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Malignant Hepatobiliary Neoplasm

MedGen UID:
167699
Concept ID:
C0854176
Neoplastic Process
Synonyms: Malignant Hepato-Biliary Neoplasm; Malignant Liver and Biliary Neoplasm; Malignant Liver and Biliary System Neoplasm

Definition

A malignant neoplasm that affects the liver parenchyma, bile ducts, and gallbladder. Representative examples include hepatocellular carcinoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Hepatobiliary Neoplasm

Professional guidelines

PubMed

McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Rizvi S, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Recent clinical studies

Etiology

Carney BW, Larson MC, Corwin MT, Lamba R
Curr Probl Cancer 2023 Apr;47(2):100964. Epub 2023 Jun 4 doi: 10.1016/j.currproblcancer.2023.100964. PMID: 37321910
Gunasekaran G, Bekki Y, Lourdusamy V, Schwartz M
Hepatology 2021 Jan;73 Suppl 1:128-136. Epub 2020 Nov 26 doi: 10.1002/hep.31325. PMID: 32438491
Lapitz A, Arbelaiz A, Olaizola P, Aranburu A, Bujanda L, Perugorria MJ, Banales JM
Front Immunol 2018;9:2270. Epub 2018 Oct 12 doi: 10.3389/fimmu.2018.02270. PMID: 30369925Free PMC Article
Norton JA, Foster DS, Blumgart LH, Poultsides GA, Visser BC, Fraker DL, Alexander HR, Jensen RT
JAMA Surg 2018 Mar 1;153(3):e175083. doi: 10.1001/jamasurg.2017.5083. PMID: 29365025Free PMC Article
Pavai S, Yap SF
Med J Malaysia 2003 Dec;58(5):667-72. PMID: 15190651

Diagnosis

Wang K, Wang X, Pan Q, Zhao B
Mol Cancer 2023 Oct 6;22(1):167. doi: 10.1186/s12943-023-01870-3. PMID: 37803304Free PMC Article
Carney BW, Larson MC, Corwin MT, Lamba R
Curr Probl Cancer 2023 Apr;47(2):100964. Epub 2023 Jun 4 doi: 10.1016/j.currproblcancer.2023.100964. PMID: 37321910
Gunasekaran G, Bekki Y, Lourdusamy V, Schwartz M
Hepatology 2021 Jan;73 Suppl 1:128-136. Epub 2020 Nov 26 doi: 10.1002/hep.31325. PMID: 32438491
Norton JA, Foster DS, Blumgart LH, Poultsides GA, Visser BC, Fraker DL, Alexander HR, Jensen RT
JAMA Surg 2018 Mar 1;153(3):e175083. doi: 10.1001/jamasurg.2017.5083. PMID: 29365025Free PMC Article
Pavai S, Yap SF
Med J Malaysia 2003 Dec;58(5):667-72. PMID: 15190651

Therapy

Nakachi K, Ikeda M, Konishi M, Nomura S, Katayama H, Kataoka T, Todaka A, Yanagimoto H, Morinaga S, Kobayashi S, Shimada K, Takahashi Y, Nakagohri T, Gotoh K, Kamata K, Shimizu Y, Ueno M, Ishii H, Okusaka T, Furuse J; Hepatobiliary and Pancreatic Oncology Group of the Japan Clinical Oncology Group (JCOG-HBPOG)
Lancet 2023 Jan 21;401(10372):195-203. doi: 10.1016/S0140-6736(22)02038-4. PMID: 36681415
Peng Z, Fan W, Zhu B, Wang G, Sun J, Xiao C, Huang F, Tang R, Cheng Y, Huang Z, Liang Y, Fan H, Qiao L, Li F, Zhuang W, Peng B, Wang J, Li J, Kuang M
J Clin Oncol 2023 Jan 1;41(1):117-127. Epub 2022 Aug 3 doi: 10.1200/JCO.22.00392. PMID: 35921605
Hou J, Karin M, Sun B
Nat Rev Clin Oncol 2021 May;18(5):261-279. Epub 2021 Jan 19 doi: 10.1038/s41571-020-00459-9. PMID: 33469195Free PMC Article
Kelley RK, Bridgewater J, Gores GJ, Zhu AX
J Hepatol 2020 Feb;72(2):353-363. doi: 10.1016/j.jhep.2019.10.009. PMID: 31954497
Cillo U, Fondevila C, Donadon M, Gringeri E, Mocchegiani F, Schlitt HJ, Ijzermans JNM, Vivarelli M, Zieniewicz K, Olde Damink SWM, Groot Koerkamp B
Liver Int 2019 May;39 Suppl 1(Suppl Suppl 1):143-155. doi: 10.1111/liv.14089. PMID: 30843343Free PMC Article

Prognosis

Mao J, Wang D, Long J, Yang X, Lin J, Song Y, Xie F, Xun Z, Wang Y, Wang Y, Li Y, Sun H, Xue J, Song Y, Zuo B, Zhang J, Bian J, Zhang T, Yang X, Zhang L, Sang X, Zhao H
J Immunother Cancer 2021 Dec;9(12) doi: 10.1136/jitc-2021-003334. PMID: 34873013Free PMC Article
Mazzaferro V, Citterio D, Bhoori S, Bongini M, Miceli R, De Carlis L, Colledan M, Salizzoni M, Romagnoli R, Antonelli B, Vivarelli M, Tisone G, Rossi M, Gruttadauria S, Di Sandro S, De Carlis R, Lucà MG, De Giorgio M, Mirabella S, Belli L, Fagiuoli S, Martini S, Iavarone M, Svegliati Baroni G, Angelico M, Ginanni Corradini S, Volpes R, Mariani L, Regalia E, Flores M, Droz Dit Busset M, Sposito C
Lancet Oncol 2020 Jul;21(7):947-956. doi: 10.1016/S1470-2045(20)30224-2. PMID: 32615109
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Bergquist A, von Seth E
Best Pract Res Clin Gastroenterol 2015 Apr;29(2):221-32. Epub 2015 Feb 16 doi: 10.1016/j.bpg.2015.02.003. PMID: 25966423
Rizvi S, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Clinical prediction guides

Jiang C, Cai YQ, Yang JJ, Ma CY, Chen JX, Huang L, Xiang Z, Wu J
Hepatobiliary Pancreat Dis Int 2023 Aug;22(4):346-351. Epub 2023 Mar 25 doi: 10.1016/j.hbpd.2023.03.010. PMID: 37019775
Lin WP, Xing KL, Fu JC, Ling YH, Li SH, Yu WS, Zhang YF, Zhong C, Wang JH, Chen ZY, Lu LH, Wei W, Guo RP
JAMA Netw Open 2021 Sep 1;4(9):e2125055. doi: 10.1001/jamanetworkopen.2021.25055. PMID: 34515782Free PMC Article
Lapitz A, Arbelaiz A, Olaizola P, Aranburu A, Bujanda L, Perugorria MJ, Banales JM
Front Immunol 2018;9:2270. Epub 2018 Oct 12 doi: 10.3389/fimmu.2018.02270. PMID: 30369925Free PMC Article
Taghavi SA, Eshraghian A, Niknam R, Sivandzadeh GR, Bagheri Lankarani K
Expert Rev Gastroenterol Hepatol 2018 Jun;12(6):575-584. Epub 2018 May 21 doi: 10.1080/17474124.2018.1473761. PMID: 29781738
Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH
Ann Surg 1999 Sep;230(3):309-18; discussion 318-21. doi: 10.1097/00000658-199909000-00004. PMID: 10493478Free PMC Article

Recent systematic reviews

Zhou Z, Chen C, Han B, Wang Y, Liu Y, Liu Q, Xu X, Yin Y, Sun B
Pathol Res Pract 2023 Sep;249:154755. Epub 2023 Aug 9 doi: 10.1016/j.prp.2023.154755. PMID: 37651837
Pothuri VS, Anzelmo M, Gallaher E, Ogunlana Y, Aliabadi-Wahle S, Tan B, Crippin JS, Hammill CW
Endocr Pract 2023 Oct;29(10):822-829. Epub 2023 Jun 5 doi: 10.1016/j.eprac.2023.05.011. PMID: 37286102
Eshmuminov D, Aminjonov B, Palm RF, Malleo G, Schmocker RK, Abdallah R, Yoo C, Shaib WL, Schneider MA, Rangelova E, Choi YJ, Kim H, Rose JB, Patel S, Wilson GC, Maloney S, Timmermann L, Sahora K, Rössler F, Lopez-Lopez V, Boyer E, Maggino L, Malinka T, Park JY, Katz MHG, Prakash L, Ahmad SA, Helton S, Jang JY, Hoffe SE, Salvia R, Taieb J, He J, Clavien PA, Held U, Lehmann K
Ann Surg Oncol 2023 Jul;30(7):4417-4428. Epub 2023 Apr 5 doi: 10.1245/s10434-023-13353-2. PMID: 37020094Free PMC Article
Lambert JE, Hayes LD, Keegan TJ, Subar DA, Gaffney CJ
Ann Surg 2021 Jul 1;274(1):70-77. doi: 10.1097/SLA.0000000000004527. PMID: 33201129
Peeraphatdit TB, Wang J, Odenwald MA, Hu S, Hart J, Charlton MR
Hepatology 2020 Jul;72(1):315-329. doi: 10.1002/hep.31227. PMID: 32167613

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