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Locally Advanced Breast Adenocarcinoma

MedGen UID:
1714254
Concept ID:
C5239505
Neoplastic Process

Definition

Breast adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Thomas M, Kelly ED, Abraham J, Kruse M
Semin Oncol 2019 Apr;46(2):121-132. Epub 2019 Jun 17 doi: 10.1053/j.seminoncol.2019.03.002. PMID: 31239068
McCARTAN D, Gemignani ML
Clin Obstet Gynecol 2016 Dec;59(4):743-755. doi: 10.1097/GRF.0000000000000232. PMID: 27660930Free PMC Article
Ahmed M, Rubio IT, Klaase JM, Douek M
Nat Rev Clin Oncol 2015 Nov;12(11):645-63. Epub 2015 Sep 29 doi: 10.1038/nrclinonc.2015.161. PMID: 26416152

Recent clinical studies

Etiology

Risom T, Glass DR, Averbukh I, Liu CC, Baranski A, Kagel A, McCaffrey EF, Greenwald NF, Rivero-Gutiérrez B, Strand SH, Varma S, Kong A, Keren L, Srivastava S, Zhu C, Khair Z, Veis DJ, Deschryver K, Vennam S, Maley C, Hwang ES, Marks JR, Bendall SC, Colditz GA, West RB, Angelo M
Cell 2022 Jan 20;185(2):299-310.e18. doi: 10.1016/j.cell.2021.12.023. PMID: 35063072Free PMC Article
Aebi S, Karlsson P, Wapnir IL
Breast 2022 Mar;62 Suppl 1(Suppl 1):S58-S62. Epub 2021 Dec 15 doi: 10.1016/j.breast.2021.12.011. PMID: 34930650Free PMC Article
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Gianni L, Eiermann W, Semiglazov V, Manikhas A, Lluch A, Tjulandin S, Zambetti M, Vazquez F, Byakhow M, Lichinitser M, Climent MA, Ciruelos E, Ojeda B, Mansutti M, Bozhok A, Baronio R, Feyereislova A, Barton C, Valagussa P, Baselga J
Lancet 2010 Jan 30;375(9712):377-84. doi: 10.1016/S0140-6736(09)61964-4. PMID: 20113825
Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Lønning PE, Børresen-Dale AL
Proc Natl Acad Sci U S A 2001 Sep 11;98(19):10869-74. doi: 10.1073/pnas.191367098. PMID: 11553815Free PMC Article

Diagnosis

Asif B, Sarvestani AL, Gamble LA, Samaranayake SG, Famiglietti AL, Fasaye GA, Quezado M, Miettinen M, Korman L, Koh C, Heller T, Davis JL
Lancet Oncol 2023 Apr;24(4):383-391. doi: 10.1016/S1470-2045(23)00057-8. PMID: 36990610Free PMC Article
Lagios MD
Breast J 2020 Jun;26(6):1132-1137. Epub 2020 May 10 doi: 10.1111/tbj.13860. PMID: 32390260
Thomas M, Kelly ED, Abraham J, Kruse M
Semin Oncol 2019 Apr;46(2):121-132. Epub 2019 Jun 17 doi: 10.1053/j.seminoncol.2019.03.002. PMID: 31239068
Loktev A, Lindner T, Mier W, Debus J, Altmann A, Jäger D, Giesel F, Kratochwil C, Barthe P, Roumestand C, Haberkorn U
J Nucl Med 2018 Sep;59(9):1423-1429. Epub 2018 Apr 6 doi: 10.2967/jnumed.118.210435. PMID: 29626120Free PMC Article
Bettegowda C, Sausen M, Leary RJ, Kinde I, Wang Y, Agrawal N, Bartlett BR, Wang H, Luber B, Alani RM, Antonarakis ES, Azad NS, Bardelli A, Brem H, Cameron JL, Lee CC, Fecher LA, Gallia GL, Gibbs P, Le D, Giuntoli RL, Goggins M, Hogarty MD, Holdhoff M, Hong SM, Jiao Y, Juhl HH, Kim JJ, Siravegna G, Laheru DA, Lauricella C, Lim M, Lipson EJ, Marie SK, Netto GJ, Oliner KS, Olivi A, Olsson L, Riggins GJ, Sartore-Bianchi A, Schmidt K, Shih lM, Oba-Shinjo SM, Siena S, Theodorescu D, Tie J, Harkins TT, Veronese S, Wang TL, Weingart JD, Wolfgang CL, Wood LD, Xing D, Hruban RH, Wu J, Allen PJ, Schmidt CM, Choti MA, Velculescu VE, Kinzler KW, Vogelstein B, Papadopoulos N, Diaz LA Jr
Sci Transl Med 2014 Feb 19;6(224):224ra24. doi: 10.1126/scitranslmed.3007094. PMID: 24553385Free PMC Article

Therapy

Asif B, Sarvestani AL, Gamble LA, Samaranayake SG, Famiglietti AL, Fasaye GA, Quezado M, Miettinen M, Korman L, Koh C, Heller T, Davis JL
Lancet Oncol 2023 Apr;24(4):383-391. doi: 10.1016/S1470-2045(23)00057-8. PMID: 36990610Free PMC Article
Aebi S, Karlsson P, Wapnir IL
Breast 2022 Mar;62 Suppl 1(Suppl 1):S58-S62. Epub 2021 Dec 15 doi: 10.1016/j.breast.2021.12.011. PMID: 34930650Free PMC Article
Deeks ED
Drugs 2021 Nov;81(16):1929-1935. doi: 10.1007/s40265-021-01614-x. PMID: 34661865
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Gianni L, Eiermann W, Semiglazov V, Manikhas A, Lluch A, Tjulandin S, Zambetti M, Vazquez F, Byakhow M, Lichinitser M, Climent MA, Ciruelos E, Ojeda B, Mansutti M, Bozhok A, Baronio R, Feyereislova A, Barton C, Valagussa P, Baselga J
Lancet 2010 Jan 30;375(9712):377-84. doi: 10.1016/S0140-6736(09)61964-4. PMID: 20113825

Prognosis

MacColl CE, Paré G, Salehi A, Hodgson N, Williams P
Am J Surg Pathol 2021 Apr 1;45(4):537-542. doi: 10.1097/PAS.0000000000001610. PMID: 33105157
Jones RH, Casbard A, Carucci M, Cox C, Butler R, Alchami F, Madden TA, Bale C, Bezecny P, Joffe J, Moon S, Twelves C, Venkitaraman R, Waters S, Foxley A, Howell SJ
Lancet Oncol 2020 Mar;21(3):345-357. Epub 2020 Feb 5 doi: 10.1016/S1470-2045(19)30817-4. PMID: 32035020Free PMC Article
Loktev A, Lindner T, Mier W, Debus J, Altmann A, Jäger D, Giesel F, Kratochwil C, Barthe P, Roumestand C, Haberkorn U
J Nucl Med 2018 Sep;59(9):1423-1429. Epub 2018 Apr 6 doi: 10.2967/jnumed.118.210435. PMID: 29626120Free PMC Article
Gianni L, Eiermann W, Semiglazov V, Manikhas A, Lluch A, Tjulandin S, Zambetti M, Vazquez F, Byakhow M, Lichinitser M, Climent MA, Ciruelos E, Ojeda B, Mansutti M, Bozhok A, Baronio R, Feyereislova A, Barton C, Valagussa P, Baselga J
Lancet 2010 Jan 30;375(9712):377-84. doi: 10.1016/S0140-6736(09)61964-4. PMID: 20113825
Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Lønning PE, Børresen-Dale AL
Proc Natl Acad Sci U S A 2001 Sep 11;98(19):10869-74. doi: 10.1073/pnas.191367098. PMID: 11553815Free PMC Article

Clinical prediction guides

Estephan F, Lap CJ, Banagan J, Antonio M, Liu S, Diao G, Rozalen AZ, Rajendran R, Krasnow S, Subrahmanyam R, Nava VE, Jain M
Ann Diagn Pathol 2023 Dec;67:152219. Epub 2023 Oct 20 doi: 10.1016/j.anndiagpath.2023.152219. PMID: 38622987
Llinàs-Arias P, Ensenyat-Mendez M, Íñiguez-Muñoz S, Orozco JIJ, Valdez B, Salomon MP, Matsuba C, Solivellas-Pieras M, Bedoya-López AF, Sesé B, Mezger A, Ormestad M, Unzueta F, Strand SH, Boiko AD, Hwang ES, Cortés J, DiNome ML, Esteller M, Lupien M, Marzese DM
Mol Cancer 2023 Nov 28;22(1):190. doi: 10.1186/s12943-023-01906-8. PMID: 38017545Free PMC Article
Nakayama I, Takahari D, Chin K, Wakatsuki T, Takamatsu M, Yamamoto N, Ogura M, Ooki A, Fukuda K, Osumi H, Fukuoka S, Shinozaki E, Yamaguchi K
ESMO Open 2023 Aug;8(4):101582. Epub 2023 Jun 20 doi: 10.1016/j.esmoop.2023.101582. PMID: 37348349Free PMC Article
Paulinelli RR, Ribeiro LFJ, Santos TD, Caires EMS, Pontes MGM, Faria BM, Luz MV, Faria SFC, Freitas-Junior R
Surg Oncol 2021 Dec;39:101660. Epub 2021 Sep 20 doi: 10.1016/j.suronc.2021.101660. PMID: 34555692
Wong SM, Chun YS, Sagara Y, Golshan M, Erdmann-Sager J
Ann Surg Oncol 2019 Oct;26(10):3194-3203. Epub 2019 Jul 24 doi: 10.1245/s10434-019-07554-x. PMID: 31342383

Recent systematic reviews

Blanckaert M, Vranckx J
Acta Chir Belg 2021 Jun;121(3):155-163. Epub 2021 May 5 doi: 10.1080/00015458.2021.1922829. PMID: 33929924
Choi B, Jegatheeswaran L, Nakhoul M, Haria P, Srivastava R, Karki S, Lupi M, Patel V, Chakravorty A, Babu E
Surg Oncol 2021 Jun;37:101557. Epub 2021 Mar 31 doi: 10.1016/j.suronc.2021.101557. PMID: 33819852
Rebelatto TF, Falavigna M, Pozzari M, Spada F, Cella CA, Laffi A, Pellicori S, Fazio N
Cancer Treat Rev 2019 Nov;80:101895. Epub 2019 Sep 6 doi: 10.1016/j.ctrv.2019.101895. PMID: 31542591
Van der Hoeven NMA, Van Wijk K, Bonfrer SE, Beltman JJ, Louwe LA, De Kroon CD, Van Asperen CJ, Gaarenstroom KN
Clin Oncol (R Coll Radiol) 2018 Aug;30(8):463-471. Epub 2018 Apr 22 doi: 10.1016/j.clon.2018.03.036. PMID: 29691126
Stuart KE, Houssami N, Taylor R, Hayen A, Boyages J
BMC Cancer 2015 Nov 10;15:890. doi: 10.1186/s12885-015-1904-7. PMID: 26555555Free PMC Article

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