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Elevated total serum tryptase

MedGen UID:
1725520
•Concept ID:
C5421558
•
Finding
HPO: HP:0031901

Definition

An abnormally elevated concentration of total tryptase (alpha and beta tryptase) in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated total serum tryptase

Professional guidelines

PubMed

Anaphylaxis: Recent advances in assessment and treatment.
Simons FE
J Allergy Clin Immunol 2009 Oct;124(4):625-36; quiz 637-8. doi: 10.1016/j.jaci.2009.08.025. PMID: 19815109

Recent clinical studies

Etiology

Mastocytosis in children: a single-center long-term follow-up study.
Popadic S, Lalosevic J, Lekic B, Gajić-Veljic M, Bonaci-Nikolic B, Nikolic M
Int J Dermatol 2023 May;62(5):616-620. Epub 2023 Feb 20 doi: 10.1111/ijd.16612. PMID: 36807903
Clinical utility of serum tryptase levels in pediatric anaphylaxis.
Şengül Emeksiz Z, Yılmaz D, Alan B, Tunc SD, Dibek Mısırlıoğlu E
Allergy Asthma Proc 2022 Sep 1;43(5):e40-e46. Epub 2022 Jul 1 doi: 10.2500/aap.2022.43.220042. PMID: 35777955
Elevated Basal Serum Tryptase: Disease Distribution and Variability in a Regional Health System.
Waters AM, Park HJ, Weskamp AL, Mateja A, Kachur ME, Lyons JJ, Rosen BJ, Boggs NA
J Allergy Clin Immunol Pract 2022 Sep;10(9):2424-2435.e5. Epub 2022 Jan 12 doi: 10.1016/j.jaip.2021.12.031. PMID: 35032694Free PMC Article
Association of Elevated Serum Tryptase with Cutaneous Photodamage and Skin Cancers.
Komulainen J, Siiskonen H, Harvima IT
Int Arch Allergy Immunol 2021;182(11):1135-1142. Epub 2021 Aug 27 doi: 10.1159/000517287. PMID: 34455412
9. Anaphylaxis.
Simons FE
J Allergy Clin Immunol 2008 Feb;121(2 Suppl):S402-7; quiz S420. doi: 10.1016/j.jaci.2007.08.061. PMID: 18241691

Diagnosis

Mastocytosis in children: a single-center long-term follow-up study.
Popadic S, Lalosevic J, Lekic B, Gajić-Veljic M, Bonaci-Nikolic B, Nikolic M
Int J Dermatol 2023 May;62(5):616-620. Epub 2023 Feb 20 doi: 10.1111/ijd.16612. PMID: 36807903
Elevated Basal Serum Tryptase: Disease Distribution and Variability in a Regional Health System.
Waters AM, Park HJ, Weskamp AL, Mateja A, Kachur ME, Lyons JJ, Rosen BJ, Boggs NA
J Allergy Clin Immunol Pract 2022 Sep;10(9):2424-2435.e5. Epub 2022 Jan 12 doi: 10.1016/j.jaip.2021.12.031. PMID: 35032694Free PMC Article
Diagnostic role of serum tryptase in anaphylactic deaths in forensic medicine: a systematic review and meta-analysis.
Sun KJ, He JT, Huang HY, Xue Y, Xie XL, Wang Q
Forensic Sci Med Pathol 2018 Jun;14(2):209-215. Epub 2018 Apr 21 doi: 10.1007/s12024-018-9980-z. PMID: 29679215
9. Anaphylaxis.
Simons FE
J Allergy Clin Immunol 2008 Feb;121(2 Suppl):S402-7; quiz S420. doi: 10.1016/j.jaci.2007.08.061. PMID: 18241691
Diagnostic value of tryptase in anaphylaxis and mastocytosis.
Schwartz LB
Immunol Allergy Clin North Am 2006 Aug;26(3):451-63. doi: 10.1016/j.iac.2006.05.010. PMID: 16931288

Therapy

Serological profiling reveals hsa-miR-451a as a possible biomarker of anaphylaxis.
Francuzik W, Pažur K, Dalke M, Dölle-Bierke S, Babina M, Worm M
JCI Insight 2022 Apr 8;7(7) doi: 10.1172/jci.insight.156669. PMID: 35202004Free PMC Article
Anaphylaxis: Recent advances in assessment and treatment.
Simons FE
J Allergy Clin Immunol 2009 Oct;124(4):625-36; quiz 637-8. doi: 10.1016/j.jaci.2009.08.025. PMID: 19815109
9. Anaphylaxis.
Simons FE
J Allergy Clin Immunol 2008 Feb;121(2 Suppl):S402-7; quiz S420. doi: 10.1016/j.jaci.2007.08.061. PMID: 18241691
Heparin-induced recurrent anaphylaxis.
Berkun Y, Haviv YS, Schwartz LB, Shalit M
Clin Exp Allergy 2004 Dec;34(12):1916-8. doi: 10.1111/j.1365-2222.2004.02129.x. PMID: 15663568
Anaphylactoid reaction to pentastarch.
McHugh GJ
Can J Anaesth 1998 Mar;45(3):270-2. doi: 10.1007/BF03012915. PMID: 9579268

Prognosis

Mastocytosis in children: a single-center long-term follow-up study.
Popadic S, Lalosevic J, Lekic B, Gajić-Veljic M, Bonaci-Nikolic B, Nikolic M
Int J Dermatol 2023 May;62(5):616-620. Epub 2023 Feb 20 doi: 10.1111/ijd.16612. PMID: 36807903
Severity of SARS-CoV-2 infection is associated with high numbers of alveolar mast cells and their degranulation.
Krysko O, Bourne JH, Kondakova E, Galova EA, Whitworth K, Newby ML, Bachert C, Hill H, Crispin M, Stamataki Z, Cunningham AF, Pugh M, Khan AO, Rayes J, Vedunova M, Krysko DV, Brill A
Front Immunol 2022;13:968981. Epub 2022 Sep 26 doi: 10.3389/fimmu.2022.968981. PMID: 36225927Free PMC Article
Clinical utility of serum tryptase levels in pediatric anaphylaxis.
Şengül Emeksiz Z, Yılmaz D, Alan B, Tunc SD, Dibek Mısırlıoğlu E
Allergy Asthma Proc 2022 Sep 1;43(5):e40-e46. Epub 2022 Jul 1 doi: 10.2500/aap.2022.43.220042. PMID: 35777955
Serological profiling reveals hsa-miR-451a as a possible biomarker of anaphylaxis.
Francuzik W, Pažur K, Dalke M, Dölle-Bierke S, Babina M, Worm M
JCI Insight 2022 Apr 8;7(7) doi: 10.1172/jci.insight.156669. PMID: 35202004Free PMC Article
Postmortem serum levels of tryptase and total and specific IgE in fatal asthma.
Salkie ML, Mitchell I, Revers CW, Karkhanis A, Butt J, Tough S, Green FH
Allergy Asthma Proc 1998 May-Jun;19(3):131-3. doi: 10.2500/108854198778604121. PMID: 9642435

Clinical prediction guides

Clinical utility of serum tryptase levels in pediatric anaphylaxis.
Şengül Emeksiz Z, Yılmaz D, Alan B, Tunc SD, Dibek Mısırlıoğlu E
Allergy Asthma Proc 2022 Sep 1;43(5):e40-e46. Epub 2022 Jul 1 doi: 10.2500/aap.2022.43.220042. PMID: 35777955
Defining baseline variability of serum tryptase levels improves accuracy in identifying anaphylaxis.
Mateja A, Wang Q, Chovanec J, Kim J, Wilson KJ, Schwartz LB, Glover SC, Carter MC, Metcalfe DD, Brittain E, Lyons JJ
J Allergy Clin Immunol 2022 Mar;149(3):1010-1017.e10. Epub 2021 Aug 20 doi: 10.1016/j.jaci.2021.08.007. PMID: 34425177Free PMC Article
Small intestinal immunopathology and GI-associated antibody formation in hereditary alpha-tryptasemia.
Konnikova L, Robinson TO, Owings AH, Shirley JF, Davis E, Tang Y, Wall S, Li J, Hasan MH, Gharaibeh RZ, Mendoza Alvarez LB, Ryan LK, Doty A, Chovanec JF, O'Connell MP, Grunes DE, Daley WP, Mayer E, Chang L, Liu J, Snapper SB, Milner JD, Glover SC, Lyons JJ
J Allergy Clin Immunol 2021 Sep;148(3):813-821.e7. Epub 2021 Apr 15 doi: 10.1016/j.jaci.2021.04.004. PMID: 33865872Free PMC Article
Diagnostic role of serum tryptase in anaphylactic deaths in forensic medicine: a systematic review and meta-analysis.
Sun KJ, He JT, Huang HY, Xue Y, Xie XL, Wang Q
Forensic Sci Med Pathol 2018 Jun;14(2):209-215. Epub 2018 Apr 21 doi: 10.1007/s12024-018-9980-z. PMID: 29679215
Usefulness and limitations of sequential serum tryptase for the diagnosis of anaphylaxis in 102 patients.
Sala-Cunill A, Cardona V, Labrador-Horrillo M, Luengo O, Esteso O, Garriga T, Vicario M, Guilarte M
Int Arch Allergy Immunol 2013;160(2):192-9. Epub 2012 Sep 25 doi: 10.1159/000339749. PMID: 23018683

Recent systematic reviews

Diagnostic role of serum tryptase in anaphylactic deaths in forensic medicine: a systematic review and meta-analysis.
Sun KJ, He JT, Huang HY, Xue Y, Xie XL, Wang Q
Forensic Sci Med Pathol 2018 Jun;14(2):209-215. Epub 2018 Apr 21 doi: 10.1007/s12024-018-9980-z. PMID: 29679215

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