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Epididymal Melanotic Neuroectodermal Tumor

MedGen UID:
1702204
•Concept ID:
C5206592
•
Neoplastic Process
Synonym: Paratesticular Melanotic Neuroectodermal Tumor

Definition

A rare neoplasm that arises from the epididymis and is characterized by the presence of a mixture of melanin-containing epithelial cells and smaller neuroblast-like cells. It usually occurs in infants and has a benign clinical course. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpididymal Melanotic Neuroectodermal Tumor

Recent clinical studies

Etiology

Appendageal tumors and tumor-like lesions of the testis and paratestis: a 32-year experience at a single institution.
Al-Obaidy KI, Alruwaii FI, Ulbright TM, Idrees MT
Hum Pathol 2020 Sep;103:25-33. Epub 2020 Jun 30 doi: 10.1016/j.humpath.2020.06.006. PMID: 32619438
Diagnostic cytologic features of an epididymal melanotic neuroectodermal tumor of infancy present in scrotal fluid: a case report.
Pantanowitz L, Galan A, Gang DL, Crisi GM, LaPolice P, Goulart RA
Acta Cytol 2006 Jul-Aug;50(4):460-5. doi: 10.1159/000325993. PMID: 16901015
Melanotic neuroectodermal tumor of the epididymis in infancy: case report and review of the literature.
Calabrese F, Danieli D, Valente M
Urology 1995 Sep;46(3):415-8. doi: 10.1016/S0090-4295(99)80234-9. PMID: 7660523
Melanotic neuroectodermal tumor of infancy (MNTI) in the epididymis. A case report with immunohistological studies and special consideration of malignant features.
Jurincic-Winkler C, Metz KA, Klippel KF
Zentralbl Pathol 1994 Jul;140(2):181-5. PMID: 7947625

Diagnosis

Melanotic Neuroectodermal Tumor of Infancy in the Epididymis: A Case Report.
Zhang C, Yu W, Jin M, Qu L
Int J Surg Pathol 2024 Apr;32(2):380-385. Epub 2023 May 25 doi: 10.1177/10668969231176026. PMID: 37229663
Appendageal tumors and tumor-like lesions of the testis and paratestis: a 32-year experience at a single institution.
Al-Obaidy KI, Alruwaii FI, Ulbright TM, Idrees MT
Hum Pathol 2020 Sep;103:25-33. Epub 2020 Jun 30 doi: 10.1016/j.humpath.2020.06.006. PMID: 32619438
Melanotic neuroectodermal tumor of infancy in ovary: A rare case report.
Liu Z, Li M, Tang X, Xiao Y, Xiao Z, Li Y
Medicine (Baltimore) 2019 Dec;98(49):e18181. doi: 10.1097/MD.0000000000018181. PMID: 31804335Free PMC Article
Epididymal melanotic neuroectodermal tumor of infancy: A rare cause of scrotal mass in an infant.
Burton KR, Ngan BY, Navarro OM
J Clin Ultrasound 2019 Feb;47(2):100-103. Epub 2018 Nov 5 doi: 10.1002/jcu.22658. PMID: 30393869
Melanotic Neuroectodermal Tumor of Infancy Presenting With Fast-Growing Scrotal Swelling: A Case Report and Literature Review.
Fabien-Dupuis C, Niver B, Shillingford N, Wang L, Kokorowski PJ, Zhou S
Pediatr Dev Pathol 2017 Sep-Oct;20(5):411-415. Epub 2017 Jan 25 doi: 10.1177/1093526616686437. PMID: 28812465

Prognosis

Melanotic neuroectodermal tumor of infancy in ovary: A rare case report.
Liu Z, Li M, Tang X, Xiao Y, Xiao Z, Li Y
Medicine (Baltimore) 2019 Dec;98(49):e18181. doi: 10.1097/MD.0000000000018181. PMID: 31804335Free PMC Article
Miscellaneous rare paratesticular tumors.
Henley JD, Ferry J, Ulbright TM
Semin Diagn Pathol 2000 Nov;17(4):319-39. PMID: 11202548
Melanotic neuroectodermal tumor of the epididymis in infancy: case report and review of the literature.
Calabrese F, Danieli D, Valente M
Urology 1995 Sep;46(3):415-8. doi: 10.1016/S0090-4295(99)80234-9. PMID: 7660523
Melanotic neuroectodermal tumor of infancy.
Carpenter BF, Jimenez C, Robb IA
Pediatr Pathol 1985;3(2-4):227-44. doi: 10.3109/15513818509078784. PMID: 3006007
Epididymal melanotic neuroectodermal tumor of infancy.
Ricketts RR, Majmudarr B
Hum Pathol 1985 Apr;16(4):416-20. doi: 10.1016/s0046-8177(85)80235-5. PMID: 2579889

Clinical prediction guides

Melanotic neuroectodermal tumor of infancy. A reexamination of a histogenetic problem based on immunohistochemical, flow cytometric, and ultrastructural study of 10 cases.
Pettinato G, Manivel JC, d'Amore ES, Jaszcz W, Gorlin RJ
Am J Surg Pathol 1991 Mar;15(3):233-45. PMID: 1847607

Recent systematic reviews

Melanotic neuroectodermal tumor of infancy: systematic review of the literature and presentation of a case.
Kruse-Lösler B, Gaertner C, Bürger H, Seper L, Joos U, Kleinheinz J
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006 Aug;102(2):204-16. Epub 2006 Jun 8 doi: 10.1016/j.tripleo.2005.08.010. PMID: 16876064

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