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Endometrial Neuroendocrine Carcinoma

MedGen UID:
1721793
•Concept ID:
C5421319
•
Neoplastic Process

Definition

A small cell or large cell neuroendocrine carcinoma arising from the endometrium. [from NCI]

Professional guidelines

PubMed

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
Beyond Serous: Treatment Options for Rare Endometrial Cancers.
Crane E
Curr Treat Options Oncol 2022 Nov;23(11):1590-1600. Epub 2022 Oct 7 doi: 10.1007/s11864-022-01014-7. PMID: 36205807
Neuroendocrine carcinoma of the endometrium: Disease course, treatment, and outcomes.
Schlechtweg K, Chen L, St Clair CM, Tergas AI, Khoury-Collado F, Hou JY, Melamed A, Neugut AI, Hershman DL, Wright JD
Gynecol Oncol 2019 Nov;155(2):254-261. Epub 2019 Sep 10 doi: 10.1016/j.ygyno.2019.09.004. PMID: 31519319

Recent clinical studies

Etiology

Clinical characteristic and prognostic factors in high-grade endometrial neuroendocrine carcinoma.
Zhang Z, Wang J, Wu X, Liu Y, Xi X
J Obstet Gynaecol Res 2022 Aug;48(8):2180-2188. Epub 2022 Jul 1 doi: 10.1111/jog.15321. PMID: 35778826Free PMC Article
Clinicopathological and molecular characteristics of endometrial neuroendocrine carcinomas reveal preexisting endometrial carcinoma origin.
Ono K, Kasajima R, Katayama K, Miyagi Y, Yokose T
Pathol Int 2021 Aug;71(8):491-499. Epub 2021 May 20 doi: 10.1111/pin.13108. PMID: 34015161

Diagnosis

Clinical characteristic and prognostic factors in high-grade endometrial neuroendocrine carcinoma.
Zhang Z, Wang J, Wu X, Liu Y, Xi X
J Obstet Gynaecol Res 2022 Aug;48(8):2180-2188. Epub 2022 Jul 1 doi: 10.1111/jog.15321. PMID: 35778826Free PMC Article
Endometrial neuroendocrine carcinoma and undifferentiated carcinoma are distinct entities with overlap in neuroendocrine marker expression.
Tessier-Cloutier B, Kang EY, Alex D, Stewart CJR, McCluggage WG, Köbel M, Lee CH
Histopathology 2022 Jul;81(1):44-54. Epub 2022 May 5 doi: 10.1111/his.14639. PMID: 35394077
Mixed large and small cell neuroendocrine carcinoma of the endometrium with serous carcinoma: A case report and literature review.
Hu R, Jiang J, Song G, Zhu C, Chen L, Wang C, Wang X
Medicine (Baltimore) 2019 Jul;98(29):e16433. doi: 10.1097/MD.0000000000016433. PMID: 31335697Free PMC Article

Therapy

Mixed large and small cell neuroendocrine carcinoma of the endometrium with serous carcinoma: A case report and literature review.
Hu R, Jiang J, Song G, Zhu C, Chen L, Wang C, Wang X
Medicine (Baltimore) 2019 Jul;98(29):e16433. doi: 10.1097/MD.0000000000016433. PMID: 31335697Free PMC Article

Prognosis

Clinical characteristic and prognostic factors in high-grade endometrial neuroendocrine carcinoma.
Zhang Z, Wang J, Wu X, Liu Y, Xi X
J Obstet Gynaecol Res 2022 Aug;48(8):2180-2188. Epub 2022 Jul 1 doi: 10.1111/jog.15321. PMID: 35778826Free PMC Article
Mixed large and small cell neuroendocrine carcinoma of the endometrium with serous carcinoma: A case report and literature review.
Hu R, Jiang J, Song G, Zhu C, Chen L, Wang C, Wang X
Medicine (Baltimore) 2019 Jul;98(29):e16433. doi: 10.1097/MD.0000000000016433. PMID: 31335697Free PMC Article

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