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Hormone Receptor-Negative Breast Carcinoma

MedGen UID:
1713331
Concept ID:
C5237420
Neoplastic Process
Synonyms: ER and PR Negative Breast Carcinoma; Estrogen Receptor and Progesterone Receptor Negative Breast Carcinoma; Hormone Receptor Negative Breast Adenocarcinoma; Hormone Receptor Negative Breast Carcinoma

Definition

Breast adenocarcinoma that is negative for hormone receptors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHormone Receptor-Negative Breast Carcinoma

Professional guidelines

PubMed

Roy AM, Kumarasamy VM, Dhakal A, O'Regan R, Gandhi S
Cancer 2023 Sep 15;129(18):2773-2788. Epub 2023 Jun 22 doi: 10.1002/cncr.34904. PMID: 37349954Free PMC Article
Wong SM, Golshan M
Ann Surg Oncol 2018 Oct;25(10):2846-2851. Epub 2018 Jun 26 doi: 10.1245/s10434-018-6605-4. PMID: 29947005
Dawood S
Drugs 2010 Dec 3;70(17):2247-58. doi: 10.2165/11538150-000000000-00000. PMID: 21080741

Recent clinical studies

Etiology

Nitz U, Gluz O, Graeser M, Christgen M, Kuemmel S, Grischke EM, Braun M, Augustin D, Potenberg J, Krauss K, Schumacher C, Forstbauer H, Reimer T, Stefek A, Fischer HH, Pelz E, Zu Eulenburg C, Kates R, Wuerstlein R, Kreipe HH, Harbeck N; WSG-ADAPT investigators
Lancet Oncol 2022 May;23(5):625-635. Epub 2022 Apr 8 doi: 10.1016/S1470-2045(22)00159-0. PMID: 35405088
Trabert B, Sherman ME, Kannan N, Stanczyk FZ
Endocr Rev 2020 Apr 1;41(2):320-44. doi: 10.1210/endrev/bnz001. PMID: 31512725Free PMC Article
Collaborative Group on Hormonal Factors in Breast Cancer
Lancet 2019 Sep 28;394(10204):1159-1168. Epub 2019 Aug 29 doi: 10.1016/S0140-6736(19)31709-X. PMID: 31474332Free PMC Article
Moore HC, Unger JM, Phillips KA, Boyle F, Hitre E, Porter D, Francis PA, Goldstein LJ, Gomez HL, Vallejos CS, Partridge AH, Dakhil SR, Garcia AA, Gralow J, Lombard JM, Forbes JF, Martino S, Barlow WE, Fabian CJ, Minasian L, Meyskens FL Jr, Gelber RD, Hortobagyi GN, Albain KS; POEMS/S0230 Investigators
N Engl J Med 2015 Mar 5;372(10):923-32. doi: 10.1056/NEJMoa1413204. PMID: 25738668Free PMC Article
Cortazar P, Zhang L, Untch M, Mehta K, Costantino JP, Wolmark N, Bonnefoi H, Cameron D, Gianni L, Valagussa P, Swain SM, Prowell T, Loibl S, Wickerham DL, Bogaerts J, Baselga J, Perou C, Blumenthal G, Blohmer J, Mamounas EP, Bergh J, Semiglazov V, Justice R, Eidtmann H, Paik S, Piccart M, Sridhara R, Fasching PA, Slaets L, Tang S, Gerber B, Geyer CE Jr, Pazdur R, Ditsch N, Rastogi P, Eiermann W, von Minckwitz G
Lancet 2014 Jul 12;384(9938):164-72. Epub 2014 Feb 14 doi: 10.1016/S0140-6736(13)62422-8. PMID: 24529560

Diagnosis

Monaco ME
Oncotarget 2023 Jun 12;14:563-575. doi: 10.18632/oncotarget.28453. PMID: 37306503Free PMC Article
Quinn CM, D'Arcy C, Wells C
Virchows Arch 2022 Jan;480(1):177-189. Epub 2021 Sep 18 doi: 10.1007/s00428-021-03185-4. PMID: 34537861Free PMC Article
Denkert C, Seither F, Schneeweiss A, Link T, Blohmer JU, Just M, Wimberger P, Forberger A, Tesch H, Jackisch C, Schmatloch S, Reinisch M, Solomayer EF, Schmitt WD, Hanusch C, Fasching PA, Lübbe K, Solbach C, Huober J, Rhiem K, Marmé F, Reimer T, Schmidt M, Sinn BV, Janni W, Stickeler E, Michel L, Stötzer O, Hahnen E, Furlanetto J, Seiler S, Nekljudova V, Untch M, Loibl S
Lancet Oncol 2021 Aug;22(8):1151-1161. Epub 2021 Jul 9 doi: 10.1016/S1470-2045(21)00301-6. PMID: 34252375
Froehlich K, Schmidt A, Heger JI, Al-Kawlani B, Aberl CA, Jeschke U, Loibl S, Markert UR
Eur J Cancer 2019 Jul;115:68-78. Epub 2019 May 20 doi: 10.1016/j.ejca.2019.03.021. PMID: 31121525
Moore HC, Unger JM, Phillips KA, Boyle F, Hitre E, Porter D, Francis PA, Goldstein LJ, Gomez HL, Vallejos CS, Partridge AH, Dakhil SR, Garcia AA, Gralow J, Lombard JM, Forbes JF, Martino S, Barlow WE, Fabian CJ, Minasian L, Meyskens FL Jr, Gelber RD, Hortobagyi GN, Albain KS; POEMS/S0230 Investigators
N Engl J Med 2015 Mar 5;372(10):923-32. doi: 10.1056/NEJMoa1413204. PMID: 25738668Free PMC Article

Therapy

Poggio F, Del Mastro L, Bruzzone M, Ceppi M, Razeti MG, Fregatti P, Ruelle T, Pronzato P, Massarotti C, Franzoi MA, Lambertini M, Tagliamento M
Breast Cancer Res Treat 2022 Jan;191(2):269-275. Epub 2021 Nov 3 doi: 10.1007/s10549-021-06436-9. PMID: 34731351
Tyagi A, Sharma S, Wu K, Wu SY, Xing F, Liu Y, Zhao D, Deshpande RP, D'Agostino RB Jr, Watabe K
Nat Commun 2021 Jan 20;12(1):474. doi: 10.1038/s41467-020-20733-9. PMID: 33473115Free PMC Article
Collaborative Group on Hormonal Factors in Breast Cancer
Lancet 2019 Sep 28;394(10204):1159-1168. Epub 2019 Aug 29 doi: 10.1016/S0140-6736(19)31709-X. PMID: 31474332Free PMC Article
Schmid P, Adams S, Rugo HS, Schneeweiss A, Barrios CH, Iwata H, Diéras V, Hegg R, Im SA, Shaw Wright G, Henschel V, Molinero L, Chui SY, Funke R, Husain A, Winer EP, Loi S, Emens LA; IMpassion130 Trial Investigators
N Engl J Med 2018 Nov 29;379(22):2108-2121. Epub 2018 Oct 20 doi: 10.1056/NEJMoa1809615. PMID: 30345906
Cortazar P, Zhang L, Untch M, Mehta K, Costantino JP, Wolmark N, Bonnefoi H, Cameron D, Gianni L, Valagussa P, Swain SM, Prowell T, Loibl S, Wickerham DL, Bogaerts J, Baselga J, Perou C, Blumenthal G, Blohmer J, Mamounas EP, Bergh J, Semiglazov V, Justice R, Eidtmann H, Paik S, Piccart M, Sridhara R, Fasching PA, Slaets L, Tang S, Gerber B, Geyer CE Jr, Pazdur R, Ditsch N, Rastogi P, Eiermann W, von Minckwitz G
Lancet 2014 Jul 12;384(9938):164-72. Epub 2014 Feb 14 doi: 10.1016/S0140-6736(13)62422-8. PMID: 24529560

Prognosis

van Mackelenbergh MT, Loibl S, Untch M, Buyse M, Geyer CE Jr, Gianni L, Schneeweiss A, Conte P, Piccart M, Bonnefoi H, Jackisch C, Nekljudova V, Tang G, Valagussa P, Neate C, Gelber R, Poncet C, Squifflet P, Saad ED, Heinzmann D, Denkert C, Rastogi P, Cortes J, Guarneri V, de Azambuja E, Cameron D, Ismael G, Wolmark N, Cortazar P; CTNeoBC project
J Clin Oncol 2023 Jun 1;41(16):2998-3008. Epub 2023 Apr 19 doi: 10.1200/JCO.22.02241. PMID: 37075276
Marvalim C, Datta A, Lee SC
Theranostics 2023;13(4):1421-1442. Epub 2023 Feb 27 doi: 10.7150/thno.81847. PMID: 36923534Free PMC Article
Giaquinto AN, Sung H, Miller KD, Kramer JL, Newman LA, Minihan A, Jemal A, Siegel RL
CA Cancer J Clin 2022 Nov;72(6):524-541. Epub 2022 Oct 3 doi: 10.3322/caac.21754. PMID: 36190501
Kuksis M, Gao Y, Tran W, Hoey C, Kiss A, Komorowski AS, Dhaliwal AJ, Sahgal A, Das S, Chan KK, Jerzak KJ
Neuro Oncol 2021 Jun 1;23(6):894-904. doi: 10.1093/neuonc/noaa285. PMID: 33367836Free PMC Article
Cortazar P, Zhang L, Untch M, Mehta K, Costantino JP, Wolmark N, Bonnefoi H, Cameron D, Gianni L, Valagussa P, Swain SM, Prowell T, Loibl S, Wickerham DL, Bogaerts J, Baselga J, Perou C, Blumenthal G, Blohmer J, Mamounas EP, Bergh J, Semiglazov V, Justice R, Eidtmann H, Paik S, Piccart M, Sridhara R, Fasching PA, Slaets L, Tang S, Gerber B, Geyer CE Jr, Pazdur R, Ditsch N, Rastogi P, Eiermann W, von Minckwitz G
Lancet 2014 Jul 12;384(9938):164-72. Epub 2014 Feb 14 doi: 10.1016/S0140-6736(13)62422-8. PMID: 24529560

Clinical prediction guides

van Mackelenbergh MT, Loibl S, Untch M, Buyse M, Geyer CE Jr, Gianni L, Schneeweiss A, Conte P, Piccart M, Bonnefoi H, Jackisch C, Nekljudova V, Tang G, Valagussa P, Neate C, Gelber R, Poncet C, Squifflet P, Saad ED, Heinzmann D, Denkert C, Rastogi P, Cortes J, Guarneri V, de Azambuja E, Cameron D, Ismael G, Wolmark N, Cortazar P; CTNeoBC project
J Clin Oncol 2023 Jun 1;41(16):2998-3008. Epub 2023 Apr 19 doi: 10.1200/JCO.22.02241. PMID: 37075276
Yau C, Osdoit M, van der Noordaa M, Shad S, Wei J, de Croze D, Hamy AS, Laé M, Reyal F, Sonke GS, Steenbruggen TG, van Seijen M, Wesseling J, Martín M, Del Monte-Millán M, López-Tarruella S; I-SPY 2 Trial Consortium, Boughey JC, Goetz MP, Hoskin T, Gould R, Valero V, Edge SB, Abraham JE, Bartlett JMS, Caldas C, Dunn J, Earl H, Hayward L, Hiller L, Provenzano E, Sammut SJ, Thomas JS, Cameron D, Graham A, Hall P, Mackintosh L, Fan F, Godwin AK, Schwensen K, Sharma P, DeMichele AM, Cole K, Pusztai L, Kim MO, van 't Veer LJ, Esserman LJ, Symmans WF
Lancet Oncol 2022 Jan;23(1):149-160. Epub 2021 Dec 11 doi: 10.1016/S1470-2045(21)00589-1. PMID: 34902335Free PMC Article
Froehlich K, Schmidt A, Heger JI, Al-Kawlani B, Aberl CA, Jeschke U, Loibl S, Markert UR
Eur J Cancer 2019 Jul;115:68-78. Epub 2019 May 20 doi: 10.1016/j.ejca.2019.03.021. PMID: 31121525
Cortazar P, Zhang L, Untch M, Mehta K, Costantino JP, Wolmark N, Bonnefoi H, Cameron D, Gianni L, Valagussa P, Swain SM, Prowell T, Loibl S, Wickerham DL, Bogaerts J, Baselga J, Perou C, Blumenthal G, Blohmer J, Mamounas EP, Bergh J, Semiglazov V, Justice R, Eidtmann H, Paik S, Piccart M, Sridhara R, Fasching PA, Slaets L, Tang S, Gerber B, Geyer CE Jr, Pazdur R, Ditsch N, Rastogi P, Eiermann W, von Minckwitz G
Lancet 2014 Jul 12;384(9938):164-72. Epub 2014 Feb 14 doi: 10.1016/S0140-6736(13)62422-8. PMID: 24529560
Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L, Wolmark N
J Natl Cancer Inst 1998 Sep 16;90(18):1371-88. doi: 10.1093/jnci/90.18.1371. PMID: 9747868

Recent systematic reviews

Poggio F, Del Mastro L, Bruzzone M, Ceppi M, Razeti MG, Fregatti P, Ruelle T, Pronzato P, Massarotti C, Franzoi MA, Lambertini M, Tagliamento M
Breast Cancer Res Treat 2022 Jan;191(2):269-275. Epub 2021 Nov 3 doi: 10.1007/s10549-021-06436-9. PMID: 34731351
Hoon SN, Lau PK, White AM, Bulsara MK, Banks PD, Redfern AD
Cochrane Database Syst Rev 2021 May 26;5(5):CD011220. doi: 10.1002/14651858.CD011220.pub2. PMID: 34037241Free PMC Article
Kuksis M, Gao Y, Tran W, Hoey C, Kiss A, Komorowski AS, Dhaliwal AJ, Sahgal A, Das S, Chan KK, Jerzak KJ
Neuro Oncol 2021 Jun 1;23(6):894-904. doi: 10.1093/neuonc/noaa285. PMID: 33367836Free PMC Article
Islami F, Liu Y, Jemal A, Zhou J, Weiderpass E, Colditz G, Boffetta P, Weiss M
Ann Oncol 2015 Dec;26(12):2398-407. Epub 2015 Oct 26 doi: 10.1093/annonc/mdv379. PMID: 26504151Free PMC Article
Althuis MD, Fergenbaum JH, Garcia-Closas M, Brinton LA, Madigan MP, Sherman ME
Cancer Epidemiol Biomarkers Prev 2004 Oct;13(10):1558-68. PMID: 15466970

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