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Locally Advanced Unresectable Breast Carcinoma

MedGen UID:
1698790
Concept ID:
C5206400
Neoplastic Process

Definition

A breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Unresectable Breast Carcinoma

Professional guidelines

PubMed

Pérez-García J, Soberino J, Racca F, Gion M, Stradella A, Cortés J
Expert Opin Biol Ther 2020 Sep;20(9):981-989. Epub 2020 May 25 doi: 10.1080/14712598.2020.1769063. PMID: 32450725
Reddy SM, Carroll E, Nanda R
Expert Rev Anticancer Ther 2020 Mar;20(3):151-158. Epub 2020 Feb 27 doi: 10.1080/14737140.2020.1732211. PMID: 32067545
Gomez P, Lacouture ME
Oncologist 2011;16(11):1508-19. Epub 2011 Oct 20 doi: 10.1634/theoncologist.2011-0115. PMID: 22016478Free PMC Article

Recent clinical studies

Etiology

Latif F, Bint Abdul Jabbar H, Malik H, Sadaf H, Sarfraz A, Sarfraz Z, Cherrez-Ojeda I
Expert Rev Anticancer Ther 2022 Feb;22(2):229-235. Epub 2022 Jan 24 doi: 10.1080/14737140.2022.2023011. PMID: 34949142
Schmid P, Rugo HS, Adams S, Schneeweiss A, Barrios CH, Iwata H, Diéras V, Henschel V, Molinero L, Chui SY, Maiya V, Husain A, Winer EP, Loi S, Emens LA; IMpassion130 Investigators
Lancet Oncol 2020 Jan;21(1):44-59. Epub 2019 Nov 27 doi: 10.1016/S1470-2045(19)30689-8. PMID: 31786121
Schmid P, Adams S, Rugo HS, Schneeweiss A, Barrios CH, Iwata H, Diéras V, Hegg R, Im SA, Shaw Wright G, Henschel V, Molinero L, Chui SY, Funke R, Husain A, Winer EP, Loi S, Emens LA; IMpassion130 Trial Investigators
N Engl J Med 2018 Nov 29;379(22):2108-2121. Epub 2018 Oct 20 doi: 10.1056/NEJMoa1809615. PMID: 30345906
Hasskarl J
Recent Results Cancer Res 2018;211:101-123. doi: 10.1007/978-3-319-91442-8_8. PMID: 30069763
Diéras V, Miles D, Verma S, Pegram M, Welslau M, Baselga J, Krop IE, Blackwell K, Hoersch S, Xu J, Green M, Gianni L
Lancet Oncol 2017 Jun;18(6):732-742. Epub 2017 May 16 doi: 10.1016/S1470-2045(17)30312-1. PMID: 28526536Free PMC Article

Diagnosis

Zhang W, He Y, Tang Y, Dai W, Si Y, Mao F, Xu J, Yu C, Sun X
Immunotherapy 2023 Sep;15(13):1073-1088. Epub 2023 Jun 20 doi: 10.2217/imt-2023-0023. PMID: 37337734
Pérez-García J, Soberino J, Racca F, Gion M, Stradella A, Cortés J
Expert Opin Biol Ther 2020 Sep;20(9):981-989. Epub 2020 May 25 doi: 10.1080/14712598.2020.1769063. PMID: 32450725
Reddy SM, Carroll E, Nanda R
Expert Rev Anticancer Ther 2020 Mar;20(3):151-158. Epub 2020 Feb 27 doi: 10.1080/14737140.2020.1732211. PMID: 32067545
Mateo AM, Mazor AM, DeMora L, Sigurdson ER, Handorf EA, Daly JM, Aggon AA, Obeid E, Hayes SB, Bleicher RJ
Clin Breast Cancer 2019 Aug;19(4):292-303. Epub 2019 Feb 16 doi: 10.1016/j.clbc.2019.02.003. PMID: 30871966Free PMC Article
Yee C, Alayed Y, Drost L, Karam I, Vesprini D, McCann C, Soliman H, Zhang L, Chow E, Chan S, Lee J
Ann Palliat Med 2018 Oct;7(4):373-384. Epub 2018 Jun 12 doi: 10.21037/apm.2018.05.13. PMID: 30180725

Therapy

Latif F, Bint Abdul Jabbar H, Malik H, Sadaf H, Sarfraz A, Sarfraz Z, Cherrez-Ojeda I
Expert Rev Anticancer Ther 2022 Feb;22(2):229-235. Epub 2022 Jan 24 doi: 10.1080/14737140.2022.2023011. PMID: 34949142
Emens LA, Adams S, Barrios CH, Diéras V, Iwata H, Loi S, Rugo HS, Schneeweiss A, Winer EP, Patel S, Henschel V, Swat A, Kaul M, Molinero L, Patel S, Chui SY, Schmid P
Ann Oncol 2021 Aug;32(8):983-993. Epub 2021 Jul 1 doi: 10.1016/j.annonc.2021.05.355. PMID: 34272041
Miles D, Gligorov J, André F, Cameron D, Schneeweiss A, Barrios C, Xu B, Wardley A, Kaen D, Andrade L, Semiglazov V, Reinisch M, Patel S, Patre M, Morales L, Patel SL, Kaul M, Barata T, O'Shaughnessy J; IMpassion131 investigators
Ann Oncol 2021 Aug;32(8):994-1004. Epub 2021 Jul 1 doi: 10.1016/j.annonc.2021.05.801. PMID: 34219000
Kwapisz D
Cancer Immunol Immunother 2021 Mar;70(3):607-617. Epub 2020 Oct 5 doi: 10.1007/s00262-020-02736-z. PMID: 33015734
Schmid P, Adams S, Rugo HS, Schneeweiss A, Barrios CH, Iwata H, Diéras V, Hegg R, Im SA, Shaw Wright G, Henschel V, Molinero L, Chui SY, Funke R, Husain A, Winer EP, Loi S, Emens LA; IMpassion130 Trial Investigators
N Engl J Med 2018 Nov 29;379(22):2108-2121. Epub 2018 Oct 20 doi: 10.1056/NEJMoa1809615. PMID: 30345906

Prognosis

Zhang W, He Y, Tang Y, Dai W, Si Y, Mao F, Xu J, Yu C, Sun X
Immunotherapy 2023 Sep;15(13):1073-1088. Epub 2023 Jun 20 doi: 10.2217/imt-2023-0023. PMID: 37337734
Kwapisz D
Cancer Immunol Immunother 2021 Mar;70(3):607-617. Epub 2020 Oct 5 doi: 10.1007/s00262-020-02736-z. PMID: 33015734
Reddy SM, Carroll E, Nanda R
Expert Rev Anticancer Ther 2020 Mar;20(3):151-158. Epub 2020 Feb 27 doi: 10.1080/14737140.2020.1732211. PMID: 32067545
Schmid P, Rugo HS, Adams S, Schneeweiss A, Barrios CH, Iwata H, Diéras V, Henschel V, Molinero L, Chui SY, Maiya V, Husain A, Winer EP, Loi S, Emens LA; IMpassion130 Investigators
Lancet Oncol 2020 Jan;21(1):44-59. Epub 2019 Nov 27 doi: 10.1016/S1470-2045(19)30689-8. PMID: 31786121
Diéras V, Miles D, Verma S, Pegram M, Welslau M, Baselga J, Krop IE, Blackwell K, Hoersch S, Xu J, Green M, Gianni L
Lancet Oncol 2017 Jun;18(6):732-742. Epub 2017 May 16 doi: 10.1016/S1470-2045(17)30312-1. PMID: 28526536Free PMC Article

Clinical prediction guides

Emens LA, Adams S, Barrios CH, Diéras V, Iwata H, Loi S, Rugo HS, Schneeweiss A, Winer EP, Patel S, Henschel V, Swat A, Kaul M, Molinero L, Patel S, Chui SY, Schmid P
Ann Oncol 2021 Aug;32(8):983-993. Epub 2021 Jul 1 doi: 10.1016/j.annonc.2021.05.355. PMID: 34272041
Heeke AL, Tan AR
Cancer Metastasis Rev 2021 Jun;40(2):537-547. Epub 2021 Jun 8 doi: 10.1007/s10555-021-09972-4. PMID: 34101053Free PMC Article
Emens LA, Molinero L, Loi S, Rugo HS, Schneeweiss A, Diéras V, Iwata H, Barrios CH, Nechaeva M, Nguyen-Duc A, Chui SY, Husain A, Winer EP, Adams S, Schmid P
J Natl Cancer Inst 2021 Aug 2;113(8):1005-1016. doi: 10.1093/jnci/djab004. PMID: 33523233Free PMC Article
Pérez-García J, Soberino J, Racca F, Gion M, Stradella A, Cortés J
Expert Opin Biol Ther 2020 Sep;20(9):981-989. Epub 2020 May 25 doi: 10.1080/14712598.2020.1769063. PMID: 32450725
Tolaney SM, Wardley AM, Zambelli S, Hilton JF, Troso-Sandoval TA, Ricci F, Im SA, Kim SB, Johnston SR, Chan A, Goel S, Catron K, Chapman SC, Price GL, Yang Z, Gainford MC, André F
Lancet Oncol 2020 Jun;21(6):763-775. Epub 2020 Apr 27 doi: 10.1016/S1470-2045(20)30112-1. PMID: 32353342

Recent systematic reviews

Supplemental Content

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