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Peripheral nerve disease

MedGen UID:: 1668548
•Concept ID:: C4721453
•: Disease or Syndrome

Synonyms:	Nerve Disease, Peripheral; Nerve Diseases, Peripheral; Neuropathy, Peripheral; Peripheral Nerve Disease; Peripheral Nerve Diseases; Peripheral Nervous System Disease; Peripheral Nervous System Diseases; Peripheral Nervous System Disorders; Peripheral Neuropathies; Peripheral Neuropathy; PNS (Peripheral Nervous System) Diseases; PNS Disease; PNS Diseases
SNOMED CT:	Peripheral neuropathy (302226006); Peripheral nerve disease (302226006); Disorder of the peripheral nervous system (42658009)

Definition

A non-neoplastic or neoplastic disorder that affects the peripheral nervous system. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVPeripheral nerve disease

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Disorder of nervous system
        Peripheral nerve disease
        Brachial plexus neuropathy
        Brachial plexus neuritis
        Neonatal Brachial Plexus Palsy
        Complex regional pain syndrome
        Complex regional pain syndrome type 1
        Complex regional pain syndrome type 2
        Compression Syndromes, Nerve
        Carpal tunnel syndrome
        Carpal tunnel syndrome 1
        Cauda equina syndrome
        Cauda equina syndrome with neurogenic bladder
        Piriformis syndrome
        Pudendal neuralgia
        Tarsal tunnel syndrome
        Thoracic outlet syndrome
        Arterial thoracic outlet syndrome
        Arterial thoracic outlet syndrome due to cervical rib
        Neurogenic thoracic outlet syndrome
        Venous thoracic outlet syndrome
        Ulnar Nerve Compression Syndromes
        Cubital tunnel syndrome
        Congenital Indifference to Pain
        Diabetic neuropathy
        Diabetic autonomic neuropathy
        Diabetic foot
        Giant axonal neuropathy
        Giant axonal neuropathy 1
        Giant axonal neuropathy 2
        Guillain-Barre syndrome
        Acute inflammatory demyelinating polyradiculoneuropathy
        Acute motor and sensory axonal neuropathy
        Acute motor axonal neuropathy
        Miller Fisher syndrome
        Isaac syndrome
        Mononeuropathy
        Femoral neuropathy
        Median nerve neuropathy
        Peroneal neuropathy
        Radial neuropathy
        Sciatic neuropathy
        Sciatica
        Tibial neuropathy
        Ulnar neuropathy
        Neoplasm of the peripheral nervous system
        Autonomic nervous system neoplasm
        Ganglioneuroma
        Paraganglioma
        Benign peripheral nerve granular cell tumor
        Childhood mediastinal neurogenic neoplasm
        Cranial nerve neoplasm
        Abducens nerve neoplasm
        Acoustic neuroma
        Facial nerve neoplasm
        Glossopharyngeal nerve neoplasm
        Hypoglossal nerve neoplasm
        Malignant cranial nerve neoplasm
        Oculomotor nerve neoplasm
        Olfactory nerve neoplasm
        Optic nerve neoplasm
        Spinal accessory nerve neoplasm
        Trigeminal nerve neoplasm
        Trochlear nerve neoplasm
        Vagus nerve neoplasm
        Vestibulocochlear nerve neoplasm
        Cutaneous Neural Neoplasm
        Benign dermal neurilemmoma
        Cutaneous ganglioneuroma
        Cutaneous granular cell tumor
        Cutaneous Neurofibroma
        Cutaneous Perineurioma
        Dermal Nerve Sheath Myxoma
        Malignant Peripheral Nerve Sheath Tumor of the Skin
        Hemangioma of peripheral nerve
        Intraneural perineurioma
        Lipomatosis of Nerve
        Nerve plexus neoplasm
        Brachial plexus neoplasm
        Lumbar plexus neoplasm
        Nerve sheath neoplasm
        Atypical Neurofibromatous Neoplasm of Uncertain Biologic Potential
        Granular cell tumor
        Hybrid Nerve Sheath Tumor
        Malignant peripheral nerve sheath tumor
        Melanotic neurilemmoma
        Neurofibroma
        Neuroma
        Neurothekeoma
        Perineurioma
        Schwannoma
        Solitary Circumscribed Neuroma
        Neurofibromatosis
        Aggravated Neurofibromatosis
        Neurofibroma by anatomical location
        Neurofibromatosis, type 1
        Neurofibromatosis, type 2
        Neurofibromatosis, type IV, of Riccardi
        Plexiform neurofibroma
        Peripheral nerve schwannoma
        Adrenal Gland Schwannoma
        Bone Schwannoma
        Breast Schwannoma
        Cardiac Schwannoma
        Colorectal Schwannoma
        Esophageal Schwannoma
        Gastric Schwannoma
        Intraocular Schwannoma
        Kidney Schwannoma
        Mediastinal schwannoma
        Neurilemmoma of the pleura
        Paratesticular Schwannoma
        Penile Schwannoma
        Schwannoma of jugular foramen
        Schwannoma of ureter
        Sternal Intraosseous Schwannoma
        Sympathetic neurilemmoma
        Thyroid Gland Schwannoma
        Peripheral nervous system cancer
        Granular cell cancer
        Metastatic Paraganglioma
        Peripheral ganglioneuroblastoma
        Peripheral Neuroblastoma
        Peripheral primitive neuroectodermal tumor
        Peripheral neuroepithelioma
        Askin tumor
        Ewing sarcoma
        Neuralgia
        Morton neuroma
        Occipital neuralgia
        Postherpetic neuralgia
        Trigeminal neuralgia
        Neuritis
        Polyneuritis
        Acute infective polyneuritis
        Non-Neoplastic Peripheral Nervous System Disorder
        Abnormal autonomic nervous system physiology
        Abnormal sudomotor regulation
        Autonomic bladder dysfunction
        Familial dysautonomia
        Horner syndrome
        Multiple system atrophy
        Neurocirculatory asthenia
        Orthostatic hypotension
        Orthostatic tachycardia
        Pure autonomic failure
        Reduced sympathoneural responses to the cold pressor test
        Infectious disease with peripheral neuropathy
        Geniculate herpes zoster
        Leprosy
        Lyme disease
        Laryngeal Nerve Paralysis
        Vagus nerve laryngeal paralysis
        Median Nerve Paralysis
        Peroneal nerve paralysis
        Radiculitis
        Perineural cyst
        Peripheral neuropathy
        Acute episodes of neuropathic symptoms
        Chronic sensorineural polyneuropathy
        Congenital peripheral neuropathy
        Entrapment neuropathy
        Constrictive median neuropathy
        Entrapment neuropathy of suprascapular nerve
        Entrapment neuropathy of the ulnar nerve at elbow
        Episodic peripheral neuropathy
        Mononeuritis multiplex
        Motor nerve neuritis
        Asymmetric motor neuropathy
        Glossopharyngeal motor neuropathy
        Motor polyneuropathy
        Demyelinating motor neuropathy
        Peripheral axonal neuropathy
        Chronic axonal neuropathy
        Motor axonal neuropathy
        Sensory axonal neuropathy
        Polyneuropathy
        Alcoholic polyneuropathy
        Chronic polyneuropathy
        Demyelinating peripheral neuropathy
        Hereditary motor and sensory neuropathy
        Hereditary sensory and autonomic neuropathy
        Paraneoplastic polyneuropathy
        POEMS syndrome
        Polyradiculoneuropathy
        Radiculoneuropathy
        Tangier disease
        Toxic polyneuropathy
        Progressive peripheral neuropathy
        Sensorimotor neuropathy
        Sensorimotor polyneuropathy affecting arms more than legs
        Sensory neuropathy
        Congenital sensory neuropathy with selective loss of small myelinated fibers
        Distal peripheral sensory neuropathy
        Distal sensory impairment of all modalities
        Hereditary insensitivity to pain with anhidrosis
        Hereditary sensory and autonomic neuropathy type 1
        Hereditary sensory and autonomic neuropathy type 7
        Sensory ataxic neuropathy
        Polyneuropathy due to amyloidosis
        Familial amyloid polyneuropathy
        Radiculopathy
        Small fiber neuropathy

Professional guidelines

PubMed

Diagnostic and Treatment Considerations in Restless Legs Syndrome Complicated by Diabetic Neuropathy.

Garg A, Chilakamarri P, Koo BB
Curr Diab Rep 2021 Dec 24;21(12):66. doi: 10.1007/s11892-021-01431-2. PMID: 34950962

Treatment of neuropsychiatric systemic lupus erythematosus: clinical challenges and future perspectives.

Nikolopoulos D, Fanouriakis A, Bertsias G
Expert Rev Clin Immunol 2021 Apr;17(4):317-330. Epub 2021 Mar 18 doi: 10.1080/1744666X.2021.1899810. PMID: 33682602

Not all neuropathy in diabetes is of diabetic etiology: differential diagnosis of diabetic neuropathy.

Freeman R
Curr Diab Rep 2009 Dec;9(6):423-31. doi: 10.1007/s11892-009-0069-7. PMID: 19954686

See all (7)

Recent clinical studies

Etiology

Genetic mechanisms of peripheral nerve disease.

Stavrou M, Sargiannidou I, Christofi T, Kleopa KA
Neurosci Lett 2021 Jan 18;742:135357. Epub 2020 Nov 26 doi: 10.1016/j.neulet.2020.135357. PMID: 33249104

Peripheral nerve disease.

Ramdharry G
Handb Clin Neurol 2018;159:403-415. doi: 10.1016/B978-0-444-63916-5.00026-4. PMID: 30482330

Nervous System Abnormalities and Legionnaire's Disease.

Halperin JJ
Infect Dis Clin North Am 2017 Mar;31(1):55-68. Epub 2016 Dec 12 doi: 10.1016/j.idc.2016.10.005. PMID: 27979685

Intravenous immunoglobulin for Guillain-Barré syndrome.

Hughes RA, Swan AV, van Doorn PA
Cochrane Database Syst Rev 2014 Sep 19;2014(9):CD002063. doi: 10.1002/14651858.CD002063.pub6. PMID: 25238327 Free PMC Article

Peripheral nerve disease in pregnancy.

Klein A
Clin Obstet Gynecol 2013 Jun;56(2):382-8. doi: 10.1097/GRF.0b013e31828f260e. PMID: 23563878

See all (60)

Diagnosis

Paraproteinemias and Peripheral Nerve Disease.

Leavell Y, Shin SC
Clin Geriatr Med 2021 May;37(2):301-312. doi: 10.1016/j.cger.2021.01.004. PMID: 33858612

Cancer and Peripheral Nerve Disease.

Sarezky J, Sachs G, Elinzano H, Stavros K
Clin Geriatr Med 2021 May;37(2):289-300. Epub 2021 Mar 23 doi: 10.1016/j.cger.2021.01.003. PMID: 33858611

Diabetes and Peripheral Nerve Disease.

Zilliox LA
Clin Geriatr Med 2021 May;37(2):253-267. Epub 2021 Mar 23 doi: 10.1016/j.cger.2020.12.001. PMID: 33858608

Lupus Vasculitis.

Calle-Botero E, Abril A
Curr Rheumatol Rep 2020 Aug 26;22(10):71. doi: 10.1007/s11926-020-00937-0. PMID: 32845454

Neurologic Manifestations of Primary Sjögren Syndrome.

Margaretten M
Rheum Dis Clin North Am 2017 Nov;43(4):519-529. Epub 2017 Aug 23 doi: 10.1016/j.rdc.2017.06.002. PMID: 29061239

See all (183)

Therapy

Adalimumab-induced sensory vasculitic neuropathy.

Sim NK, Ismail A, Alam T, Shanmugarajah PD
Drug Ther Bull 2023 Sep;61(9):140-143. Epub 2023 Jan 17 doi: 10.1136/dtb.2022.246401.rep. PMID: 36649976

Adalimumab-induced sensory vasculitic neuropathy.

Sim NK, Ismail A, Alam T, Shanmugarajah PD
BMJ Case Rep 2022 Jan 17;15(1) doi: 10.1136/bcr-2021-246401. PMID: 35039360 Free PMC Article

Cancer and Peripheral Nerve Disease.

Sarezky J, Sachs G, Elinzano H, Stavros K
Clin Geriatr Med 2021 May;37(2):289-300. Epub 2021 Mar 23 doi: 10.1016/j.cger.2021.01.003. PMID: 33858611

Chronic Neurological Disease Due to Methylmercury Poisoning.

Jackson AC
Can J Neurol Sci 2018 Nov;45(6):620-623. Epub 2018 Oct 3 doi: 10.1017/cjn.2018.323. PMID: 30278852

Intravenous immunoglobulin for Guillain-Barré syndrome.

Hughes RA, Swan AV, van Doorn PA
Cochrane Database Syst Rev 2014 Sep 19;2014(9):CD002063. doi: 10.1002/14651858.CD002063.pub6. PMID: 25238327 Free PMC Article

See all (99)

Prognosis

Rare cutaneous manifestation of COVID-19.

Killion L, Beatty PE, Salim A
BMJ Case Rep 2021 Jan 28;14(1) doi: 10.1136/bcr-2020-240863. PMID: 33509895 Free PMC Article

High-Resolution Nerve Ultrasound to Assess Nerve Echogenicity, Fascicular Count, and Cross-Sectional Area Using Semiautomated Analysis.

Gamber D, Motte J, Kerasnoudis A, Yoon MS, Gold R, Pitarokoili K, Fisse AL
J Neuroimaging 2020 Jul;30(4):493-502. Epub 2020 Jun 10 doi: 10.1111/jon.12717. PMID: 32521091

US of the Peripheral Nerves of the Lower Extremity: A Landmark Approach.

Yablon CM, Hammer MR, Morag Y, Brandon CJ, Fessell DP, Jacobson JA
Radiographics 2016 Mar-Apr;36(2):464-78. Epub 2016 Feb 12 doi: 10.1148/rg.2016150120. PMID: 26871986

Ultrasonographic Evaluation of Peripheral Nerves.

Ali ZS, Pisapia JM, Ma TS, Zager EL, Heuer GG, Khoury V
World Neurosurg 2016 Jan;85:333-9. Epub 2015 Oct 14 doi: 10.1016/j.wneu.2015.10.005. PMID: 26463397

Hereditary and acquired polyneuropathies. Electrophysiologic aspects.

Miller RG
Neurol Clin 1985 Aug;3(3):543-56. PMID: 2413343

See all (36)

Clinical prediction guides

Effects of repetitive peripheral magnetic stimulation vs. conventional therapy in the management of carpal tunnel syndrome: a pilot randomized controlled trial.

Panathoop A, Saengsuwan J, Vichiansiri R
PeerJ 2023;11:e15398. Epub 2023 May 18 doi: 10.7717/peerj.15398. PMID: 37220528 Free PMC Article

Diffusion MRI in Peripheral Nerves: Optimized b Values and the Role of Non-Gaussian Diffusion.

Foesleitner O, Sulaj A, Sturm V, Kronlage M, Godel T, Preisner F, Nawroth PP, Bendszus M, Heiland S, Schwarz D
Radiology 2022 Jan;302(1):153-161. Epub 2021 Oct 19 doi: 10.1148/radiol.2021204740. PMID: 34665029

High-Resolution Nerve Ultrasound to Assess Nerve Echogenicity, Fascicular Count, and Cross-Sectional Area Using Semiautomated Analysis.

Gamber D, Motte J, Kerasnoudis A, Yoon MS, Gold R, Pitarokoili K, Fisse AL
J Neuroimaging 2020 Jul;30(4):493-502. Epub 2020 Jun 10 doi: 10.1111/jon.12717. PMID: 32521091

Ultrasonographic Evaluation of Peripheral Nerves.

Ali ZS, Pisapia JM, Ma TS, Zager EL, Heuer GG, Khoury V
World Neurosurg 2016 Jan;85:333-9. Epub 2015 Oct 14 doi: 10.1016/j.wneu.2015.10.005. PMID: 26463397

Accuracy of MRI in diagnosing peripheral nerve disease: a systematic review of the literature.

Kwee RM, Chhabra A, Wang KC, Marker DR, Carrino JA
AJR Am J Roentgenol 2014 Dec;203(6):1303-9. doi: 10.2214/AJR.13.12403. PMID: 25415709

See all (32)

Recent systematic reviews

Accuracy of MRI in diagnosing peripheral nerve disease: a systematic review of the literature.

Kwee RM, Chhabra A, Wang KC, Marker DR, Carrino JA
AJR Am J Roentgenol 2014 Dec;203(6):1303-9. doi: 10.2214/AJR.13.12403. PMID: 25415709

Intravenous immunoglobulin for Guillain-Barré syndrome.

Hughes RA, Swan AV, van Doorn PA
Cochrane Database Syst Rev 2014 Sep 19;2014(9):CD002063. doi: 10.1002/14651858.CD002063.pub6. PMID: 25238327 Free PMC Article

Intravenous immunoglobulin for Guillain-Barré syndrome.

Hughes RA, Swan AV, van Doorn PA
Cochrane Database Syst Rev 2012 Jul 11;(7):CD002063. doi: 10.1002/14651858.CD002063.pub5. PMID: 22786476

Intravenous immunoglobulin for Guillain-Barré syndrome.

Hughes RA, Swan AV, van Doorn PA
Cochrane Database Syst Rev 2010 Jun 16;(6):CD002063. doi: 10.1002/14651858.CD002063.pub4. PMID: 20556755

Intravenous immunoglobulin for Guillain-Barré syndrome.

Hughes RA, Raphaël JC, Swan AV, van Doorn PA
Cochrane Database Syst Rev 2006 Jan 25;(1):CD002063. doi: 10.1002/14651858.CD002063.pub3. PMID: 16437439

See all (6)

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Peripheral nerve disease

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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