U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal Schwann cell morphology

MedGen UID:
1741566
•Concept ID:
C5421564
•
Finding
Synonyms: Abnormal neurilemmal cell morphology; Abnormal neurilemmocyte morphology
 
HPO: HP:0033035

Definition

Abnormality of schwann cells, glial cells that ensheath axons of neurons in the peripheral nervous system and are necessary for their maintenance and function. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal Schwann cell morphology

Professional guidelines

PubMed

Pathology-supported genetic testing as a method for disability prevention in multiple sclerosis (MS). Part I. Targeting a metabolic model rather than autoimmunity.
van Rensburg SJ, van Toorn R, Erasmus RT, Hattingh C, Johannes C, Moremi KE, Kemp MC, Engel-Hills P, Kotze MJ
Metab Brain Dis 2021 Aug;36(6):1151-1167. Epub 2021 Apr 28 doi: 10.1007/s11011-021-00711-w. PMID: 33909200
Quetiapine fumarate for the treatment of multiple sclerosis: focus on myelin repair.
Zhornitsky S, Wee Yong V, Koch MW, Mackie A, Potvin S, Patten SB, Metz LM
CNS Neurosci Ther 2013 Oct;19(10):737-44. Epub 2013 Jul 22 doi: 10.1111/cns.12154. PMID: 23870612Free PMC Article
Charcot-Marie-Tooth neuropathies: diagnosis and management.
Jani-Acsadi A, Krajewski K, Shy ME
Semin Neurol 2008 Apr;28(2):185-94. doi: 10.1055/s-2008-1062264. PMID: 18351520

Recent clinical studies

Etiology

SOX10: 20 years of phenotypic plurality and current understanding of its developmental function.
Pingault V, Zerad L, Bertani-Torres W, Bondurand N
J Med Genet 2022 Feb;59(2):105-114. Epub 2021 Oct 19 doi: 10.1136/jmedgenet-2021-108105. PMID: 34667088Free PMC Article
Genetic mechanisms of peripheral nerve disease.
Stavrou M, Sargiannidou I, Christofi T, Kleopa KA
Neurosci Lett 2021 Jan 18;742:135357. Epub 2020 Nov 26 doi: 10.1016/j.neulet.2020.135357. PMID: 33249104
White matter changes in Alzheimer's disease: a focus on myelin and oligodendrocytes.
Nasrabady SE, Rizvi B, Goldman JE, Brickman AM
Acta Neuropathol Commun 2018 Mar 2;6(1):22. doi: 10.1186/s40478-018-0515-3. PMID: 29499767Free PMC Article
Update on Charcot-Marie-Tooth disease.
Patzkó A, Shy ME
Curr Neurol Neurosci Rep 2011 Feb;11(1):78-88. doi: 10.1007/s11910-010-0158-7. PMID: 21080241Free PMC Article
Neurofibroma and schwannoma.
Ferner RE, O'Doherty MJ
Curr Opin Neurol 2002 Dec;15(6):679-84. doi: 10.1097/01.wco.0000044763.39452.aa. PMID: 12447105

Diagnosis

SOX10: 20 years of phenotypic plurality and current understanding of its developmental function.
Pingault V, Zerad L, Bertani-Torres W, Bondurand N
J Med Genet 2022 Feb;59(2):105-114. Epub 2021 Oct 19 doi: 10.1136/jmedgenet-2021-108105. PMID: 34667088Free PMC Article
The Complex Clinical and Genetic Landscape of Hereditary Peripheral Neuropathy.
Ghosh S, Tourtellotte WG
Annu Rev Pathol 2021 Jan 24;16:487-509. doi: 10.1146/annurev-pathol-030320-100822. PMID: 33497257
Congenital Opticmeningoceles.
Cruz AAV, Akaishi PMS, Bernardini F, Chahud F
Ophthalmic Plast Reconstr Surg 2021 May-Jun 01;37(3):e109-e111. doi: 10.1097/IOP.0000000000001864. PMID: 33229952
Neurofibroma and schwannoma.
Ferner RE, O'Doherty MJ
Curr Opin Neurol 2002 Dec;15(6):679-84. doi: 10.1097/01.wco.0000044763.39452.aa. PMID: 12447105
Pelizaeus-Merzbacher disease.
Koeppen AH, Robitaille Y
J Neuropathol Exp Neurol 2002 Sep;61(9):747-59. doi: 10.1093/jnen/61.9.747. PMID: 12230321

Therapy

Abnormal oligodendrocyte function in schizophrenia explains the long latent interval in some patients.
Fessel J
Transl Psychiatry 2022 Mar 25;12(1):120. doi: 10.1038/s41398-022-01879-0. PMID: 35338111Free PMC Article
Drug-Induced Demyelinating Neuropathies.
Niimi N, Takaku S, Yako H, Sango K
Adv Exp Med Biol 2019;1190:357-369. doi: 10.1007/978-981-32-9636-7_23. PMID: 31760656
Axonal Guillain-Barré syndrome: concepts and controversies.
Kuwabara S, Yuki N
Lancet Neurol 2013 Dec;12(12):1180-8. doi: 10.1016/S1474-4422(13)70215-1. PMID: 24229616
Non-vision adverse events with vigabatrin therapy.
Walker SD, Kälviäinen R
Acta Neurol Scand Suppl 2011;(192):72-82. doi: 10.1111/j.1600-0404.2011.01602.x. PMID: 22061182
Charcot-Marie-Tooth disease: an update.
Shy ME
Curr Opin Neurol 2004 Oct;17(5):579-85. doi: 10.1097/00019052-200410000-00008. PMID: 15367862

Prognosis

Biological categories of neuroblastoma based on the international neuroblastoma pathology classification for treatment stratification.
Nakazawa A
Pathol Int 2021 Apr;71(4):232-244. Epub 2021 Mar 3 doi: 10.1111/pin.13085. PMID: 33657257
New evidence for secondary axonal degeneration in demyelinating neuropathies.
Moss KR, Bopp TS, Johnson AE, Höke A
Neurosci Lett 2021 Jan 23;744:135595. Epub 2020 Dec 24 doi: 10.1016/j.neulet.2020.135595. PMID: 33359733Free PMC Article
Nodopathies of the peripheral nerve: an emerging concept.
Uncini A, Kuwabara S
J Neurol Neurosurg Psychiatry 2015 Nov;86(11):1186-95. Epub 2015 Feb 19 doi: 10.1136/jnnp-2014-310097. PMID: 25699569
Cytokines and myelination in the central nervous system.
Schmitz T, Chew LJ
ScientificWorldJournal 2008 Nov 2;8:1119-47. doi: 10.1100/tsw.2008.140. PMID: 18979053Free PMC Article
Intrapulmonary schwannoma.
Ohtsuka T, Nomori H, Naruke T, Orikasa H, Yamazaki K, Suemasu K
Jpn J Thorac Cardiovasc Surg 2005 Mar;53(3):154-6. doi: 10.1007/s11748-005-0023-9. PMID: 15828297

Clinical prediction guides

SOX10: 20 years of phenotypic plurality and current understanding of its developmental function.
Pingault V, Zerad L, Bertani-Torres W, Bondurand N
J Med Genet 2022 Feb;59(2):105-114. Epub 2021 Oct 19 doi: 10.1136/jmedgenet-2021-108105. PMID: 34667088Free PMC Article
Central nervous system diseases related to pathological microglial phagocytosis.
Wang K, Li J, Zhang Y, Huang Y, Chen D, Shi Z, Smith AD, Li W, Gao Y
CNS Neurosci Ther 2021 May;27(5):528-539. Epub 2021 Mar 2 doi: 10.1111/cns.13619. PMID: 33650762Free PMC Article
Glial Cell-Derived Neurotrophic Factor Induces Enteric Neurogenesis and Improves Colon Structure and Function in Mouse Models of Hirschsprung Disease.
Soret R, Schneider S, Bernas G, Christophers B, Souchkova O, Charrier B, Righini-Grunder F, Aspirot A, Landry M, Kembel SW, Faure C, Heuckeroth RO, Pilon N
Gastroenterology 2020 Nov;159(5):1824-1838.e17. Epub 2020 Jul 17 doi: 10.1053/j.gastro.2020.07.018. PMID: 32687927
Origin and initiation mechanisms of neuroblastoma.
Tsubota S, Kadomatsu K
Cell Tissue Res 2018 May;372(2):211-221. Epub 2018 Feb 14 doi: 10.1007/s00441-018-2796-z. PMID: 29445860
Schwann cells and the pathogenesis of inherited motor and sensory neuropathies (Charcot-Marie-Tooth disease).
Berger P, Niemann A, Suter U
Glia 2006 Sep;54(4):243-57. doi: 10.1002/glia.20386. PMID: 16856148

Recent systematic reviews

Intraneural perineurioma: a systematic review with illustrative cases.
Boyanton BL Jr, Jones JK, Shenaq SM, Hicks MJ, Bhattacharjee MB
Arch Pathol Lab Med 2007 Sep;131(9):1382-92. doi: 10.5858/2007-131-1382-IPASRW. PMID: 17824794

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...