acral melanoma: A review of clinical, dermoscopic, histopathologic, and molecular characteristics.

Darmawan CC, Jo G, Montenegro SE, Kwak Y, Cheol L, Cho KH, Mun JH
J Am Acad Dermatol 2019 Sep;81(3):805-812. Epub 2019 Feb 5 doi: 10.1016/j.jaad.2019.01.081. PMID: 30731177

Melanoma of the Foot.

Bristow I, Bower C
Clin Podiatr Med Surg 2016 Jul;33(3):409-22. Epub 2016 Apr 13 doi: 10.1016/j.cpm.2016.02.008. PMID: 27215160

Acral Lentiginous Melanoma.

Goydos JS, Shoen SL
Cancer Treat Res 2016;167:321-9. doi: 10.1007/978-3-319-22539-5_14. PMID: 26601870

See all (1268)

Therapy

Isolated limb infusion: Institutional protocol and implementation.

Carr MJ, Sun J, Zager JS
J Surg Oncol 2020 Jul;122(1):99-105. Epub 2020 Mar 11 doi: 10.1002/jso.25886. PMID: 32162353

Primary excision margins, sentinel lymph node biopsy, and completion lymph node dissection in cutaneous melanoma: a clinical practice guideline.

Regional therapies for locoregionally advanced and unresectable melanoma.

Weitman ES, Zager JS
Clin Exp Metastasis 2018 Aug;35(5-6):495-502. Epub 2018 May 8 doi: 10.1007/s10585-018-9890-1. PMID: 29736626

Diagnosis and treatment of in-transit melanoma metastases.

Testori A, Ribero S, Bataille V
Eur J Surg Oncol 2017 Mar;43(3):544-560. Epub 2016 Oct 27 doi: 10.1016/j.ejso.2016.10.005. PMID: 27923593

Is UV an etiological factor of acral melanoma?

Liu L, Zhang W, Gao T, Li C
J Expo Sci Environ Epidemiol 2016 Nov;26(6):539-545. Epub 2015 Oct 14 doi: 10.1038/jes.2015.60. PMID: 26464096

See all (998)

Prognosis

Plantar Melanoma: An Investigation of Its Incidence.

An M, Blekher L, Liu M, Pitre M, Shaner R, Silva D, Vlahovic TC
Clin Podiatr Med Surg 2021 Oct;38(4):595-599. doi: 10.1016/j.cpm.2021.06.012. PMID: 34538438

More than just acral melanoma: the controversies of defining the disease.

Bernardes SS, Ferreira I, Elder DE, Nobre AB, Martínez-Said H, Adams DJ, Robles-Espinoza CD, Possik PA
J Pathol Clin Res 2021 Nov;7(6):531-541. Epub 2021 Jul 2 doi: 10.1002/cjp2.233. PMID: 34213090 Free PMC Article

Primary dermal melanoma: clinical behaviour, prognosis and treatment.

Harris CG, Lo S, Ahmed T, Scolyer RA, Ferguson PM, Karim RZ, Lam TK, Lee KK, Shannon KF, Spillane AJ, Stretch JR, Thompson JF, Saw RP
Eur J Surg Oncol 2020 Nov;46(11):2131-2139. Epub 2020 May 1 doi: 10.1016/j.ejso.2020.04.043. PMID: 32417156

Subungual Melanoma of the Hand.

Chakera AH, Quinn MJ, Lo S, Drummond M, Haydu LE, Bond JS, Stretch JR, Saw RPM, Lee KJ, McCarthy WH, Scolyer RA, Thompson JF
Ann Surg Oncol 2019 Apr;26(4):1035-1043. Epub 2018 Dec 18 doi: 10.1245/s10434-018-07094-w. PMID: 30565042

Skin cancers of the hand and upper extremity.

Ilyas EN, Leinberry CF, Ilyas AM
J Hand Surg Am 2012 Jan;37(1):171-8. doi: 10.1016/j.jhsa.2011.10.042. PMID: 22196297

See all (1194)

Clinical prediction guides

Dermoscopy of melanoma according to different body sites: Head and neck, trunk, limbs, nail, mucosal and acral.

Longo C, Pampena R, Moscarella E, Chester J, Starace M, Cinotti E, Piraccini BM, Argenziano G, Peris K, Pellacani G
J Eur Acad Dermatol Venereol 2023 Sep;37(9):1718-1730. Epub 2023 May 27 doi: 10.1111/jdv.19221. PMID: 37210653

More than just acral melanoma: the controversies of defining the disease.

Primary dermal melanoma: clinical behaviour, prognosis and treatment.

Primary excision margins, sentinel lymph node biopsy, and completion lymph node dissection in cutaneous melanoma: a clinical practice guideline.

Subungual Melanoma of the Hand.

See all (700)

Recent systematic reviews

Anatomical variants of the intercostobrachial nerve and its preservation during surgery, a systematic review and meta-analysis.

Cirocchi R, Matteucci M, Randolph J, Duro F, Properzi L, Avenia S, Amato B, Iandoli R, Tebala G, Boselli C, Covarelli P, Sapienza P
World J Surg Oncol 2024 Apr 11;22(1):92. doi: 10.1186/s12957-024-03374-w. PMID: 38605346 Free PMC Article

Hyperthermia in the treatment of high-risk soft tissue sarcomas: a systematic review.

Metastases to the nail unit and distal phalanx: a systematic review.

Curtis KL, Lipner SR
Arch Dermatol Res 2023 Apr;315(3):347-358. Epub 2022 Oct 19 doi: 10.1007/s00403-022-02411-6. PMID: 36260150

A systematic review of axillary web syndrome (AWS).

Yeung WM, McPhail SM, Kuys SS
J Cancer Surviv 2015 Dec;9(4):576-98. Epub 2015 Feb 15 doi: 10.1007/s11764-015-0435-1. PMID: 25682072

Melanoma of the hand and foot: epidemiological, prognostic and genetic features. A systematic review.

Durbec F, Martin L, Derancourt C, Grange F
Br J Dermatol 2012 Apr;166(4):727-39. doi: 10.1111/j.1365-2133.2011.10772.x. PMID: 22175696

See all (17)