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Unresectable Neuroendocrine Tumor

MedGen UID:
1715529
•Concept ID:
C5237194
•
Neoplastic Process
Synonym: Unresectable Well Differentiated Neuroendocrine Neoplasm

Definition

A neuroendocrine tumor that is not amenable to surgical resection. [from NCI]

Professional guidelines

PubMed

Initial Treatment of Unresectable Neuroendocrine Tumor Liver Metastases with Transarterial Chemoembolization using Streptozotocin: A 20-Year Experience.
Dhir M, Shrestha R, Steel JL, Marsh JW, Tsung A, Tublin ME, Amesur NB, Orons PD, Santos E, Geller DA
Ann Surg Oncol 2017 Feb;24(2):450-459. Epub 2016 Sep 23 doi: 10.1245/s10434-016-5591-7. PMID: 27663565

Recent clinical studies

Etiology

Initial Treatment of Unresectable Neuroendocrine Tumor Liver Metastases with Transarterial Chemoembolization using Streptozotocin: A 20-Year Experience.
Dhir M, Shrestha R, Steel JL, Marsh JW, Tsung A, Tublin ME, Amesur NB, Orons PD, Santos E, Geller DA
Ann Surg Oncol 2017 Feb;24(2):450-459. Epub 2016 Sep 23 doi: 10.1245/s10434-016-5591-7. PMID: 27663565
Efficacy of endoscopic ultrasonography-guided fine needle aspiration for pancreatic neuroendocrine tumor grading.
Sugimoto M, Takagi T, Hikichi T, Suzuki R, Watanabe K, Nakamura J, Kikuchi H, Konno N, Waragai Y, Asama H, Takasumi M, Watanabe H, Obara K, Ohira H
World J Gastroenterol 2015 Jul 14;21(26):8118-24. doi: 10.3748/wjg.v21.i26.8118. PMID: 26185384Free PMC Article
Radioembolization with yttrium-90 resin microspheres for neuroendocrine tumor liver metastases.
Peker A, Çiçek O, Soydal Ç, Küçük NÖ, Bilgiç S
Diagn Interv Radiol 2015 Jan-Feb;21(1):54-9. doi: 10.5152/dir.2014.14036. PMID: 25430526Free PMC Article
Liver transplantation for unresectable neuroendocrine tumor liver metastases.
Rossi RE, Burroughs AK, Caplin ME
Ann Surg Oncol 2014 Jul;21(7):2398-405. Epub 2014 Feb 22 doi: 10.1245/s10434-014-3523-y. PMID: 24562931

Diagnosis

Efficacy of endoscopic ultrasonography-guided fine needle aspiration for pancreatic neuroendocrine tumor grading.
Sugimoto M, Takagi T, Hikichi T, Suzuki R, Watanabe K, Nakamura J, Kikuchi H, Konno N, Waragai Y, Asama H, Takasumi M, Watanabe H, Obara K, Ohira H
World J Gastroenterol 2015 Jul 14;21(26):8118-24. doi: 10.3748/wjg.v21.i26.8118. PMID: 26185384Free PMC Article
Liver transplantation for unresectable neuroendocrine tumor liver metastases.
Rossi RE, Burroughs AK, Caplin ME
Ann Surg Oncol 2014 Jul;21(7):2398-405. Epub 2014 Feb 22 doi: 10.1245/s10434-014-3523-y. PMID: 24562931

Therapy

Phase 1b study of pasireotide, everolimus, and selective internal radioembolization therapy for unresectable neuroendocrine tumors with hepatic metastases.
Kim HS, Shaib WL, Zhang C, Nagaraju GP, Wu C, Alese OB, Chen Z, Brutcher E, Renfroe M, El-Rayes BF
Cancer 2018 May 1;124(9):1992-2000. Epub 2018 Feb 16 doi: 10.1002/cncr.31192. PMID: 29451701
Initial Treatment of Unresectable Neuroendocrine Tumor Liver Metastases with Transarterial Chemoembolization using Streptozotocin: A 20-Year Experience.
Dhir M, Shrestha R, Steel JL, Marsh JW, Tsung A, Tublin ME, Amesur NB, Orons PD, Santos E, Geller DA
Ann Surg Oncol 2017 Feb;24(2):450-459. Epub 2016 Sep 23 doi: 10.1245/s10434-016-5591-7. PMID: 27663565
Radioembolization with yttrium-90 resin microspheres for neuroendocrine tumor liver metastases.
Peker A, Çiçek O, Soydal Ç, Küçük NÖ, Bilgiç S
Diagn Interv Radiol 2015 Jan-Feb;21(1):54-9. doi: 10.5152/dir.2014.14036. PMID: 25430526Free PMC Article
Liver transplantation for unresectable neuroendocrine tumor liver metastases.
Rossi RE, Burroughs AK, Caplin ME
Ann Surg Oncol 2014 Jul;21(7):2398-405. Epub 2014 Feb 22 doi: 10.1245/s10434-014-3523-y. PMID: 24562931
Factors predicting response and survival after yttrium-90 radioembolization of unresectable neuroendocrine tumor liver metastases: a critical appraisal of 48 cases.
Saxena A, Chua TC, Bester L, Kokandi A, Morris DL
Ann Surg 2010 May;251(5):910-6. doi: 10.1097/SLA.0b013e3181d3d24a. PMID: 20395859

Prognosis

Initial Treatment of Unresectable Neuroendocrine Tumor Liver Metastases with Transarterial Chemoembolization using Streptozotocin: A 20-Year Experience.
Dhir M, Shrestha R, Steel JL, Marsh JW, Tsung A, Tublin ME, Amesur NB, Orons PD, Santos E, Geller DA
Ann Surg Oncol 2017 Feb;24(2):450-459. Epub 2016 Sep 23 doi: 10.1245/s10434-016-5591-7. PMID: 27663565
Efficacy of endoscopic ultrasonography-guided fine needle aspiration for pancreatic neuroendocrine tumor grading.
Sugimoto M, Takagi T, Hikichi T, Suzuki R, Watanabe K, Nakamura J, Kikuchi H, Konno N, Waragai Y, Asama H, Takasumi M, Watanabe H, Obara K, Ohira H
World J Gastroenterol 2015 Jul 14;21(26):8118-24. doi: 10.3748/wjg.v21.i26.8118. PMID: 26185384Free PMC Article
Radioembolization with yttrium-90 resin microspheres for neuroendocrine tumor liver metastases.
Peker A, Çiçek O, Soydal Ç, Küçük NÖ, Bilgiç S
Diagn Interv Radiol 2015 Jan-Feb;21(1):54-9. doi: 10.5152/dir.2014.14036. PMID: 25430526Free PMC Article
Liver transplantation for unresectable neuroendocrine tumor liver metastases.
Rossi RE, Burroughs AK, Caplin ME
Ann Surg Oncol 2014 Jul;21(7):2398-405. Epub 2014 Feb 22 doi: 10.1245/s10434-014-3523-y. PMID: 24562931
Factors predicting response and survival after yttrium-90 radioembolization of unresectable neuroendocrine tumor liver metastases: a critical appraisal of 48 cases.
Saxena A, Chua TC, Bester L, Kokandi A, Morris DL
Ann Surg 2010 May;251(5):910-6. doi: 10.1097/SLA.0b013e3181d3d24a. PMID: 20395859

Clinical prediction guides

Phase 1b study of pasireotide, everolimus, and selective internal radioembolization therapy for unresectable neuroendocrine tumors with hepatic metastases.
Kim HS, Shaib WL, Zhang C, Nagaraju GP, Wu C, Alese OB, Chen Z, Brutcher E, Renfroe M, El-Rayes BF
Cancer 2018 May 1;124(9):1992-2000. Epub 2018 Feb 16 doi: 10.1002/cncr.31192. PMID: 29451701
Initial Treatment of Unresectable Neuroendocrine Tumor Liver Metastases with Transarterial Chemoembolization using Streptozotocin: A 20-Year Experience.
Dhir M, Shrestha R, Steel JL, Marsh JW, Tsung A, Tublin ME, Amesur NB, Orons PD, Santos E, Geller DA
Ann Surg Oncol 2017 Feb;24(2):450-459. Epub 2016 Sep 23 doi: 10.1245/s10434-016-5591-7. PMID: 27663565
Efficacy of endoscopic ultrasonography-guided fine needle aspiration for pancreatic neuroendocrine tumor grading.
Sugimoto M, Takagi T, Hikichi T, Suzuki R, Watanabe K, Nakamura J, Kikuchi H, Konno N, Waragai Y, Asama H, Takasumi M, Watanabe H, Obara K, Ohira H
World J Gastroenterol 2015 Jul 14;21(26):8118-24. doi: 10.3748/wjg.v21.i26.8118. PMID: 26185384Free PMC Article
Liver transplantation for unresectable neuroendocrine tumor liver metastases.
Rossi RE, Burroughs AK, Caplin ME
Ann Surg Oncol 2014 Jul;21(7):2398-405. Epub 2014 Feb 22 doi: 10.1245/s10434-014-3523-y. PMID: 24562931
Factors predicting response and survival after yttrium-90 radioembolization of unresectable neuroendocrine tumor liver metastases: a critical appraisal of 48 cases.
Saxena A, Chua TC, Bester L, Kokandi A, Morris DL
Ann Surg 2010 May;251(5):910-6. doi: 10.1097/SLA.0b013e3181d3d24a. PMID: 20395859

Recent systematic reviews

Radioembolization and chemoembolization for unresectable neuroendocrine liver metastases - a systematic review.
Yang TX, Chua TC, Morris DL
Surg Oncol 2012 Dec;21(4):299-308. Epub 2012 Jul 28 doi: 10.1016/j.suronc.2012.07.001. PMID: 22846894

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