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Sural nerve atrophy

MedGen UID:
1706390
•Concept ID:
C5139159
•
Pathologic Function
Synonym: Atrophy of sural nerve
 
HPO: HP:0032145

Definition

Wasting of the sural nerve, a sensory nerve in the calf region of the leg. [from HPO]

Professional guidelines

PubMed

Primary achilles tendon repair with mini-dorsolateral incision technique and accelerated rehabilitation.
Hrnack SA, Crates JM, Barber FA
Foot Ankle Int 2012 Oct;33(10):848-51. doi: 10.3113/FAI.2012.0848. PMID: 23050708
MFN2 mutation distribution and genotype/phenotype correlation in Charcot-Marie-Tooth type 2.
Verhoeven K, Claeys KG, Züchner S, Schröder JM, Weis J, Ceuterick C, Jordanova A, Nelis E, De Vriendt E, Van Hul M, Seeman P, Mazanec R, Saifi GM, Szigeti K, Mancias P, Butler IJ, Kochanski A, Ryniewicz B, De Bleecker J, Van den Bergh P, Verellen C, Van Coster R, Goemans N, Auer-Grumbach M, Robberecht W, Milic Rasic V, Nevo Y, Tournev I, Guergueltcheva V, Roelens F, Vieregge P, Vinci P, Moreno MT, Christen HJ, Shy ME, Lupski JR, Vance JM, De Jonghe P, Timmerman V
Brain 2006 Aug;129(Pt 8):2093-102. Epub 2006 May 19 doi: 10.1093/brain/awl126. PMID: 16714318
Orthopaedic management of childhood neuromuscular disease. Part I: Spinal muscular atrophy.
Shapiro F, Bresnan MJ
J Bone Joint Surg Am 1982 Jun;64(5):785-9. PMID: 7085707

Recent clinical studies

Etiology

Nerve ultrasound detects abnormally small nerves in patients with spinal and bulbar muscular atrophy.
Pelosi L, Ghosh A, Leadbetter R, Lance S, Rodrigues M, Roxburgh R
Muscle Nerve 2022 May;65(5):599-602. Epub 2022 Feb 14 doi: 10.1002/mus.27509. PMID: 35092036
Phosphorylated α-synuclein and phosphorylated tau-protein in sural nerves may contribute to differentiate Parkinson's disease from multiple system atrophy and progressive supranuclear paralysis.
Rong Z, Shen F, Wang Y, Sun L, Wu J, Zhang H, Yuan Y, Jiang W, Li X, Ji P, Zhang K
Neurosci Lett 2021 Jun 21;756:135964. Epub 2021 May 19 doi: 10.1016/j.neulet.2021.135964. PMID: 34022266
Cranial nerve involvement in Charcot-Marie-Tooth Disease.
Das N, Kandalaft S, Wu X, Malhotra A
J Clin Neurosci 2017 Mar;37:59-62. Epub 2016 Nov 22 doi: 10.1016/j.jocn.2016.10.049. PMID: 27884603
Peripheral nerve abnormalities in pediatric patients with spinal muscular atrophy.
Yonekawa T, Komaki H, Saito Y, Sugai K, Sasaki M
Brain Dev 2013 Feb;35(2):165-71. Epub 2012 Apr 17 doi: 10.1016/j.braindev.2012.03.009. PMID: 22512990
Microsurgical management of hypoglossal schwannomas over 3 decades: a modified grading scale to guide surgical approach.
Nonaka Y, Grossi PM, Bulsara KR, Taniguchi RM, Friedman AH, Fukushima T
Neurosurgery 2011 Dec;69(2 Suppl Operative):ons121-40; discussion ons140. doi: 10.1227/NEU.0b013e31822a547b. PMID: 21709593

Diagnosis

Genetic and clinical characteristics of NEFL-related Charcot-Marie-Tooth disease.
Horga A, Laurà M, Jaunmuktane Z, Jerath NU, Gonzalez MA, Polke JM, Poh R, Blake JC, Liu YT, Wiethoff S, Bettencourt C, Lunn MP, Manji H, Hanna MG, Houlden H, Brandner S, Züchner S, Shy M, Reilly MM
J Neurol Neurosurg Psychiatry 2017 Jul;88(7):575-585. Epub 2017 May 13 doi: 10.1136/jnnp-2016-315077. PMID: 28501821Free PMC Article
Peripheral nerve entrapments.
Hirose CB, McGarvey WC
Foot Ankle Clin 2004 Jun;9(2):255-69. doi: 10.1016/j.fcl.2004.02.001. PMID: 15165581
Overview of hereditary neuropathy with liability to pressure palsies.
Chance PF
Ann N Y Acad Sci 1999 Sep 14;883:14-21. PMID: 10586225
Current principles in microsurgical nerve repair.
Hausamen JE, Schmelzeisen R
Br J Oral Maxillofac Surg 1996 Apr;34(2):143-57. doi: 10.1016/s0266-4356(96)90369-1. PMID: 8861290
Churg-Strauss syndrome.
Gargulinski RB, Simpson DA, Wishnow R, Rentz LE, Jones MZ
J Am Osteopath Assoc 1996 Jul;96(7):428-32. PMID: 8758878

Therapy

Mutations in the MORC2 gene cause axonal Charcot-Marie-Tooth disease.
Sevilla T, Lupo V, Martínez-Rubio D, Sancho P, Sivera R, Chumillas MJ, García-Romero M, Pascual-Pascual SI, Muelas N, Dopazo J, Vílchez JJ, Palau F, Espinós C
Brain 2016 Jan;139(Pt 1):62-72. Epub 2015 Oct 24 doi: 10.1093/brain/awv311. PMID: 26497905
Churg-Strauss syndrome.
Gargulinski RB, Simpson DA, Wishnow R, Rentz LE, Jones MZ
J Am Osteopath Assoc 1996 Jul;96(7):428-32. PMID: 8758878
What causes neuropathic pain?
Boulton A
J Diabetes Complications 1992 Jan-Mar;6(1):58-63. doi: 10.1016/1056-8727(92)90050-u. PMID: 1562760
Ethylene oxide polyneuropathy.
Kuzuhara S, Kanazawa I, Nakanishi T, Egashira T
Neurology 1983 Mar;33(3):377-80. doi: 10.1212/wnl.33.3.377. PMID: 6298660
Glue sniffer's neuropathy.
Towfighi J, Gonatas NK, Pleasure D, Cooper HS, McCree L
Neurology 1976 Mar;26(3):238-43. doi: 10.1212/wnl.26.3.238. PMID: 175315

Prognosis

Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder.
Lossos A, Elazar N, Lerer I, Schueler-Furman O, Fellig Y, Glick B, Zimmerman BE, Azulay H, Dotan S, Goldberg S, Gomori JM, Ponger P, Newman JP, Marreed H, Steck AJ, Schaeren-Wiemers N, Mor N, Harel M, Geiger T, Eshed-Eisenbach Y, Meiner V, Peles E
Brain 2015 Sep;138(Pt 9):2521-36. Epub 2015 Jul 15 doi: 10.1093/brain/awv204. PMID: 26179919Free PMC Article
Muscle atrophy in chronic inflammatory demyelinating polyneuropathy: a computed tomography assessment.
Ohyama K, Koike H, Katsuno M, Takahashi M, Hashimoto R, Kawagashira Y, Iijima M, Adachi H, Watanabe H, Sobue G
Eur J Neurol 2014 Jul;21(7):1002-10. Epub 2014 Mar 29 doi: 10.1111/ene.12426. PMID: 24684299
Inherited focal, episodic neuropathies: hereditary neuropathy with liability to pressure palsies and hereditary neuralgic amyotrophy.
Chance PF
Neuromolecular Med 2006;8(1-2):159-74. doi: 10.1385/NMM:8:1:159. PMID: 16775374
Peripheral nerve entrapments.
Hirose CB, McGarvey WC
Foot Ankle Clin 2004 Jun;9(2):255-69. doi: 10.1016/j.fcl.2004.02.001. PMID: 15165581
Cytomegalovirus and the peripheral nervous system in AIDS.
Fuller GN
J Acquir Immune Defic Syndr (1988) 1992;5 Suppl 1:S33-6. PMID: 1318366

Clinical prediction guides

Mutations in COA7 cause spinocerebellar ataxia with axonal neuropathy.
Higuchi Y, Okunushi R, Hara T, Hashiguchi A, Yuan J, Yoshimura A, Murayama K, Ohtake A, Ando M, Hiramatsu Y, Ishihara S, Tanabe H, Okamoto Y, Matsuura E, Ueda T, Toda T, Yamashita S, Yamada K, Koide T, Yaguchi H, Mitsui J, Ishiura H, Yoshimura J, Doi K, Morishita S, Sato K, Nakagawa M, Yamaguchi M, Tsuji S, Takashima H
Brain 2018 Jun 1;141(6):1622-1636. doi: 10.1093/brain/awy104. PMID: 29718187Free PMC Article
Neurofibromatous neuropathy: An ultrastructural study.
Terracciano C, Pachatz C, Rastelli E, Pastore FS, Melone MAB, Massa R
Ultrastruct Pathol 2018 May-Jun;42(3):312-316. Epub 2018 Mar 27 doi: 10.1080/01913123.2018.1454562. PMID: 29583067
Genetic and clinical characteristics of NEFL-related Charcot-Marie-Tooth disease.
Horga A, Laurà M, Jaunmuktane Z, Jerath NU, Gonzalez MA, Polke JM, Poh R, Blake JC, Liu YT, Wiethoff S, Bettencourt C, Lunn MP, Manji H, Hanna MG, Houlden H, Brandner S, Züchner S, Shy M, Reilly MM
J Neurol Neurosurg Psychiatry 2017 Jul;88(7):575-585. Epub 2017 May 13 doi: 10.1136/jnnp-2016-315077. PMID: 28501821Free PMC Article
Overview of hereditary neuropathy with liability to pressure palsies.
Chance PF
Ann N Y Acad Sci 1999 Sep 14;883:14-21. PMID: 10586225
What causes neuropathic pain?
Boulton A
J Diabetes Complications 1992 Jan-Mar;6(1):58-63. doi: 10.1016/1056-8727(92)90050-u. PMID: 1562760

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