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Advanced Pancreatic Adenocarcinoma

MedGen UID:
1686406
Concept ID:
C5206374
Neoplastic Process

Definition

Pancreatic adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Pancreatic Adenocarcinoma

Professional guidelines

PubMed

Attiyeh MA, Amini A, Chung V, Melstrom LG
J Surg Oncol 2021 May;123(6):1395-1404. doi: 10.1002/jso.26415. PMID: 33831247
Salgado M, Arévalo S, Hernando O, Martínez A, Yaya R, Hidalgo M
Clin Transl Oncol 2018 Feb;20(2):113-118. Epub 2017 Jun 13 doi: 10.1007/s12094-017-1679-1. PMID: 28612202
Pollom EL, Koong AC, Ko AH
Hematol Oncol Clin North Am 2015 Aug;29(4):741-59. Epub 2015 May 30 doi: 10.1016/j.hoc.2015.04.005. PMID: 26226908

Recent clinical studies

Etiology

Ejlsmark MW, Schytte T, Bernchou U, Bahij R, Weber B, Mortensen MB, Pfeiffer P
Curr Oncol 2023 Jul 18;30(7):6820-6837. doi: 10.3390/curroncol30070499. PMID: 37504359Free PMC Article
Ma LX, Wang Y, Espin-Garcia O, Allen MJ, Jang GH, Zhang A, Dodd A, Ramotar S, Hutchinson S, Tehfe M, Ramjeesingh R, Biagi J, Wilson JM, Notta F, Fischer SE, Zogopoulos G, Gallinger S, Grant RC, Khokha R, Chan N, Grünwald BT, Knox JJ, O'Kane GM
Br J Cancer 2023 May;128(10):1916-1921. Epub 2023 Mar 16 doi: 10.1038/s41416-023-02214-0. PMID: 36927977Free PMC Article
Wainberg ZA, Bekaii-Saab T, Boland PM, Dayyani F, Macarulla T, Mody K, Belanger B, Maxwell F, Moore Y, Thiagalingam A, Wang T, Zhang B, Dean A
Eur J Cancer 2021 Jul;151:14-24. Epub 2021 May 4 doi: 10.1016/j.ejca.2021.03.028. PMID: 33957442
Kunzmann V, Siveke JT, Algül H, Goekkurt E, Siegler G, Martens U, Waldschmidt D, Pelzer U, Fuchs M, Kullmann F, Boeck S, Ettrich TJ, Held S, Keller R, Klein I, Germer CT, Stein H, Friess H, Bahra M, Jakobs R, Hartlapp I, Heinemann V; German Pancreatic Cancer Working Group (AIO-PAK) and NEOLAP investigators
Lancet Gastroenterol Hepatol 2021 Feb;6(2):128-138. Epub 2020 Dec 16 doi: 10.1016/S2468-1253(20)30330-7. PMID: 33338442
Rashid MF, Hecht EM, Steinman JA, Kluger MD
Abdom Radiol (NY) 2018 Feb;43(2):457-466. doi: 10.1007/s00261-017-1349-3. PMID: 29051982

Diagnosis

Temraz S, Nassar F, Hammoud MS, Mukherji D, O'Reilly EM, Dbouk H, Farhat F, Charafeddine M, Faraj W, Khalifeh MJ, Abou-Alfa GK, Shamseddine A
Asia Pac J Clin Oncol 2022 Dec;18(6):735-742. Epub 2022 Mar 31 doi: 10.1111/ajco.13775. PMID: 35362216
Wainberg ZA, Bekaii-Saab T, Boland PM, Dayyani F, Macarulla T, Mody K, Belanger B, Maxwell F, Moore Y, Thiagalingam A, Wang T, Zhang B, Dean A
Eur J Cancer 2021 Jul;151:14-24. Epub 2021 May 4 doi: 10.1016/j.ejca.2021.03.028. PMID: 33957442
Álvarez R, Carrato A, Adeva J, Alés I, Prados S, Valladares M, Macarulla T, Muñoz A, Hidalgo M
Eur J Cancer 2018 May;94:26-36. Epub 2018 Mar 20 doi: 10.1016/j.ejca.2018.01.078. PMID: 29505968
Salgado M, Arévalo S, Hernando O, Martínez A, Yaya R, Hidalgo M
Clin Transl Oncol 2018 Feb;20(2):113-118. Epub 2017 Jun 13 doi: 10.1007/s12094-017-1679-1. PMID: 28612202
Brand RE, Tempero MA
Curr Opin Oncol 1998 Jul;10(4):362-6. doi: 10.1097/00001622-199807000-00014. PMID: 9702405

Therapy

Ma LX, Wang Y, Espin-Garcia O, Allen MJ, Jang GH, Zhang A, Dodd A, Ramotar S, Hutchinson S, Tehfe M, Ramjeesingh R, Biagi J, Wilson JM, Notta F, Fischer SE, Zogopoulos G, Gallinger S, Grant RC, Khokha R, Chan N, Grünwald BT, Knox JJ, O'Kane GM
Br J Cancer 2023 May;128(10):1916-1921. Epub 2023 Mar 16 doi: 10.1038/s41416-023-02214-0. PMID: 36927977Free PMC Article
Wainberg ZA, Bekaii-Saab T, Boland PM, Dayyani F, Macarulla T, Mody K, Belanger B, Maxwell F, Moore Y, Thiagalingam A, Wang T, Zhang B, Dean A
Eur J Cancer 2021 Jul;151:14-24. Epub 2021 May 4 doi: 10.1016/j.ejca.2021.03.028. PMID: 33957442
Attiyeh MA, Amini A, Chung V, Melstrom LG
J Surg Oncol 2021 May;123(6):1395-1404. doi: 10.1002/jso.26415. PMID: 33831247
Kunzmann V, Siveke JT, Algül H, Goekkurt E, Siegler G, Martens U, Waldschmidt D, Pelzer U, Fuchs M, Kullmann F, Boeck S, Ettrich TJ, Held S, Keller R, Klein I, Germer CT, Stein H, Friess H, Bahra M, Jakobs R, Hartlapp I, Heinemann V; German Pancreatic Cancer Working Group (AIO-PAK) and NEOLAP investigators
Lancet Gastroenterol Hepatol 2021 Feb;6(2):128-138. Epub 2020 Dec 16 doi: 10.1016/S2468-1253(20)30330-7. PMID: 33338442
Pollom EL, Koong AC, Ko AH
Hematol Oncol Clin North Am 2015 Aug;29(4):741-59. Epub 2015 May 30 doi: 10.1016/j.hoc.2015.04.005. PMID: 26226908

Prognosis

Ma LX, Wang Y, Espin-Garcia O, Allen MJ, Jang GH, Zhang A, Dodd A, Ramotar S, Hutchinson S, Tehfe M, Ramjeesingh R, Biagi J, Wilson JM, Notta F, Fischer SE, Zogopoulos G, Gallinger S, Grant RC, Khokha R, Chan N, Grünwald BT, Knox JJ, O'Kane GM
Br J Cancer 2023 May;128(10):1916-1921. Epub 2023 Mar 16 doi: 10.1038/s41416-023-02214-0. PMID: 36927977Free PMC Article
Kunzmann V, Siveke JT, Algül H, Goekkurt E, Siegler G, Martens U, Waldschmidt D, Pelzer U, Fuchs M, Kullmann F, Boeck S, Ettrich TJ, Held S, Keller R, Klein I, Germer CT, Stein H, Friess H, Bahra M, Jakobs R, Hartlapp I, Heinemann V; German Pancreatic Cancer Working Group (AIO-PAK) and NEOLAP investigators
Lancet Gastroenterol Hepatol 2021 Feb;6(2):128-138. Epub 2020 Dec 16 doi: 10.1016/S2468-1253(20)30330-7. PMID: 33338442
Rashid MF, Hecht EM, Steinman JA, Kluger MD
Abdom Radiol (NY) 2018 Feb;43(2):457-466. doi: 10.1007/s00261-017-1349-3. PMID: 29051982
Salgado M, Arévalo S, Hernando O, Martínez A, Yaya R, Hidalgo M
Clin Transl Oncol 2018 Feb;20(2):113-118. Epub 2017 Jun 13 doi: 10.1007/s12094-017-1679-1. PMID: 28612202
Cao H, LE D, Yang LX
Anticancer Res 2013 May;33(5):1785-91. PMID: 23645722

Clinical prediction guides

Ma LX, Wang Y, Espin-Garcia O, Allen MJ, Jang GH, Zhang A, Dodd A, Ramotar S, Hutchinson S, Tehfe M, Ramjeesingh R, Biagi J, Wilson JM, Notta F, Fischer SE, Zogopoulos G, Gallinger S, Grant RC, Khokha R, Chan N, Grünwald BT, Knox JJ, O'Kane GM
Br J Cancer 2023 May;128(10):1916-1921. Epub 2023 Mar 16 doi: 10.1038/s41416-023-02214-0. PMID: 36927977Free PMC Article
Temraz S, Nassar F, Hammoud MS, Mukherji D, O'Reilly EM, Dbouk H, Farhat F, Charafeddine M, Faraj W, Khalifeh MJ, Abou-Alfa GK, Shamseddine A
Asia Pac J Clin Oncol 2022 Dec;18(6):735-742. Epub 2022 Mar 31 doi: 10.1111/ajco.13775. PMID: 35362216
Mohindroo C, Hasanov M, Rogers JE, Dong W, Prakash LR, Baydogan S, Mizrahi JD, Overman MJ, Varadhachary GR, Wolff RA, Javle MM, Fogelman DR, Lotze MT, Kim MP, Katz MHG, Pant S, Tzeng CD, McAllister F
Cancer Med 2021 Aug;10(15):5041-5050. Epub 2021 Jul 11 doi: 10.1002/cam4.3870. PMID: 34250759Free PMC Article
Wainberg ZA, Bekaii-Saab T, Boland PM, Dayyani F, Macarulla T, Mody K, Belanger B, Maxwell F, Moore Y, Thiagalingam A, Wang T, Zhang B, Dean A
Eur J Cancer 2021 Jul;151:14-24. Epub 2021 May 4 doi: 10.1016/j.ejca.2021.03.028. PMID: 33957442
Mian OY, Ram AN, Tuli R, Herman JM
Curr Oncol Rep 2014 Jun;16(6):388. doi: 10.1007/s11912-014-0388-y. PMID: 24740136

Recent systematic reviews

Landers A, Donaldson F, Brown H, McKenzie C, Pendharkar S
Pancreas 2022 May 1;51(5):405-414. doi: 10.1097/MPA.0000000000002049. PMID: 35973015
Vornhülz M, Anton S, Eross B, Szakács Z, Hegyi P, Regel I, Belka C, Niyazi M, Mayerle J, Beyer G
Radiat Oncol 2022 Jun 17;17(1):108. doi: 10.1186/s13014-022-02076-5. PMID: 35715808Free PMC Article
Sugumar K, Hurtado A, Naik I, Hue JJ, Rothermel LD, Ammori JB, Hardacre JM, Winter JM, Ocuin LM
HPB (Oxford) 2022 May;24(5):586-595. Epub 2021 Dec 24 doi: 10.1016/j.hpb.2021.12.014. PMID: 35000842
Usón PLS Junior, Tolentino FDS, Santos VM, Rother ET, Maluf FC
PLoS One 2020;15(3):e0230060. Epub 2020 Mar 4 doi: 10.1371/journal.pone.0230060. PMID: 32130264Free PMC Article
Thota R, Maitra A, Berlin JD
Pancreas 2017 Feb;46(2):143-150. doi: 10.1097/MPA.0000000000000753. PMID: 28085753Free PMC Article

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