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Encapsulated Variant Thyroid Gland Papillary Carcinoma

MedGen UID:
1665610
•Concept ID:
C4744519
•
Neoplastic Process

Definition

A typical papillary thyroid gland carcinoma that is totally surrounded by a fibrous capsule, which may be intact or only focally infiltrated by tumor growth. It accounts for about 10% of all cases of papillary thyroid gland carcinoma and has an excellent prognosis. Regional nodal metastases may be present, but bloodborne metastases are rare. The survival rate is nearly 100%. (WHO 2017) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEncapsulated Variant Thyroid Gland Papillary Carcinoma

Professional guidelines

PubMed

Management of the central compartment in differentiated thyroid carcinoma.
Goepfert RP, Clayman GL
Eur J Surg Oncol 2018 Mar;44(3):327-331. Epub 2017 Sep 13 doi: 10.1016/j.ejso.2017.09.004. PMID: 28964612
Evolution of the histologic classification of thyroid neoplasms and its impact on clinical management.
Xu B, Ghossein R
Eur J Surg Oncol 2018 Mar;44(3):338-347. Epub 2017 May 18 doi: 10.1016/j.ejso.2017.05.002. PMID: 28554832Free PMC Article
American Thyroid Association Guidelines on the Management of Thyroid Nodules and Differentiated Thyroid Cancer Task Force Review and Recommendation on the Proposed Renaming of Encapsulated Follicular Variant Papillary Thyroid Carcinoma Without Invasion to Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features.
Haugen BR, Sawka AM, Alexander EK, Bible KC, Caturegli P, Doherty GM, Mandel SJ, Morris JC, Nassar A, Pacini F, Schlumberger M, Schuff K, Sherman SI, Somerset H, Sosa JA, Steward DL, Wartofsky L, Williams MD
Thyroid 2017 Apr;27(4):481-483. Epub 2017 Feb 21 doi: 10.1089/thy.2016.0628. PMID: 28114862

Recent clinical studies

Etiology

Thyroid Nodules and Follicular Cell-Derived Thyroid Carcinomas in Children.
Slack JC, Hollowell M, Barletta JA
Endocr Pathol 2023 Jun;34(2):165-175. Epub 2023 May 9 doi: 10.1007/s12022-023-09764-2. PMID: 37160531
Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
The thyroid cancer epidemic, 2017 perspective.
Roman BR, Morris LG, Davies L
Curr Opin Endocrinol Diabetes Obes 2017 Oct;24(5):332-336. doi: 10.1097/MED.0000000000000359. PMID: 28692457Free PMC Article
Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors.
Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LD, Barletta JA, Wenig BM, Al Ghuzlan A, Kakudo K, Giordano TJ, Alves VA, Khanafshar E, Asa SL, El-Naggar AK, Gooding WE, Hodak SP, Lloyd RV, Maytal G, Mete O, Nikiforova MN, Nosé V, Papotti M, Poller DN, Sadow PM, Tischler AS, Tuttle RM, Wall KB, LiVolsi VA, Randolph GW, Ghossein RA
JAMA Oncol 2016 Aug 1;2(8):1023-9. doi: 10.1001/jamaoncol.2016.0386. PMID: 27078145Free PMC Article

Diagnosis

Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
A closer look at NIFTP.
Dhanushika T, Priyani AAH, Ranaweera MEM, Ranaweera GG, de Silva MVC, Dassanayake RS
Hormones (Athens) 2020 Sep;19(3):285-290. Epub 2020 May 16 doi: 10.1007/s42000-020-00206-w. PMID: 32415648
The thyroid cancer epidemic, 2017 perspective.
Roman BR, Morris LG, Davies L
Curr Opin Endocrinol Diabetes Obes 2017 Oct;24(5):332-336. doi: 10.1097/MED.0000000000000359. PMID: 28692457Free PMC Article
Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors.
Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LD, Barletta JA, Wenig BM, Al Ghuzlan A, Kakudo K, Giordano TJ, Alves VA, Khanafshar E, Asa SL, El-Naggar AK, Gooding WE, Hodak SP, Lloyd RV, Maytal G, Mete O, Nikiforova MN, Nosé V, Papotti M, Poller DN, Sadow PM, Tischler AS, Tuttle RM, Wall KB, LiVolsi VA, Randolph GW, Ghossein RA
JAMA Oncol 2016 Aug 1;2(8):1023-9. doi: 10.1001/jamaoncol.2016.0386. PMID: 27078145Free PMC Article

Therapy

Large (>4 cm) Intrathyroidal Encapsulated Well-Differentiated Follicular Cell-Derived Carcinoma Without Vascular Invasion May Have Negligible Risk of Recurrence Even When Treated with Lobectomy Alone.
Ghossein R, Ganly I, Tuttle RM, Xu B
Thyroid 2023 May;33(5):586-592. Epub 2023 Apr 18 doi: 10.1089/thy.2023.0032. PMID: 36884299Free PMC Article
Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: Epidemiology and Long-Term Outcomes in a Strictly Defined Cohort.
Chung R, Guan H, Ponchiardi C, Cerda S, Marwaha N, Yilmaz OH, Pinjic E, McAneny D, Lee SL, Drake FT
Thyroid 2021 Jan;31(1):68-75. Epub 2020 Jul 23 doi: 10.1089/thy.2019.0616. PMID: 32539676Free PMC Article
NIFT-P: Are they indolent tumors? Results of a multi-institutional study.
Chereau N, Greilsamer T, Mirallié E, Sadowski SM, Pusztaszeri M, Triponez F, Baud G, Pattou F, Christou N, Mathonnet M, Brunaud L, Santucci N, Goudet P, Guérin C, Sebag F, Donatini G, Kraimps JL, Tissier F, Lussey-Lepoutre C, Leenhardt L, Menegaux F
Surgery 2019 Jan;165(1):12-16. Epub 2018 Nov 9 doi: 10.1016/j.surg.2018.04.089. PMID: 30420090
Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Cancer: Clinical Lessons from a Community-Based Endocrine Surgical Practice.
Golding A, Shively D, Bimston DN, Harrell RM
Int J Surg Oncol 2017;2017:4689465. Epub 2017 Apr 13 doi: 10.1155/2017/4689465. PMID: 28487771Free PMC Article
Topographic Distribution of Papillary Thyroid Carcinoma by Mapping in Coronal Sections of 125 Consecutive Thyroidectomy Specimens.
Mai KT, Gulavita P, Lai C, Swift J, Levac J, Olberg B, Purgina B
Int J Surg Pathol 2014 Jun;22(4):303-15. Epub 2013 Sep 18 doi: 10.1177/1066896913503491. PMID: 24050958

Prognosis

Thyroid Nodules and Follicular Cell-Derived Thyroid Carcinomas in Children.
Slack JC, Hollowell M, Barletta JA
Endocr Pathol 2023 Jun;34(2):165-175. Epub 2023 May 9 doi: 10.1007/s12022-023-09764-2. PMID: 37160531
The solid variant of papillary thyroid carcinoma: a multi-institutional retrospective study.
Xu B, Viswanathan K, Zhang L, Edmund LN, Ganly O, Tuttle RM, Lubin D, Ghossein RA
Histopathology 2022 Aug;81(2):171-182. Epub 2022 May 18 doi: 10.1111/his.14668. PMID: 35474588
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
The History of the Follicular Variant of Papillary Thyroid Carcinoma.
Tallini G, Tuttle RM, Ghossein RA
J Clin Endocrinol Metab 2017 Jan 1;102(1):15-22. doi: 10.1210/jc.2016-2976. PMID: 27732333
Encapsulated Thyroid Carcinoma of Follicular Cell Origin.
Xu B, Ghossein R
Endocr Pathol 2015 Sep;26(3):191-9. doi: 10.1007/s12022-015-9376-5. PMID: 26003547

Clinical prediction guides

Large (>4 cm) Intrathyroidal Encapsulated Well-Differentiated Follicular Cell-Derived Carcinoma Without Vascular Invasion May Have Negligible Risk of Recurrence Even When Treated with Lobectomy Alone.
Ghossein R, Ganly I, Tuttle RM, Xu B
Thyroid 2023 May;33(5):586-592. Epub 2023 Apr 18 doi: 10.1089/thy.2023.0032. PMID: 36884299Free PMC Article
Non-invasive follicular thyroid neoplasm with papillary-like nuclearfeatures (NIFTP): a review and update.
Geramizadeh B, Maleki Z
Endocrine 2019 Jun;64(3):433-440. Epub 2019 Mar 13 doi: 10.1007/s12020-019-01887-z. PMID: 30868412
Clinical Characteristics of Subtypes of Follicular Variant Papillary Thyroid Carcinoma.
Kim MJ, Won JK, Jung KC, Kim JH, Cho SW, Park DJ, Park YJ
Thyroid 2018 Mar;28(3):311-318. Epub 2018 Feb 16 doi: 10.1089/thy.2016.0671. PMID: 29343212
Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors.
Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LD, Barletta JA, Wenig BM, Al Ghuzlan A, Kakudo K, Giordano TJ, Alves VA, Khanafshar E, Asa SL, El-Naggar AK, Gooding WE, Hodak SP, Lloyd RV, Maytal G, Mete O, Nikiforova MN, Nosé V, Papotti M, Poller DN, Sadow PM, Tischler AS, Tuttle RM, Wall KB, LiVolsi VA, Randolph GW, Ghossein RA
JAMA Oncol 2016 Aug 1;2(8):1023-9. doi: 10.1001/jamaoncol.2016.0386. PMID: 27078145Free PMC Article
Variants of Papillary Thyroid Carcinoma: Multiple Faces of a Familiar Tumor.
Sak SD
Turk Patoloji Derg 2015;31 Suppl 1:34-47. doi: 10.5146/tjpath.2015.01313. PMID: 26177316

Recent systematic reviews

Pathological findings of the retrospective diagnosis of NIFTP (non-invasive follicular thyroid neoplasm with papillary-like nuclear features) in 84 cases from Turkey and systematic review.
Turan G, Özkara SK
Ann Diagn Pathol 2021 Aug;53:151764. Epub 2021 Jun 9 doi: 10.1016/j.anndiagpath.2021.151764. PMID: 34118581
High risk of malignancy in cases with atypia of undetermined significance on fine needle aspiration of thyroid nodules even after exclusion of NIFTP.
Özkara SK, Bayrak BY, Turan G
Diagn Cytopathol 2020 Nov;48(11):986-997. Epub 2020 Aug 3 doi: 10.1002/dc.24533. PMID: 32745375
Cytological Diagnoses Associated with Noninvasive Follicular Thyroid Neoplasms with Papillary-Like Nuclear Features According to the Bethesda System for Reporting Thyroid Cytopathology: A Systematic Review and Meta-Analysis.
Bongiovanni M, Giovanella L, Romanelli F, Trimboli P
Thyroid 2019 Feb;29(2):222-228. Epub 2018 Dec 21 doi: 10.1089/thy.2018.0394. PMID: 30426887

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