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Tubulointerstitial microganismal infiltration

MedGen UID:
1719430
•Concept ID:
C5397652
•
Finding
HPO: HP:0032635

Definition

Infiltration of microorganisms into renal tubulointerstitial tissues as observed by appropriate staining procedures, e.g., bacteria on a bacterial stain (Brown and Hopps) or fungi on PAS or silver stain. [from HPO]

Professional guidelines

PubMed

Prediction of treatment response in lupus nephritis using density of tubulointerstitial macrophage infiltration.
Wang J, Lou W, Zhu M, Tu Y, Chen D, Qiu D, Xu F, Liang D, Cheng Z, Zhang H
Front Immunol 2024;15:1321507. Epub 2024 Feb 13 doi: 10.3389/fimmu.2024.1321507. PMID: 38415246Free PMC Article
Tubulointerstitial nephritis: diagnosis, treatment, and monitoring.
Joyce E, Glasner P, Ranganathan S, Swiatecka-Urban A
Pediatr Nephrol 2017 Apr;32(4):577-587. Epub 2016 May 7 doi: 10.1007/s00467-016-3394-5. PMID: 27155873Free PMC Article
Renal fibrosis: insights into pathogenesis and treatment.
el Nahas AM, Muchaneta-Kubara EC, Essawy M, Soylemezoglu O
Int J Biochem Cell Biol 1997 Jan;29(1):55-62. doi: 10.1016/s1357-2725(96)00119-7. PMID: 9076941

Recent clinical studies

Etiology

The Mechanistic Role of Different Mediators in the Pathophysiology of Nephropathy: A Review.
Singh J, Jain A, Bhamra R, Rathi V, Dhingra AK
Curr Drug Targets 2023;24(2):104-117. doi: 10.2174/1389450124666221026152647. PMID: 36305150
Tubulointerstitial B-cell infiltration and tertiary lymphoid tissue in adult-onset immunoglobulin A vasculitis with nephritis.
Togashi R, Tamura Y, Arai S, Asakawa S, Yamazaki O, Uchida S, Shibata S, Fujigaki Y
Int Urol Nephrol 2023 Mar;55(3):749-758. Epub 2022 Sep 26 doi: 10.1007/s11255-022-03373-4. PMID: 36155873
Facing the Challenge of Drug-Induced Acute Interstitial Nephritis.
Sanchez-Alamo B, Cases-Corona C, Fernandez-Juarez G
Nephron 2023;147(2):78-90. Epub 2022 Jul 13 doi: 10.1159/000525561. PMID: 35830831
Kidney biopsy findings in vancomycin-induced acute kidney injury: a pooled analysis.
Bellos I, Pergialiotis V, Perrea DN
Int Urol Nephrol 2022 Jan;54(1):137-148. Epub 2021 Mar 14 doi: 10.1007/s11255-021-02831-9. PMID: 33715061
Renal involvement in primary Sjögren syndrome.
François H, Mariette X
Nat Rev Nephrol 2016 Feb;12(2):82-93. Epub 2015 Nov 16 doi: 10.1038/nrneph.2015.174. PMID: 26568188

Diagnosis

Facing the Challenge of Drug-Induced Acute Interstitial Nephritis.
Sanchez-Alamo B, Cases-Corona C, Fernandez-Juarez G
Nephron 2023;147(2):78-90. Epub 2022 Jul 13 doi: 10.1159/000525561. PMID: 35830831
IgG4-related disease: a clinical perspective.
Maritati F, Peyronel F, Vaglio A
Rheumatology (Oxford) 2020 May 1;59(Suppl 3):iii123-iii131. doi: 10.1093/rheumatology/kez667. PMID: 32348524
IgG4-related disease: what a hematologist needs to know.
Chen LYC, Mattman A, Seidman MA, Carruthers MN
Haematologica 2019 Mar;104(3):444-455. Epub 2019 Jan 31 doi: 10.3324/haematol.2018.205526. PMID: 30705099Free PMC Article
Tubulointerstitial nephritis: diagnosis, treatment, and monitoring.
Joyce E, Glasner P, Ranganathan S, Swiatecka-Urban A
Pediatr Nephrol 2017 Apr;32(4):577-587. Epub 2016 May 7 doi: 10.1007/s00467-016-3394-5. PMID: 27155873Free PMC Article
Renal involvement in primary Sjögren syndrome.
François H, Mariette X
Nat Rev Nephrol 2016 Feb;12(2):82-93. Epub 2015 Nov 16 doi: 10.1038/nrneph.2015.174. PMID: 26568188

Therapy

Facing the Challenge of Drug-Induced Acute Interstitial Nephritis.
Sanchez-Alamo B, Cases-Corona C, Fernandez-Juarez G
Nephron 2023;147(2):78-90. Epub 2022 Jul 13 doi: 10.1159/000525561. PMID: 35830831
VX-765 ameliorates renal injury and fibrosis in diabetes by regulating caspase-1-mediated pyroptosis and inflammation.
Wen S, Deng F, Li L, Xu L, Li X, Fan Q
J Diabetes Investig 2022 Jan;13(1):22-33. Epub 2021 Oct 12 doi: 10.1111/jdi.13660. PMID: 34494385Free PMC Article
Tubulointerstitial Nephritis.
Ruebner RL, Fadrowski JJ
Pediatr Clin North Am 2019 Feb;66(1):111-119. doi: 10.1016/j.pcl.2018.08.009. PMID: 30454737
Tubulointerstitial nephritis: diagnosis, treatment, and monitoring.
Joyce E, Glasner P, Ranganathan S, Swiatecka-Urban A
Pediatr Nephrol 2017 Apr;32(4):577-587. Epub 2016 May 7 doi: 10.1007/s00467-016-3394-5. PMID: 27155873Free PMC Article
IgG4-related kidney disease.
Saeki T, Kawano M
Kidney Int 2014 Feb;85(2):251-7. Epub 2013 Oct 9 doi: 10.1038/ki.2013.393. PMID: 24107849

Prognosis

Facing the Challenge of Drug-Induced Acute Interstitial Nephritis.
Sanchez-Alamo B, Cases-Corona C, Fernandez-Juarez G
Nephron 2023;147(2):78-90. Epub 2022 Jul 13 doi: 10.1159/000525561. PMID: 35830831
IgG4-related disease: what a hematologist needs to know.
Chen LYC, Mattman A, Seidman MA, Carruthers MN
Haematologica 2019 Mar;104(3):444-455. Epub 2019 Jan 31 doi: 10.3324/haematol.2018.205526. PMID: 30705099Free PMC Article
Tubulointerstitial Nephritis.
Ruebner RL, Fadrowski JJ
Pediatr Clin North Am 2019 Feb;66(1):111-119. doi: 10.1016/j.pcl.2018.08.009. PMID: 30454737
Tubulointerstitial nephritis: diagnosis, treatment, and monitoring.
Joyce E, Glasner P, Ranganathan S, Swiatecka-Urban A
Pediatr Nephrol 2017 Apr;32(4):577-587. Epub 2016 May 7 doi: 10.1007/s00467-016-3394-5. PMID: 27155873Free PMC Article
Renal involvement in primary Sjögren syndrome.
François H, Mariette X
Nat Rev Nephrol 2016 Feb;12(2):82-93. Epub 2015 Nov 16 doi: 10.1038/nrneph.2015.174. PMID: 26568188

Clinical prediction guides

Tubulointerstitial B-cell infiltration and tertiary lymphoid tissue in adult-onset immunoglobulin A vasculitis with nephritis.
Togashi R, Tamura Y, Arai S, Asakawa S, Yamazaki O, Uchida S, Shibata S, Fujigaki Y
Int Urol Nephrol 2023 Mar;55(3):749-758. Epub 2022 Sep 26 doi: 10.1007/s11255-022-03373-4. PMID: 36155873
IgG4-related nephropathy.
Quattrocchio G, Roccatello D
J Nephrol 2016 Aug;29(4):487-93. Epub 2016 Mar 14 doi: 10.1007/s40620-016-0279-4. PMID: 26972314
IgG4-related disease and the kidney.
Cortazar FB, Stone JH
Nat Rev Nephrol 2015 Oct;11(10):599-609. Epub 2015 Jun 30 doi: 10.1038/nrneph.2015.95. PMID: 26122730
IgG4-related kidney disease.
Saeki T, Kawano M
Kidney Int 2014 Feb;85(2):251-7. Epub 2013 Oct 9 doi: 10.1038/ki.2013.393. PMID: 24107849
IgG4-related kidney disease.
Cornell LD
Semin Diagn Pathol 2012 Nov;29(4):245-50. doi: 10.1053/j.semdp.2012.07.004. PMID: 23068304

Recent systematic reviews

An Emerging Role of TIM3 Expression on T Cells in Chronic Kidney Inflammation.
Lu C, Chen H, Wang C, Yang F, Li J, Liu H, Chen G
Front Immunol 2021;12:798683. Epub 2022 Jan 26 doi: 10.3389/fimmu.2021.798683. PMID: 35154075Free PMC Article
Acute Tubulointerstitial Nephritis in Clinical Oncology: A Comprehensive Review.
Martínez-Valenzuela L, Draibe J, Fulladosa X, Gomà M, Gómez F, Antón P, Cruzado JM, Torras J
Int J Mol Sci 2021 Feb 26;22(5) doi: 10.3390/ijms22052326. PMID: 33652638Free PMC Article

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