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Chronic Cutaneous Graft Versus Host Disease

MedGen UID:
1703247
•Concept ID:
C5205621
•
Disease or Syndrome
Synonym: Chronic Cutaneous GvHD

Definition

Chronic graft versus host disease (GvHD) occurring in the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic Cutaneous Graft Versus Host Disease

Professional guidelines

PubMed

Survey of European Blood and Marrow Transplant (EBMT) nurses to explore the current topical skin management of chronic cutaneous graft versus host disease in the real-world clinical environment.
Murray J, Liptrott S, Canesi M, Mooyaart J, Kisch A, Piepenbroek B, Stringer J
Eur J Oncol Nurs 2024 Apr;69:102547. Epub 2024 Mar 5 doi: 10.1016/j.ejon.2024.102547. PMID: 38467081
Prospects for ultraviolet A1 phototherapy as a treatment for chronic cutaneous graft-versus-host disease.
Calzavara Pinton P, Porta F, Izzi T, Venturini M, Capezzera R, Zane C, Notarangelo LD
Haematologica 2003 Oct;88(10):1169-75. PMID: 14555314
Treatment of acute graft-versus-host disease with PUVA (psoralen and ultraviolet irradiation): results of a pilot study.
Wiesmann A, Weller A, Lischka G, Klingebiel T, Kanz L, Einsele H
Bone Marrow Transplant 1999 Jan;23(2):151-5. doi: 10.1038/sj.bmt.1701537. PMID: 10197800

Recent clinical studies

Etiology

Risk factors and clinical characteristics of acute and chronic cutaneous graft-versus-host disease in pediatric patients undergoing hematopoietic stem cell transplantation.
González-Cruz C, Repiso T, Ferrándiz-Pulido C, Navarro A, García-Patos V
Pediatr Dermatol 2023 Nov-Dec;40(6):1077-1080. Epub 2023 Oct 13 doi: 10.1111/pde.15447. PMID: 37830789
Evaluating differential expression of fibrosis-related genes and their correlation with blood vessel density in chronic cutaneous graft-versus-host disease.
Greenberger S, Warshavsky K, Goldstein G, Leichner GS, Tsafrir Y, Manevitz-Mendelson E, Baum S, Barzilai A
J Dermatol Sci 2022 Jul;107(1):41-47. Epub 2022 May 13 doi: 10.1016/j.jdermsci.2022.05.004. PMID: 35672202
Chronic cutaneous graft-versus-host disease in children: A report of 14 patients from a tertiary care pediatric dermatology clinic.
Nanda A, Husain MAA, Al-Herz W, Almekaimi A, Al-Sabah H, Al-Otaibi M
Pediatr Dermatol 2018 May;35(3):343-353. Epub 2018 Mar 14 doi: 10.1111/pde.13432. PMID: 29536565
Atopic dermatitis-like presentation of graft-versus-host disease: a novel form of chronic cutaneous graft-versus-host disease.
Wei J, Zhang Y, Xu H, Jin J, Zhang J
J Am Acad Dermatol 2013 Jul;69(1):34-9. Epub 2013 Feb 1 doi: 10.1016/j.jaad.2012.12.970. PMID: 23375455
Prospects for ultraviolet A1 phototherapy as a treatment for chronic cutaneous graft-versus-host disease.
Calzavara Pinton P, Porta F, Izzi T, Venturini M, Capezzera R, Zane C, Notarangelo LD
Haematologica 2003 Oct;88(10):1169-75. PMID: 14555314

Diagnosis

Interrater reproducibility of the Myoton and durometer devices to quantify sclerotic chronic graft-versus-host disease.
Ghosh S, Baker L, Chen F, Khera Z, Vain A, Zhang K, Hood A, Smith H, Chen H, Jagasia M, Tkaczyk E
Arch Dermatol Res 2023 Nov;315(9):2545-2554. Epub 2023 May 25 doi: 10.1007/s00403-023-02626-1. PMID: 37227518
Efficacy of manual lymph drainage plus exercise on range of motion and flexibility in refractory chronic cutaneous graft-versus-host disease: A case report.
Ozdemir K, Keser I, Yegin ZA, Kaynar LA
Curr Res Transl Med 2020 Jan;68(1):1-4. Epub 2019 Nov 21 doi: 10.1016/j.retram.2019.11.001. PMID: 31761680
Chronic cutaneous graft-versus-host disease in children: A report of 14 patients from a tertiary care pediatric dermatology clinic.
Nanda A, Husain MAA, Al-Herz W, Almekaimi A, Al-Sabah H, Al-Otaibi M
Pediatr Dermatol 2018 May;35(3):343-353. Epub 2018 Mar 14 doi: 10.1111/pde.13432. PMID: 29536565
Atopic dermatitis-like presentation of graft-versus-host disease: a novel form of chronic cutaneous graft-versus-host disease.
Wei J, Zhang Y, Xu H, Jin J, Zhang J
J Am Acad Dermatol 2013 Jul;69(1):34-9. Epub 2013 Feb 1 doi: 10.1016/j.jaad.2012.12.970. PMID: 23375455
Photochemotherapy improves chronic cutaneous graft-versus-host disease.
Volc-Platzer B, Hönigsmann H, Hinterberger W, Wolff K
J Am Acad Dermatol 1990 Aug;23(2 Pt 1):220-8. doi: 10.1016/0190-9622(90)70202-s. PMID: 2212117

Therapy

Risk factors and clinical characteristics of acute and chronic cutaneous graft-versus-host disease in pediatric patients undergoing hematopoietic stem cell transplantation.
González-Cruz C, Repiso T, Ferrándiz-Pulido C, Navarro A, García-Patos V
Pediatr Dermatol 2023 Nov-Dec;40(6):1077-1080. Epub 2023 Oct 13 doi: 10.1111/pde.15447. PMID: 37830789
Skin ulcers caused by ruxolitinib in a patient with chronic cutaneous graft-versus-host disease.
Aslan Candır B, Yiğenoğlu TN, Kızıl Çakar M, Dal MS, Altuntaş F
J Oncol Pharm Pract 2022 Jun;28(4):983-985. Epub 2022 Jan 12 doi: 10.1177/10781552211073881. PMID: 35019785
Chronic cutaneous graft-versus-host disease in children: A report of 14 patients from a tertiary care pediatric dermatology clinic.
Nanda A, Husain MAA, Al-Herz W, Almekaimi A, Al-Sabah H, Al-Otaibi M
Pediatr Dermatol 2018 May;35(3):343-353. Epub 2018 Mar 14 doi: 10.1111/pde.13432. PMID: 29536565
Type I IFNs Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-versus-Host Disease.
Delaney TA, Morehouse C, Brohawn PZ, Groves C, Colonna M, Yao Y, Sanjuan M, Coyle AJ
J Immunol 2016 Jul 1;197(1):42-50. Epub 2016 May 25 doi: 10.4049/jimmunol.1502190. PMID: 27226090
Chronic cutaneous graft-versus-host disease in man.
Shulman HM, Sale GE, Lerner KG, Barker EA, Weiden PL, Sullivan K, Gallucci B, Thomas ED, Storb R
Am J Pathol 1978 Jun;91(3):545-70. PMID: 26221Free PMC Article

Prognosis

Efficacy of acitretin for porokeratosis in a child with chronic cutaneous graft versus host disease.
Borroni RG, Poddighe D, Zecca M, Brazzelli V
Pediatr Dermatol 2013 Jan-Feb;30(1):148-50. Epub 2011 Nov 16 doi: 10.1111/j.1525-1470.2011.01610.x. PMID: 22085032
Chronic cutaneous graft-versus-host disease in man.
Shulman HM, Sale GE, Lerner KG, Barker EA, Weiden PL, Sullivan K, Gallucci B, Thomas ED, Storb R
Am J Pathol 1978 Jun;91(3):545-70. PMID: 26221Free PMC Article

Clinical prediction guides

Interrater reproducibility of the Myoton and durometer devices to quantify sclerotic chronic graft-versus-host disease.
Ghosh S, Baker L, Chen F, Khera Z, Vain A, Zhang K, Hood A, Smith H, Chen H, Jagasia M, Tkaczyk E
Arch Dermatol Res 2023 Nov;315(9):2545-2554. Epub 2023 May 25 doi: 10.1007/s00403-023-02626-1. PMID: 37227518
Skin ulcers caused by ruxolitinib in a patient with chronic cutaneous graft-versus-host disease.
Aslan Candır B, Yiğenoğlu TN, Kızıl Çakar M, Dal MS, Altuntaş F
J Oncol Pharm Pract 2022 Jun;28(4):983-985. Epub 2022 Jan 12 doi: 10.1177/10781552211073881. PMID: 35019785
Chronic cutaneous graft-versus-host disease in children: A report of 14 patients from a tertiary care pediatric dermatology clinic.
Nanda A, Husain MAA, Al-Herz W, Almekaimi A, Al-Sabah H, Al-Otaibi M
Pediatr Dermatol 2018 May;35(3):343-353. Epub 2018 Mar 14 doi: 10.1111/pde.13432. PMID: 29536565
Type I IFNs Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-versus-Host Disease.
Delaney TA, Morehouse C, Brohawn PZ, Groves C, Colonna M, Yao Y, Sanjuan M, Coyle AJ
J Immunol 2016 Jul 1;197(1):42-50. Epub 2016 May 25 doi: 10.4049/jimmunol.1502190. PMID: 27226090
Treatment of acute graft-versus-host disease with PUVA (psoralen and ultraviolet irradiation): results of a pilot study.
Wiesmann A, Weller A, Lischka G, Klingebiel T, Kanz L, Einsele H
Bone Marrow Transplant 1999 Jan;23(2):151-5. doi: 10.1038/sj.bmt.1701537. PMID: 10197800

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