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Eye Melanocytoma

MedGen UID:
1742372
•Concept ID:
C5421369
•
Neoplastic Process

Definition

A benign neoplastic melanocytic proliferation affecting the optic disk and optic nerve or the uvea. [from NCI]

Professional guidelines

PubMed

Value of the strain ratio in the differential diagnosis of intraocular tumors by elastosonography: A retrospective case-control study.
Chen W, Yang W, Li D, Wang Z, Zhao Q, Li Y, Cui R, Shen L
Indian J Ophthalmol 2023 Mar;71(3):983-988. doi: 10.4103/ijo.IJO_1397_22. PMID: 36872722Free PMC Article
ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants.
de la Fouchardiere A, Blokx W, van Kempen LC, Luzar B, Piperno-Neumann S, Puig S, Alos L, Calonje E, Massi D; ESP Dermatopathology Working Group; EORTC Melanoma Group; EURACAN
Virchows Arch 2021 Jul;479(1):3-11. Epub 2021 Jan 12 doi: 10.1007/s00428-020-03005-1. PMID: 33432480
Autofluorescence imaging in the differential diagnosis of optic disc melanocytoma.
Salvanos P, Utheim TP, Moe MC, Eide N, Bragadόttir R
Acta Ophthalmol 2015 Aug;93(5):476-480. Epub 2015 Apr 28 doi: 10.1111/aos.12725. PMID: 25923254

Recent clinical studies

Etiology

Partial lamellar sclerouvectomy surgery for anteriorly located uveal tumour resection: a 20-year experience.
Mirzayev I, Gündüz AK, Okçu Heper A
Eye (Lond) 2022 May;36(5):969-977. Epub 2021 May 3 doi: 10.1038/s41433-021-01545-7. PMID: 33941875Free PMC Article
Optic nerve head melanocytoma: Optical coherence tomography/angiography features.
Raval V, Reddy R, Kaliki S, Das T, Singh AD
Indian J Ophthalmol 2021 Feb;69(2):332-336. doi: 10.4103/ijo.IJO_710_20. PMID: 33463586Free PMC Article
Usefulness of PAX8 Immunohistochemistry in Adult Intraocular Tumor Diagnosis.
Mudhar HS, Milman T, Eagle RC Jr, Sanderson T, Pheasey L, Paine S, Salvi S, Rennie IG, Rundle P, Shields CL, Shields JA
Ophthalmology 2021 May;128(5):765-778. Epub 2020 Sep 29 doi: 10.1016/j.ophtha.2020.09.033. PMID: 33002562
Uveal melanoma.
Jager MJ, Shields CL, Cebulla CM, Abdel-Rahman MH, Grossniklaus HE, Stern MH, Carvajal RD, Belfort RN, Jia R, Shields JA, Damato BE
Nat Rev Dis Primers 2020 Apr 9;6(1):24. doi: 10.1038/s41572-020-0158-0. PMID: 32273508
Iris melanocytoma: clinical features and natural course in 47 cases.
Demirci H, Mashayekhi A, Shields CL, Eagle RC Jr, Shields JA
Am J Ophthalmol 2005 Mar;139(3):468-75. doi: 10.1016/j.ajo.2004.10.008. PMID: 15767055

Diagnosis

Clinicopathologic analysis of 32 ciliary body tumors.
Goto H, Yamakawa N, Tsubota K, Umazume K, Usui Y
Jpn J Ophthalmol 2021 Mar;65(2):237-249. Epub 2021 Feb 19 doi: 10.1007/s10384-021-00814-y. PMID: 33606097
Uveal melanoma.
Jager MJ, Shields CL, Cebulla CM, Abdel-Rahman MH, Grossniklaus HE, Stern MH, Carvajal RD, Belfort RN, Jia R, Shields JA, Damato BE
Nat Rev Dis Primers 2020 Apr 9;6(1):24. doi: 10.1038/s41572-020-0158-0. PMID: 32273508
BRCA1-associated protein (BAP1)-inactivated melanocytic tumors.
Zhang AJ, Rush PS, Tsao H, Duncan LM
J Cutan Pathol 2019 Dec;46(12):965-972. Epub 2019 Jul 11 doi: 10.1111/cup.13530. PMID: 31233225
Congenital uveal melanoma?
Singh AD, Schoenfield LA, Bastian BC, Aziz HA, Marino MJ, Biscotti CV
Surv Ophthalmol 2016 Jan-Feb;61(1):59-64. Epub 2015 Aug 12 doi: 10.1016/j.survophthal.2015.07.005. PMID: 26277063
Iris melanocytoma: clinical features and natural course in 47 cases.
Demirci H, Mashayekhi A, Shields CL, Eagle RC Jr, Shields JA
Am J Ophthalmol 2005 Mar;139(3):468-75. doi: 10.1016/j.ajo.2004.10.008. PMID: 15767055

Therapy

Optic disk melanocytoma associated with polypoidal choroidal vasculopathy lesions, after combination treatment of photodynamic therapy and intavitreal aflibercept (Eylea), a case report.
Rouvas A, Gouliopoulos NS, Moschos MM, Theodossiadis P
BMC Ophthalmol 2018 Oct 12;18(1):267. doi: 10.1186/s12886-018-0927-7. PMID: 30309335Free PMC Article
Pigment dispersion syndrome associated with optic nerve melanocytoma.
Asorey-García A, Méndez-Hernández CD, Santos-Bueso E, García-Feijoo J
Arch Soc Esp Oftalmol 2015 Oct;90(10):484-6. Epub 2015 May 23 doi: 10.1016/j.oftal.2015.04.005. PMID: 26008928
Choroidal neovascularization of optic disk melanocytoma treated with bevacizumab.
Kamisasanuk T, Uchino E, Sakamoto T
Eur J Ophthalmol 2012 May-Jun;22(3):503-5. doi: 10.5301/ejo.5000060. PMID: 21959681
Aggressive management of orbital meningeal melanocytoma.
de Tella OI Jr, Agner C, Aguiar PH, Herculano MA, Prandini MN, Stavile JN
Acta Neurochir (Wien) 2003 Dec;145(12):1121-6. Epub 2003 Oct 13 doi: 10.1007/s00701-003-0121-3. PMID: 14663571
Clinical evaluation of posterior embryotoxon in one institution.
Ozeki H, Shirai S, Majima A, Sano M, Ikeda K
Jpn J Ophthalmol 1997 Nov-Dec;41(6):422-5. doi: 10.1016/s0021-5155(97)00080-4. PMID: 9509311

Prognosis

Primary Optic Disc Tumors - Case Series and Literature Overview.
Leclaire MD, Schatten H, Biermann J
Klin Monbl Augenheilkd 2022 Nov;239(11):1325-1336. Epub 2022 Aug 18 doi: 10.1055/a-1927-4111. PMID: 35981557
Iris melanocytoma and secondary glaucoma.
Xavier C, Hipolito-Fernandes D, Cardigos J, Magriço A
BMJ Case Rep 2020 Dec 13;13(12) doi: 10.1136/bcr-2020-237269. PMID: 33318246Free PMC Article
Isolated choroidal melanocytosis: clinical update on 37 cases.
Augsburger JJ, Brooks CC, Correa ZM
Graefes Arch Clin Exp Ophthalmol 2020 Dec;258(12):2819-2829. Epub 2020 Sep 9 doi: 10.1007/s00417-020-04919-x. PMID: 32902757Free PMC Article
Uveal melanoma.
Jager MJ, Shields CL, Cebulla CM, Abdel-Rahman MH, Grossniklaus HE, Stern MH, Carvajal RD, Belfort RN, Jia R, Shields JA, Damato BE
Nat Rev Dis Primers 2020 Apr 9;6(1):24. doi: 10.1038/s41572-020-0158-0. PMID: 32273508
Iris melanocytoma: clinical features and natural course in 47 cases.
Demirci H, Mashayekhi A, Shields CL, Eagle RC Jr, Shields JA
Am J Ophthalmol 2005 Mar;139(3):468-75. doi: 10.1016/j.ajo.2004.10.008. PMID: 15767055

Clinical prediction guides

Ocular circulation change in optic disc melanocytoma - a case report and a review of the literature.
Tsai TY, Tsai YJ, Chu YC, Hwang YS, Liao YL
BMC Ophthalmol 2023 Jan 23;23(1):33. doi: 10.1186/s12886-023-02785-9. PMID: 36690981Free PMC Article
Partial lamellar sclerouvectomy surgery for anteriorly located uveal tumour resection: a 20-year experience.
Mirzayev I, Gündüz AK, Okçu Heper A
Eye (Lond) 2022 May;36(5):969-977. Epub 2021 May 3 doi: 10.1038/s41433-021-01545-7. PMID: 33941875Free PMC Article
Clinicopathologic analysis of 32 ciliary body tumors.
Goto H, Yamakawa N, Tsubota K, Umazume K, Usui Y
Jpn J Ophthalmol 2021 Mar;65(2):237-249. Epub 2021 Feb 19 doi: 10.1007/s10384-021-00814-y. PMID: 33606097
Usefulness of PAX8 Immunohistochemistry in Adult Intraocular Tumor Diagnosis.
Mudhar HS, Milman T, Eagle RC Jr, Sanderson T, Pheasey L, Paine S, Salvi S, Rennie IG, Rundle P, Shields CL, Shields JA
Ophthalmology 2021 May;128(5):765-778. Epub 2020 Sep 29 doi: 10.1016/j.ophtha.2020.09.033. PMID: 33002562
Iris melanocytoma: clinical features and natural course in 47 cases.
Demirci H, Mashayekhi A, Shields CL, Eagle RC Jr, Shields JA
Am J Ophthalmol 2005 Mar;139(3):468-75. doi: 10.1016/j.ajo.2004.10.008. PMID: 15767055

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