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Advanced Pancreatic Ductal Adenocarcinoma

MedGen UID:
1708529
Concept ID:
C5236063
Neoplastic Process

Definition

Pancreatic ductal adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Pancreatic Ductal Adenocarcinoma

Professional guidelines

PubMed

Babiker HM, Karass M, Recio-Boiles A, Chandana SR, McBride A, Mahadevan D
Expert Opin Investig Drugs 2019 Jul;28(7):583-592. Epub 2019 Jun 21 doi: 10.1080/13543784.2019.1632289. PMID: 31215251Free PMC Article
Diwakarla C, Hannan K, Hein N, Yip D
World J Gastroenterol 2017 Apr 7;23(13):2276-2285. doi: 10.3748/wjg.v23.i13.2276. PMID: 28428707Free PMC Article
Loehrer AP, Kinnier CV, Ferrone CR
Adv Surg 2016 Sep;50(1):115-28. Epub 2016 Jul 7 doi: 10.1016/j.yasu.2016.03.010. PMID: 27520867

Recent clinical studies

Etiology

Ma LX, Wang Y, Espin-Garcia O, Allen MJ, Jang GH, Zhang A, Dodd A, Ramotar S, Hutchinson S, Tehfe M, Ramjeesingh R, Biagi J, Wilson JM, Notta F, Fischer SE, Zogopoulos G, Gallinger S, Grant RC, Khokha R, Chan N, Grünwald BT, Knox JJ, O'Kane GM
Br J Cancer 2023 May;128(10):1916-1921. Epub 2023 Mar 16 doi: 10.1038/s41416-023-02214-0. PMID: 36927977Free PMC Article
Schneider M, Hackert T, Strobel O, Büchler MW
Br J Surg 2021 Jul 23;108(7):777-785. doi: 10.1093/bjs/znab133. PMID: 34046668
Gutierrez-Sainz L, Viñal D, Villamayor J, Martinez-Perez D, Garcia-Cuesta JA, Ghanem I, Custodio A, Feliu J
Clin Transl Oncol 2021 Sep;23(9):1838-1846. Epub 2021 Apr 17 doi: 10.1007/s12094-021-02589-7. PMID: 33866520
O'Kane GM, Grünwald BT, Jang GH, Masoomian M, Picardo S, Grant RC, Denroche RE, Zhang A, Wang Y, Lam B, Krzyzanowski PM, Lungu IM, Bartlett JMS, Peralta M, Vyas F, Khokha R, Biagi J, Chadwick D, Ramotar S, Hutchinson S, Dodd A, Wilson JM, Notta F, Zogopoulos G, Gallinger S, Knox JJ, Fischer SE
Clin Cancer Res 2020 Sep 15;26(18):4901-4910. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3724. PMID: 32156747
Chin V, Nagrial A, Sjoquist K, O'Connor CA, Chantrill L, Biankin AV, Scholten RJ, Yip D
Cochrane Database Syst Rev 2018 Mar 20;3(3):CD011044. doi: 10.1002/14651858.CD011044.pub2. PMID: 29557103Free PMC Article

Diagnosis

Bai RL, Wang NY, Zhao LL, Zhang YF, Cui JW
Hepatobiliary Pancreat Dis Int 2022 Feb;21(1):10-24. Epub 2021 Sep 8 doi: 10.1016/j.hbpd.2021.08.012. PMID: 34538570
O'Kane GM, Grünwald BT, Jang GH, Masoomian M, Picardo S, Grant RC, Denroche RE, Zhang A, Wang Y, Lam B, Krzyzanowski PM, Lungu IM, Bartlett JMS, Peralta M, Vyas F, Khokha R, Biagi J, Chadwick D, Ramotar S, Hutchinson S, Dodd A, Wilson JM, Notta F, Zogopoulos G, Gallinger S, Knox JJ, Fischer SE
Clin Cancer Res 2020 Sep 15;26(18):4901-4910. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3724. PMID: 32156747
Zhou R, Xu X, Liu M, Wu X, Li R
Digestion 2019;99(3):247-251. Epub 2018 Sep 11 doi: 10.1159/000492861. PMID: 30205390
Aung KL, Fischer SE, Denroche RE, Jang GH, Dodd A, Creighton S, Southwood B, Liang SB, Chadwick D, Zhang A, O'Kane GM, Albaba H, Moura S, Grant RC, Miller JK, Mbabaali F, Pasternack D, Lungu IM, Bartlett JMS, Ghai S, Lemire M, Holter S, Connor AA, Moffitt RA, Yeh JJ, Timms L, Krzyzanowski PM, Dhani N, Hedley D, Notta F, Wilson JM, Moore MJ, Gallinger S, Knox JJ
Clin Cancer Res 2018 Mar 15;24(6):1344-1354. Epub 2017 Dec 29 doi: 10.1158/1078-0432.CCR-17-2994. PMID: 29288237Free PMC Article
Alemi F, Alseidi A, Scott Helton W, Rocha FG
Curr Probl Surg 2015 Sep;52(9):362-98. Epub 2015 Jul 17 doi: 10.1067/j.cpsurg.2015.07.003. PMID: 26363649

Therapy

Ma LX, Wang Y, Espin-Garcia O, Allen MJ, Jang GH, Zhang A, Dodd A, Ramotar S, Hutchinson S, Tehfe M, Ramjeesingh R, Biagi J, Wilson JM, Notta F, Fischer SE, Zogopoulos G, Gallinger S, Grant RC, Khokha R, Chan N, Grünwald BT, Knox JJ, O'Kane GM
Br J Cancer 2023 May;128(10):1916-1921. Epub 2023 Mar 16 doi: 10.1038/s41416-023-02214-0. PMID: 36927977Free PMC Article
Ma Y, Li J, Wang H, Chiu Y, Kingsley CV, Fry D, Delaney SN, Wei SC, Zhang J, Maitra A, Yee C
Gastroenterology 2020 Jul;159(1):306-319.e12. Epub 2020 Mar 14 doi: 10.1053/j.gastro.2020.03.018. PMID: 32179091Free PMC Article
O'Kane GM, Grünwald BT, Jang GH, Masoomian M, Picardo S, Grant RC, Denroche RE, Zhang A, Wang Y, Lam B, Krzyzanowski PM, Lungu IM, Bartlett JMS, Peralta M, Vyas F, Khokha R, Biagi J, Chadwick D, Ramotar S, Hutchinson S, Dodd A, Wilson JM, Notta F, Zogopoulos G, Gallinger S, Knox JJ, Fischer SE
Clin Cancer Res 2020 Sep 15;26(18):4901-4910. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3724. PMID: 32156747
Babiker HM, Karass M, Recio-Boiles A, Chandana SR, McBride A, Mahadevan D
Expert Opin Investig Drugs 2019 Jul;28(7):583-592. Epub 2019 Jun 21 doi: 10.1080/13543784.2019.1632289. PMID: 31215251Free PMC Article
Aung KL, Fischer SE, Denroche RE, Jang GH, Dodd A, Creighton S, Southwood B, Liang SB, Chadwick D, Zhang A, O'Kane GM, Albaba H, Moura S, Grant RC, Miller JK, Mbabaali F, Pasternack D, Lungu IM, Bartlett JMS, Ghai S, Lemire M, Holter S, Connor AA, Moffitt RA, Yeh JJ, Timms L, Krzyzanowski PM, Dhani N, Hedley D, Notta F, Wilson JM, Moore MJ, Gallinger S, Knox JJ
Clin Cancer Res 2018 Mar 15;24(6):1344-1354. Epub 2017 Dec 29 doi: 10.1158/1078-0432.CCR-17-2994. PMID: 29288237Free PMC Article

Prognosis

Zhang X, Lao M, Xu J, Duan Y, Yang H, Li M, Ying H, He L, Sun K, Guo C, Chen W, Jiang H, Zhang X, Bai X, Liang T
J Immunother Cancer 2022 Mar;10(3) doi: 10.1136/jitc-2021-003982. PMID: 35260434Free PMC Article
Buss EJ, Kachnic LA, Horowitz DP
Semin Oncol 2021 Feb;48(1):106-110. Epub 2021 Feb 23 doi: 10.1053/j.seminoncol.2021.02.005. PMID: 33771355
O'Kane GM, Grünwald BT, Jang GH, Masoomian M, Picardo S, Grant RC, Denroche RE, Zhang A, Wang Y, Lam B, Krzyzanowski PM, Lungu IM, Bartlett JMS, Peralta M, Vyas F, Khokha R, Biagi J, Chadwick D, Ramotar S, Hutchinson S, Dodd A, Wilson JM, Notta F, Zogopoulos G, Gallinger S, Knox JJ, Fischer SE
Clin Cancer Res 2020 Sep 15;26(18):4901-4910. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3724. PMID: 32156747
Aung KL, Fischer SE, Denroche RE, Jang GH, Dodd A, Creighton S, Southwood B, Liang SB, Chadwick D, Zhang A, O'Kane GM, Albaba H, Moura S, Grant RC, Miller JK, Mbabaali F, Pasternack D, Lungu IM, Bartlett JMS, Ghai S, Lemire M, Holter S, Connor AA, Moffitt RA, Yeh JJ, Timms L, Krzyzanowski PM, Dhani N, Hedley D, Notta F, Wilson JM, Moore MJ, Gallinger S, Knox JJ
Clin Cancer Res 2018 Mar 15;24(6):1344-1354. Epub 2017 Dec 29 doi: 10.1158/1078-0432.CCR-17-2994. PMID: 29288237Free PMC Article
Diwakarla C, Hannan K, Hein N, Yip D
World J Gastroenterol 2017 Apr 7;23(13):2276-2285. doi: 10.3748/wjg.v23.i13.2276. PMID: 28428707Free PMC Article

Clinical prediction guides

Ma LX, Wang Y, Espin-Garcia O, Allen MJ, Jang GH, Zhang A, Dodd A, Ramotar S, Hutchinson S, Tehfe M, Ramjeesingh R, Biagi J, Wilson JM, Notta F, Fischer SE, Zogopoulos G, Gallinger S, Grant RC, Khokha R, Chan N, Grünwald BT, Knox JJ, O'Kane GM
Br J Cancer 2023 May;128(10):1916-1921. Epub 2023 Mar 16 doi: 10.1038/s41416-023-02214-0. PMID: 36927977Free PMC Article
Keyl J, Kasper S, Wiesweg M, Götze J, Schönrock M, Sinn M, Berger A, Nasca E, Kostbade K, Schumacher B, Markus P, Albers D, Treckmann J, Schmid KW, Schildhaus HU, Siveke JT, Schuler M, Kleesiek J
ESMO Open 2022 Oct;7(5):100555. Epub 2022 Aug 18 doi: 10.1016/j.esmoop.2022.100555. PMID: 35988455Free PMC Article
O'Kane GM, Grünwald BT, Jang GH, Masoomian M, Picardo S, Grant RC, Denroche RE, Zhang A, Wang Y, Lam B, Krzyzanowski PM, Lungu IM, Bartlett JMS, Peralta M, Vyas F, Khokha R, Biagi J, Chadwick D, Ramotar S, Hutchinson S, Dodd A, Wilson JM, Notta F, Zogopoulos G, Gallinger S, Knox JJ, Fischer SE
Clin Cancer Res 2020 Sep 15;26(18):4901-4910. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3724. PMID: 32156747
Christenson ES, Jaffee E, Azad NS
Lancet Oncol 2020 Mar;21(3):e135-e145. doi: 10.1016/S1470-2045(19)30795-8. PMID: 32135117Free PMC Article
Aung KL, Fischer SE, Denroche RE, Jang GH, Dodd A, Creighton S, Southwood B, Liang SB, Chadwick D, Zhang A, O'Kane GM, Albaba H, Moura S, Grant RC, Miller JK, Mbabaali F, Pasternack D, Lungu IM, Bartlett JMS, Ghai S, Lemire M, Holter S, Connor AA, Moffitt RA, Yeh JJ, Timms L, Krzyzanowski PM, Dhani N, Hedley D, Notta F, Wilson JM, Moore MJ, Gallinger S, Knox JJ
Clin Cancer Res 2018 Mar 15;24(6):1344-1354. Epub 2017 Dec 29 doi: 10.1158/1078-0432.CCR-17-2994. PMID: 29288237Free PMC Article

Recent systematic reviews

Buwenge M, Arcelli A, Cellini F, Deodato F, Macchia G, Cilla S, Galietta E, Strigari L, Malizia C, Cammelli S, Morganti AG
Curr Oncol 2022 Apr 11;29(4):2616-2629. doi: 10.3390/curroncol29040214. PMID: 35448188Free PMC Article
Lindemann J, du Toit L, Kotze U, Bernon M, Krige J, Jonas E
HPB (Oxford) 2021 Feb;23(2):173-186. Epub 2020 Oct 22 doi: 10.1016/j.hpb.2020.09.022. PMID: 33268268
Chin V, Nagrial A, Sjoquist K, O'Connor CA, Chantrill L, Biankin AV, Scholten RJ, Yip D
Cochrane Database Syst Rev 2018 Mar 20;3(3):CD011044. doi: 10.1002/14651858.CD011044.pub2. PMID: 29557103Free PMC Article
Schorn S, Demir IE, Reyes CM, Saricaoglu C, Samm N, Schirren R, Tieftrunk E, Hartmann D, Friess H, Ceyhan GO
Cancer Treat Rev 2017 Apr;55:96-106. Epub 2017 Mar 14 doi: 10.1016/j.ctrv.2017.03.003. PMID: 28342938
Nagrial AM, Chin VT, Sjoquist KM, Pajic M, Horvath LG, Biankin AV, Yip D
Crit Rev Oncol Hematol 2015 Dec;96(3):483-97. Epub 2015 Jul 26 doi: 10.1016/j.critrevonc.2015.07.007. PMID: 26481952

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