U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Advanced Endometrial Carcinoma

MedGen UID:
1699444
•Concept ID:
C5204617
•
Neoplastic Process

Definition

An endometrial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Evaluation of the optimal sequence of adjuvant chemotherapy and radiation therapy in the treatment of advanced endometrial cancer.
McEachron J, Zhou N, Spencer C, Shanahan L, Chatterton C, Singhal P, Lee YC
J Gynecol Oncol 2020 Nov;31(6):e90. doi: 10.3802/jgo.2020.31.e90. PMID: 33078595Free PMC Article
Adjuvant treatment for stage IIIC endometrial cancer: options and controversies.
Shah PH, Kudrimoti M, Feddock J, Randall M
Gynecol Oncol 2011 Sep;122(3):675-83. Epub 2011 Jun 12 doi: 10.1016/j.ygyno.2011.05.018. PMID: 21664661
Treatment options for advanced endometrial carcinoma.
Dizon DS
Gynecol Oncol 2010 May;117(2):373-81. Epub 2010 Mar 12 doi: 10.1016/j.ygyno.2010.02.007. PMID: 20223510

Recent clinical studies

Etiology

Evaluation of the efficiency and safety of adjuvant chemotherapy alone for patients with advanced endometrial carcinoma: A protocol for systematic review and meta-analysis.
Guo J, Li S, Wu Y
Medicine (Baltimore) 2022 Jul 15;101(28):e29156. doi: 10.1097/MD.0000000000029156. PMID: 35839048
Evaluation on curative effects of adjuvant chemotherapy alone in treating with advanced endometrial carcinoma: A protocol for systematic review and meta-analysis.
Jiang J, Chen L, Tian Y
Medicine (Baltimore) 2022 Mar 4;101(9):e28817. doi: 10.1097/MD.0000000000028817. PMID: 35244039Free PMC Article
Patient reported outcomes for cisplatin and radiation followed by carboplatin/paclitaxel versus carboplatin/paclitaxel for locally advanced endometrial carcinoma: An NRG oncology study.
Matulonis UA, Huang HQ, Filiaci VL, Randall M, DiSilvestro PA, Moxley KM, Fowler JM, Powell MA, Spirtos NM, Tewari KS, Richards WE, Nakayama JM, Mutch DG, Miller DS, Matei D, Wenzel LB
Gynecol Oncol 2022 Feb;164(2):428-436. Epub 2021 Dec 11 doi: 10.1016/j.ygyno.2021.11.021. PMID: 34903380Free PMC Article
Lenvatinib plus pembrolizumab in patients with advanced endometrial cancer: an interim analysis of a multicentre, open-label, single-arm, phase 2 trial.
Makker V, Rasco D, Vogelzang NJ, Brose MS, Cohn AL, Mier J, Di Simone C, Hyman DM, Stepan DE, Dutcus CE, Schmidt EV, Guo M, Sachdev P, Shumaker R, Aghajanian C, Taylor M
Lancet Oncol 2019 May;20(5):711-718. Epub 2019 Mar 25 doi: 10.1016/S1470-2045(19)30020-8. PMID: 30922731
Medical therapy of endometrial cancer: current status and promising novel treatments.
Hill EK, Dizon DS
Drugs 2012 Mar 26;72(5):705-13. doi: 10.2165/11631840-000000000-00000. PMID: 22439671

Diagnosis

Development and validation of a prognostic nomogram for predicting cancer-specific survival in advanced endometrial carcinoma after surgery: a retrospective analysis of the SEER Database.
Zheng C, Chen W, Zheng Z, Liang X, Xu X, Fang D, Ma R, Fan F, Ni Y, Zhang P, Wu X
BMJ Open 2023 Sep 15;13(9):e070893. doi: 10.1136/bmjopen-2022-070893. PMID: 37714671Free PMC Article
Pembrolizumab plus lenvatinib combination therapy for advanced endometrial carcinoma.
Walker CA, Spirtos AN, Miller DS
Expert Rev Anticancer Ther 2023 Apr;23(4):361-368. Epub 2023 Mar 28 doi: 10.1080/14737140.2023.2194634. PMID: 36944439
Evaluation of the efficiency and safety of adjuvant chemotherapy alone for patients with advanced endometrial carcinoma: A protocol for systematic review and meta-analysis.
Guo J, Li S, Wu Y
Medicine (Baltimore) 2022 Jul 15;101(28):e29156. doi: 10.1097/MD.0000000000029156. PMID: 35839048
Clinical evaluation of women with PMB. Is it always necessary an endometrial biopsy to be performed? A review of the literature.
Dimitraki M, Tsikouras P, Bouchlariotou S, Dafopoulos A, Liberis V, Maroulis G, Teichmann AT
Arch Gynecol Obstet 2011 Feb;283(2):261-6. Epub 2010 Aug 4 doi: 10.1007/s00404-010-1601-3. PMID: 20683604Free PMC Article
Treatment options for advanced endometrial carcinoma.
Dizon DS
Gynecol Oncol 2010 May;117(2):373-81. Epub 2010 Mar 12 doi: 10.1016/j.ygyno.2010.02.007. PMID: 20223510

Therapy

Pembrolizumab plus lenvatinib combination therapy for advanced endometrial carcinoma.
Walker CA, Spirtos AN, Miller DS
Expert Rev Anticancer Ther 2023 Apr;23(4):361-368. Epub 2023 Mar 28 doi: 10.1080/14737140.2023.2194634. PMID: 36944439
A Phase Ib/II Study of Lenvatinib and Pembrolizumab in Advanced Endometrial Carcinoma (Study 111/KEYNOTE-146): Long-Term Efficacy and Safety Update.
Makker V, Aghajanian C, Cohn AL, Romeo M, Bratos R, Brose MS, Messing M, Dutta L, Dutcus CE, Huang J, Schmidt EV, Orlowski R, Taylor MH
J Clin Oncol 2023 Feb 10;41(5):974-979. Epub 2023 Jan 6 doi: 10.1200/JCO.22.01021. PMID: 36608305Free PMC Article
Characterization and Management of Adverse Reactions in Patients with Advanced Endometrial Carcinoma Treated with Lenvatinib Plus Pembrolizumab.
Makker V, Taylor MH, Oaknin A, Casado Herraez A, Orlowski R, Dutta L, Ren M, Zale M, O'Malley DM
Oncologist 2021 Sep;26(9):e1599-e1608. Epub 2021 Jul 30 doi: 10.1002/onco.13883. PMID: 34190370Free PMC Article
Lenvatinib Plus Pembrolizumab in Patients With Advanced Endometrial Cancer.
Makker V, Taylor MH, Aghajanian C, Oaknin A, Mier J, Cohn AL, Romeo M, Bratos R, Brose MS, DiSimone C, Messing M, Stepan DE, Dutcus CE, Wu J, Schmidt EV, Orlowski R, Sachdev P, Shumaker R, Casado Herraez A
J Clin Oncol 2020 Sep 10;38(26):2981-2992. Epub 2020 Mar 13 doi: 10.1200/JCO.19.02627. PMID: 32167863Free PMC Article
Lenvatinib plus pembrolizumab in patients with advanced endometrial cancer: an interim analysis of a multicentre, open-label, single-arm, phase 2 trial.
Makker V, Rasco D, Vogelzang NJ, Brose MS, Cohn AL, Mier J, Di Simone C, Hyman DM, Stepan DE, Dutcus CE, Schmidt EV, Guo M, Sachdev P, Shumaker R, Aghajanian C, Taylor M
Lancet Oncol 2019 May;20(5):711-718. Epub 2019 Mar 25 doi: 10.1016/S1470-2045(19)30020-8. PMID: 30922731

Prognosis

Endometrial Cancer-Infiltrating Mesenchymal Stem Cells Exhibit Immunosuppressive Effects.
Wang KH, Chang YH, Harnod T, Ding DC
Cell Transplant 2022 Jan-Dec;31:9636897221104452. doi: 10.1177/09636897221104452. PMID: 35712817Free PMC Article
Evaluation on curative effects of adjuvant chemotherapy alone in treating with advanced endometrial carcinoma: A protocol for systematic review and meta-analysis.
Jiang J, Chen L, Tian Y
Medicine (Baltimore) 2022 Mar 4;101(9):e28817. doi: 10.1097/MD.0000000000028817. PMID: 35244039Free PMC Article
Randomized Phase II Trial of Ridaforolimus in Advanced Endometrial Carcinoma.
Oza AM, Pignata S, Poveda A, McCormack M, Clamp A, Schwartz B, Cheng J, Li X, Campbell K, Dodion P, Haluska FG
J Clin Oncol 2015 Nov 1;33(31):3576-82. Epub 2015 Jun 15 doi: 10.1200/JCO.2014.58.8871. PMID: 26077241
Medical therapy of endometrial cancer: current status and promising novel treatments.
Hill EK, Dizon DS
Drugs 2012 Mar 26;72(5):705-13. doi: 10.2165/11631840-000000000-00000. PMID: 22439671
Treatment options for advanced endometrial carcinoma.
Dizon DS
Gynecol Oncol 2010 May;117(2):373-81. Epub 2010 Mar 12 doi: 10.1016/j.ygyno.2010.02.007. PMID: 20223510

Clinical prediction guides

Pembrolizumab as a single agent for patients with MSI-H advanced endometrial carcinoma.
Turinetto M, Lombardo V, Pisano C, Musacchio L, Pignata S
Expert Rev Anticancer Ther 2022 Oct;22(10):1039-1047. Epub 2022 Sep 22 doi: 10.1080/14737140.2022.2126356. PMID: 36111897
Endometrial Cancer-Infiltrating Mesenchymal Stem Cells Exhibit Immunosuppressive Effects.
Wang KH, Chang YH, Harnod T, Ding DC
Cell Transplant 2022 Jan-Dec;31:9636897221104452. doi: 10.1177/09636897221104452. PMID: 35712817Free PMC Article
Patient reported outcomes for cisplatin and radiation followed by carboplatin/paclitaxel versus carboplatin/paclitaxel for locally advanced endometrial carcinoma: An NRG oncology study.
Matulonis UA, Huang HQ, Filiaci VL, Randall M, DiSilvestro PA, Moxley KM, Fowler JM, Powell MA, Spirtos NM, Tewari KS, Richards WE, Nakayama JM, Mutch DG, Miller DS, Matei D, Wenzel LB
Gynecol Oncol 2022 Feb;164(2):428-436. Epub 2021 Dec 11 doi: 10.1016/j.ygyno.2021.11.021. PMID: 34903380Free PMC Article
Chemotherapy response score as a prognostic tool in patients with advanced stage endometrial carcinoma treated with neoadjuvant chemotherapy.
Jani I, Lastra RR, Brito KS, Liao C, Lazo I, Lee NK, Yamada SD, Kurnit KC
Int J Gynecol Cancer 2021 Jun;31(6):852-858. Epub 2021 Apr 8 doi: 10.1136/ijgc-2020-002202. PMID: 33833085
Clinical evaluation of women with PMB. Is it always necessary an endometrial biopsy to be performed? A review of the literature.
Dimitraki M, Tsikouras P, Bouchlariotou S, Dafopoulos A, Liberis V, Maroulis G, Teichmann AT
Arch Gynecol Obstet 2011 Feb;283(2):261-6. Epub 2010 Aug 4 doi: 10.1007/s00404-010-1601-3. PMID: 20683604Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...