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Metastatic Endometrial Endometrioid Adenocarcinoma

MedGen UID:
1742500
•Concept ID:
C5418810
•
Neoplastic Process

Definition

An endometrial endometrioid adenocarcinoma that has spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Endometrial Endometrioid Adenocarcinoma

Professional guidelines

PubMed

Non-exenterative surgical management of recurrent endometrial carcinoma.
Moukarzel LA, Braxton KF, Zhou QC, Pedra Nobre S, Iasonos A, Alektiar KM, Tew WP, Abu-Rustum NR, Leitao MM Jr, Chi DS, Mueller JJ
Gynecol Oncol 2021 Aug;162(2):268-276. Epub 2021 Jun 2 doi: 10.1016/j.ygyno.2021.05.020. PMID: 34090704Free PMC Article
Undifferentiated Endometrial Carcinomas: Clinicopathologic Characteristics and Treatment Outcomes.
Ganju RG, Tawfik O, Brown L, Chen AM, Jewell A, TenNapel M, Hoover A
Int J Gynecol Cancer 2018 Sep;28(7):1271-1277. doi: 10.1097/IGC.0000000000001302. PMID: 30036218
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article

Recent clinical studies

Etiology

PORTEC-4a: international randomized trial of molecular profile-based adjuvant treatment for women with high-intermediate risk endometrial cancer.
van den Heerik ASVM, Horeweg N, Nout RA, Lutgens LCHW, van der Steen-Banasik EM, Westerveld GH, van den Berg HA, Slot A, Koppe FLA, Kommoss S, Mens JWM, Nowee ME, Bijmolt S, Cibula D, Stam TC, Jurgenliemk-Schulz IM, Snyers A, Hamann M, Zwanenburg AG, Coen VLMA, Vandecasteele K, Gillham C, Chargari C, Verhoeven-Adema KW, Putter H, van den Hout WB, Wortman BG, Nijman HW, Bosse T, Creutzberg CL
Int J Gynecol Cancer 2020 Dec;30(12):2002-2007. Epub 2020 Oct 12 doi: 10.1136/ijgc-2020-001929. PMID: 33046573Free PMC Article
Clinicopathological and molecular characterisation of 'multiple-classifier' endometrial carcinomas.
León-Castillo A, Gilvazquez E, Nout R, Smit VT, McAlpine JN, McConechy M, Kommoss S, Brucker SY, Carlson JW, Epstein E, Rau TT, Soslow RA, Ganesan R, Matias-Guiu X, Oliva E, Harrison BT, Church DN, Gilks CB, Bosse T
J Pathol 2020 Mar;250(3):312-322. Epub 2020 Jan 12 doi: 10.1002/path.5373. PMID: 31829447Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523
Substantial lymph-vascular space invasion (LVSI) is a significant risk factor for recurrence in endometrial cancer--A pooled analysis of PORTEC 1 and 2 trials.
Bosse T, Peters EE, Creutzberg CL, Jürgenliemk-Schulz IM, Jobsen JJ, Mens JW, Lutgens LC, van der Steen-Banasik EM, Smit VT, Nout RA
Eur J Cancer 2015 Sep;51(13):1742-50. Epub 2015 Jun 3 doi: 10.1016/j.ejca.2015.05.015. PMID: 26049688

Diagnosis

Endometrial carcinosarcoma.
Bogani G, Ray-Coquard I, Concin N, Ngoi NYL, Morice P, Caruso G, Enomoto T, Takehara K, Denys H, Lorusso D, Coleman R, Vaughan MM, Takano M, Provencher DM, Sagae S, Wimberger P, Póka R, Segev Y, Kim SI, Kim JW, Candido Dos Reis FJ, Ramirez PT, Mariani A, Leitao M, Makker V, Abu-Rustum NR, Vergote I, Zannoni G, Tan D, McCormack M, Paolini B, Bini M, Raspagliesi F, Benedetti Panici P, Di Donato V, Muzii L, Colombo N, Pignata S, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Feb 6;33(2):147-174. doi: 10.1136/ijgc-2022-004073. PMID: 36585027
PORTEC-4a: international randomized trial of molecular profile-based adjuvant treatment for women with high-intermediate risk endometrial cancer.
van den Heerik ASVM, Horeweg N, Nout RA, Lutgens LCHW, van der Steen-Banasik EM, Westerveld GH, van den Berg HA, Slot A, Koppe FLA, Kommoss S, Mens JWM, Nowee ME, Bijmolt S, Cibula D, Stam TC, Jurgenliemk-Schulz IM, Snyers A, Hamann M, Zwanenburg AG, Coen VLMA, Vandecasteele K, Gillham C, Chargari C, Verhoeven-Adema KW, Putter H, van den Hout WB, Wortman BG, Nijman HW, Bosse T, Creutzberg CL
Int J Gynecol Cancer 2020 Dec;30(12):2002-2007. Epub 2020 Oct 12 doi: 10.1136/ijgc-2020-001929. PMID: 33046573Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Cervical Adenocarcinoma: Diagnosis of Human Papillomavirus-Positive and Human Papillomavirus-Negative Tumors.
Pirog EC
Arch Pathol Lab Med 2017 Dec;141(12):1653-1667. Epub 2017 Jun 23 doi: 10.5858/arpa.2016-0356-RA. PMID: 28644686
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523

Therapy

Endometrial carcinosarcoma.
Bogani G, Ray-Coquard I, Concin N, Ngoi NYL, Morice P, Caruso G, Enomoto T, Takehara K, Denys H, Lorusso D, Coleman R, Vaughan MM, Takano M, Provencher DM, Sagae S, Wimberger P, Póka R, Segev Y, Kim SI, Kim JW, Candido Dos Reis FJ, Ramirez PT, Mariani A, Leitao M, Makker V, Abu-Rustum NR, Vergote I, Zannoni G, Tan D, McCormack M, Paolini B, Bini M, Raspagliesi F, Benedetti Panici P, Di Donato V, Muzii L, Colombo N, Pignata S, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Feb 6;33(2):147-174. doi: 10.1136/ijgc-2022-004073. PMID: 36585027
A randomized phase II trial of everolimus and letrozole or hormonal therapy in women with advanced, persistent or recurrent endometrial carcinoma: A GOG Foundation study.
Slomovitz BM, Filiaci VL, Walker JL, Taub MC, Finkelstein KA, Moroney JW, Fleury AC, Muller CY, Holman LL, Copeland LJ, Miller DS, Coleman RL
Gynecol Oncol 2022 Mar;164(3):481-491. Epub 2022 Jan 19 doi: 10.1016/j.ygyno.2021.12.031. PMID: 35063278
PORTEC-4a: international randomized trial of molecular profile-based adjuvant treatment for women with high-intermediate risk endometrial cancer.
van den Heerik ASVM, Horeweg N, Nout RA, Lutgens LCHW, van der Steen-Banasik EM, Westerveld GH, van den Berg HA, Slot A, Koppe FLA, Kommoss S, Mens JWM, Nowee ME, Bijmolt S, Cibula D, Stam TC, Jurgenliemk-Schulz IM, Snyers A, Hamann M, Zwanenburg AG, Coen VLMA, Vandecasteele K, Gillham C, Chargari C, Verhoeven-Adema KW, Putter H, van den Hout WB, Wortman BG, Nijman HW, Bosse T, Creutzberg CL
Int J Gynecol Cancer 2020 Dec;30(12):2002-2007. Epub 2020 Oct 12 doi: 10.1136/ijgc-2020-001929. PMID: 33046573Free PMC Article
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523
Substantial lymph-vascular space invasion (LVSI) is a significant risk factor for recurrence in endometrial cancer--A pooled analysis of PORTEC 1 and 2 trials.
Bosse T, Peters EE, Creutzberg CL, Jürgenliemk-Schulz IM, Jobsen JJ, Mens JW, Lutgens LC, van der Steen-Banasik EM, Smit VT, Nout RA
Eur J Cancer 2015 Sep;51(13):1742-50. Epub 2015 Jun 3 doi: 10.1016/j.ejca.2015.05.015. PMID: 26049688

Prognosis

Clinicopathological and molecular characterisation of 'multiple-classifier' endometrial carcinomas.
León-Castillo A, Gilvazquez E, Nout R, Smit VT, McAlpine JN, McConechy M, Kommoss S, Brucker SY, Carlson JW, Epstein E, Rau TT, Soslow RA, Ganesan R, Matias-Guiu X, Oliva E, Harrison BT, Church DN, Gilks CB, Bosse T
J Pathol 2020 Mar;250(3):312-322. Epub 2020 Jan 12 doi: 10.1002/path.5373. PMID: 31829447Free PMC Article
p53 immunohistochemistry is an accurate surrogate for TP53 mutational analysis in endometrial carcinoma biopsies.
Singh N, Piskorz AM, Bosse T, Jimenez-Linan M, Rous B, Brenton JD, Gilks CB, Köbel M
J Pathol 2020 Mar;250(3):336-345. Epub 2020 Jan 29 doi: 10.1002/path.5375. PMID: 31829441
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523
Substantial lymph-vascular space invasion (LVSI) is a significant risk factor for recurrence in endometrial cancer--A pooled analysis of PORTEC 1 and 2 trials.
Bosse T, Peters EE, Creutzberg CL, Jürgenliemk-Schulz IM, Jobsen JJ, Mens JW, Lutgens LC, van der Steen-Banasik EM, Smit VT, Nout RA
Eur J Cancer 2015 Sep;51(13):1742-50. Epub 2015 Jun 3 doi: 10.1016/j.ejca.2015.05.015. PMID: 26049688

Clinical prediction guides

A randomized phase II trial of everolimus and letrozole or hormonal therapy in women with advanced, persistent or recurrent endometrial carcinoma: A GOG Foundation study.
Slomovitz BM, Filiaci VL, Walker JL, Taub MC, Finkelstein KA, Moroney JW, Fleury AC, Muller CY, Holman LL, Copeland LJ, Miller DS, Coleman RL
Gynecol Oncol 2022 Mar;164(3):481-491. Epub 2022 Jan 19 doi: 10.1016/j.ygyno.2021.12.031. PMID: 35063278
PORTEC-4a: international randomized trial of molecular profile-based adjuvant treatment for women with high-intermediate risk endometrial cancer.
van den Heerik ASVM, Horeweg N, Nout RA, Lutgens LCHW, van der Steen-Banasik EM, Westerveld GH, van den Berg HA, Slot A, Koppe FLA, Kommoss S, Mens JWM, Nowee ME, Bijmolt S, Cibula D, Stam TC, Jurgenliemk-Schulz IM, Snyers A, Hamann M, Zwanenburg AG, Coen VLMA, Vandecasteele K, Gillham C, Chargari C, Verhoeven-Adema KW, Putter H, van den Hout WB, Wortman BG, Nijman HW, Bosse T, Creutzberg CL
Int J Gynecol Cancer 2020 Dec;30(12):2002-2007. Epub 2020 Oct 12 doi: 10.1136/ijgc-2020-001929. PMID: 33046573Free PMC Article
Clinicopathological and molecular characterisation of 'multiple-classifier' endometrial carcinomas.
León-Castillo A, Gilvazquez E, Nout R, Smit VT, McAlpine JN, McConechy M, Kommoss S, Brucker SY, Carlson JW, Epstein E, Rau TT, Soslow RA, Ganesan R, Matias-Guiu X, Oliva E, Harrison BT, Church DN, Gilks CB, Bosse T
J Pathol 2020 Mar;250(3):312-322. Epub 2020 Jan 12 doi: 10.1002/path.5373. PMID: 31829447Free PMC Article
p53 immunohistochemistry is an accurate surrogate for TP53 mutational analysis in endometrial carcinoma biopsies.
Singh N, Piskorz AM, Bosse T, Jimenez-Linan M, Rous B, Brenton JD, Gilks CB, Köbel M
J Pathol 2020 Mar;250(3):336-345. Epub 2020 Jan 29 doi: 10.1002/path.5375. PMID: 31829441
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article

Recent systematic reviews

Levonorgestrel-releasing intrauterine system-based therapies for early-stage endometrial cancer: a systematic review and meta-analysis.
Wei H, Pan N, Zhang W, Xiong G, Guo W, Dong Z, Ma C
J Gynecol Oncol 2023 Mar;34(2):e36. Epub 2023 Jan 18 doi: 10.3802/jgo.2023.34.e36. PMID: 36731895Free PMC Article
Mismatch-repair deficiency, microsatellite instability, and lynch syndrome in ovarian cancer: A systematic review and meta-analysis.
Mitric C, Salman L, Abrahamyan L, Kim SR, Pechlivanoglou P, Chan KKW, Gien LT, Ferguson SE
Gynecol Oncol 2023 Mar;170:133-142. Epub 2023 Jan 20 doi: 10.1016/j.ygyno.2022.12.008. PMID: 36682091
Port-site metastasis after laparoscopic surgical staging of endometrial cancer: a systematic review of the published and unpublished data.
Palomba S, Falbo A, Russo T, La Sala GB
J Minim Invasive Gynecol 2012 Jul-Aug;19(4):531-7. doi: 10.1016/j.jmig.2012.03.023. PMID: 22748961
A systematic review of tests for lymph node status in primary endometrial cancer.
Selman TJ, Mann CH, Zamora J, Khan KS
BMC Womens Health 2008 May 5;8:8. doi: 10.1186/1472-6874-8-8. PMID: 18457596Free PMC Article

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