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Abnormal conus terminalis morphology

MedGen UID:
1671014
•Concept ID:
C4732765
•
Anatomical Abnormality
Synonym: Abnormal conus medullaris morphology
 
HPO: HP:0031938

Definition

Any structural anomaly of the conus terminalis, which is the distal bulbous part of the spinal cord at the location where the spinal cord tapers and ends (usually between the L1 and L2 lumbar vertebrae). [from HPO]

Professional guidelines

PubMed

Diagnostic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS).
Tobin WO, Guo Y, Krecke KN, Parisi JE, Lucchinetti CF, Pittock SJ, Mandrekar J, Dubey D, Debruyne J, Keegan BM
Brain 2017 Sep 1;140(9):2415-2425. doi: 10.1093/brain/awx200. PMID: 29050399
International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery.
Cox BW, Spratt DE, Lovelock M, Bilsky MH, Lis E, Ryu S, Sheehan J, Gerszten PC, Chang E, Gibbs I, Soltys S, Sahgal A, Deasy J, Flickinger J, Quader M, Mindea S, Yamada Y
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):e597-605. Epub 2012 May 19 doi: 10.1016/j.ijrobp.2012.03.009. PMID: 22608954
Differential diagnosis of T2 hyperintense spinal cord lesions: part B.
Bou-Haidar P, Peduto AJ, Karunaratne N
J Med Imaging Radiat Oncol 2009 Apr;53(2):152-9. doi: 10.1111/j.1754-9485.2009.02067.x. PMID: 19527360

Recent clinical studies

Etiology

Imaging of Congenital Spine Malformations.
White C, Milla SS, Maloney JA, Neuberger I
Clin Perinatol 2022 Sep;49(3):623-640. doi: 10.1016/j.clp.2022.05.003. PMID: 36113926
Spinal cavernous malformations.
Clark AJ, Wang DD, Lawton MT
Handb Clin Neurol 2017;143:303-308. doi: 10.1016/B978-0-444-63640-9.00030-8. PMID: 28552154
Spinal cord malformations.
Zerah M, Kulkarni AV
Handb Clin Neurol 2013;112:975-91. doi: 10.1016/B978-0-444-52910-7.00018-0. PMID: 23622306
Iatrogenic spinal deformity.
Jagannathan J, Sansur CA, Shaffrey CI
Neurosurgery 2008 Sep;63(3 Suppl):104-16. doi: 10.1227/01.NEU.0000320386.08993.BE. PMID: 18812912
Tethered cord syndrome: an updated review.
Lew SM, Kothbauer KF
Pediatr Neurosurg 2007;43(3):236-48. doi: 10.1159/000098836. PMID: 17409793

Diagnosis

Imaging of Congenital Spine Malformations.
White C, Milla SS, Maloney JA, Neuberger I
Clin Perinatol 2022 Sep;49(3):623-640. doi: 10.1016/j.clp.2022.05.003. PMID: 36113926
Arteriovenous fistulae of the filum terminale.
Giordan E, Brinjikji W, Ciceri E, Lanzino G
J Neurointerv Surg 2018 Feb;10(2):191-197. Epub 2017 Sep 26 doi: 10.1136/neurintsurg-2017-013309. PMID: 28951393
Spinal cord malformations.
Zerah M, Kulkarni AV
Handb Clin Neurol 2013;112:975-91. doi: 10.1016/B978-0-444-52910-7.00018-0. PMID: 23622306
Congenital Chiari malformations.
Vannemreddy P, Nourbakhsh A, Willis B, Guthikonda B
Neurol India 2010 Jan-Feb;58(1):6-14. doi: 10.4103/0028-3886.60387. PMID: 20228456
Tethered cord syndrome: an updated review.
Lew SM, Kothbauer KF
Pediatr Neurosurg 2007;43(3):236-48. doi: 10.1159/000098836. PMID: 17409793

Therapy

Superficial abdominal reflex in syringomyelia: Associations with Chiari I malformation.
Nadel JL, Ziats C, Mossner JM, Starr JB, Smith BW, Kelly MP, Muraszko KM, Farley FA, Maher CO, Garton HJL, Strahle JM
J Clin Neurosci 2022 Apr;98:1-5. Epub 2022 Jan 31 doi: 10.1016/j.jocn.2021.12.037. PMID: 35114475
White matter as a monitoring biomarker for neurodevelopmental disorder intervention studies.
Swanson MR, Hazlett HC
J Neurodev Disord 2019 Dec 16;11(1):33. doi: 10.1186/s11689-019-9295-8. PMID: 31839003Free PMC Article
Neural tube defects--disorders of neurulation and related embryonic processes.
Copp AJ, Greene ND
Wiley Interdiscip Rev Dev Biol 2013 Mar-Apr;2(2):213-27. Epub 2012 May 29 doi: 10.1002/wdev.71. PMID: 24009034Free PMC Article
Fetal surgery for myelomeningocele: a critical appraisal.
Meuli M, Moehrlen U
Eur J Pediatr Surg 2013 Apr;23(2):103-9. Epub 2013 Apr 9 doi: 10.1055/s-0033-1343082. PMID: 23572465
Stem cell therapies for spinal cord injury.
Sahni V, Kessler JA
Nat Rev Neurol 2010 Jul;6(7):363-72. Epub 2010 Jun 15 doi: 10.1038/nrneurol.2010.73. PMID: 20551948Free PMC Article

Prognosis

Long-term urology outcomes of anorectal malformation.
Chong C, Hamza Y, Tan YW, Paul A, Garriboli M, Wright AJ, Olsburgh J, Taylor C, Sinha MD, Mishra P, Taghizadeh A
J Pediatr Urol 2022 Apr;18(2):150.e1-150.e6. Epub 2022 Feb 7 doi: 10.1016/j.jpurol.2022.01.019. PMID: 35283020
Incomplete Cord Syndromes: Clinical and Imaging Review.
Kunam VK, Velayudhan V, Chaudhry ZA, Bobinski M, Smoker WRK, Reede DL
Radiographics 2018 Jul-Aug;38(4):1201-1222. doi: 10.1148/rg.2018170178. PMID: 29995620
Vascular Disorders of the Spinal Cord.
Kramer CL
Continuum (Minneap Minn) 2018 Apr;24(2, Spinal Cord Disorders):407-426. doi: 10.1212/CON.0000000000000595. PMID: 29613893
Spinal vascular malformations.
Krings T, Mull M, Gilsbach JM, Thron A
Eur Radiol 2005 Feb;15(2):267-78. Epub 2004 Oct 22 doi: 10.1007/s00330-004-2510-2. PMID: 15538580
Open myelomeningocele.
Hahn YS
Neurosurg Clin N Am 1995 Apr;6(2):231-41. PMID: 7620350

Clinical prediction guides

Segmentation of the human spinal cord.
De Leener B, Taso M, Cohen-Adad J, Callot V
MAGMA 2016 Apr;29(2):125-53. Epub 2016 Jan 2 doi: 10.1007/s10334-015-0507-2. PMID: 26724926
Pearls: myelopathy.
Kumar N
Semin Neurol 2010 Feb;30(1):38-43. Epub 2010 Feb 1 doi: 10.1055/s-0029-1244993. PMID: 20127580
Conventional MR imaging.
Traboulsee A, Li DK
Neuroimaging Clin N Am 2008 Nov;18(4):651-73, x. doi: 10.1016/j.nic.2008.07.001. PMID: 19068407
Anorectal malformations.
Levitt MA, Peña A
Orphanet J Rare Dis 2007 Jul 26;2:33. doi: 10.1186/1750-1172-2-33. PMID: 17651510Free PMC Article
Congenital scoliosis.
Arlet V, Odent T, Aebi M
Eur Spine J 2003 Oct;12(5):456-63. Epub 2003 Jun 14 doi: 10.1007/s00586-003-0555-6. PMID: 14618384Free PMC Article

Recent systematic reviews

A systematic review on the outcome of intramedullary spinal cord cavernous malformations.
Asimakidou E, Meszaros LT, Anestis DM, Tsitsopoulos PP
Eur Spine J 2022 Nov;31(11):3119-3129. Epub 2022 Aug 6 doi: 10.1007/s00586-022-07332-6. PMID: 35931791
White matter microstructure in children and adolescents with ADHD.
Connaughton M, Whelan R, O'Hanlon E, McGrath J
Neuroimage Clin 2022;33:102957. Epub 2022 Feb 7 doi: 10.1016/j.nicl.2022.102957. PMID: 35149304Free PMC Article
Novel Clinical Insights into Spinal Hemangioblastoma in Adults: A Systematic Review.
Jankovic D, Hanissian A, Rotim K, Splavski B, Arnautovic KI
World Neurosurg 2022 Feb;158:1-10. Epub 2021 Oct 21 doi: 10.1016/j.wneu.2021.10.105. PMID: 34687932
Systematic review of bladder cancer outcomes in patients with spina bifida.
Rove KO, Husmann DA, Wilcox DT, Vricella GJ, Higuchi TT
J Pediatr Urol 2017 Oct;13(5):456.e1-456.e9. Epub 2017 Jun 1 doi: 10.1016/j.jpurol.2017.05.006. PMID: 28687411
Neuroinflammation and white matter pathology in schizophrenia: systematic review.
Najjar S, Pearlman DM
Schizophr Res 2015 Jan;161(1):102-12. Epub 2014 Jun 16 doi: 10.1016/j.schres.2014.04.041. PMID: 24948485

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