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Recurrent Acute Leukemia

MedGen UID:
1668204
•Concept ID:
C4725025
•
Neoplastic Process

Definition

The reemergence of acute leukemia after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Acute Leukemia

Professional guidelines

PubMed

Leukocytapheresis for the treatment of hyperleukocytosis secondary to acute leukemia.
Aqui N, O'Doherty U
Hematology Am Soc Hematol Educ Program 2014 Dec 5;2014(1):457-60. Epub 2014 Nov 18 doi: 10.1182/asheducation-2014.1.457. PMID: 25696894

Recent clinical studies

Etiology

Clinical characteristics and outcome of invasive fungal infections in pediatric acute myeloid leukemia patients in a medical center in Taiwan.
Lin GL, Chang HH, Lu CY, Chen CM, Lu MY, Lee PI, Jou ST, Yang YL, Huang LM, Chang LY
J Microbiol Immunol Infect 2018 Apr;51(2):251-259. Epub 2016 Dec 19 doi: 10.1016/j.jmii.2016.08.011. PMID: 28089099
Steroid-refractory cutaneous graft-versus-host disease after transplantation of haploidentical parental CD34+ cells in children with Down's syndrome and recurrent acute leukemia.
Mogul MJ, Forte KJ, Holland HK, Turner CW, Benyunes MC, Yeager AM
J Pediatr Hematol Oncol 1997 Mar-Apr;19(2):142-4. doi: 10.1097/00043426-199703000-00009. PMID: 9149745
Ifosfamide with mesna uroprotection and etoposide in recurrent, refractory acute leukemia in childhood. A Pediatric Oncology Group Study.
Bernstein ML, Whitehead VM, Devine S, Grier H, Kung F, Krischer J, Dreyer Z, Bell B, Land V, Buchanan GR
Cancer 1993 Sep 1;72(5):1790-4. doi: 10.1002/1097-0142(19930901)72:5<1790::aid-cncr2820720545>3.0.co;2-4. PMID: 8348510
Therapy of refractory/relapsed acute leukemia with cytosine arabinoside plus tetrahydrouridine (an inhibitor of cytidine deaminase)--a pilot study.
Kreis W, Budman DR, Chan K, Allen SL, Schulman P, Lichtman S, Weiselberg L, Schuster M, Freeman J, Akerman S
Leukemia 1991 Nov;5(11):991-8. PMID: 1961042
Rubidazone in the treatment of recurrent acute leukemia in children. A Pediatric Oncology Group Study.
Ragab AH, Boyett JM, Frankel L, Falletta J
Cancer 1986 Apr 15;57(8):1461-3. doi: 10.1002/1097-0142(19860415)57:8<1461::aid-cncr2820570804>3.0.co;2-r. PMID: 3948126

Diagnosis

A Review of DNA Methylation and microRNA Expression in Recurrent Pediatric Acute Leukemia.
Hale V, Hale GA, Brown PA, Amankwah EK
Oncology 2017;92(2):61-67. Epub 2016 Nov 2 doi: 10.1159/000452091. PMID: 27802447
A case of type B lactic acidosis in acute leukemia.
Lee HS, Kim HJ, Choi S, Kim CK, Lee NS, Lee KT, Won JH, Park HS, Hong DS
Yonsei Med J 2010 May;51(3):460-2. doi: 10.3349/ymj.2010.51.3.460. PMID: 20376904Free PMC Article
Increased expression of the multidrug resistance-associated protein gene in relapsed acute leukemia.
Schneider E, Cowan KH, Bader H, Toomey S, Schwartz GN, Karp JE, Burke PJ, Kaufmann SH
Blood 1995 Jan 1;85(1):186-93. PMID: 7528566

Therapy

Clinical characteristics and outcome of invasive fungal infections in pediatric acute myeloid leukemia patients in a medical center in Taiwan.
Lin GL, Chang HH, Lu CY, Chen CM, Lu MY, Lee PI, Jou ST, Yang YL, Huang LM, Chang LY
J Microbiol Immunol Infect 2018 Apr;51(2):251-259. Epub 2016 Dec 19 doi: 10.1016/j.jmii.2016.08.011. PMID: 28089099
Treatment of refractory acute leukemia with timed sequential chemotherapy using topotecan followed by etoposide + mitoxantrone (T-EM) and correlation with topoisomerase II levels.
Mainwaring MG, Rimsza LM, Chen SF, Gomez SP, Weeks FW, Reddy V, Lynch J, May WS, Kahn S, Moreb J, Leather H, Braylan R, Rowe TC, Fieniewicz KJ, Wingard JR
Leuk Lymphoma 2002 May;43(5):989-99. doi: 10.1080/10428190290021339. PMID: 12148910
Ifosfamide with mesna uroprotection and etoposide in recurrent, refractory acute leukemia in childhood. A Pediatric Oncology Group Study.
Bernstein ML, Whitehead VM, Devine S, Grier H, Kung F, Krischer J, Dreyer Z, Bell B, Land V, Buchanan GR
Cancer 1993 Sep 1;72(5):1790-4. doi: 10.1002/1097-0142(19930901)72:5<1790::aid-cncr2820720545>3.0.co;2-4. PMID: 8348510
Therapy of refractory/relapsed acute leukemia with cytosine arabinoside plus tetrahydrouridine (an inhibitor of cytidine deaminase)--a pilot study.
Kreis W, Budman DR, Chan K, Allen SL, Schulman P, Lichtman S, Weiselberg L, Schuster M, Freeman J, Akerman S
Leukemia 1991 Nov;5(11):991-8. PMID: 1961042
Rubidazone in the treatment of recurrent acute leukemia in children. A Pediatric Oncology Group Study.
Ragab AH, Boyett JM, Frankel L, Falletta J
Cancer 1986 Apr 15;57(8):1461-3. doi: 10.1002/1097-0142(19860415)57:8<1461::aid-cncr2820570804>3.0.co;2-r. PMID: 3948126

Prognosis

Steroid-refractory cutaneous graft-versus-host disease after transplantation of haploidentical parental CD34+ cells in children with Down's syndrome and recurrent acute leukemia.
Mogul MJ, Forte KJ, Holland HK, Turner CW, Benyunes MC, Yeager AM
J Pediatr Hematol Oncol 1997 Mar-Apr;19(2):142-4. doi: 10.1097/00043426-199703000-00009. PMID: 9149745
Escalating systemic exposure of continuous infusion topotecan in children with recurrent acute leukemia.
Furman WL, Baker SD, Pratt CB, Rivera GK, Evans WE, Stewart CF
J Clin Oncol 1996 May;14(5):1504-11. doi: 10.1200/JCO.1996.14.5.1504. PMID: 8622064
Ifosfamide with mesna uroprotection and etoposide in recurrent, refractory acute leukemia in childhood. A Pediatric Oncology Group Study.
Bernstein ML, Whitehead VM, Devine S, Grier H, Kung F, Krischer J, Dreyer Z, Bell B, Land V, Buchanan GR
Cancer 1993 Sep 1;72(5):1790-4. doi: 10.1002/1097-0142(19930901)72:5<1790::aid-cncr2820720545>3.0.co;2-4. PMID: 8348510

Clinical prediction guides

Clinical characteristics and outcome of invasive fungal infections in pediatric acute myeloid leukemia patients in a medical center in Taiwan.
Lin GL, Chang HH, Lu CY, Chen CM, Lu MY, Lee PI, Jou ST, Yang YL, Huang LM, Chang LY
J Microbiol Immunol Infect 2018 Apr;51(2):251-259. Epub 2016 Dec 19 doi: 10.1016/j.jmii.2016.08.011. PMID: 28089099
Steroid-refractory cutaneous graft-versus-host disease after transplantation of haploidentical parental CD34+ cells in children with Down's syndrome and recurrent acute leukemia.
Mogul MJ, Forte KJ, Holland HK, Turner CW, Benyunes MC, Yeager AM
J Pediatr Hematol Oncol 1997 Mar-Apr;19(2):142-4. doi: 10.1097/00043426-199703000-00009. PMID: 9149745
Escalating systemic exposure of continuous infusion topotecan in children with recurrent acute leukemia.
Furman WL, Baker SD, Pratt CB, Rivera GK, Evans WE, Stewart CF
J Clin Oncol 1996 May;14(5):1504-11. doi: 10.1200/JCO.1996.14.5.1504. PMID: 8622064
Increased expression of the multidrug resistance-associated protein gene in relapsed acute leukemia.
Schneider E, Cowan KH, Bader H, Toomey S, Schwartz GN, Karp JE, Burke PJ, Kaufmann SH
Blood 1995 Jan 1;85(1):186-93. PMID: 7528566
Rubidazone in the treatment of recurrent acute leukemia in children. A Pediatric Oncology Group Study.
Ragab AH, Boyett JM, Frankel L, Falletta J
Cancer 1986 Apr 15;57(8):1461-3. doi: 10.1002/1097-0142(19860415)57:8<1461::aid-cncr2820570804>3.0.co;2-r. PMID: 3948126

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