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Recurrent Myelofibrosis

MedGen UID:
1699341
•Concept ID:
C5206558
•
Disease or Syndrome

Definition

The reemergence of myelofibrosis after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Myelofibrosis

Professional guidelines

PubMed

Blast phase myeloproliferative neoplasm: contemporary review and 2024 treatment algorithm.
Tefferi A, Alkhateeb H, Gangat N
Blood Cancer J 2023 Jul 18;13(1):108. doi: 10.1038/s41408-023-00878-8. PMID: 37460550Free PMC Article
Unmet clinical needs in the use of zanubrutinib in malignant lymphomas (Waldenström macroglobulinemia, marginal zone lymphoma and mantle cell lymphoma): A consensus-based position paper from an ad hoc expert panel.
Zinzani PL, Mauro FR, Tedeschi A, Varettoni M, Zaja F, Barosi G
Hematol Oncol 2023 Dec;41(5):795-808. Epub 2023 May 11 doi: 10.1002/hon.3172. PMID: 37165730
Thrombotic complications of myeloproliferative neoplasms: risk assessment and risk-guided management.
Casini A, Fontana P, Lecompte TP
J Thromb Haemost 2013 Jul;11(7):1215-27. doi: 10.1111/jth.12265. PMID: 23601811

Recent clinical studies

Etiology

Blast phase myeloproliferative neoplasm: contemporary review and 2024 treatment algorithm.
Tefferi A, Alkhateeb H, Gangat N
Blood Cancer J 2023 Jul 18;13(1):108. doi: 10.1038/s41408-023-00878-8. PMID: 37460550Free PMC Article
The clinical and molecular spectrum of ETV6 mutated myeloid neoplasms.
Gurney M, Chekkaf I, Baranwal A, Basmaci R, Katamesh B, Greipp P, Foran JM, Badar T, Mangaonkar AA, Begna KH, Gangat N, Patnaik MM, Litzow MR, Shah MV, Viswanatha DS, He R, Alkhateeb HB, Al-Kali A
Br J Haematol 2023 Jul;202(2):279-283. Epub 2023 May 5 doi: 10.1111/bjh.18850. PMID: 37144345
Molecular pathogenesis of the myeloproliferative neoplasms.
Greenfield G, McMullin MF, Mills K
J Hematol Oncol 2021 Jun 30;14(1):103. doi: 10.1186/s13045-021-01116-z. PMID: 34193229Free PMC Article
Myeloproliferative neoplasms and pregnancy: Overview and practice recommendations.
Gangat N, Tefferi A
Am J Hematol 2021 Mar 1;96(3):354-366. Epub 2020 Dec 28 doi: 10.1002/ajh.26067. PMID: 33296529
Pathogenesis and Management of Thrombotic Disease in Myeloproliferative Neoplasms.
Arachchillage DR, Laffan M
Semin Thromb Hemost 2019 Sep;45(6):604-611. Epub 2019 Aug 5 doi: 10.1055/s-0039-1693477. PMID: 31382304

Diagnosis

Progression in Myeloid Neoplasms: Beyond the Myeloblast.
Faria C, Tzankov A
Pathobiology 2024;91(1):55-75. Epub 2023 May 11 doi: 10.1159/000530940. PMID: 37232015Free PMC Article
Blast phase myeloproliferative neoplasm: contemporary review and 2024 treatment algorithm.
Tefferi A, Alkhateeb H, Gangat N
Blood Cancer J 2023 Jul 18;13(1):108. doi: 10.1038/s41408-023-00878-8. PMID: 37460550Free PMC Article
Molecular pathogenesis of the myeloproliferative neoplasms.
Greenfield G, McMullin MF, Mills K
J Hematol Oncol 2021 Jun 30;14(1):103. doi: 10.1186/s13045-021-01116-z. PMID: 34193229Free PMC Article
Myeloproliferative neoplasms: Diagnostic workup of the cythemic patient.
Wong WJ, Pozdnyakova O
Int J Lab Hematol 2019 May;41 Suppl 1:142-150. doi: 10.1111/ijlh.13005. PMID: 31069979
Polycythemia vera and essential thrombocythemia: algorithmic approach.
Vannucchi AM, Guglielmelli P, Tefferi A
Curr Opin Hematol 2018 Mar;25(2):112-119. doi: 10.1097/MOH.0000000000000402. PMID: 29194068

Therapy

Improving allogeneic stem cell transplantation in myelofibrosis.
Gagelmann N, Kröger N
Int J Hematol 2022 May;115(5):619-625. Epub 2022 Apr 13 doi: 10.1007/s12185-022-03340-w. PMID: 35419771
Myeloproliferative neoplasms and pregnancy: Overview and practice recommendations.
Gangat N, Tefferi A
Am J Hematol 2021 Mar 1;96(3):354-366. Epub 2020 Dec 28 doi: 10.1002/ajh.26067. PMID: 33296529
Pathogenesis and Management of Thrombotic Disease in Myeloproliferative Neoplasms.
Arachchillage DR, Laffan M
Semin Thromb Hemost 2019 Sep;45(6):604-611. Epub 2019 Aug 5 doi: 10.1055/s-0039-1693477. PMID: 31382304
Splanchnic vein thrombosis in myeloproliferative neoplasms: treatment algorithm 2018.
Finazzi G, De Stefano V, Barbui T
Blood Cancer J 2018 Jun 26;8(7):64. doi: 10.1038/s41408-018-0100-9. PMID: 29946154Free PMC Article
JAK-mutant myeloproliferative neoplasms.
Levine RL
Curr Top Microbiol Immunol 2012;355:119-33. doi: 10.1007/82_2011_170. PMID: 21823028

Prognosis

Blast phase myeloproliferative neoplasm: contemporary review and 2024 treatment algorithm.
Tefferi A, Alkhateeb H, Gangat N
Blood Cancer J 2023 Jul 18;13(1):108. doi: 10.1038/s41408-023-00878-8. PMID: 37460550Free PMC Article
The clinical and molecular spectrum of ETV6 mutated myeloid neoplasms.
Gurney M, Chekkaf I, Baranwal A, Basmaci R, Katamesh B, Greipp P, Foran JM, Badar T, Mangaonkar AA, Begna KH, Gangat N, Patnaik MM, Litzow MR, Shah MV, Viswanatha DS, He R, Alkhateeb HB, Al-Kali A
Br J Haematol 2023 Jul;202(2):279-283. Epub 2023 May 5 doi: 10.1111/bjh.18850. PMID: 37144345
Molecular pathogenesis of the myeloproliferative neoplasms.
Greenfield G, McMullin MF, Mills K
J Hematol Oncol 2021 Jun 30;14(1):103. doi: 10.1186/s13045-021-01116-z. PMID: 34193229Free PMC Article
The Genetic Basis of Primary Myelofibrosis and Its Clinical Relevance.
Rumi E, Trotti C, Vanni D, Casetti IC, Pietra D, Sant'Antonio E
Int J Mol Sci 2020 Nov 24;21(23) doi: 10.3390/ijms21238885. PMID: 33255170Free PMC Article
Myeloproliferative neoplasms: Diagnostic workup of the cythemic patient.
Wong WJ, Pozdnyakova O
Int J Lab Hematol 2019 May;41 Suppl 1:142-150. doi: 10.1111/ijlh.13005. PMID: 31069979

Clinical prediction guides

A simple prognostic system in patients with myelofibrosis undergoing allogeneic stem cell transplantation: a CIBMTR/EBMT analysis.
Tamari R, McLornan DP, Ahn KW, Estrada-Merly N, Hernández-Boluda JC, Giralt S, Palmer J, Gale RP, DeFilipp Z, Marks DI, van der Poel M, Verdonck LF, Battiwalla M, Diaz MA, Gupta V, Ali H, Litzow MR, Lazarus HM, Gergis U, Bashey A, Liesveld J, Hashmi S, Pu JJ, Beitinjaneh A, Bredeson C, Rizzieri D, Savani BN, Abid MB, Ganguly S, Agrawal V, Ulrike Bacher V, Wirk B, Jain T, Cutler C, Aljurf M, Kindwall-Keller T, Kharfan-Dabaja MA, Hildebrandt GC, Pawarode A, Solh MM, Yared JA, Grunwald MR, Nathan S, Nishihori T, Seo S, Scott BL, Nakamura R, Oran B, Czerw T, Yakoub-Agha I, Saber W
Blood Adv 2023 Aug 8;7(15):3993-4002. doi: 10.1182/bloodadvances.2023009886. PMID: 37134306Free PMC Article
The Genetic Basis of Primary Myelofibrosis and Its Clinical Relevance.
Rumi E, Trotti C, Vanni D, Casetti IC, Pietra D, Sant'Antonio E
Int J Mol Sci 2020 Nov 24;21(23) doi: 10.3390/ijms21238885. PMID: 33255170Free PMC Article
Splanchnic vein thrombosis in myeloproliferative neoplasms: treatment algorithm 2018.
Finazzi G, De Stefano V, Barbui T
Blood Cancer J 2018 Jun 26;8(7):64. doi: 10.1038/s41408-018-0100-9. PMID: 29946154Free PMC Article
Clinical and molecular genetic characterization of myelofibrosis.
Hobbs GS, Rampal RK
Curr Opin Hematol 2015 Mar;22(2):177-83. doi: 10.1097/MOH.0000000000000122. PMID: 25635755
JAK2 mutation-related disease and thrombosis.
Vannucchi AM, Guglielmelli P
Semin Thromb Hemost 2013 Jul;39(5):496-506. Epub 2013 Apr 30 doi: 10.1055/s-0033-1343890. PMID: 23633193

Recent systematic reviews

A systematic review of antithrombotic treatment of venous thromboembolism in patients with myeloproliferative neoplasms.
Hamulyák EN, Daams JG, Leebeek FWG, Biemond BJ, Te Boekhorst PAW, Middeldorp S, Lauw MN
Blood Adv 2021 Jan 12;5(1):113-121. doi: 10.1182/bloodadvances.2020003628. PMID: 33570633Free PMC Article
Leukocytosis and thrombosis in essential thrombocythemia and polycythemia vera: a systematic review and meta-analysis.
Carobbio A, Ferrari A, Masciulli A, Ghirardi A, Barosi G, Barbui T
Blood Adv 2019 Jun 11;3(11):1729-1737. doi: 10.1182/bloodadvances.2019000211. PMID: 31175128Free PMC Article
State-of-the-art review: allogeneic stem cell transplantation for myelofibrosis in 2019.
McLornan DP, Yakoub-Agha I, Robin M, Chalandon Y, Harrison CN, Kroger N
Haematologica 2019 Apr;104(4):659-668. Epub 2019 Mar 14 doi: 10.3324/haematol.2018.206151. PMID: 30872371Free PMC Article

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