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Zygotic cleavage failure

MedGen UID:
1741839
•Concept ID:
C5436598
•
Cell or Molecular Dysfunction
Synonym: Failure of zygotic cell division
 
HPO: HP:0033336

Definition

Failure of a fertilized oocyte to undergo the first round of cell division. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVZygotic cleavage failure

Conditions with this feature

Oocyte maturation defect 8
MedGen UID:
1776094
•Concept ID:
C5436597
•
Disease or Syndrome
Oocyte/zygote/embryo maturation arrest-8 (OZEMA8) is characterized by female infertility due to failure of the fertilized ovum to undergo zygotic cleavage (Zheng et al., 2020). For a discussion of genetic heterogeneity of OZEMA, see 615774.
See: Condition Record
Oocyte maturation defect 9
MedGen UID:
1724427
•Concept ID:
C5436599
•
Disease or Syndrome
Oocyte/zygote/embryo maturation arrest-9 (OZEMA9) is characterized by female infertility due to oocyte meiotic arrest at metaphase I in most patients. Abnormal zygotic cleavage has also been observed (Zhang et al., 2020). For a discussion of genetic heterogeneity of OZEMA, see 615774.
See: Condition Record
Oocyte maturation defect 8
Oocyte maturation defect 9

Professional guidelines

PubMed

Increased cleavage rate of human nuclear transfer embryos after 5-aza-2'-deoxycytidine treatment.
Sun L, Wu KL, Zhang D, Wang HY, Wang Y, Xu ZY, Huang XY, Chen ZJ, Liu HQ
Reprod Biomed Online 2012 Oct;25(4):425-33. Epub 2012 Jul 8 doi: 10.1016/j.rbmo.2012.06.018. PMID: 22874064

Recent clinical studies

Diagnosis

Genetic mechanisms of fertilization failure and early embryonic arrest: a comprehensive review.
Wei Y, Wang J, Qu R, Zhang W, Tan Y, Sha Y, Li L, Yin T
Hum Reprod Update 2024 Jan 3;30(1):48-80. doi: 10.1093/humupd/dmad026. PMID: 37758324
A novel homozygous C-terminal deletion in BTG4 causes zygotic cleavage failure and female infertility.
Wang Y, Qin Q, Yang Y, Dong S, Liu Y, Wang M, Zou Y, Gong Y, Zhou H, Jiang B
J Assist Reprod Genet 2023 Jan;40(1):75-81. Epub 2022 Dec 6 doi: 10.1007/s10815-022-02664-0. PMID: 36471203Free PMC Article
A novel homozygous missense variant in BTG4 causes zygotic cleavage failure and female infertility.
Liu R, Zhou Y, Li Q, Chen B, Zhou Z, Wang L, Wang L, Sang Q, Jin L
J Assist Reprod Genet 2021 Dec;38(12):3261-3266. Epub 2021 Oct 14 doi: 10.1007/s10815-021-02340-9. PMID: 34647228Free PMC Article

Therapy

A novel homozygous C-terminal deletion in BTG4 causes zygotic cleavage failure and female infertility.
Wang Y, Qin Q, Yang Y, Dong S, Liu Y, Wang M, Zou Y, Gong Y, Zhou H, Jiang B
J Assist Reprod Genet 2023 Jan;40(1):75-81. Epub 2022 Dec 6 doi: 10.1007/s10815-022-02664-0. PMID: 36471203Free PMC Article

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