U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal diffusion weighted cerebral MRI morphology

MedGen UID:
1716407
•Concept ID:
C5397636
•
Finding
Synonyms: Diffusion weighted imaging (DWI) abnormality; Diffusion weighted magnetic resonance imaging (DWI) abnormality; MRI diffusion abnormality of the cerebrum
 
HPO: HP:0032615

Definition

A diffusion abnormality observed in diffusion-weighted magnetic resonance imaging (MRI) of the brain. Molecular diffusion refers to the notion that any type of molecule in a fluid (eg, water) is randomly displaced as the molecule is agitated by thermal energy. Restricted diffusion of water appears bright on diffusion-weighted images. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal diffusion weighted cerebral MRI morphology

Conditions with this feature

Mitochondrial complex 1 deficiency, nuclear type 34
MedGen UID:
1720533
•Concept ID:
C5394053
•
Disease or Syndrome
See: Condition Record
Mitochondrial complex 1 deficiency, nuclear type 34

Professional guidelines

PubMed

Expert consensus on the clinical practice of neonatal brain magnetic resonance imaging.
Neonatologist Society, Chinese Medical Doctor Association; Editorial Board of Chinese Journal of Contemporary Pediatrics
Zhongguo Dang Dai Er Ke Za Zhi 2022 Jan 15;24(1):14-25. doi: 10.7499/j.issn.1008-8830.2110018. PMID: 35177171Free PMC Article
Diffusion-weighted MRI as a biomarker for treatment response in glioma.
Schmainda KM
CNS Oncol 2012 Nov;1(2):169-80. doi: 10.2217/cns.12.25. PMID: 23936625Free PMC Article
Significance of MRI in diagnosis and differential diagnosis of Parkinson's disease.
Mahlknecht P, Hotter A, Hussl A, Esterhammer R, Schocke M, Seppi K
Neurodegener Dis 2010;7(5):300-18. Epub 2010 Jul 9 doi: 10.1159/000314495. PMID: 20616565

Recent clinical studies

Etiology

Ultra-strong diffusion-weighted MRI reveals cerebellar grey matter abnormalities in movement disorders.
Tax CMW, Genc S, MacIver CL, Nilsson M, Wardle M, Szczepankiewicz F, Jones DK, Peall KJ
Neuroimage Clin 2023;38:103419. Epub 2023 Apr 28 doi: 10.1016/j.nicl.2023.103419. PMID: 37192563Free PMC Article
Diffusely abnormal white matter in multiple sclerosis.
Cairns J, Vavasour IM, Traboulsee A, Carruthers R, Kolind SH, Li DKB, Moore GRW, Laule C
J Neuroimaging 2022 Jan;32(1):5-16. Epub 2021 Nov 9 doi: 10.1111/jon.12945. PMID: 34752664
Methadone-induced encephalopathy: a case series and literature review.
Haghighi-Morad M, Naseri Z, Jamshidi N, Hassanian-Moghaddam H, Zamani N, Ahmad-Molaei L
BMC Med Imaging 2020 Jan 17;20(1):6. doi: 10.1186/s12880-020-0410-9. PMID: 31952488Free PMC Article
Brain imaging in the assessment for epilepsy surgery.
Duncan JS, Winston GP, Koepp MJ, Ourselin S
Lancet Neurol 2016 Apr;15(4):420-33. Epub 2016 Feb 24 doi: 10.1016/S1474-4422(15)00383-X. PMID: 26925532Free PMC Article
The clinical significance of diffusion-weighted MR imaging in stroke and TIA patients.
Engelter ST, Wetzel SG, Bonati LH, Fluri F, Lyrer PA
Swiss Med Wkly 2008 Dec 13;138(49-50):729-40. doi: 10.4414/smw.2008.12249. PMID: 19130326

Diagnosis

Ultra-strong diffusion-weighted MRI reveals cerebellar grey matter abnormalities in movement disorders.
Tax CMW, Genc S, MacIver CL, Nilsson M, Wardle M, Szczepankiewicz F, Jones DK, Peall KJ
Neuroimage Clin 2023;38:103419. Epub 2023 Apr 28 doi: 10.1016/j.nicl.2023.103419. PMID: 37192563Free PMC Article
Using diffusion anisotropy to study cerebral cortical gray matter development.
Kroenke CD
J Magn Reson 2018 Jul;292:106-116. Epub 2018 Apr 26 doi: 10.1016/j.jmr.2018.04.011. PMID: 29705039Free PMC Article
Brain MRI in Parkinson's disease.
Meijer FJ, Goraj B
Front Biosci (Elite Ed) 2014 Jun 1;6(2):360-9. doi: 10.2741/E711. PMID: 24896211
Conventional and diffusion-weighted MRI of the hippocampus.
Szabo K, Förster A, Gass A
Front Neurol Neurosci 2014;34:71-84. Epub 2014 Apr 16 doi: 10.1159/000357925. PMID: 24777132
Parkinson's disease: diagnosis.
Brooks DJ
Parkinsonism Relat Disord 2012 Jan;18 Suppl 1:S31-3. doi: 10.1016/S1353-8020(11)70012-8. PMID: 22166447

Therapy

The vigabatrin-associated brain abnormalities on MRI and their differential diagnosis.
Corrêa DG, Telles B, Freddi TAL
Clin Radiol 2024 Feb;79(2):94-101. Epub 2023 Nov 29 doi: 10.1016/j.crad.2023.11.010. PMID: 38092645
Neonatal encephalopathy prediction of poor outcome with diffusion-weighted imaging connectome and fixel-based analysis.
Jeong JW, Lee MH, Fernandes N, Deol S, Mody S, Arslanturk S, Chinnam RB, Tan S
Pediatr Res 2022 May;91(6):1505-1515. Epub 2021 May 8 doi: 10.1038/s41390-021-01550-2. PMID: 33966055Free PMC Article
Extension of therapeutic window in ischemic stroke by selective mismatch imaging.
Heiss WD, Zaro-Weber O
Int J Stroke 2019 Jun;14(4):351-358. Epub 2019 Apr 1 doi: 10.1177/1747493019840936. PMID: 30935350
Review of diffusion tensor imaging and its application in children.
Vorona GA, Berman JI
Pediatr Radiol 2015 Sep;45 Suppl 3:S375-81. Epub 2015 Sep 7 doi: 10.1007/s00247-015-3277-0. PMID: 26346143
The clinical significance of diffusion-weighted MR imaging in stroke and TIA patients.
Engelter ST, Wetzel SG, Bonati LH, Fluri F, Lyrer PA
Swiss Med Wkly 2008 Dec 13;138(49-50):729-40. doi: 10.4414/smw.2008.12249. PMID: 19130326

Prognosis

Ultra-strong diffusion-weighted MRI reveals cerebellar grey matter abnormalities in movement disorders.
Tax CMW, Genc S, MacIver CL, Nilsson M, Wardle M, Szczepankiewicz F, Jones DK, Peall KJ
Neuroimage Clin 2023;38:103419. Epub 2023 Apr 28 doi: 10.1016/j.nicl.2023.103419. PMID: 37192563Free PMC Article
Defining the phenotypic spectrum of sporadic Creutzfeldt-Jakob disease MV2K: the kuru plaque type.
Baiardi S, Mammana A, Dellavalle S, Rossi M, Redaelli V, Colaizzo E, Di Fede G, Ladogana A, Capellari S, Parchi P
Brain 2023 Aug 1;146(8):3289-3300. doi: 10.1093/brain/awad074. PMID: 36883639Free PMC Article
The new insights into human brain imaging after stroke.
Sagnier S, Sibon I
J Neurosci Res 2022 May;100(5):1171-1181. Epub 2019 Sep 9 doi: 10.1002/jnr.24525. PMID: 31498491
Neuroimaging in rabies.
Laothamatas J, Sungkarat W, Hemachudha T
Adv Virus Res 2011;79:309-27. doi: 10.1016/B978-0-12-387040-7.00014-7. PMID: 21601052
The clinical significance of diffusion-weighted MR imaging in stroke and TIA patients.
Engelter ST, Wetzel SG, Bonati LH, Fluri F, Lyrer PA
Swiss Med Wkly 2008 Dec 13;138(49-50):729-40. doi: 10.4414/smw.2008.12249. PMID: 19130326

Clinical prediction guides

Diffusely abnormal white matter in multiple sclerosis.
Cairns J, Vavasour IM, Traboulsee A, Carruthers R, Kolind SH, Li DKB, Moore GRW, Laule C
J Neuroimaging 2022 Jan;32(1):5-16. Epub 2021 Nov 9 doi: 10.1111/jon.12945. PMID: 34752664
The new insights into human brain imaging after stroke.
Sagnier S, Sibon I
J Neurosci Res 2022 May;100(5):1171-1181. Epub 2019 Sep 9 doi: 10.1002/jnr.24525. PMID: 31498491
Methadone-induced encephalopathy: a case series and literature review.
Haghighi-Morad M, Naseri Z, Jamshidi N, Hassanian-Moghaddam H, Zamani N, Ahmad-Molaei L
BMC Med Imaging 2020 Jan 17;20(1):6. doi: 10.1186/s12880-020-0410-9. PMID: 31952488Free PMC Article
Traumatic brain injury: neuropathological, neurocognitive and neurobehavioral sequelae.
Pavlovic D, Pekic S, Stojanovic M, Popovic V
Pituitary 2019 Jun;22(3):270-282. doi: 10.1007/s11102-019-00957-9. PMID: 30929221
Neuroimaging Applications in Chronic Ataxias.
Mascalchi M, Vella A
Int Rev Neurobiol 2018;143:109-162. Epub 2018 Oct 29 doi: 10.1016/bs.irn.2018.09.011. PMID: 30473193

Recent systematic reviews

Structural magnetic resonance imaging in dystonia: A systematic review of methodological approaches and findings.
MacIver CL, Tax CMW, Jones DK, Peall KJ
Eur J Neurol 2022 Nov;29(11):3418-3448. Epub 2022 Jul 22 doi: 10.1111/ene.15483. PMID: 35785410Free PMC Article
Predicting developmental outcomes in premature infants by term equivalent MRI: systematic review and meta-analysis.
Van't Hooft J, van der Lee JH, Opmeer BC, Aarnoudse-Moens CS, Leenders AG, Mol BW, de Haan TR
Syst Rev 2015 May 17;4:71. doi: 10.1186/s13643-015-0058-7. PMID: 25982565Free PMC Article
A systematic review of diffusion weighted MRI studies of white matter microstructure in adolescent substance users.
Baker ST, Yücel M, Fornito A, Allen NB, Lubman DI
Neurosci Biobehav Rev 2013 Sep;37(8):1713-23. Epub 2013 Jul 8 doi: 10.1016/j.neubiorev.2013.06.015. PMID: 23845745
Alcohol and the human brain: a systematic review of different neuroimaging methods.
Bühler M, Mann K
Alcohol Clin Exp Res 2011 Oct;35(10):1771-93. Epub 2011 Jul 20 doi: 10.1111/j.1530-0277.2011.01540.x. PMID: 21777260
The clinical significance of diffusion-weighted MR imaging in stroke and TIA patients.
Engelter ST, Wetzel SG, Bonati LH, Fluri F, Lyrer PA
Swiss Med Wkly 2008 Dec 13;138(49-50):729-40. doi: 10.4414/smw.2008.12249. PMID: 19130326

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...