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Increased circulating pancreatic triacylglycerol lipase level

MedGen UID:
1719031
•Concept ID:
C5397937
•
Finding
Synonym: Elevated circulating pancreatic triacylglycerol lipase activity
 
HPO: HP:0032932

Definition

An increased level of triacylglycerol lipase in the blood circulation (can be measured in serum or plasma). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating pancreatic triacylglycerol lipase level

Professional guidelines

PubMed

Striated muscle gene therapy for the treatment of lipoprotein lipase deficiency.
Gadek KE, Wang H, Hall MN, Sungello M, Libby A, MacLaskey D, Eckel RH, Olwin BB
PLoS One 2018;13(1):e0190963. Epub 2018 Jan 5 doi: 10.1371/journal.pone.0190963. PMID: 29304082Free PMC Article

Recent clinical studies

Etiology

Associations between Intra-Pancreatic Fat Deposition, Pancreas Size, and Pancreatic Enzymes in Health and after an Attack of Acute Pancreatitis.
Ko J, Skudder-Hill L, Priya S, Kimita W, Bharmal SH, Petrov MS
Obes Facts 2022;15(1):70-82. Epub 2021 Nov 9 doi: 10.1159/000519621. PMID: 34753126Free PMC Article
Striated muscle gene therapy for the treatment of lipoprotein lipase deficiency.
Gadek KE, Wang H, Hall MN, Sungello M, Libby A, MacLaskey D, Eckel RH, Olwin BB
PLoS One 2018;13(1):e0190963. Epub 2018 Jan 5 doi: 10.1371/journal.pone.0190963. PMID: 29304082Free PMC Article
Prolactin and insulin ultradian secretion and adipose tissue lipoprotein lipase expression in severely obese women after bariatric surgery.
Mingrone G, Manco M, Iaconelli A, Gniuli D, Bracaglia R, Leccesi L, Calvani M, Nolfe G, Basu S, Berria R
Obesity (Silver Spring) 2008 Aug;16(8):1831-7. Epub 2008 Jun 5 doi: 10.1038/oby.2008.297. PMID: 18535540
The interrelationship of nutrition and pulmonary function in patients with cystic fibrosis.
Borowitz D
Curr Opin Pulm Med 1996 Nov;2(6):457-61. PMID: 9363185
Serum levels of immunoreactive trypsin during development: comparison with levels of lipase and amylase.
Colombo C, Maiavacca R, Ronchi M, Bottani P, Stripparo L, Corbetta C, Sereni LP
J Pediatr Gastroenterol Nutr 1989 Aug;9(2):194-9. doi: 10.1097/00005176-198908000-00011. PMID: 2478689

Diagnosis

Interpretation of serum pancreatic enzymes in pancreatic and nonpancreatic conditions.
Bush N, Akshintala VS
Curr Opin Gastroenterol 2023 Sep 1;39(5):403-410. Epub 2023 Jun 22 doi: 10.1097/MOG.0000000000000961. PMID: 37389417
Elevated serum pancreatic enzyme levels after hemorrhagic shock predict organ failure and death.
Malinoski DJ, Hadjizacharia P, Salim A, Kim H, Dolich MO, Cinat M, Barrios C, Lekawa ME, Hoyt DB
J Trauma 2009 Sep;67(3):445-9. doi: 10.1097/TA.0b013e3181b5dc11. PMID: 19741384
Prolactin and insulin ultradian secretion and adipose tissue lipoprotein lipase expression in severely obese women after bariatric surgery.
Mingrone G, Manco M, Iaconelli A, Gniuli D, Bracaglia R, Leccesi L, Calvani M, Nolfe G, Basu S, Berria R
Obesity (Silver Spring) 2008 Aug;16(8):1831-7. Epub 2008 Jun 5 doi: 10.1038/oby.2008.297. PMID: 18535540
Role of CCK in regulation of pancreaticobiliary functions and GI motility in humans: effects of loxiglumide.
Schmidt WE, Creutzfeldt W, Schleser A, Choudhury AR, Nustede R, Höcker M, Nitsche R, Sostmann H, Rovati LC, Fölsch UR
Am J Physiol 1991 Feb;260(2 Pt 1):G197-206. doi: 10.1152/ajpgi.1991.260.2.G197. PMID: 1996640

Therapy

Regulation of lipoprotein lipase-mediated lipolysis of triglycerides.
Basu D, Goldberg IJ
Curr Opin Lipidol 2020 Jun;31(3):154-160. doi: 10.1097/MOL.0000000000000676. PMID: 32332431Free PMC Article
The interrelationship of nutrition and pulmonary function in patients with cystic fibrosis.
Borowitz D
Curr Opin Pulm Med 1996 Nov;2(6):457-61. PMID: 9363185
The effect of ERCP on circulating pancreatic enzymes and pancreatic protease inhibitors.
Conn M, Goldenberg A, Concepcion L, Mandeli J
Am J Gastroenterol 1991 Aug;86(8):1011-4. PMID: 1713406
Effect of octreotide acetate on pancreatic exocrine function.
Williams ST, Woltering EA, O'Dorisio TM, Fletcher WS
Am J Surg 1989 May;157(5):459-62. doi: 10.1016/0002-9610(89)90634-x. PMID: 2469337
Hypertriglyceridemia and carbohydrate intolerance: interrelations and therapeutic implications.
Steiner G
Am J Cardiol 1986 May 30;57(14):27G-30G. doi: 10.1016/0002-9149(86)90662-4. PMID: 3521248

Prognosis

A review of animal models of nonneoplastic pancreatic diseases.
Foster JR
Toxicol Pathol 2014 Jan;42(1):243-59. Epub 2013 Oct 31 doi: 10.1177/0192623313508479. PMID: 24178571
Elevated serum pancreatic enzyme levels after hemorrhagic shock predict organ failure and death.
Malinoski DJ, Hadjizacharia P, Salim A, Kim H, Dolich MO, Cinat M, Barrios C, Lekawa ME, Hoyt DB
J Trauma 2009 Sep;67(3):445-9. doi: 10.1097/TA.0b013e3181b5dc11. PMID: 19741384
Prolactin and insulin ultradian secretion and adipose tissue lipoprotein lipase expression in severely obese women after bariatric surgery.
Mingrone G, Manco M, Iaconelli A, Gniuli D, Bracaglia R, Leccesi L, Calvani M, Nolfe G, Basu S, Berria R
Obesity (Silver Spring) 2008 Aug;16(8):1831-7. Epub 2008 Jun 5 doi: 10.1038/oby.2008.297. PMID: 18535540
The interrelationship of nutrition and pulmonary function in patients with cystic fibrosis.
Borowitz D
Curr Opin Pulm Med 1996 Nov;2(6):457-61. PMID: 9363185
Variations in time of serum pancreatic enzyme levels in chronic pancreatitis and clinical course of the disease.
Benini L, Caliari S, Vaona B, Brocco G, Micciolo R, Rizzotti P, Fioretta A, Castellani G, Cavallini G, Scuro LA
Int J Pancreatol 1991 May;8(4):279-87. doi: 10.1007/BF02952721. PMID: 1724259

Clinical prediction guides

Pancreatic enzymes and abdominal adipose tissue distribution in new-onset prediabetes/diabetes after acute pancreatitis.
Ko J, Skudder-Hill L, Cho J, Bharmal SH, Petrov MS
World J Gastroenterol 2021 Jun 21;27(23):3357-3371. doi: 10.3748/wjg.v27.i23.3357. PMID: 34163117Free PMC Article
Elevated serum pancreatic enzyme levels after hemorrhagic shock predict organ failure and death.
Malinoski DJ, Hadjizacharia P, Salim A, Kim H, Dolich MO, Cinat M, Barrios C, Lekawa ME, Hoyt DB
J Trauma 2009 Sep;67(3):445-9. doi: 10.1097/TA.0b013e3181b5dc11. PMID: 19741384
Prolactin and insulin ultradian secretion and adipose tissue lipoprotein lipase expression in severely obese women after bariatric surgery.
Mingrone G, Manco M, Iaconelli A, Gniuli D, Bracaglia R, Leccesi L, Calvani M, Nolfe G, Basu S, Berria R
Obesity (Silver Spring) 2008 Aug;16(8):1831-7. Epub 2008 Jun 5 doi: 10.1038/oby.2008.297. PMID: 18535540
The interrelationship of nutrition and pulmonary function in patients with cystic fibrosis.
Borowitz D
Curr Opin Pulm Med 1996 Nov;2(6):457-61. PMID: 9363185
Elastase-1 vs trypsin, lipase and amylase serum levels in pancreatic diseases.
Benini L, Rizzotti P, Vaona B, Sembenini C, Brocco G, Micciolo R, Chiarioni G, Pederzoli P, Vantini I, Cavallini G
Int J Pancreatol 1987 Oct-Dec;2(5-6):361-70. doi: 10.1007/BF02788435. PMID: 2447209

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