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Hypertensive renal disease(HNP1)

MedGen UID:
167258
•Concept ID:
C0848548
•
Disease or Syndrome
Synonyms: HNP1; HYPERTENSIVE NEPHROPATHY
SNOMED CT: Renal disease due to hypertension (38481006); Hypertensive renal disease (38481006); Hypertensive nephropathy (38481006)
 
Monarch Initiative: MONDO:0024633
OMIM®: 608026

Definition

Kidney damage that results from chronically elevated blood pressure; complications include glomerular damage resulting in proteinuria and hematuria. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypertensive renal disease

Professional guidelines

PubMed

Current strategies for management of hypertensive renal disease.
Moore MA, Epstein M, Agodoa L, Dworkin LD
Arch Intern Med 1999 Jan 11;159(1):23-8. doi: 10.1001/archinte.159.1.23. PMID: 9892326
Diagnosis and management of vascular disease in systemic sclerosis.
Yost JH, Spencer-Green G
Compr Ther 1993;19(2):53-9. PMID: 8370246
Case-mix and treatment in end-stage renal disease: hemodialysis v peritoneal dialysis.
Radecki SE, Mendenhall RC, Nissenson AR, Freeman RB, Blagg CR, Capelli JP, Gentile DE, Feinstein EI
Am J Kidney Dis 1988 Jan;11(1):7-14. doi: 10.1016/s0272-6386(88)80167-7. PMID: 3122560

Recent clinical studies

Etiology

Mendelian and trans-generational inheritance in hypertensive renal disease.
Braun MC, Doris PA
Ann Med 2012 Jun;44 Suppl 1(Suppl 1):S65-73. doi: 10.3109/07853890.2012.665473. PMID: 22713151Free PMC Article
Genetic susceptibility to hypertensive renal disease.
Doris PA
Cell Mol Life Sci 2012 Nov;69(22):3751-63. Epub 2012 May 5 doi: 10.1007/s00018-012-0996-3. PMID: 22562581Free PMC Article
Cardiovascular disease mortality.
Onwuanyi AE, Clarke A, Vanderbush E
J Natl Med Assoc 2003 Dec;95(12):1146-51. PMID: 14717470Free PMC Article
Prevention of the development and progression of renal disease.
Hostetter TH
J Am Soc Nephrol 2003 Jul;14(7 Suppl 2):S144-7. doi: 10.1097/01.asn.0000070150.60928.06. PMID: 12819320
Microalbuminuria in essential hypertension.
Mimran A, Ribstein J, Du Cailar G
Curr Opin Nephrol Hypertens 1999 May;8(3):359-63. doi: 10.1097/00041552-199905000-00014. PMID: 10456269

Diagnosis

Contributions of obesity to kidney health and disease: insights from Mendelian randomization and the human kidney transcriptomics.
Xu X, Eales JM, Jiang X, Sanderson E, Drzal M, Saluja S, Scannali D, Williams B, Morris AP, Guzik TJ, Charchar FJ, Holmes MV, Tomaszewski M
Cardiovasc Res 2022 Dec 9;118(15):3151-3161. doi: 10.1093/cvr/cvab357. PMID: 34893803Free PMC Article
Susceptibility to Hypertensive Renal Disease in the Spontaneously Hypertensive Rat Is Influenced by 2 Loci Affecting Blood Pressure and Immunoglobulin Repertoire.
Dhande IS, Cranford SM, Zhu Y, Kneedler SC, Hicks MJ, Wenderfer SE, Braun MC, Doris PA
Hypertension 2018 Apr;71(4):700-708. Epub 2018 Feb 5 doi: 10.1161/HYPERTENSIONAHA.117.10593. PMID: 29437896Free PMC Article
The immune system: role in hypertension.
Schiffrin EL
Can J Cardiol 2013 May;29(5):543-8. Epub 2012 Aug 15 doi: 10.1016/j.cjca.2012.06.009. PMID: 22902155
Prevention of the development and progression of renal disease.
Hostetter TH
J Am Soc Nephrol 2003 Jul;14(7 Suppl 2):S144-7. doi: 10.1097/01.asn.0000070150.60928.06. PMID: 12819320
Salt. A perpetrator of hypertensive target organ disease?
Messerli FH, Schmieder RE, Weir MR
Arch Intern Med 1997 Nov 24;157(21):2449-52. doi: 10.1001/archinte.157.21.2449. PMID: 9385295

Therapy

Contributions of obesity to kidney health and disease: insights from Mendelian randomization and the human kidney transcriptomics.
Xu X, Eales JM, Jiang X, Sanderson E, Drzal M, Saluja S, Scannali D, Williams B, Morris AP, Guzik TJ, Charchar FJ, Holmes MV, Tomaszewski M
Cardiovasc Res 2022 Dec 9;118(15):3151-3161. doi: 10.1093/cvr/cvab357. PMID: 34893803Free PMC Article
Prevention of the development and progression of renal disease.
Hostetter TH
J Am Soc Nephrol 2003 Jul;14(7 Suppl 2):S144-7. doi: 10.1097/01.asn.0000070150.60928.06. PMID: 12819320
Microalbuminuria in essential hypertension.
Mimran A, Ribstein J, Du Cailar G
Curr Opin Nephrol Hypertens 1999 May;8(3):359-63. doi: 10.1097/00041552-199905000-00014. PMID: 10456269
Hypertension and endstage renal disease.
Brown TE, Carter BL
Ann Pharmacother 1994 Mar;28(3):359-66. doi: 10.1177/106002809402800312. PMID: 8193427
Carvedilol and the kidney.
Dupont AG
Clin Investig 1992;70 Suppl 1:S127-31. doi: 10.1007/BF00207623. PMID: 1350479

Prognosis

Contributions of obesity to kidney health and disease: insights from Mendelian randomization and the human kidney transcriptomics.
Xu X, Eales JM, Jiang X, Sanderson E, Drzal M, Saluja S, Scannali D, Williams B, Morris AP, Guzik TJ, Charchar FJ, Holmes MV, Tomaszewski M
Cardiovasc Res 2022 Dec 9;118(15):3151-3161. doi: 10.1093/cvr/cvab357. PMID: 34893803Free PMC Article
Susceptibility to Hypertensive Renal Disease in the Spontaneously Hypertensive Rat Is Influenced by 2 Loci Affecting Blood Pressure and Immunoglobulin Repertoire.
Dhande IS, Cranford SM, Zhu Y, Kneedler SC, Hicks MJ, Wenderfer SE, Braun MC, Doris PA
Hypertension 2018 Apr;71(4):700-708. Epub 2018 Feb 5 doi: 10.1161/HYPERTENSIONAHA.117.10593. PMID: 29437896Free PMC Article
Hypertension and kidney disease: a deadly connection.
Barri YM
Curr Hypertens Rep 2008 Feb;10(1):39-45. doi: 10.1007/s11906-008-0009-y. PMID: 18367025
Microalbuminuria in essential hypertension.
Mimran A, Ribstein J, Du Cailar G
Curr Opin Nephrol Hypertens 1999 May;8(3):359-63. doi: 10.1097/00041552-199905000-00014. PMID: 10456269
Renal disease in hypertensive adults: effect of race and type II diabetes mellitus.
Tierney WM, McDonald CJ, Luft FC
Am J Kidney Dis 1989 Jun;13(6):485-93. doi: 10.1016/s0272-6386(89)80006-x. PMID: 2729268

Clinical prediction guides

Contributions of obesity to kidney health and disease: insights from Mendelian randomization and the human kidney transcriptomics.
Xu X, Eales JM, Jiang X, Sanderson E, Drzal M, Saluja S, Scannali D, Williams B, Morris AP, Guzik TJ, Charchar FJ, Holmes MV, Tomaszewski M
Cardiovasc Res 2022 Dec 9;118(15):3151-3161. doi: 10.1093/cvr/cvab357. PMID: 34893803Free PMC Article
Genetic susceptibility to hypertensive renal disease.
Doris PA
Cell Mol Life Sci 2012 Nov;69(22):3751-63. Epub 2012 May 5 doi: 10.1007/s00018-012-0996-3. PMID: 22562581Free PMC Article
Microalbuminuria in essential hypertension.
Mimran A, Ribstein J, Du Cailar G
Curr Opin Nephrol Hypertens 1999 May;8(3):359-63. doi: 10.1097/00041552-199905000-00014. PMID: 10456269
The impact of ethnicity on response to antihypertensive therapy.
Jamerson K, DeQuattro V
Am J Med 1996 Sep 30;101(3A):22S-32S. doi: 10.1016/s0002-9343(96)00265-3. PMID: 8876472
Renal disease in hypertensive adults: effect of race and type II diabetes mellitus.
Tierney WM, McDonald CJ, Luft FC
Am J Kidney Dis 1989 Jun;13(6):485-93. doi: 10.1016/s0272-6386(89)80006-x. PMID: 2729268

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