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Abnormal serum bicarbonate concentration

MedGen UID:
1671084
•Concept ID:
C4732832
•
Finding
Synonym: Abnormal serum HCO3 concentration
 
HPO: HP:0032065

Definition

Any deviation from the normal concentration of bicarbonate, HCO3[-], in the circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal serum bicarbonate concentration

Professional guidelines

PubMed

Renal Tubular Acidosis and Management Strategies: A Narrative Review.
Palmer BF, Kelepouris E, Clegg DJ
Adv Ther 2021 Feb;38(2):949-968. Epub 2020 Dec 26 doi: 10.1007/s12325-020-01587-5. PMID: 33367987Free PMC Article
Metabolic acidosis: pathophysiology, diagnosis and management.
Kraut JA, Madias NE
Nat Rev Nephrol 2010 May;6(5):274-85. Epub 2010 Mar 23 doi: 10.1038/nrneph.2010.33. PMID: 20308999
Toxic alcohol ingestions: clinical features, diagnosis, and management.
Kraut JA, Kurtz I
Clin J Am Soc Nephrol 2008 Jan;3(1):208-25. Epub 2007 Nov 28 doi: 10.2215/CJN.03220807. PMID: 18045860

Recent clinical studies

Etiology

Current Perspectives on Sudden Cardiac Death in Hemodialysis Patients.
Joki N, Tokumoto M, Takahashi N, Nishimura M
Contrib Nephrol 2018;196:5-12. Epub 2018 Jul 24 doi: 10.1159/000485690. PMID: 30041198
Hyperkalemia and Hypokalemia in CKD: Prevalence, Risk Factors, and Clinical Outcomes.
Gilligan S, Raphael KL
Adv Chronic Kidney Dis 2017 Sep;24(5):315-318. doi: 10.1053/j.ackd.2017.06.004. PMID: 29031358
Diet-induced metabolic acidosis.
Adeva MM, Souto G
Clin Nutr 2011 Aug;30(4):416-21. Epub 2011 Apr 9 doi: 10.1016/j.clnu.2011.03.008. PMID: 21481501
Metabolic acidosis: pathophysiology, diagnosis and management.
Kraut JA, Madias NE
Nat Rev Nephrol 2010 May;6(5):274-85. Epub 2010 Mar 23 doi: 10.1038/nrneph.2010.33. PMID: 20308999
Uric acid nephrolithiasis.
Liebman SE, Taylor JG, Bushinsky DA
Curr Rheumatol Rep 2007 Jun;9(3):251-7. doi: 10.1007/s11926-007-0040-z. PMID: 17531180

Diagnosis

COVID-19 and kidney: role of SARS-CoV-2 infection in the induction of renal damage.
Perrotta AM, Rotondi S, Mazzaferro S, Bosi L, Letizia C, Muscaritoli M, Gigante A, Salciccia S, Pasculli P, Ciardi MR, Tinti F, Galani A, Errigo F, Menè P, Cianci R, Mitterhofer AP, Mastroianni CM, Palange P, Lai S
Eur Rev Med Pharmacol Sci 2023 Aug;27(16):7861-7867. doi: 10.26355/eurrev_202308_33441. PMID: 37667963
Renal Tubular Acidosis and Management Strategies: A Narrative Review.
Palmer BF, Kelepouris E, Clegg DJ
Adv Ther 2021 Feb;38(2):949-968. Epub 2020 Dec 26 doi: 10.1007/s12325-020-01587-5. PMID: 33367987Free PMC Article
The assessment of acid-base analysis: comparison of the "traditional" and the "modern" approaches.
Todorović J, Nešovic-Ostojić J, Milovanović A, Brkić P, Ille M, Čemerikić D
Med Glas (Zenica) 2015 Feb;12(1):7-18. PMID: 25669331
Metabolic acidosis: pathophysiology, diagnosis and management.
Kraut JA, Madias NE
Nat Rev Nephrol 2010 May;6(5):274-85. Epub 2010 Mar 23 doi: 10.1038/nrneph.2010.33. PMID: 20308999
Uric acid nephrolithiasis.
Liebman SE, Taylor JG, Bushinsky DA
Curr Rheumatol Rep 2007 Jun;9(3):251-7. doi: 10.1007/s11926-007-0040-z. PMID: 17531180

Therapy

Antidotal Sodium Bicarbonate Therapy: Delayed QTc Prolongation and Cardiovascular Events.
Shastry S, Ellis J, Loo G, Vedanthan R, Richardson LD, Manini AF
J Med Toxicol 2021 Jan;17(1):27-36. Epub 2020 Jul 31 doi: 10.1007/s13181-020-00799-z. PMID: 32737857Free PMC Article
Current Perspectives on Sudden Cardiac Death in Hemodialysis Patients.
Joki N, Tokumoto M, Takahashi N, Nishimura M
Contrib Nephrol 2018;196:5-12. Epub 2018 Jul 24 doi: 10.1159/000485690. PMID: 30041198
Hyperkalemia and Hypokalemia in CKD: Prevalence, Risk Factors, and Clinical Outcomes.
Gilligan S, Raphael KL
Adv Chronic Kidney Dis 2017 Sep;24(5):315-318. doi: 10.1053/j.ackd.2017.06.004. PMID: 29031358
Diet-induced metabolic acidosis.
Adeva MM, Souto G
Clin Nutr 2011 Aug;30(4):416-21. Epub 2011 Apr 9 doi: 10.1016/j.clnu.2011.03.008. PMID: 21481501
Metabolic acidosis: pathophysiology, diagnosis and management.
Kraut JA, Madias NE
Nat Rev Nephrol 2010 May;6(5):274-85. Epub 2010 Mar 23 doi: 10.1038/nrneph.2010.33. PMID: 20308999

Prognosis

COVID-19 and kidney: role of SARS-CoV-2 infection in the induction of renal damage.
Perrotta AM, Rotondi S, Mazzaferro S, Bosi L, Letizia C, Muscaritoli M, Gigante A, Salciccia S, Pasculli P, Ciardi MR, Tinti F, Galani A, Errigo F, Menè P, Cianci R, Mitterhofer AP, Mastroianni CM, Palange P, Lai S
Eur Rev Med Pharmacol Sci 2023 Aug;27(16):7861-7867. doi: 10.26355/eurrev_202308_33441. PMID: 37667963
Urinary citrate as a marker of renal function in patients with autosomal dominant polycystic kidney disease.
Borrego Utiel FJ, Herrera Contreras I, Merino García E, Camacho Reina MV, Moriana Domínguez C, Ocaña Pérez E
Int Urol Nephrol 2022 Apr;54(4):873-881. Epub 2021 Jul 19 doi: 10.1007/s11255-021-02953-0. PMID: 34279821
Antidotal Sodium Bicarbonate Therapy: Delayed QTc Prolongation and Cardiovascular Events.
Shastry S, Ellis J, Loo G, Vedanthan R, Richardson LD, Manini AF
J Med Toxicol 2021 Jan;17(1):27-36. Epub 2020 Jul 31 doi: 10.1007/s13181-020-00799-z. PMID: 32737857Free PMC Article
Dialysate and serum potassium in hemodialysis.
Hung AM, Hakim RM
Am J Kidney Dis 2015 Jul;66(1):125-32. Epub 2015 Mar 28 doi: 10.1053/j.ajkd.2015.02.322. PMID: 25828570
Diet-induced metabolic acidosis.
Adeva MM, Souto G
Clin Nutr 2011 Aug;30(4):416-21. Epub 2011 Apr 9 doi: 10.1016/j.clnu.2011.03.008. PMID: 21481501

Clinical prediction guides

COVID-19 and kidney: role of SARS-CoV-2 infection in the induction of renal damage.
Perrotta AM, Rotondi S, Mazzaferro S, Bosi L, Letizia C, Muscaritoli M, Gigante A, Salciccia S, Pasculli P, Ciardi MR, Tinti F, Galani A, Errigo F, Menè P, Cianci R, Mitterhofer AP, Mastroianni CM, Palange P, Lai S
Eur Rev Med Pharmacol Sci 2023 Aug;27(16):7861-7867. doi: 10.26355/eurrev_202308_33441. PMID: 37667963
Acid-base balance in hemodialysis patients in everyday practice.
Wieliczko M, Małyszko J
Ren Fail 2022 Dec;44(1):1090-1097. doi: 10.1080/0886022X.2022.2094805. PMID: 35793495Free PMC Article
Renal Tubular Acidosis and Management Strategies: A Narrative Review.
Palmer BF, Kelepouris E, Clegg DJ
Adv Ther 2021 Feb;38(2):949-968. Epub 2020 Dec 26 doi: 10.1007/s12325-020-01587-5. PMID: 33367987Free PMC Article
Current Perspectives on Sudden Cardiac Death in Hemodialysis Patients.
Joki N, Tokumoto M, Takahashi N, Nishimura M
Contrib Nephrol 2018;196:5-12. Epub 2018 Jul 24 doi: 10.1159/000485690. PMID: 30041198
Diet-induced metabolic acidosis.
Adeva MM, Souto G
Clin Nutr 2011 Aug;30(4):416-21. Epub 2011 Apr 9 doi: 10.1016/j.clnu.2011.03.008. PMID: 21481501

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