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Silent Stroke

MedGen UID:
1744033
Concept ID:
C2728316
Disease or Syndrome
Synonym: Silent Cerebral Infarction

Definition

An asymptomatic cerebral infarction that was incidentally noted by T2 or fluid-attenuated inversion recovery (FLAIR) hyperintensities on an MRI of the brain. [from NCI]

Professional guidelines

PubMed

Hernández-Pinilla A, Clua-Espuny JL, Satué-Gracia EM, Pallejà-Millán M, Martín-Luján FM; PREFA-TE Study-Group
BMJ Open 2024 Feb 19;14(2):e080736. doi: 10.1136/bmjopen-2023-080736. PMID: 38373864Free PMC Article
Wu S, Wu B, Liu M, Chen Z, Wang W, Anderson CS, Sandercock P, Wang Y, Huang Y, Cui L, Pu C, Jia J, Zhang T, Liu X, Zhang S, Xie P, Fan D, Ji X, Wong KL, Wang L; China Stroke Study Collaboration
Lancet Neurol 2019 Apr;18(4):394-405. doi: 10.1016/S1474-4422(18)30500-3. PMID: 30878104
Lim JS, Kwon HM
Clin Interv Aging 2010 Sep 7;5:239-51. doi: 10.2147/cia.s7382. PMID: 20852671Free PMC Article

Recent clinical studies

Etiology

Wu S, Wu B, Liu M, Chen Z, Wang W, Anderson CS, Sandercock P, Wang Y, Huang Y, Cui L, Pu C, Jia J, Zhang T, Liu X, Zhang S, Xie P, Fan D, Ji X, Wong KL, Wang L; China Stroke Study Collaboration
Lancet Neurol 2019 Apr;18(4):394-405. doi: 10.1016/S1474-4422(18)30500-3. PMID: 30878104
Chopard R, Piazza G, Gale SA, Campia U, Albertsen IE, Kim J, Goldhaber SZ
Am J Med 2018 Dec;131(12):1408-1417. Epub 2018 Aug 1 doi: 10.1016/j.amjmed.2018.06.035. PMID: 30076825
Jordan LC, DeBaun MR
J Cereb Blood Flow Metab 2018 Sep;38(9):1438-1448. Epub 2017 Apr 18 doi: 10.1177/0271678X17701763. PMID: 28417646Free PMC Article
Hahne K, Mönnig G, Samol A
Vasc Health Risk Manag 2016;12:65-74. Epub 2016 Mar 7 doi: 10.2147/VHRM.S81807. PMID: 27022272Free PMC Article
Buchanan GR, DeBaun MR, Quinn CT, Steinberg MH
Hematology Am Soc Hematol Educ Program 2004:35-47. doi: 10.1182/asheducation-2004.1.35. PMID: 15561675

Diagnosis

Ben Halima M, Ezzaouia K, Boudiche S, Rekik B, Mghaieth F, Ouali S, Zidi A, Mourali MS
Tunis Med 2021 Avril;99(4):416-422. PMID: 35244926Free PMC Article
Hahne K, Mönnig G, Samol A
Vasc Health Risk Manag 2016;12:65-74. Epub 2016 Mar 7 doi: 10.2147/VHRM.S81807. PMID: 27022272Free PMC Article
Pilato F, Profice P, Dileone M, Ranieri F, Capone F, Minicuci G, Tagliente D, Florio L, Di Iorio R, Plantone D, Tonali PA, Di Lazzaro V
Minerva Anestesiol 2009 May;75(5):245-50. Epub 2008 Jul 18 PMID: 18636061
Adams RJ, Ohene-Frempong K, Wang W
Hematology Am Soc Hematol Educ Program 2001:31-46. doi: 10.1182/asheducation-2001.1.31. PMID: 11722977
Masuda J, Nabika T, Notsu Y
Curr Opin Neurol 2001 Feb;14(1):77-82. doi: 10.1097/00019052-200102000-00012. PMID: 11176221

Therapy

Ben Halima M, Ezzaouia K, Boudiche S, Rekik B, Mghaieth F, Ouali S, Zidi A, Mourali MS
Tunis Med 2021 Avril;99(4):416-422. PMID: 35244926Free PMC Article
Chopard R, Piazza G, Gale SA, Campia U, Albertsen IE, Kim J, Goldhaber SZ
Am J Med 2018 Dec;131(12):1408-1417. Epub 2018 Aug 1 doi: 10.1016/j.amjmed.2018.06.035. PMID: 30076825
Grabert S, Lange R, Bleiziffer S
Interact Cardiovasc Thorac Surg 2016 Sep;23(3):469-76. Epub 2016 May 30 doi: 10.1093/icvts/ivw142. PMID: 27241049
Hahne K, Mönnig G, Samol A
Vasc Health Risk Manag 2016;12:65-74. Epub 2016 Mar 7 doi: 10.2147/VHRM.S81807. PMID: 27022272Free PMC Article
Hauville C, Ben-Dor I, Lindsay J, Pichard AD, Waksman R
Cardiovasc Revasc Med 2012 Mar-Apr;13(2):133-40. Epub 2012 Jan 5 doi: 10.1016/j.carrev.2011.11.001. PMID: 22226171

Prognosis

Ben Halima M, Ezzaouia K, Boudiche S, Rekik B, Mghaieth F, Ouali S, Zidi A, Mourali MS
Tunis Med 2021 Avril;99(4):416-422. PMID: 35244926Free PMC Article
Grabert S, Lange R, Bleiziffer S
Interact Cardiovasc Thorac Surg 2016 Sep;23(3):469-76. Epub 2016 May 30 doi: 10.1093/icvts/ivw142. PMID: 27241049
Hahne K, Mönnig G, Samol A
Vasc Health Risk Manag 2016;12:65-74. Epub 2016 Mar 7 doi: 10.2147/VHRM.S81807. PMID: 27022272Free PMC Article
Hauville C, Ben-Dor I, Lindsay J, Pichard AD, Waksman R
Cardiovasc Revasc Med 2012 Mar-Apr;13(2):133-40. Epub 2012 Jan 5 doi: 10.1016/j.carrev.2011.11.001. PMID: 22226171
Buchanan GR, DeBaun MR, Quinn CT, Steinberg MH
Hematology Am Soc Hematol Educ Program 2004:35-47. doi: 10.1182/asheducation-2004.1.35. PMID: 15561675

Clinical prediction guides

Mahmoud AA, Abd El Naby SA, Abdelgawad AS, Rizq MS, Abd El Hady NMS
Pediatr Res 2023 Jun;93(7):1922-1926. Epub 2023 Feb 11 doi: 10.1038/s41390-023-02513-5. PMID: 36774398Free PMC Article
Ben Halima M, Ezzaouia K, Boudiche S, Rekik B, Mghaieth F, Ouali S, Zidi A, Mourali MS
Tunis Med 2021 Avril;99(4):416-422. PMID: 35244926Free PMC Article
Hahne K, Mönnig G, Samol A
Vasc Health Risk Manag 2016;12:65-74. Epub 2016 Mar 7 doi: 10.2147/VHRM.S81807. PMID: 27022272Free PMC Article
Meller SM, Baumbach A, Brickman AM, Lansky AJ
Catheter Cardiovasc Interv 2014 Feb 15;83(3):502-8. Epub 2013 Apr 9 doi: 10.1002/ccd.24904. PMID: 23460315
Buchanan GR, DeBaun MR, Quinn CT, Steinberg MH
Hematology Am Soc Hematol Educ Program 2004:35-47. doi: 10.1182/asheducation-2004.1.35. PMID: 15561675

Recent systematic reviews

Hasson C, Veling L, Rico J, Mhaskar R
Medicine (Baltimore) 2019 Dec;98(51):e18225. doi: 10.1097/MD.0000000000018225. PMID: 31860969Free PMC Article

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