U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Renal interstitial hemorrhage

MedGen UID:
1715002
•Concept ID:
C5397638
•
Pathologic Function
Synonym: Renal interstitial haemorrhage
 
HPO: HP:0032617

Definition

A focal collection of 20 or more red blood cells within the interstitium, that is irregular in shape (i.e., collections do not conform to the shape of tubules or capillary networks), without surrounding endothelium or tubular epithelium, and is in an area of intact core. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRenal interstitial hemorrhage

Professional guidelines

PubMed

Management of acute kidney injury in symptomatic multiple myeloma.
Bridoux F, Leung N, Belmouaz M, Royal V, Ronco P, Nasr SH, Fermand JP; International Kidney and Monoclonal Gammopathy Research Group
Kidney Int 2021 Mar;99(3):570-580. Epub 2021 Jan 10 doi: 10.1016/j.kint.2020.11.010. PMID: 33440212
Urine Sediment Examination in the Diagnosis and Management of Kidney Disease: Core Curriculum 2019.
Cavanaugh C, Perazella MA
Am J Kidney Dis 2019 Feb;73(2):258-272. Epub 2018 Sep 21 doi: 10.1053/j.ajkd.2018.07.012. PMID: 30249419
International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease.
Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, Simpson D, Liu AY, Menke D, Chandrakasan S, Lechowicz MJ, Wong RS, Pierson S, Paessler M, Rossi JF, Ide M, Ruth J, Croglio M, Suarez A, Krymskaya V, Chadburn A, Colleoni G, Nasta S, Jayanthan R, Nabel CS, Casper C, Dispenzieri A, Fosså A, Kelleher D, Kurzrock R, Voorhees P, Dogan A, Yoshizaki K, van Rhee F, Oksenhendler E, Jaffe ES, Elenitoba-Johnson KS, Lim MS
Blood 2017 Mar 23;129(12):1646-1657. Epub 2017 Jan 13 doi: 10.1182/blood-2016-10-746933. PMID: 28087540Free PMC Article

Recent clinical studies

Etiology

Imaging findings of COPA Syndrome.
Nguyen HN, Salman R, Vogel TP, Silva-Carmona M, DeGuzman M, Guillerman RP
Pediatr Radiol 2023 May;53(5):844-853. Epub 2023 Feb 7 doi: 10.1007/s00247-023-05600-1. PMID: 36746811
The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials.
Haas M, Loupy A, Lefaucheur C, Roufosse C, Glotz D, Seron D, Nankivell BJ, Halloran PF, Colvin RB, Akalin E, Alachkar N, Bagnasco S, Bouatou Y, Becker JU, Cornell LD, Duong van Huyen JP, Gibson IW, Kraus ES, Mannon RB, Naesens M, Nickeleit V, Nickerson P, Segev DL, Singh HK, Stegall M, Randhawa P, Racusen L, Solez K, Mengel M
Am J Transplant 2018 Feb;18(2):293-307. Epub 2018 Jan 21 doi: 10.1111/ajt.14625. PMID: 29243394Free PMC Article
International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease.
Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, Simpson D, Liu AY, Menke D, Chandrakasan S, Lechowicz MJ, Wong RS, Pierson S, Paessler M, Rossi JF, Ide M, Ruth J, Croglio M, Suarez A, Krymskaya V, Chadburn A, Colleoni G, Nasta S, Jayanthan R, Nabel CS, Casper C, Dispenzieri A, Fosså A, Kelleher D, Kurzrock R, Voorhees P, Dogan A, Yoshizaki K, van Rhee F, Oksenhendler E, Jaffe ES, Elenitoba-Johnson KS, Lim MS
Blood 2017 Mar 23;129(12):1646-1657. Epub 2017 Jan 13 doi: 10.1182/blood-2016-10-746933. PMID: 28087540Free PMC Article
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001
Leptospiral nephropathy.
Sitprija V, Losuwanrak K, Kanjanabuch T
Semin Nephrol 2003 Jan;23(1):42-8. doi: 10.1053/snep.2003.50004. PMID: 12563600

Diagnosis

Glomerulonephritis Histopathological Pattern Change.
AlYousef A, AlSahow A, AlHelal B, Alqallaf A, Abdallah E, Abdellatif M, Nawar H, Elmahalawy R
BMC Nephrol 2020 May 18;21(1):186. doi: 10.1186/s12882-020-01836-3. PMID: 32423387Free PMC Article
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001
IgG4-related kidney disease.
Saeki T, Kawano M
Kidney Int 2014 Feb;85(2):251-7. Epub 2013 Oct 9 doi: 10.1038/ki.2013.393. PMID: 24107849
Eosinophiluria.
Nolan CR 3rd, Kelleher SP
Clin Lab Med 1988 Sep;8(3):555-65. PMID: 2458885
Urinary eosinophils.
Sutton JM
Arch Intern Med 1986 Nov;146(11):2243-4. PMID: 3535716

Therapy

Acute Kidney Injury in Cancer Immunotherapy Recipients.
Joseph A, Lafarge A, Azoulay E, Zafrani L
Cells 2022 Dec 10;11(24) doi: 10.3390/cells11243991. PMID: 36552755Free PMC Article
Mouse Models of Diabetes, Obesity and Related Kidney Disease.
Glastras SJ, Chen H, Teh R, McGrath RT, Chen J, Pollock CA, Wong MG, Saad S
PLoS One 2016;11(8):e0162131. Epub 2016 Aug 31 doi: 10.1371/journal.pone.0162131. PMID: 27579698Free PMC Article
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001
IgG4-related kidney disease.
Saeki T, Kawano M
Kidney Int 2014 Feb;85(2):251-7. Epub 2013 Oct 9 doi: 10.1038/ki.2013.393. PMID: 24107849
Snakebite nephropathy.
Sitprija V
Nephrology (Carlton) 2006 Oct;11(5):442-8. doi: 10.1111/j.1440-1797.2006.00599.x. PMID: 17014559

Prognosis

Comparative study on clinicopathological features and prognosis of IgA vasculitis nephritis and IgA nephropathy in children.
Lv Y, Fu R, Peng XJ, Wang Y, Yin TT, Deng YQ
BMC Pediatr 2023 Aug 24;23(1):423. doi: 10.1186/s12887-023-04243-3. PMID: 37620917Free PMC Article
Acute Kidney Injury in Cancer Immunotherapy Recipients.
Joseph A, Lafarge A, Azoulay E, Zafrani L
Cells 2022 Dec 10;11(24) doi: 10.3390/cells11243991. PMID: 36552755Free PMC Article
The Incidence, Causes, and Risk Factors of Acute Kidney Injury in Patients Receiving Immune Checkpoint Inhibitors.
Seethapathy H, Zhao S, Chute DF, Zubiri L, Oppong Y, Strohbehn I, Cortazar FB, Leaf DE, Mooradian MJ, Villani AC, Sullivan RJ, Reynolds K, Sise ME
Clin J Am Soc Nephrol 2019 Dec 6;14(12):1692-1700. Epub 2019 Oct 31 doi: 10.2215/CJN.00990119. PMID: 31672794Free PMC Article
Monoclonal gammopathies of renal significance.
Caravaca-Fontán F, Gutiérrez E, Delgado Lillo R, Praga M
Nefrologia 2017 Sep-Oct;37(5):465-477. doi: 10.1016/j.nefro.2017.03.012. PMID: 28946960
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001

Clinical prediction guides

Glomerulonephritis Histopathological Pattern Change.
AlYousef A, AlSahow A, AlHelal B, Alqallaf A, Abdallah E, Abdellatif M, Nawar H, Elmahalawy R
BMC Nephrol 2020 May 18;21(1):186. doi: 10.1186/s12882-020-01836-3. PMID: 32423387Free PMC Article
Fluid Volume Overload and Congestion in Heart Failure: Time to Reconsider Pathophysiology and How Volume Is Assessed.
Miller WL
Circ Heart Fail 2016 Aug;9(8):e002922. doi: 10.1161/CIRCHEARTFAILURE.115.002922. PMID: 27436837
IgG4-related kidney disease.
Saeki T, Kawano M
Kidney Int 2014 Feb;85(2):251-7. Epub 2013 Oct 9 doi: 10.1038/ki.2013.393. PMID: 24107849
IgG4-related kidney disease.
Cornell LD
Semin Diagn Pathol 2012 Nov;29(4):245-50. doi: 10.1053/j.semdp.2012.07.004. PMID: 23068304
Leptospiral nephropathy.
Sitprija V, Losuwanrak K, Kanjanabuch T
Semin Nephrol 2003 Jan;23(1):42-8. doi: 10.1053/snep.2003.50004. PMID: 12563600

Recent systematic reviews

Potential Renal Damage Biomarkers in Alport Syndrome-A Review of the Literature.
Gomes AM, Lopes D, Almeida C, Santos S, Malheiro J, Lousa I, Caldas Afonso A, Beirão I
Int J Mol Sci 2022 Jun 30;23(13) doi: 10.3390/ijms23137276. PMID: 35806283Free PMC Article
Biopsy-proven kidney involvement in hypocomplementemic urticarial vasculitis.
Corthier A, Jachiet M, Bertin D, Servais A, Barbet C, Bigot A, Doutre MS, Bessis D, Bouffandeau A, Moranne O, Jarrot PA, Bardin N, Terrier B, Burtey S, Puéchal X, Daniel L, Jourde-Chiche N
BMC Nephrol 2022 Feb 16;23(1):67. doi: 10.1186/s12882-022-02689-8. PMID: 35172758Free PMC Article
Predictability of the Oxford classification of IgA nephropathy in Henoch-Schonlein purpura nephritis.
Luo X, Tan J, Wan D, Chen J, Hu Y
Int Urol Nephrol 2022 Jan;54(1):99-109. Epub 2021 Apr 27 doi: 10.1007/s11255-021-02861-3. PMID: 33905044
Survival after lung transplantation in systemic sclerosis. A systematic review.
Khan IY, Singer LG, de Perrot M, Granton JT, Keshavjee S, Chau C, Kron A, Johnson SR
Respir Med 2013 Dec;107(12):2081-7. Epub 2013 Sep 26 doi: 10.1016/j.rmed.2013.09.015. PMID: 24113572
Evaluation of the Oxford Classification of IgA nephropathy: a systematic review and meta-analysis.
Lv J, Shi S, Xu D, Zhang H, Troyanov S, Cattran DC, Wang H
Am J Kidney Dis 2013 Nov;62(5):891-9. Epub 2013 Jun 29 doi: 10.1053/j.ajkd.2013.04.021. PMID: 23820066

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...