Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Refractory Lymphoproliferative Disorder

MedGen UID:: 1675052
•Concept ID:: C4763790
•: Disease or Syndrome

Definition

Lymphoproliferative disorder that is resistant to treatment. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVRefractory Lymphoproliferative Disorder

Pathological process
- Disease
  - Disorder by Site
    - Hematopoietic and Lymphoid System Disorder
      - Hematologic disorder
        Lymphoproliferative disorder
        Refractory Lymphoproliferative Disorder
        Refractory Malignant Lymphoid Neoplasm
        Refractory Acute Lymphoblastic Leukemia
        Refractory Adult Acute Lymphoblastic Leukemia
        Refractory B Acute Lymphoblastic Leukemia
        Refractory B Acute Lymphoblastic Leukemia with BCR-ABL1-Like Features
        Refractory Childhood Acute Lymphoblastic Leukemia
        Refractory T Acute Lymphoblastic Leukemia
        Refractory B-Cell Prolymphocytic Leukemia
        Refractory Burkitt Leukemia
        Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
        Refractory Chronic Lymphocytic Leukemia
        Refractory Small Lymphocytic Lymphoma
        Refractory hairy cell leukemia
        Refractory Hairy Cell Leukemia Variant
        Refractory Lymphoma
        Refractory B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma
        Refractory Breast Lymphoma
        Refractory Central Nervous System Lymphoma
        Refractory EBV-Related Lymphoma
        Refractory Hodgkin Lymphoma
        Refractory Mediastinal Lymphoma
        Refractory Non-Hodgkin Lymphoma
        Refractory Primary Bone Lymphoma
        Refractory Primary Cutaneous Lymphoma
        Refractory Testicular Lymphoma
        Refractory Mature T-Cell and NK-Cell Neoplasm
        Refractory Aggressive NK-Cell Leukemia
        Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma
        Refractory T-Cell Large Granular Lymphocyte Leukemia
        Refractory T-Cell Prolymphocytic Leukemia
        Refractory Monomorphic Post-Transplant Lymphoproliferative Disorder
        Refractory plasma cell neoplasm
        Refractory Plasma Cell Myeloma
        Refractory Primary Amyloidosis
        Refractory precursor T-lymphoblastic lymphoma/leukemia
        Refractory T Lymphoblastic Lymphoma
        Refractory Polymorphic Post-Transplant Lymphoproliferative Disorder

Professional guidelines

PubMed

Diagnosis and Treatment of AL Amyloidosis.

Palladini G, Milani P
Drugs 2023 Feb;83(3):203-216. Epub 2023 Jan 18 doi: 10.1007/s40265-022-01830-z. PMID: 36652193

Multiple myeloma: 2020 update on diagnosis, risk-stratification and management.

Rajkumar SV
Am J Hematol 2020 May;95(5):548-567. doi: 10.1002/ajh.25791. PMID: 32212178

Hodgkin Lymphoma: Diagnosis and Treatment.

Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251

See all (2127)

Recent clinical studies

Etiology

How I treat posttransplant lymphoproliferative disorder.

Amengual JE, Pro B
Blood 2023 Oct 26;142(17):1426-1437. doi: 10.1182/blood.2023020075. PMID: 37540819 Free PMC Article

Update on follicular lymphoma.

Friedberg JW
Hematol Oncol 2023 Jun;41 Suppl 1(Suppl 1):43-47. doi: 10.1002/hon.3138. PMID: 37294960 Free PMC Article

Recent Advances in Managing Acute Lymphoblastic Leukemia.

DeAngelo DJ, Jabbour E, Advani A
Am Soc Clin Oncol Educ Book 2020 May;40:330-342. doi: 10.1200/EDBK_280175. PMID: 32421447

Acute lymphoblastic leukaemia.

Malard F, Mohty M
Lancet 2020 Apr 4;395(10230):1146-1162. doi: 10.1016/S0140-6736(19)33018-1. PMID: 32247396

Transformed follicular lymphoma.

Fischer T, Zing NPC, Chiattone CS, Federico M, Luminari S
Ann Hematol 2018 Jan;97(1):17-29. Epub 2017 Oct 18 doi: 10.1007/s00277-017-3151-2. PMID: 29043381

See all (6010)

Diagnosis

Update on follicular lymphoma.

Friedberg JW
Hematol Oncol 2023 Jun;41 Suppl 1(Suppl 1):43-47. doi: 10.1002/hon.3138. PMID: 37294960 Free PMC Article

Sarcoidosis.

Brito-Zerón P, Pérez-Álvarez R, Ramos-Casals M
Med Clin (Barc) 2022 Aug 26;159(4):195-204. Epub 2022 Jun 6 doi: 10.1016/j.medcli.2022.03.009. PMID: 35680449

Recent Advances in Diagnosis and Therapy of Angioimmunoblastic T Cell Lymphoma.

Mohammed Saleh MF, Kotb A, Abdallah GEM, Muhsen IN, El Fakih R, Aljurf M
Curr Oncol 2021 Dec 20;28(6):5480-5498. doi: 10.3390/curroncol28060456. PMID: 34940095 Free PMC Article

Acute lymphoblastic leukaemia.

Malard F, Mohty M
Lancet 2020 Apr 4;395(10230):1146-1162. doi: 10.1016/S0140-6736(19)33018-1. PMID: 32247396

Sarcoidosis.

Valeyre D, Prasse A, Nunes H, Uzunhan Y, Brillet PY, Müller-Quernheim J
Lancet 2014 Mar 29;383(9923):1155-67. Epub 2013 Oct 1 doi: 10.1016/S0140-6736(13)60680-7. PMID: 24090799

See all (4397)

Therapy

How I treat posttransplant lymphoproliferative disorder.

Amengual JE, Pro B
Blood 2023 Oct 26;142(17):1426-1437. doi: 10.1182/blood.2023020075. PMID: 37540819 Free PMC Article

Tabelecleucel: First Approval.

Keam SJ
Mol Diagn Ther 2023 May;27(3):425-431. Epub 2023 Apr 5 doi: 10.1007/s40291-023-00648-z. PMID: 37016096

Chronic lymphocytic leukemia: 2022 update on diagnostic and therapeutic procedures.

Hallek M, Al-Sawaf O
Am J Hematol 2021 Dec 1;96(12):1679-1705. doi: 10.1002/ajh.26367. PMID: 34625994

Immunotherapy in pediatric acute lymphoblastic leukemia.

Inaba H, Pui CH
Cancer Metastasis Rev 2019 Dec;38(4):595-610. doi: 10.1007/s10555-019-09834-0. PMID: 31811553 Free PMC Article

Primary CNS Lymphoma.

Grommes C, DeAngelis LM
J Clin Oncol 2017 Jul 20;35(21):2410-2418. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.72.7602. PMID: 28640701 Free PMC Article

See all (11143)

Prognosis

Impact of Epstein-Barr virus infection in patients with inflammatory bowel disease.

Zhang H, Zhao S, Cao Z
Front Immunol 2022;13:1001055. Epub 2022 Oct 28 doi: 10.3389/fimmu.2022.1001055. PMID: 36389673 Free PMC Article

Enteropathy-Associated T cell Lymphoma.

Al Somali Z, Hamadani M, Kharfan-Dabaja M, Sureda A, El Fakih R, Aljurf M
Curr Hematol Malig Rep 2021 Apr;16(2):140-147. Epub 2021 May 19 doi: 10.1007/s11899-021-00634-4. PMID: 34009525

Effect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.

Locatelli F, Zugmaier G, Rizzari C, Morris JD, Gruhn B, Klingebiel T, Parasole R, Linderkamp C, Flotho C, Petit A, Micalizzi C, Mergen N, Mohammad A, Kormany WN, Eckert C, Möricke A, Sartor M, Hrusak O, Peters C, Saha V, Vinti L, von Stackelberg A
JAMA 2021 Mar 2;325(9):843-854. doi: 10.1001/jama.2021.0987. PMID: 33651091 Free PMC Article

Hodgkin lymphoma.

Connors JM, Cozen W, Steidl C, Carbone A, Hoppe RT, Flechtner HH, Bartlett NL
Nat Rev Dis Primers 2020 Jul 23;6(1):61. doi: 10.1038/s41572-020-0189-6. PMID: 32703953

Tafasitamab plus lenalidomide in relapsed or refractory diffuse large B-cell lymphoma (L-MIND): a multicentre, prospective, single-arm, phase 2 study.

Salles G, Duell J, González Barca E, Tournilhac O, Jurczak W, Liberati AM, Nagy Z, Obr A, Gaidano G, André M, Kalakonda N, Dreyling M, Weirather J, Dirnberger-Hertweck M, Ambarkhane S, Fingerle-Rowson G, Maddocks K
Lancet Oncol 2020 Jul;21(7):978-988. Epub 2020 Jun 5 doi: 10.1016/S1470-2045(20)30225-4. PMID: 32511983

See all (5630)

Clinical prediction guides

Hodgkin lymphoma.

Connors JM, Cozen W, Steidl C, Carbone A, Hoppe RT, Flechtner HH, Bartlett NL
Nat Rev Dis Primers 2020 Jul 23;6(1):61. doi: 10.1038/s41572-020-0189-6. PMID: 32703953

The Changing Landscape of Autoimmune Hemolytic Anemia.

Barcellini W, Fattizzo B
Front Immunol 2020;11:946. Epub 2020 Jun 3 doi: 10.3389/fimmu.2020.00946. PMID: 32655543 Free PMC Article

Update on mantle cell lymphoma.

Maddocks K
Blood 2018 Oct 18;132(16):1647-1656. Epub 2018 Aug 28 doi: 10.1182/blood-2018-03-791392. PMID: 30154113

Pulmonary sarcoidosis.

Spagnolo P, Rossi G, Trisolini R, Sverzellati N, Baughman RP, Wells AU
Lancet Respir Med 2018 May;6(5):389-402. Epub 2018 Apr 3 doi: 10.1016/S2213-2600(18)30064-X. PMID: 29625772

Sarcoidosis.

Valeyre D, Prasse A, Nunes H, Uzunhan Y, Brillet PY, Müller-Quernheim J
Lancet 2014 Mar 29;383(9923):1155-67. Epub 2013 Oct 1 doi: 10.1016/S0140-6736(13)60680-7. PMID: 24090799

See all (4028)

Recent systematic reviews

Late relapse after CAR-T cell therapy for adult patients with hematologic malignancies: A definite evidence from systematic review and meta-analysis on individual data.

Zinzi A, Gaio M, Liguori V, Cagnotta C, Paolino D, Paolisso G, Castaldo G, Nicoletti GF, Rossi F, Capuano A, Rafaniello C
Pharmacol Res 2023 Apr;190:106742. Epub 2023 Mar 22 doi: 10.1016/j.phrs.2023.106742. PMID: 36963592

Relapsed and refractory multiple myeloma: A systematic review and network meta-analysis of the efficacy of novel therapies.

Minakata D, Fujiwara SI, Yokoyama D, Noguchi A, Aoe S, Oyama T, Koyama S, Murahashi R, Nakashima H, Hyodo K, Ikeda T, Kawaguchi SI, Toda Y, Ito S, Nagayama T, Mashima K, Umino K, Morita K, Ashizawa M, Yamamoto C, Hatano K, Sato K, Ohmine K, Kanda Y
Br J Haematol 2023 Mar;200(6):694-703. Epub 2023 Jan 20 doi: 10.1111/bjh.18654. PMID: 36661264

CAR-T cell therapy for patients with hematological malignancies. A systematic review.

Pasqui DM, Latorraca CDOC, Pacheco RL, Riera R
Eur J Haematol 2022 Dec;109(6):601-618. Epub 2022 Sep 18 doi: 10.1111/ejh.13851. PMID: 36018500

Extramedullary disease in multiple myeloma: a systematic literature review.

Bladé J, Beksac M, Caers J, Jurczyszyn A, von Lilienfeld-Toal M, Moreau P, Rasche L, Rosiñol L, Usmani SZ, Zamagni E, Richardson P
Blood Cancer J 2022 Mar 21;12(3):45. doi: 10.1038/s41408-022-00643-3. PMID: 35314675 Free PMC Article

Bortezomib for the treatment of multiple myeloma.

Scott K, Hayden PJ, Will A, Wheatley K, Coyne I
Cochrane Database Syst Rev 2016 Apr 20;4(4):CD010816. doi: 10.1002/14651858.CD010816.pub2. PMID: 27096326 Free PMC Article

See all (216)

MedGen

National Center for Biotechnology Information

Send to:

Refractory Lymphoproliferative Disorder

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity